In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic status model correlates with greater aberrant fascia dentata excitatory and inhibitory axon sprouting, and increased staining for N-methyl-D-aspartate, AMPA and GABAA receptors

Neuroscience

Volumn 77, Issue 4, 1997, Pages 1003-1019

  Mathern, G W ^a,b   Bertram III, E H ^c   Babb, T L ^d   Pretorius, J K ^a   Kuhlman, P A ^a   Spradlin, S ^c   Mendoza, D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Complex partial seizures; Epilepsy; Excitation; Inhibition; NIH image; Reactive synaptogenesis

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AMPA RECEPTOR; GLUTAMATE DECARBOXYLASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPILEPSY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; KINDLING; MALE; NERVE CELL PLASTICITY; NERVE SPROUTING; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALS; AXONS; CELL COUNT; DENTATE GYRUS; EPILEPSY, COMPLEX PARTIAL; IMMUNOHISTOCHEMISTRY; KINDLING, NEUROLOGIC; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, GABA-A; RECEPTORS, N-METHYL-D-ASPARTATE; STAINING AND LABELING; SYNAPSES;

EID: 0030891017     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0306-4522(96)00516-7     Document Type: Article

References (9)

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3. Babb T. L., Kupfer W. R., Pretorius J. K., Crandall P. H. and Levesque M. F. (1991) Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience 42, 351-363.
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6. Babb T. L., Pretorius J. K., Kupfer W. R. and Crandall P. H. (1989) Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus. J. Neurosci. 9, 2562-2574.
7. Babb T. L., Pretorius J. K., Kupfer W. R., Mathern G. W., Crandall P. H. and Levesque M. F. (1992) Aberrant synaptic reorganization in human epileptic hippocampus: evidence for feedforward excitation. Dendron 1, 7-25.
8. Bertram E. H. and Cornell J. (1993) The ontogeny of seizures in a rat model of limbic epilepsy: evidence for a kindling process in the developmenl of chronic spontaneous seizures. Brain Res. 625, 295-300.
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