-
2
-
-
0034109921
-
Carcinogenesis in mouse and human cells: Parallels and paradoxes
-
Balmain A, Harris CC. Carcinogenesis in mouse and human cells: parallels and paradoxes. Carcinogenesis. 2000;21(3):371-7.
-
(2000)
Carcinogenesis
, vol.21
, Issue.3
, pp. 371-377
-
-
Balmain, A.1
Harris, C.C.2
-
4
-
-
33845573537
-
Investigation of age-related cognitive decline using mice as a model system: Behavioral correlates
-
Murphy GS, Rahnama NP, Silva AJ. Investigation of age-related cognitive decline using mice as a model system: behavioral correlates. Am J Geriatr Psychiatry. 2006;14(12):1004-11.
-
(2006)
Am J Geriatr Psychiatry
, vol.14
, Issue.12
, pp. 1004-1011
-
-
Murphy, G.S.1
Rahnama, N.P.2
Silva, A.J.3
-
5
-
-
0036346458
-
Generation of genetically altered mouse models for aging studies
-
Treuting P, Hopkins H, Ware C, Rabinovitch P, Ladiges W. Generation of genetically altered mouse models for aging studies. Exp Mol Pathol. 2002;72(1):49-55.
-
(2002)
Exp Mol Pathol
, vol.72
, Issue.1
, pp. 49-55
-
-
Treuting, P.1
Hopkins, H.2
Ware, C.3
Rabinovitch, P.4
Ladiges, W.5
-
6
-
-
0027265595
-
GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function
-
Godfrey P, Rahal JO, Beamer WG, Copeland NG, Jenkins NA, Mayo KE. GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet. 1993;4(3):227-32.
-
(1993)
Nat Genet
, vol.4
, Issue.3
, pp. 227-232
-
-
Godfrey, P.1
Rahal, J.O.2
Beamer, W.G.3
Copeland, N.G.4
Jenkins, N.A.5
Mayo, K.E.6
-
7
-
-
0036210847
-
A personal retrospective on the genetics of aging
-
Johnson TE. A personal retrospective on the genetics of aging. Biogerontology. 2002;3(1-2):7-12.
-
(2002)
Biogerontology
, vol.3
, Issue.1-2
, pp. 7-12
-
-
Johnson, T.E.1
-
8
-
-
10944235398
-
Large-scale identification in yeast of conserved ageing genes
-
Kaeberlein M, Kennedy BK. Large-scale identification in yeast of conserved ageing genes. Mech Ageing Dev. 2005;126(1):17-21.
-
(2005)
Mech Ageing Dev
, vol.126
, Issue.1
, pp. 17-21
-
-
Kaeberlein, M.1
Kennedy, B.K.2
-
9
-
-
0037047423
-
Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity
-
Niswender CM, Ishihara RW, Judge LM, Zhang C, Shokat KM, McKnight GS. Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity. J Biol Chem. 2002;277(32):28916-22.
-
(2002)
J Biol Chem
, vol.277
, Issue.32
, pp. 28916-28922
-
-
Niswender, C.M.1
Ishihara, R.W.2
Judge, L.M.3
Zhang, C.4
Shokat, K.M.5
McKnight, G.S.6
-
10
-
-
0038687689
-
The Ras and Sch9 pathways regulate stress resistance and longevity
-
Longo VD. The Ras and Sch9 pathways regulate stress resistance and longevity. Exp Gerontol. 2003;38(7):807-811.
-
(2003)
Exp Gerontol
, vol.38
, Issue.7
, pp. 807-811
-
-
Longo, V.D.1
-
11
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia K, Chen D, Riddle D. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development. 2004;131(16):3897-906.
-
(2004)
Development
, vol.131
, Issue.16
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.3
-
12
-
-
22344443522
-
A systematic RNAi screen for longevity genes in C. elegans
-
Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 2005;19(13):1544-55.
-
(2005)
Genes Dev
, vol.19
, Issue.13
, pp. 1544-1555
-
-
Hamilton, B.1
Dong, Y.2
Shindo, M.3
Liu, W.4
Odell, I.5
Ruvkun, G.6
Lee, S.S.7
-
13
-
-
0029737861
-
Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A
-
Cummings DE, Brandon EP, Planas JV, Motamed K, Idzerda RL, McKnight GS. Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A. Nature. 1996;382(6592):622-6.
-
(1996)
Nature
, vol.382
, Issue.6592
, pp. 622-626
-
-
Cummings, D.E.1
Brandon, E.P.2
Planas, J.V.3
Motamed, K.4
Idzerda, R.L.5
McKnight, G.S.6
-
14
-
-
0035516189
-
Mutation of the RIIβ subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice
-
Schreyer SA, Cummings DE, McKnight GS, LeBoeuf RC. Mutation of the RIIβ subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice. Diabetes. 2001;50(11):2555-62.
-
(2001)
Diabetes
, vol.50
, Issue.11
, pp. 2555-2562
-
-
Schreyer, S.A.1
Cummings, D.E.2
McKnight, G.S.3
LeBoeuf, R.C.4
-
15
-
-
15444377729
-
Deletion of the RIIβ-subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptin-deficient ob/ob mouse
-
Newhall KJ, Cummings DE, Nolan MA, McKnight GS. Deletion of the RIIβ-subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptin-deficient ob/ob mouse. Mol Endocrinol. 2005;19(4):982-91.
-
(2005)
Mol Endocrinol
, vol.19
, Issue.4
, pp. 982-991
-
-
Newhall, K.J.1
Cummings, D.E.2
Nolan, M.A.3
McKnight, G.S.4
-
16
-
-
4544235732
-
The role of uncoupling protein 1 in the metabolism and adiposity of RIIβ-protein kinase A-deficient mice
-
Nolan MA, Sikorski MA, McKnight GS. The role of uncoupling protein 1 in the metabolism and adiposity of RIIβ-protein kinase A-deficient mice. Mol Endocrinol. 2004;18(4):2302-11.
-
(2004)
Mol Endocrinol
, vol.18
, Issue.4
, pp. 2302-2311
-
-
Nolan, M.A.1
Sikorski, M.A.2
McKnight, G.S.3
-
17
-
-
20144386666
-
Pancreatic β cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum stress response gene P58IPK
-
Ladiges WC, Knoblaugh SE, Morton JF, Korth MJ, Sopher BL, Baskin CR, MacAuley A, Goodman AG, LeBoeuf RC, Katze MG. Pancreatic β cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum stress response gene P58IPK. Diabetes. 2005;54(4):1074-81.
-
(2005)
Diabetes
, vol.54
, Issue.4
, pp. 1074-1081
-
-
Ladiges, W.C.1
Knoblaugh, S.E.2
Morton, J.F.3
Korth, M.J.4
Sopher, B.L.5
Baskin, C.R.6
MacAuley, A.7
Goodman, A.G.8
LeBoeuf, R.C.9
Katze, M.G.10
-
18
-
-
0042859792
-
Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation
-
Okumura S, Kawabe J, Yatani A, Takagi G, Lee MC, Hong C, Liu J, Takagi I, Sadoshima J, Vatner DE, Vantner SF, Ishikawa Y. Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation. Circ Res. 2003;93(4):364-74.
-
(2003)
Circ Res
, vol.93
, Issue.4
, pp. 364-374
-
-
Okumura, S.1
Kawabe, J.2
Yatani, A.3
Takagi, G.4
Lee, M.C.5
Hong, C.6
Liu, J.7
Takagi, I.8
Sadoshima, J.9
Vatner, D.E.10
Vantner, S.F.11
Ishikawa, Y.12
-
19
-
-
14544267529
-
Accelerated Barnes maze test in mice for assessment of stress effects on memory
-
Dawood MY, Lumley LA, Robison CL, Saviolakis GA, Meyerhoff JL. Accelerated Barnes maze test in mice for assessment of stress effects on memory. Ann N Y Acad Sci. 2004;1032:304-7.
-
(2004)
Ann N Y Acad Sci
, vol.1032
, pp. 304-307
-
-
Dawood, M.Y.1
Lumley, L.A.2
Robison, C.L.3
Saviolakis, G.A.4
Meyerhoff, J.L.5
-
20
-
-
5644244817
-
Requirement for the RIIβ isoform of PKA, but not calcium-stimulated adenylyl cyclase, in visual cortical plasticity
-
Fischer QS, Beaver CJ, Yang Y, Rao Y, Jakobsdottir KB, Storm DR, McKnight GS, Daw NW. Requirement for the RIIβ isoform of PKA, but not calcium-stimulated adenylyl cyclase, in visual cortical plasticity. J Neurosci. 2004;24(41):9049-58.
-
(2004)
J Neurosci
, vol.24
, Issue.41
, pp. 9049-9058
-
-
Fischer, Q.S.1
Beaver, C.J.2
Yang, Y.3
Rao, Y.4
Jakobsdottir, K.B.5
Storm, D.R.6
McKnight, G.S.7
Daw, N.W.8
-
21
-
-
0036351299
-
Molecular and behavioral effects of a null mutation in all PKA C β isoforms
-
Howe DG, Wiley JC, McKnight GS. Molecular and behavioral effects of a null mutation in all PKA C β isoforms. Mol Cell Neurosci. 2002;20(3):515-24.
-
(2002)
Mol Cell Neurosci
, vol.20
, Issue.3
, pp. 515-524
-
-
Howe, D.G.1
Wiley, J.C.2
McKnight, G.S.3
-
22
-
-
0036008839
-
Mutation of the Cα subunit of PKA leads to growth retardation and sperm dysfunction
-
Skalhegg BS, Huang Y, Su T, Idzerda RL, McKnight GS, Burton KA. Mutation of the Cα subunit of PKA leads to growth retardation and sperm dysfunction. Mol Endocrinol. 2002;16(3):630-9.
-
(2002)
Mol Endocrinol
, vol.16
, Issue.3
, pp. 630-639
-
-
Skalhegg, B.S.1
Huang, Y.2
Su, T.3
Idzerda, R.L.4
McKnight, G.S.5
Burton, K.A.6
-
23
-
-
0032426667
-
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
-
Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci U S A. 1998;95(25):15020-5.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.25
, pp. 15020-15025
-
-
Barad, M.1
Bourtchouladze, R.2
Winder, D.G.3
Golan, H.4
Kandel, E.5
-
24
-
-
85036979983
-
-
Langreth R. Viagra for the brain. Forbes. 2002; February 4.
-
Langreth R. Viagra for the brain. Forbes. 2002; February 4.
-
-
-
-
25
-
-
34047151226
-
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
-
Tong JJ, Schriner SE, McCleary D, Day BJ, Wallace DC. Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet. 2007;39(4):476-485.
-
(2007)
Nat Genet
, vol.39
, Issue.4
, pp. 476-485
-
-
Tong, J.J.1
Schriner, S.E.2
McCleary, D.3
Day, B.J.4
Wallace, D.C.5
-
26
-
-
0242460552
-
Dysregulation of protein kinase A signaling in the aged prefrontal cortex: New strategy for treating age-related cognitive decline
-
Ramos BP, Birnbaum SG, Lindenmayer I, Newton SS, Duman RS, Arnsten AF. Dysregulation of protein kinase A signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline. Neuron. 2003;40(4):835-45.
-
(2003)
Neuron
, vol.40
, Issue.4
, pp. 835-845
-
-
Ramos, B.P.1
Birnbaum, S.G.2
Lindenmayer, I.3
Newton, S.S.4
Duman, R.S.5
Arnsten, A.F.6
-
27
-
-
0019644298
-
The aging process
-
Harman D. The aging process. Proc Natl Acad Sci U S A. 1981;78(11):7124-8.
-
(1981)
Proc Natl Acad Sci U S A
, vol.78
, Issue.11
, pp. 7124-7128
-
-
Harman, D.1
-
28
-
-
0031916984
-
The free radical theory of aging matures
-
Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998;78(2):547-81.
-
(1998)
Physiol Rev
, vol.78
, Issue.2
, pp. 547-581
-
-
Beckman, K.B.1
Ames, B.N.2
-
29
-
-
0028220114
-
Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
-
Orr WC, Sohal RS. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 1994;263(5150):1128- 30.
-
(1994)
Science
, vol.263
, Issue.5150
, pp. 1128-1130
-
-
Orr, W.C.1
Sohal, R.S.2
-
30
-
-
0024758449
-
-
Rose MR. Genetics of increased lifespan in Drosophila. Bioessays. 191989;11(5):132-5.
-
Rose MR. Genetics of increased lifespan in Drosophila. Bioessays. 191989;11(5):132-5.
-
-
-
-
31
-
-
0031968477
-
Immunological confirmation of elevated levels of CuZn superoxide dismutase protein in an artificially selected long-lived strain of Drosophila melanogaster
-
Hari R, Burde V, Arking R. Immunological confirmation of elevated levels of CuZn superoxide dismutase protein in an artificially selected long-lived strain of Drosophila melanogaster. Exp Gerontol. 1998;33(3):227-37.
-
(1998)
Exp Gerontol
, vol.33
, Issue.3
, pp. 227-237
-
-
Hari, R.1
Burde, V.2
Arking, R.3
-
32
-
-
0027515616
-
Aging and resistance to oxidative damage in Caenorhabditis elegans
-
Larsen PL. Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1993;90(19):8905-9.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, Issue.19
, pp. 8905-8909
-
-
Larsen, P.L.1
-
33
-
-
0034006162
-
Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice
-
Huang T-T, Carlson EJ, Gillespie AM, Shi Y, Epstein CJ. Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. J Gerontol A Biol Sci Med Sci. 2000;55(1):B5-9.
-
(2000)
J Gerontol A Biol Sci Med Sci
, vol.55
, Issue.1
-
-
Huang, T.-T.1
Carlson, E.J.2
Gillespie, A.M.3
Shi, Y.4
Epstein, C.J.5
-
34
-
-
0036671827
-
Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span
-
Mitsui A, Hamuro J, Nakamura H, Kondo N, Hirabayashi Y, Ishizaki-Koizumi S, Hirakawa T, Inoue T, Yodoi J. Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxid Redox Signal.. 2002;4(4):693-6.
-
(2002)
Antioxid Redox Signal
, vol.4
, Issue.4
, pp. 693-696
-
-
Mitsui, A.1
Hamuro, J.2
Nakamura, H.3
Kondo, N.4
Hirabayashi, Y.5
Ishizaki-Koizumi, S.6
Hirakawa, T.7
Inoue, T.8
Yodoi, J.9
-
35
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges WC, Wolf N, Remmen HV, Wallace DC, Rabinovitch PS. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005;308 (5730):1909-11.
-
(2005)
Science
, vol.308
, Issue.5730
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
Treuting, P.4
Ogburn, C.E.5
Emond, M.6
Coskun, P.E.7
Ladiges, W.C.8
Wolf, N.9
Remmen, H.V.10
Wallace, D.C.11
Rabinovitch, P.S.12
-
36
-
-
25444515720
-
Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons
-
Ryu H, Lee J, Impey S, Ratan RR, Ferrante RJ. Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons. Proc Natl Acad Sci U S A. 2005;102(39):13915-20.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.39
, pp. 13915-13920
-
-
Ryu, H.1
Lee, J.2
Impey, S.3
Ratan, R.R.4
Ferrante, R.J.5
|