Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: Correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients

Journal of Neuropathology and Experimental Neurology

Volumn 59, Issue 1, 2000, Pages 1-10

  Blümcke, Ingmar ^a   Becker, Albert J ^a   Klein, Carsten ^a   Scheiwe, Christian ^a   Lie, Ailing A ^a   Beck, Heinz ^a   Waha, Andreas ^a   Friedl, Marcus G ^a   Kuhn, Rainer ^b   Emson, Piers ^c   Elger, Christian ^a   Wiestler, Otmar D ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Hippocampus; Immunohistochemistry; Kainate; Kindling; Seizures

Indexed keywords

KAINIC ACID; MESSENGER RNA; METABOTROPIC RECEPTOR; RECEPTOR SUBTYPE;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; DENTATE GYRUS; GENE EXPRESSION; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KINDLING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RECEPTOR UPREGULATION; TEMPORAL LOBE EPILEPSY;

EID: 0342980411     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/59.1.1     Document Type: Article

References (50)

1. Blümcke I, Beck H, Lie AA, Wiestler OD. Molecular neuropathology of human mesial temporal lobe epilepsy. Epilepsy Res 1999; 36:205-23.
2. Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Coulter DA. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat Med 1998;4: 1166-72
3. Nusser Z, Hajos N, Somogyi P, Mody I. Increased number of synaptic GABA(A) receptors underlies potentiation at hippocampal inhibitory synapses. Nature 1998;395:172-77
4. Shumate MD, Lin DD, Gibbs JWr, Holloway KL, Coulter DA. GABA(A) receptor function in epileptic human dentate granule cells: Comparison to epileptic and control rat. Epilepsy Res 1998;32:114-28
5. Conn PJ, Pin JP. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 1997;37:205-37
6. Nicoletti F, Bruno V, Copani A, Casabona G, Knöpfel T. Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders? Trends Neurosci 1996;19:267-71
7. Baude A, Nusser Z, Roberts JD, Mulvihill E, McIlhinney RA, Somogyi P. The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Neuron 1993;11:771-87
8. Shigemoto R, Kinoshita A, Wada E, et al. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci 1997;17:7503-22
9. Blümcke I, Behle K, Malitschek B, et al. Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3, mGluR4a and mGluR5 in human hippocampus. Brain Res 1996;736:217-26
10. Aronica EM, Gorter JA, Paupard MC, Grooms SY, Bennett MV, Zukin RS. Status epilepticus-induced alterations in metabotropic glutamate receptor expression in young and adult rats. J Neurosci 1997;17:8588-95
11. Burke JP, Hablitz JJ. Metabotropic glutamate receptor activation decreases epileptiform activity in rat neocortex. Neurosci Lett 1994;174:29-33
12. Merlin LR, Wong RK. Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro. Neuropharmacol 1995;34:1567-72
13. Thomsen C, Klitgaard H, Sheardown M, et al. (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem 1994;62:2492-95
14. Akbar MT, Rattray M, Powell JF, Meldrum BS. Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats. Mol Brain Res 1996;43:105-16
15. Nicoletti F, Wroblewski JT, Alho H, Eva C, Fadda E, Costa E. Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids. Brain Res 1987;436:103-12
16. Wolf HK, Wiestler OD. Surgical pathology of chronic epileptic seizure disorders. Brain Pathol 1993;3:371-80
17. Van Roost D, Solymosi L, Schramm J, van Oosterwyck B, Elger CE. Depth electrode implantation in the length axis of the hippocampus for the presurgical evaluation of medial temporal lobe epilepsy: A computed tomography-based stereotactic insertion technique and its accuracy. Neurosurgery 1998;43:819-26
18. Blümcke I, Beck H, Scheffler B, et al. Altered distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-D-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy. Acta Neuropathol 1996;92:576-87
19. Blümcke I, Beck H, Nitsch R, et al. Preservation of calretinin-immunoreactive neurons in the hippocampus of epilepsy patients with Ammon's horn sclerosis. J Neuropathol Exp Neurol 1996;55: 329-41
20. Ben Ari Y. Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 1985;14:375-403
21. Meldrum BS. Epileptic brain damage: A consequence and a cause of seizures. Neuropathol Appl Neurobiol 1997;23:185-202
22. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. San Diego, California: Academic Press, 1996
23. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephal Clin Neurophysiol 1972;32: 281-94
24. Woodhams PL, Celio MR, Witter MP. Morphological and functional correlates of borders in the entorhinal cortex and hippocampus. Hippocampus 1993;3:303-12
25. Kasper BS, Stefan H, Buchfelder M, Paulus W. Temporal lobe microdysgenesis in epilepsy versus control brains. J Neuropathol Exp Neurol 1999;58:22-28
26. Rojiani AM, Emery JA, Anderson KJ, Massey JK. Distribution of heterotopic neurons in normal hemispheric white matter: A morphometric analysis. J Neuropathol Exp Neurol 1996;55:178-83
27. Lie AA, Blümcke I, Beck H, Schramm J, Wiestler OD, Elger CE. Altered patterns of Ca2+/calmodulin-dependent protein kinase II and calcineurin immunoreactivity in the hippocampus of patients with temporal lobe epilepsy. J Neuropathol Exp Neurol 1998;57: 1078-88
28. Waha A, Watzka M, Koch A, et al. A rapid and sensitive protocol for competitive reverse transcriptase (cRT) PCR analysis of cellular genes. Brain Pathol 1998;8:13-18
29. Romano C, Sesma MA, MacDonald CT, O'Mmalley KL, Van den Pol AN, Olney JW. Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. J Comp Neurol 1995;355: 455-69
30. Mayat E, Lerner Natoli M, Rondouin G, Lebrun F, Sassetti I, Reasens M. Kainate-induced status epilepticus leads to a delayed increase in various specific glutamate metabotropic receptor responses in the hippocampus. Brain Res 1994;645:186-200
31. Lujan R, Nusser Z, Roberts J, Shigemoto R, Somogyi P. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Eur J Neurosci 1996;8:1488-1500
32. Behr J, Lyson KJ, Mody I. Enhanced propagation of epileptiform activity through the kindled dentate gyrus. J Neurophysiol 1998;79: 1726-32
33. Sloviter RS. The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy. Ann Neurol 1994;35:640-54
34. Scanziani M, Salin PA, Vogt KE, Malenka RC, Nicoll RA. Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors. Nature 1997;385:630-34
35. Aiba A, Chen C, Herrup K, Rosenmund C, Stevens CF, Tonegawa S. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell 1994;79:365-75
36. Ben Ari Y, Represa A. Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus. Trends Neurosci 1990;13:312-18
37. Mathern GW, Pretorius JK, Kornblum HI, et al. Human hippocampal AMPA and NMDA mRNA levels in temporal lobe epilepsy patients. Brain 1997;120:1937-59
38. Mathern GW, Pretorius JK, Mendoza D, et al. Increased hippocampal AMPA and NMDA receptor subunit immunoreactivity in temporal lobe epilepsy patients. J Neuropathol Exp Neurol 1998;57: 615-34
39. Mathern GW, Mendoza D, Lozada A, et al. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. Neurology 1999;52:453-72
40. Babb TL, Kupfer WR, Pretorius JK, Crandall PH, Levesque MF. Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience 1991;42:351-63
41. Mathern GW, Babb TL, Pretorius JK, Leite JP. Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. J Neurosci 1995;15:3990-4004
42. Sloviter RS. Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science 1987;235:73-76
43. Sutula TP, Cascino G, Cavazos J, Parada I, Ramirez L. Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol 1989;26:321-30
44. Sloviter RS. Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: The "dormant basket cell" hypothesis and its possible relevance to temporal lobe epilepsy. Hippocampus 1991;1:41-66
45. Blümcke I, Zuschratter W, Schewe JC, et al. Cellular pathology of hilar neurons in Ammon's horn sclerosis. J Comp Neurol 1999; 414:437-53.
46. von Campe G, Spencer DD, Delanerolle NC. Morphology of dentate gyrus granule cells in human epileptogenic hippocampus. Hippocampus 1997;7:472-88
47. Bruno V, Copani A, Knöpfel T, et al. Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells. Neuropharmacology 1995;34:1089-98
48. Mukhin A, Fan L, Faden AI. Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury. J Neurosci 1996;16:6012-20
49. Bruno V, Battaglia G, Copani A, et al. Activation of class II or III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration. Eur J Neurosci 1995;7:1906-13
50. Tizzano JP, Griffey KI, Schoepp DD. Induction or protection of limbic seizures in mice by mGluR subtype selective agonists. Neuropharmacology 1995;34:1063-67