Immunohistochemical nuclear positivity for WT1 in childhood acute myeloid leukemia

Fetal and Pediatric Pathology

Volumn 26, Issue 4, 2007, Pages 193-197

  Al Adnani, Mudner ^a   Williams, Susan ^a   Anderson, John ^a   Ashworth, Michael ^a   Malone, Marian ^a   Sebire, Neil J ^a  

^a GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

Acute myeloid leukemia; Granulocytic sarcoma; WT1

Indexed keywords

PARAFFIN; WT1 PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW; CHILDHOOD CANCER; CONTROLLED STUDY; GRANULOCYTIC SARCOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PEDIATRICS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SECTION;

CELL NUCLEUS; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKEMIA, MYELOID, ACUTE; WT1 PROTEINS;

EID: 37149015106     PISSN: 15513815     EISSN: 15513823     Source Type: Journal    
DOI: 10.1080/15513810701696957     Document Type: Article

References (16)

1. King-Underwood L, Pritchard-Jones K. Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance. Blood 91:2961-2968, 1998.
2. Algar E, Blackburn D, Kromykh, et al. Mutation analysis of the WT1 gene in sporadic childhood leukaemia. Leukemia 11:110-113, 1997.
3. Menssen HD, Renkl HJ, Rodeck U, et al. Detection by monoclonal antibodies of the Wilm's tumor (WT1) nuclear protein in patients with acute leukemia. Int J Cancer 70:518-523, 1997.
4. Carpentieri DF, Nichols K, Chou PM, et al. The expression of WT1 in the differentiation of rhabdomyosarcoma from other pediatric small round blue cell tumors. Mod Pathol 15:1080-1086, 2002.
5. Inoue K, Ogawa H, Sonoda Y, et al. Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia. Blood 89:1405-1412, 1997.
6. Fraizer GC. Expression of the tumor suppressor gene WT1 in both human and mouse bone marrow. Blood 86:4704-4706, 1995.
7. Menssen HD, Renkl HJ, Rodeck U, et al. Presence of Wilms' tumour gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia 9:1060-1067, 1995.
8. Brieger J, Weidmann E, Fenchel K, et al. The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukaemic blast cells. Leukemia 8:2138-2143, 1994.
9. Miwa H, Beran M, Saunders F. Expression of the Wilms' tumor gene (WT1) in human leukemias. Leukemia 6:405-409, 1992.
10. Miyagi T, Ahuja H, Kubota T, et al. Expression of the candidate Wilm's tumor gene, WT1, in human leukaemia cells. Leukemia 7:970-977, 1993.
11. Miyagawa K, Hayashi Y, Fukuda T, et al. Mutations of the Wt1 gene in childhood nonlymphoid hematological malignancies. Genes Chromosomes Cancer 25:176-183, 1999.
12. King-Underwood L, Renshaw J, Pritchard-Jones K. Mutations in the Wilms' tumor gene WT1 in leukemias. Blood 87:2171-2179, 1996.
13. Sebire NJ, Gibson S, Rampling D, et al. Immunohistochemical findings in embryonal small round cell tumors with molecular diagnostic confirmation. Appl Immunohistochem Mol Morphol 13:1-5, 2005.
14. Hylander B, Repasky E, Shrikant P, et al. Expression of Wilms tumor gene (WT1) in epithelial ovarian cancer. Gynecol Oncol 101:12-17, 2006.
15. Kumar-Singh S, Segers K, Rodeck U, et al. WT1 mutation in malignant mesothelioma and WT1 immunoreactivity in relation to p53 and growth factor receptor expression, cell-type transition, and prognosis. J Path 181:67-74, 1997.
16. Menasce LP, Banerjee SS, Beckett E, et al. Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: A study of 26 cases. Histopathology 34:391-398, 1999.