An exposed carboxyl group on sialic acid is essential for gangliosides to inhibit calcium uptake via the sarco/endoplasmic reticulum Ca 2+-ATPase: Relevance to gangliosidoses

Journal of Neurochemistry

Volumn 104, Issue 1, 2008, Pages 140-146

  Ginzburg, Luba ^a   Li, Su Chen ^b   Li, Yu Teh ^b   Futerman, Anthony H ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Ganglioside; Lysosomal storage diseases; N acetylneuraminic acid; Sandhoff disease; Sarco endoplasmic reticulum Ca2+ ATPase; Tay Sachs disease

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); AMIDE; CALCIUM; CARBOHYDRATE; CARBOXYL GROUP; CERAMIDE; ESTER DERIVATIVE; GANGLIOSIDE GM2; GANGLIOSIDE GM3; GANGLIOTETRAOSYLCERAMIDE; HYDROXYMETHYL; METHYL ESTER; METHYL GROUP; SIALIC ACID; TAURINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; DRUG INHIBITION; ENDOPLASMIC RETICULUM; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM;

ANIMALS; BRAIN; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIOSIDES; MICROSOMES; N-ACETYLNEURAMINIC ACID; NAPHTHALENESULFONATES; RATS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SPECTROPHOTOMETRY;

EID: 37249002373     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04983.x     Document Type: Article

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