WT1 mutation in malignant mesothelioma and WT1 immunoreactivity in relation to p53 and growth factor receptor expression cell-type transition, and prognosis

Journal of Pathology

Volumn 181, Issue 1, 1997, Pages 67-74

  Kumar Singh, Samir ^a   Segers, Kurt ^a   Rodeck, Ulrich ^b   Backhovens, Hubert ^a   Bogers, Johannes ^a   Weyler, Joost ^a   Van Broeckhoven, Christine ^a   Van Marck, Eric ^a,c  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b WISTAR INSTITUTE   (United States)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

cell lines; deletions; EGF R; IGF 1R; immuno electron microscopy; immunohistochemistry; lung tumours; mesothelioma; p53; prognosis

Indexed keywords

EPIDERMAL GROWTH FACTOR; PROTEIN P53; SOMATOMEDIN C RECEPTOR;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; MESOTHELIOMA; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MESOTHELIOMA; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; PLEURAL NEOPLASMS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, IGF TYPE 1; SURVIVAL RATE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; WT1 PROTEINS;

EID: 0031056053     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199701)181:1<67::AID-PATH723>3.0.CO;2-Z     Document Type: Article

References (30)

1. Call KM, Glaser T, Ito CY, et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 1990; 60: 509-520.
2. Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GA. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 1990; 343: 774-778.
3. Haber DA, Sohn RL, Buckler AJ, Pelletier J, Call KM, Housman DE. Alternative splicing and genomic structure of the Wilms tumor gene WT1. Proc Natl Acad Sci USA 1991; 88: 9618-9622.
4. Rauscher FJ, Morris JF, Tournay OE, Cook DM, Curran T. Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence. Science 1990; 250: 1259-1262.
5. Madden SL, Cook DM, Morris JF, Gashler A, Sukhatme VP, Rauscher FJ III. Transcriptional repression mediated by the WT1 Wilms tumor gene product. Science 1991; 253: 1550-1553.
6. Werner H, Re GG, Drummond IA, et al. Increased expression of the insulin-like growth factor 1 receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product. Proc Natl Acad Sci USA 1993; 90: 5828-5832.
7. Englert CX, Hou X, Maheswaran S, et al. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J 1995; 14: 4662-4675.
8. Maheswaran S, Park S, Bernard A, et al. Physical and functional interaction between WT1 and p53 proteins. Proc Natl Acad Sci USA 1993; 90: 5100-5104.
9. Wagner JC, Sleggs CA, Marchand P. Diffuse pleural mesothelioma and asbestos exposure in the North-Western Cape Province. Br J Ind Med 1960; 17: 260-270.
10. Pritchard-Jones K, Fleming S, Davidson D, et al. The candidate Wilms' tumour gene is involved in genitourinary development. Nature 1990; 346: 194-197.
11. Armstrong JF, Pritchard-Jones K, Bickmore WA, Hastie ND, Bard JB. The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo. Mech Dev 1993; 40: 85-97.
12. Park S, Bernard A, Bove KE, et al. Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour. Nature Genet 1993; 5: 363-367.
13. Walker C, Rutten F, Yuan X, Pass H, Mew DM, Everitt J. Wilms' tumor suppressor gene expression in rat and human mesothelioma. Cancer Res 1994; 54: 3101-3106.
14. Park S, Schalling M, Bernard A, et al. The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma. Nature Genet 1993; 4: 415-420.
15. Gerwin BI. Asbestos and the mesothelial cell: a molecular trail to mitogenic stimuli and suppressor gene suspects. Am J Respir Cell Mol Biol 1994; 11: 507-508.
16. Austin MB, Fechner RE, Roggli VL. Pleural malignant mesothelioma following Wilms' tumor. Am J Clin Pathol 1986; 86: 227-230.
17. Ladanyi M, Gerald W. Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. Cancer Res 1994; 54: 2837-2840.
18. Grompe M. The rapid detection of unknown mutations in nucleic acids. Nature Genet 1993; 5: 111-117.
19. Amin KM, Litzky LA, Smythe WR, et al. Wilms' tumor 1 susceptibility (WT1) gene products are selectively expressed in malignant mesothelioma. Am J Pathol 1995; 146: 344-356.
20. Bogers JJ, Nibbeling HA, Deelder AM, Van Marck EAE. Quantitative and morphological aspects of unicryl and lowicryl K4M embedding in immunoelectron microscopic studies. J Histochem Cytochem 1996; 44: 43-48.
21. Ramael M, Segers K, Buysse C, Van den Bossche J, Van Marck E. Immunohistochemical distribution patterns of epidermal growth factor receptor in malignant mesothelioma and non-neoplastic mesothelium. Virchows Arch A [Pathol Anat Histopathol] 1991; 419: 171-175.
22. Segers K, Backhovens H, Kumar Singh S, et al. Immunoreactivity for p53 and mdm2 and the detection of p53 mutations in human malignant mesothelioma. Virchows Arch 1995; 427: 431-436.
23. Kamio T, Shigematsu K, Kawai K, Tsuchiyama H. Immunoreactivity and receptor expression of insulin like growth factor I and insulin in human adrenal tumors. An immunohistochemical study of 94 cases. Am J Pathol 1991; 138: 83-91.
24. Coppes MJ, Campbell CE, Williams BR. The role of WT1 in Wilms tumorigenesis. FASEB J 1993; 7: 886-895.
25. Langerak AW, Williamson KA, Miyagawa K, Hagemeijer A, Versnel MA, Hastie ND. Expression of the Wilms' tumor gene WT1 in human malignant mesothelioma cell lines and relationship to platelet-derived growth factor A and insulin-like growth factor 2 expression. Genes Chromosom Cancer 1995; 12: 87-96.
26. Grubb GR, Yun K, Reeve AE, Eccles MR. Exclusion of the Wilms tumour gene (WT1) promoter as a site of frequent mutation in Wilms tumour. Oncogene 1995; 10: 1677-1681.
27. Mount SM. A catalogue of splice junction sequences. Nucleic Acid Res 1982; 10: 459-472.
28. Righetti SC, Della Torre G, Pilotti S, et al. A comparative study of p53 gene mutations, protein accumulation, and response to cisplantin-based chemotherapy in advanced ovarian carcinoma. Cancer Res 1996; 56: 689-693.
29. Englert C, Vidai M, Maheswaran S, et al. Truncated WT1 mutants alter the subnuclear localization of the wild-type protein. Proc Natl Acad Sci USA 1995; 92: 11960-11964.
30. Rodeck U, Bossier A, Kari C, et al. Expression of the wt1 Wilms' tumor gene by normal and malignant human melanocytes. Int J Cancer 1994; 59: 78-82.