Inflammation and Insulin Resistance in Uremia

Journal of Renal Nutrition

Volumn 18, Issue 1, 2008, Pages 70-75

  Zanetti, Michela ^a   Barazzoni, Rocco ^a   Guarnieri, Gianfranco ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; ARTICLE; CHRONIC KIDNEY FAILURE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGE; MONOCYTE; NEUTROPHIL; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; UREMIA;

ADIPOSE TISSUE; HUMANS; INFLAMMATION; INSULIN RESISTANCE; KIDNEY FAILURE, CHRONIC; MACROPHAGES; MONOCYTES; NEUTROPHILS; OXIDATIVE STRESS; UREMIA;

EID: 37149054939     PISSN: 10512276     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jrn.2007.10.015     Document Type: Article

References (71)

1. Stenvinkel P., Heimburger O., Paultre F., et al. Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney Int 55 (1999) 1899-1911
2. Siew E.D., Pupim L.B., Majchrzak K.M., et al. Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients. Kidney Int 71 (2007) 146-152
3. Shinohara K., Shoji T., Emoto M., et al. Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease. J Am Soc Nephrol 13 (2002) 1894-1900
4. Chen H.H., Wu C.J., Chen Y.C., et al. Metabolic syndrome is associated with severe coronary artery disease and poor cardiac outcome in end-stage renal disease patients with acute coronary syndrome. Coron Artery Dis 17 (2006) 593-596
5. Armstrong K.A., Campbell S.B., Hawley C.M., et al. Impact of obesity on renal transplant outcomes. Nephrology 10 (2005) 405-413
6. Locatelli F., Canaud B., Eckardt K.U., Stenvinkel P., Wanner C., and Zoccali C. Oxidative stress in end-stage renal disease: an emerging threat to patient outcome. Nephrol Dial Transplant 18 (2003) 1272-1280
7. Oberg B.P., McMenamin E., Lucas F.L., et al. Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease. Kidney Int 65 (2004) 1009-1016
8. Kalantar-Zadeh K., and Balakrishnan V.S. The kidney disease wasting: inflammation, oxidative stress, and diet-gene interaction. Hemodial Int 10 (2006) 315-325
9. Hotchkiss R.S., and Karl I.E. The pathophysiology and treatment of sepsis. N Engl J Med 348 (2003) 138-150
10. Rajala M.W., and Scherer P.E. The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144 (2003) 3765-3773
11. Lazar M.A. How obesity causes diabetes: not a tall tale. Science 307 (2005) 373-375
12. Barazzoni R., Biolo G., Zanetti M., Bernardi A., and Guarnieri G. Inflammation and adipose tissue in uremia. J Ren Nutr 16 (2006) 204-207
13. Garibotto G., Sofia A., Procopio V., et al. Peripheral tissue release of interleukin-6 in patients with chronic kidney diseases: effects of end-stage renal disease and microinflammatory state. Kidney Int 70 (2006) 384-390
14. Zanetti M., Barazzoni R., Bosutti A., Stocca A., Grassi G., and Guarnieri G. Vascular sources of oxidative stress: implications for uremia-related cardiovascular disease. J Ren Nutr 17 (2007) 53-56
15. Yoon J.W., Pahl M.V., and Vaziri N.D. Spontaneous leukocyte activation and oxygen-free radical generation in end-stage renal disease. Kidney Int 71 (2007) 167-172
16. Hasselwander O., and Young I.S. Oxidative stress in chronic renal failure. Free Radic Res 29 (1998) 1-11
17. Dounousi E., Papavasiliou E., Makedou A., et al. Oxidative stress is progressively enhanced with advancing stages of CKD. Am J Kidney Dis 48 (2006) 752-760
18. Barazzoni R., Bernardi A., Biasia F., et al. Low fat adiponectin expression is associated with oxidative stress in non-diabetic humans with chronic kidney disease-impact on plasma adiponectin concentration. Am J Physiol Regul Integr Comp Physiol 293 (2007) R47-R54
19. Descamps-Latscha B., Jungers P., and Witko-Sarsat V. Immune system dysregulation in uremia: role of oxidative stress. Blood Purif 20 (2002) 481-484
20. Herbelin A., Urena P., Nguyen A.T., et al. Elevated circulating levels of interleukin-6 in patients with chronic renal failure. Kidney Int 39 (1991) 954-960
21. Rysz J., Banach M., Cialkowska-Rysz A., et al. Blood serum levels of IL-2, IL-6, IL-8, TNF-alpha and IL-1beta in patients on maintenance hemodialysis. Cell Mol Immunol 3 (2006) 151-154
22. Guarnieri G., Toigo G., Fiotti N., et al. Mechanisms of malnutrition in uremia. Kidney Int 62 Suppl (1997) S41-S44
23. Balakrishnan V.S., Schmid C.H., Jaber B.L., et al. Interleukin-1 receptor antagonist synthesis by peripheral blood mononuclear cells: a novel predictor of morbidity among hemodialysis patients. J Am Soc Nephrol 11 (2000) 2114-2121
24. Kosch M., Levers A., Fobker M., et al. Dialysis filter type determines the acute effect of haemodialysis on endothelial function and oxidative stress. Nephrol Dial Transplant 18 (2003) 1370-1375
25. Schindler R., Christ-Kohlrausch F., Frei U., and Shaldon S. Differences in the permeability of high-flux dialyzer membranes for bacterial pyrogens. Clin Nephrol 59 (2003) 447-454
26. Biolo G., Amoroso A., Savoldi S., et al. Association of interferon-gamma +874A polymorphism with reduced long-term inflammatory response in haemodialysis patients. Nephrol Dial Transplant 21 (2006) 1317-1322
27. Balakrishnan V.S., Guo D., Rao M., et al. Cytokine gene polymorphisms in hemodialysis patients: association with comorbidity, functionality, and serum albumin. Kidney Int 65 (2004) 1449-1460
28. Liuzzo G., Santamaria M., Biasucci L.M., et al. Persistent activation of nuclear factor kappa-B signaling pathway in patients with unstable angina and elevated levels of C-reactive protein: evidence for a direct proinflammatory effect of azide and lipopolysaccharide-free C-reactive protein on human monocytes via nuclear factor kappa-B activation. J Am Coll Cardiol 49 (2007) 185-194
29. Morena M., Cristol J.P., Senecal L., et al. Oxidative stress in hemodialysis patients: is NADPH oxidase complex the culprit?. Kidney Int 61 Suppl (2002) S109-S114
30. Witko-Sarsat V., Nguyen-Khoa T., Jungers P., Drueke T.B., and Descamps-Latscha B. Advanced oxidation protein products as a novel molecular basis of oxidative stress in uraemia. Nephrol Dial Transplant 14 Suppl 1 (1999) 76-78
31. Witko-Sarsat V., Gausson V., Nguyen A.T., et al. AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients. Kidney Int 64 (2003) 82-91
32. Barazzoni R., Zanetti M., Stebel M., Biolo G., Cattin L., and Guarnieri G. Hyperleptinemia prevents increased plasma ghrelin concentration during short-term moderate caloric restriction in rats. Gastroenterology 124 (2003) 1188-1192
33. Zanetti M., Barazzoni R., Vadori M., Stebel M., Biolo G., and Guarnieri G. Lack of direct effect of moderate hyperleptinemia to improve endothelial function in lean rat aorta: role of calorie restriction. Atherosclerosis 175 (2004) 253-259
34. Cinti S., Mitchell G., Barbatelli G., et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46 (2005) 2347-2355
35. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., and Ferrante Jr. A.W. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112 (2003) 1796-1808
36. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
37. Barazzoni R., Zanetti M., Bosutti A., et al. Moderate caloric restriction, but not physiological hyperleptinemia per se, enhances mitochondrial oxidative capacity in rat liver and skeletal muscle-tissue-specific impact on tissue triglyceride content and AKT activation. Endocrinology 146 (2005) 2098-2106
38. Loffreda S., Yang S.Q., Lin H.Z., et al. Leptin regulates proinflammatory immune responses. FASEB J 12 (1998) 57-65
39. Yamauchi T., Kamon J., Minokoshi Y., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8 (2002) 1288-1295
40. Shetty G.K., Economides P.A., Horton E.S., Mantzoros C.S., and Veves A. Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care 27 (2004) 2450-2457
41. Kobashi C., Urakaze M., Kishida M., et al. Adiponectin inhibits endothelial synthesis of interleukin-8. Circ Res 97 (2005) 1245-1252
42. Kim K.Y., Kim J.K., Han S.H., et al. Adiponectin is a negative regulator of NK cell cytotoxicity. J Immunol 176 (2006) 5958-5964
43. Furukawa S., Fujita T., Shimabukuro M., et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114 (2004) 1752-1761
44. Subauste A.R., and Burant C.F. Role of FoxO1 in FFA induced oxidative stress in adipocyte. Am J Physiol Endocrinol Metab 293 (2007) E159-E164
45. Kern P.A., Di Gregorio G.B., Lu T., Rassouli N., and Ranganathan G. Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes 52 (2003) 1779-1785
46. Kern P.A., Saghizadeh M., Ong J.M., Bosch R.J., Deem R., and Simsolo R.B. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95 (1995) 2111-2119
47. Merabet E., Dagogo-Jack S., Coyne D.W., et al. Increased plasma leptin concentration in end-stage renal disease. J Clin Endocrinol Metab 82 (1997) 847-850
48. Nordfors L., Lonnqvist F., Heimburger O., Danielsson A., Schalling M., and Stenvinkel P. Low leptin gene expression and hyperleptinemia in chronic renal failure. Kidney Int 54 (1998) 1267-1275
49. Axelsson J., Rashid Qureshi A., Suliman M.E., et al. Truncal fat mass as a contributor to inflammation in end-stage renal disease. Am J Clin Nutr 80 (2004) 1222-1229
50. Axelsson J., Moller H.J., Witasp A., et al. Changes in fat mass correlate with changes in soluble sCD163, a marker of mature macrophages, in patients with CKD. Am J Kidney Dis 48 (2006) 916-925
51. Stenvinkel P., Lindholm B., Lonnqvist F., Katzarski K., and Heimburger O. Increases in serum leptin levels during peritoneal dialysis are associated with inflammation and a decrease in lean body mass. J Am Soc Nephrol 11 (2000) 1303-1309
52. Zoccali C., Tripepi G., Cambareri F., et al. Adipose tissue cytokines, insulin sensitivity, inflammation, and cardiovascular outcomes in end-stage renal disease patients. J Ren Nutr 15 (2005) 125-130
53. Barazzoni R., Zanetti M., Stulle M., et al. High circulating ghrelin is associated with preserved insulin sensitivity in humans with chronic renal failure. Clin Nutr 24 (2005) 660
54. Axelsson J., Bergsten A., Qureshi A.R., et al. Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resistance. Kidney Int 69 (2006) 596-604
55. DeFronzo R.A., Alvestrand A., Smith D., et al. Insulin resistance in uremia. J Clin Invest 67 (1981) 563-568
56. Sechi L.A., Catena C., Zingaro L., et al. Abnormalities of glucose metabolism in patients with early renal failure. Diabetes 51 (2002) 1226-1232
57. Sit D., Kadiroglu A.K., Kayabasi H., et al. The prevalence of insulin resistance in nondiabetic nonobese patients with chronic kidney disease. Adv Ther 23 (2006) 988-998
58. Tonshoff B., Kiepe D., and Ciarmatori S. Growth hormone/insulin-like growth factor system in children with chronic renal failure. Pediatr Nephrol 20 (2005) 279-289
59. Akmal M., Massry S.G., Goldstein D.A., et al. Role of parathyroid hormone in the glucose intolerance of chronic renal failure. J Clin Invest 75 (1985) 1037-1044
60. DeFronzo R.A., and Beckles A.D. Glucose intolerance following chronic metabolic acidosis in man. Am J Physiol 236 (1979) E328-E334
61. Sit D., Kadiroglu A.K., Yilmaz M.E., et al. The prevalence of insulin resistance and its relationship between anemia, secondary hyperparathyroidism, inflammation, and cardiac parameters in chronic hemodialysis patients. Ren Fail 27 (2005) 403-407
62. Birnbaum M.J. Turning down insulin signaling. J Clin Invest 108 (2001) 655-659
63. Alexandraki K., Piperi C., Kalofoutis C., et al. Inflammatory process in type 2 diabetes: the role of cytokines. Ann NY Acad Sci 1084 (2006) 89-117
64. Ruan H., Miles P.D., Ladd C.M., et al. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes 51 (2002) 3176-3188
65. Peraldi P., Xu M., and Spiegelman B.M. Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. J Clin Invest 100 (1997) 1863-1869
66. de Alvaro C., Teruel T., Hernandez R., et al. Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem 279 (2004) 17070-17078
67. Arkan M.C., Hevener A.L., Greten F.R., et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11 (2005) 191-198
68. Demoule A., Divangahi M., Yahiaoui L., et al. Endotoxin triggers nuclear factor-kappaB-dependent up-regulation of multiple proinflammatory genes in the diaphragm. Am J Respir Crit Care Med 174 (2006) 646-653
69. Jager J., Gremeaux T., Cormont M., et al. Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 148 (2007) 241-251
70. Li N., and Karin M. Is NF-kappaB the sensor of oxidative stress?. FASEB J 13 (1999) 1137-1143
71. Kaneto H., Nakatani Y., Kawamori D., et al. Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. Int J Biochem Cell Biol 38 (2006) 782-793