Structural basis for the resistance of Tay-Sachs ganglioside GM2 to enzymatic degradation

Journal of Biological Chemistry

Volumn 274, Issue 15, 1999, Pages 10014-10018

  Li, Yu Teh ^a   Li, Su Chen ^a   Hasegawa, Akira ^b   Ishida, Hideharu ^b   Kiso, Makoto ^b   Bernardi, Anna ^c   Brocca, Paola ^c   Raimondi, Laura ^c   Sonnino, Sandro ^c  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GIFU UNIVERSITY   (Japan)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; GANGLIOSIDE GM2; OLIGOSACCHARIDE; SIALIDASE;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME STRUCTURE; HUMAN; HUMAN TISSUE; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN ANALYSIS; THIN LAYER CHROMATOGRAPHY;

ACETYLGALACTOSAMINE; BETA-N-ACETYLHEXOSAMINIDASE; BRAIN CHEMISTRY; CARBOHYDRATE CONFORMATION; CHROMATOGRAPHY, THIN LAYER; CLOSTRIDIUM; G(M2) GANGLIOSIDE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; OLIGOSACCHARIDES; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033537958     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.15.10014     Document Type: Article

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