Functional and morphological changes in the dentate gyrus after experimental status epilepticus

Seizure

Volumn 17, Issue 1, 2008, Pages 76-83

  Matzen, Julia ^a   Buchheim, Katharina ^a   van Landeghem, Frank K H ^a   Meierkord, Hartmut ^a   Holtkamp, Martin ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Chronic epilepsy; Dentate gyrus; Excitation; Experimental status epilepticus; Neuronal loss

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DENTATE GYRUS; ELECTRODE; EPILEPTIC FOCUS; EPILEPTIC STATE; EPILEPTOGENESIS; HIPPOCAMPUS; MALE; NERVE CELL DEGENERATION; NERVE CELL STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CHRONIC DISEASE; DATA INTERPRETATION, STATISTICAL; DENTATE GYRUS; ELECTRIC STIMULATION; ELECTRODES, IMPLANTED; EXCITATORY POSTSYNAPTIC POTENTIALS; FLUORESCENT DYES; MALE; NEURONS; ORGANIC CHEMICALS; RATS; STATUS EPILEPTICUS; VIDEOTAPE RECORDING;

EID: 37149029178     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seizure.2007.07.008     Document Type: Article

References (40)

1. Shorvon S.D. Status epilepticus: its clinical features and treatment in children and adults (1994), Cambridge University Press, Cambridge, UK
2. Aminoff M.J., and Simon R.P. Status epilepticus. Causes, clinical features and consequences in 98 patients. Am J Med 69 (1980) 657-666
3. Shneker B.F., and Fountain N.B. Assessment of acute morbidity and mortality in nonconvulsive status epilepticus. Neurology 61 (2003) 1066-1073
4. Hesdorffer D.C., Logroscino G., Cascino G., Annegers J.F., and Hauser W.A. Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus. Ann Neurol 44 (1998) 908-912
5. Holtkamp M., Othman J., Buchheim K., and Meierkord H. Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit. J Neurol Neurosurg Psychiatry 76 (2005) 534-539
6. Chen J.W., and Wasterlain C.G. Status epilepticus: pathophysiology and management in adults. Lancet Neurol 5 (2006) 246-256
7. Heinemann U., Beck H., Dreier J.P., Ficker E., Stabel J., and Zhang C.L. The dentate gyrus as a regulated gate for the propagation of epileptiform activity. Epilepsy Res Suppl 7 (1992) 273-280
8. Lothman E.W., Stringer J.L., and Bertram E.H. The dentate gyrus as a control point for seizures in the hippocampus and beyond. Epilepsy Res Suppl 7 (1992) 301-313
9. Behr J., Lyson K.J., and Mody I. Enhanced propagation of epileptiform activity through the kindled dentate gyrus. J Neurophysiol 79 (1998) 1726-1732
10. Winson J., and Abzug C. Neuronal transmission through hippocampal pathways dependent on behavior. J Neurophysiol 41 (1978) 716-732
11. Kobayashi M., and Buckmaster P.S. Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy. J Neurosci 23 (2003) 2440-2452
12. Gorter J.A., van Vliet E.A., Aronica E., and Lopes-da-Silva F.H. Long-lasting increased excitability differs in dentate gyrus vs. CA1 in freely moving chronic epileptic rats after electrically induced status epilepticus. Hippocampus 12 (2002) 311-324
13. Bausch S.B., and McNamara J.O. Contributions of mossy fiber and CA1 pyramidal cell sprouting to dentate granule cell hyperexcitability in kainic acid-treated hippocampal slice cultures. J Neurophysiol 92 (2004) 3582-3595
14. Shirasaka Y., and Wasterlain C.G. Chronic epileptogenicity following focal status epilepticus. Brain Res 655 (1994) 33-44
15. Schmued L.C., Albertson C., and Slikker Jr. W. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res 751 (1997) 37-46
16. Schmued L.C., and Hopkins K.J. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 874 (2000) 123-130
17. Zsombok A., Toth Z., and Gallyas F. Basophilia, acidophilia and argyrophilia of "dark" (compacted) neurons during their formation, recovery or death in an otherwise undamaged environment. J Neurosci Methods 142 (2005) 145-152
18. Gorter J.A., Goncalves Pereira P.M., van Vliet E.A., Aronica E., Lopes da Silva F.H., and Lucassen P.J. Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures. Epilepsia 44 (2003) 647-658
19. Pitkanen A., Nissinen J., Nairismagi J., et al. Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy. Prog Brain Res 135 (2002) 67-83
20. Holtkamp M., Matzen J., van Landeghem F., Buchheim K., and Meierkord H. Transient loss of inhibition precedes spontaneous seizures after experimental status epilepticus. Neurobiol Dis (2005) [Epub Feb 2005]
21. Racine R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32 (1972) 281-294
22. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 6th ed. (2006), Academic Press, New York
23. Lothman E.W., Bertram E.H., Kapur J., and Stringer J.L. Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus. Epilepsy Res 6 (1990) 110-118
24. Mathern G.W., Bertram III E.H., Babb T.L., et al. In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic status model correlates with greater aberrant fascia dentata excitatory and inhibitory axon sprouting, and increased staining for N-methyl-d-aspartate, AMPA and GABA(A) receptors. Neuroscience 77 (1997) 1003-1019
25. Gorter J.A., van Vliet E.A., Aronica E., and Lopes da Silva F.H. Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons. Eur J Neurosci 13 (2001) 657-669
26. Lemos T., and Cavalheiro E.A. Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats. Exp Brain Res 102 (1995) 423-428
27. Brandt C., Glien M., Potschka H., Volk H., and Loscher W. Epileptogenesis and neuropathology after different types of status epilepticus induced by prolonged electrical stimulation of the basolateral amygdala in rats. Epilepsy Res 55 (2003) 83-103
28. Hellier J.L., Patrylo P.R., Dou P., Nett M., Rose G.M., and Dudek F.E. Assessment of inhibition and epileptiform activity in the septal dentate gyrus of freely behaving rats during the first week after kainate treatment. J Neurosci 19 (1999) 10053-10064
29. Scimemi A., Schorge S., Kullmann D.M., and Walker M.C. Epileptogenesis is associated with enhanced glutamatergic transmission in the perforant path. J Neurophysiol 95 (2006) 1213-1220
30. Blumcke I., Becker A.J., Klein C., et al. Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients. J Neuropathol Exp Neurol 59 (2000) 1-10
31. Mathern G.W., Pretorius J.K., Leite J.P., et al. Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy. Epilepsy Res 32 (1998) 154-171
32. Gorter J.A., Borgdorff A.J., van Vliet E.A., Lopes da Silva F.H., and Wadman W.J. Differential and long-lasting alterations of high-voltage activated calcium currents in CA1 and dentate granule neurons after status epilepticus. Eur J Neurosci 16 (2002) 701-712
33. Ellerkmann R.K., Remy S., Chen J., et al. Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience 119 (2003) 323-333
34. Michelson H.B., and Lothman E.W. An in vivo electrophysiological study of the ontogeny of excitatory and inhibitory processes in the rat hippocampus. Brain Res Dev Brain Res 47 (1989) 113-122
35. Joy R.M., and Albertson T.E. Factors responsible for increased excitability of dentate gyrus granule cells during exposure to lindane. Neurotoxicology 8 (1987) 517-527
36. Santhakumar V., Voipio J., Kaila K., and Soltesz I. Post-traumatic hyperexcitability is not caused by impaired buffering of extracellular potassium. J Neurosci 23 (2003) 5865-5876
37. Andersen P., Bliss T.V., and Skrede K.K. Unit analysis of hippocampal population spikes. Exp Brain Res 13 (1971) 208-221
38. Wuarin J.P., and Dudek F.E. Excitatory synaptic input to granule cells increases with time after kainate treatment. J Neurophysiol 85 (2001) 1067-1077
39. Sloviter R.S. Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: the "dormant basket cell" hypothesis and its possible relevance to temporal lobe epilepsy. Hippocampus 1 (1991) 41-66
40. Collins R.C., Tearse R.G., and Lothman E.W. Functional anatomy of limbic seizures: focal discharges from medial entorhinal cortex in rat. Brain Res 280 (1983) 25-40