-
4
-
-
0017167185
-
The clonal evolution of tumor cell population
-
Nowell PC. The clonal evolution of tumor cell population. Science. 1976;194:23-5.
-
(1976)
Science
, vol.194
, pp. 23-25
-
-
Nowell, P.C.1
-
5
-
-
0024399684
-
Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis
-
Weinberg RA. Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis. Cancer Res. 1998;49:3713-21.
-
(1998)
Cancer Res
, vol.49
, pp. 3713-3721
-
-
Weinberg, R.A.1
-
7
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61:759-67.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
8
-
-
0029132150
-
Molecular genetics of exocrine pancreatic neoplasms
-
Hahn SA, Kem SE. Molecular genetics of exocrine pancreatic neoplasms. Surg Clin North Am. 1995;75:857-69.
-
(1995)
Surg Clin North Am
, vol.75
, pp. 857-869
-
-
Hahn, S.A.1
Kem, S.E.2
-
12
-
-
0017156835
-
Morphological lesions associated with human primary invasive nonendocrine pancreas cancer
-
Cubilla AL, Fitzgerald PJ. Morphological lesions associated with human primary invasive nonendocrine pancreas cancer. Cancer Res. 1976;36:2690-8.
-
(1976)
Cancer Res
, vol.36
, pp. 2690-2698
-
-
Cubilla, A.L.1
Fitzgerald, P.J.2
-
13
-
-
0018742498
-
Relation of pancreatic duct hiperplasia to carcinoma
-
Kozuka S, Sassa R, Takai T, Masamoto K, Nagasawa S, Saga S, et al. Relation of pancreatic duct hiperplasia to carcinoma. Cancer. 1979;43:1418-28.
-
(1979)
Cancer
, vol.43
, pp. 1418-1428
-
-
Kozuka, S.1
Sassa, R.2
Takai, T.3
Masamoto, K.4
Nagasawa, S.5
Saga, S.6
-
14
-
-
0035020633
-
Pancreatic intraepitelial neoplasia: A new nomenclature and classification systems for pancreatic duct lesions
-
Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, Goodman SN, et al. Pancreatic intraepitelial neoplasia: a new nomenclature and classification systems for pancreatic duct lesions. Am J Surg Pathol. 2001;25:579-86.
-
(2001)
Am J Surg Pathol
, vol.25
, pp. 579-586
-
-
Hruban, R.H.1
Adsay, N.V.2
Albores-Saavedra, J.3
Compton, C.4
Garrett, E.S.5
Goodman, S.N.6
-
15
-
-
0036883940
-
Pancreatic cancer biology and genetics
-
Bardeesy N, De Pinho RA. Pancreatic cancer biology and genetics. Nat Rev Cancer. 2002;2:897-909.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 897-909
-
-
Bardeesy, N.1
De Pinho, R.A.2
-
16
-
-
0023068346
-
-
Barbacid M. ras genes. Annu Rev Biochem. 1987;56:770-827.
-
Barbacid M. ras genes. Annu Rev Biochem. 1987;56:770-827.
-
-
-
-
17
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant K-ras genes
-
Almoguera C, Shibata D, Forrester K, Martin J, Amheim N, Perucho M, et al. Most human carcinomas of the exocrine pancreas contain mutant K-ras genes. Cell. 1988;53:549-54.
-
(1988)
Cell
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
Shibata, D.2
Forrester, K.3
Martin, J.4
Amheim, N.5
Perucho, M.6
-
18
-
-
0024376173
-
-
Bos JL. ras oncogenes in human cancer: a review. Cancer Res. 1989;49:4682-9.
-
Bos JL. ras oncogenes in human cancer: a review. Cancer Res. 1989;49:4682-9.
-
-
-
-
19
-
-
0027733796
-
K-ras oncogenes activation in adenocarcinoma of human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polimerase chain reaction analysis and allele-specific oligonucleotide hybridization
-
Hruban RH, Van Mansfield AD, Offer Haus GJ, Van Weering DH, Allison DC, Goodman SN, et al. K-ras oncogenes activation in adenocarcinoma of human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polimerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol. 1993;143:545-54.
-
(1993)
Am J Pathol
, vol.143
, pp. 545-554
-
-
Hruban, R.H.1
Van Mansfield, A.D.2
Offer Haus, G.J.3
Van Weering, D.H.4
Allison, D.C.5
Goodman, S.N.6
-
20
-
-
0033497531
-
Sequential accumulation of K-ras mutations and p53 overexpression of pancreatic mucinous cystic neoplasms to malignancy
-
Jiménez RE, Warshaw AL, Z'Graggen K. Sequential accumulation of K-ras mutations and p53 overexpression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg. 1999;230:501-11.
-
(1999)
Ann Surg
, vol.230
, pp. 501-511
-
-
Jiménez, R.E.1
Warshaw, A.L.2
Z'Graggen, K.3
-
21
-
-
0028268635
-
K-ras and p53 gene mutations in pancreatic cancer. Ductal and nonductal tumors progress through different genetic lessions
-
Pellegata NS, Sessa F, Renault B, Bonato M, Leone BE, Soleia E, et al. K-ras and p53 gene mutations in pancreatic cancer. Ductal and nonductal tumors progress through different genetic lessions. Cancer Res. 1994;54:1556-60.
-
(1994)
Cancer Res
, vol.54
, pp. 1556-1560
-
-
Pellegata, N.S.1
Sessa, F.2
Renault, B.3
Bonato, M.4
Leone, B.E.5
Soleia, E.6
-
22
-
-
0026337295
-
Tumor suppresor genes
-
Weinberg RA. Tumor suppresor genes Science. 1991;254:1138-45.
-
(1991)
Science
, vol.254
, pp. 1138-1145
-
-
Weinberg, R.A.1
-
23
-
-
0026059515
-
Tumor suppressor genes
-
Marshall CJ. Tumor suppressor genes. Cell. 1991;64:313-26.
-
(1991)
Cell
, vol.64
, pp. 313-326
-
-
Marshall, C.J.1
-
24
-
-
14444284330
-
Tumor suppressive pathways in pancreatic carcinoma
-
Rozenblum E, Schutte M, Goggins M, Hahn SA, Panzer S, Zahurak M, et al. Tumor suppressive pathways in pancreatic carcinoma. Cancer Res. 1997;57:1731-4.
-
(1997)
Cancer Res
, vol.57
, pp. 1731-1734
-
-
Rozenblum, E.1
Schutte, M.2
Goggins, M.3
Hahn, S.A.4
Panzer, S.5
Zahurak, M.6
-
25
-
-
0028275733
-
Deletion of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
-
Nobori T, Miura K, Wu DJ. Deletion of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature. 1994;368:753-6.
-
(1994)
Nature
, vol.368
, pp. 753-756
-
-
Nobori, T.1
Miura, K.2
Wu, D.J.3
-
26
-
-
0028121279
-
A cell cycle regulator potencially involved in genesis of many tumor types
-
Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, et al. A cell cycle regulator potencially involved in genesis of many tumor types. Science. 1994;264:436-40.
-
(1994)
Science
, vol.264
, pp. 436-440
-
-
Kamb, A.1
Gruis, N.A.2
Weaver-Feldhaus, J.3
Liu, Q.4
Harshman, K.5
Tavtigian, S.V.6
-
27
-
-
0028059330
-
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
-
Caldas C, Hahn SA, Da Costa LT, Redston MS, Schutte M, Seymour AB, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet. 1994;8:27-32.
-
(1994)
Nat Genet
, vol.8
, pp. 27-32
-
-
Caldas, C.1
Hahn, S.A.2
Da Costa, L.T.3
Redston, M.S.4
Schutte, M.5
Seymour, A.B.6
-
28
-
-
16944367477
-
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
-
Schutte M, Hruban RH, Geradts J, Maynard R, Hilgers W, Rabindran SK, et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res. 1997;57:3126-30.
-
(1997)
Cancer Res
, vol.57
, pp. 3126-3130
-
-
Schutte, M.1
Hruban, R.H.2
Geradts, J.3
Maynard, R.4
Hilgers, W.5
Rabindran, S.K.6
-
29
-
-
0026053582
-
Mutant p53 protein bind DNA abnormally in vitro
-
Kern SE, Kinzler KW, Baker SJ, Nigro JM, Rotter V, Levine AJ, et al. Mutant p53 protein bind DNA abnormally in vitro. Oncogene. 1991;6:131-6.
-
(1991)
Oncogene
, vol.6
, pp. 131-136
-
-
Kern, S.E.1
Kinzler, K.W.2
Baker, S.J.3
Nigro, J.M.4
Rotter, V.5
Levine, A.J.6
-
32
-
-
0026669469
-
p53 funetion and dysfunction
-
Vogelstein B, Kinzier KW. p53 funetion and dysfunction. Cell. 1992;70:523-6.
-
(1992)
Cell
, vol.70
, pp. 523-526
-
-
Vogelstein, B.1
Kinzier, K.W.2
-
33
-
-
0034671945
-
Oncogenic mutations of the p53 tumor suppressor: The demons of the guardian of the genome
-
Signal A, Rotter V. Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res. 2000;60:6788-93.
-
(2000)
Cancer Res
, vol.60
, pp. 6788-6793
-
-
Signal, A.1
Rotter, V.2
-
34
-
-
0026334753
-
Abnormalities of p53 tumor suppressor gene in human pancreatic cancer
-
Barton CM, Staddon SL, Hughes CM. Abnormalities of p53 tumor suppressor gene in human pancreatic cancer. Br J Cancer. 1991;64:1076-85.
-
(1991)
Br J Cancer
, vol.64
, pp. 1076-1085
-
-
Barton, C.M.1
Staddon, S.L.2
Hughes, C.M.3
-
35
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q2.1
-
Hahn SA, Schutte M, Shamsul K, Hoque ATM, Moskaluk CA, Da Costa LT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q2.1. Science. 1996;271:350-3.
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Shamsul, K.3
Hoque, A.T.M.4
Moskaluk, C.A.5
Da Costa, L.T.6
-
36
-
-
0032788607
-
Tumor suppressor gene SMAD4/DPC4, its downstream target genes and regulation of cell cycle
-
Chiao PJ, Hunt KK, Grau AM. Tumor suppressor gene SMAD4/DPC4, its downstream target genes and regulation of cell cycle. Ann NY Acad Sci. 1999;880:31-7.
-
(1999)
Ann NY Acad Sci
, vol.880
, pp. 31-37
-
-
Chiao, P.J.1
Hunt, K.K.2
Grau, A.M.3
-
37
-
-
0028845919
-
DNA mismatch repair and cancer
-
Chung DC, Rustgi AK. DNA mismatch repair and cancer. Gastroenterology. 1995;109:1685-99.
-
(1995)
Gastroenterology
, vol.109
, pp. 1685-1699
-
-
Chung, D.C.1
Rustgi, A.K.2
-
38
-
-
0032898651
-
Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumors
-
Ghimenti C, Tannergard P, Wahlberg S. Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumors. Br J Cancer. 1999;80:11-21.
-
(1999)
Br J Cancer
, vol.80
, pp. 11-21
-
-
Ghimenti, C.1
Tannergard, P.2
Wahlberg, S.3
-
39
-
-
0035300547
-
Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability
-
Yamamoto H, Itoh F, Nakamura H, Fukushima H, Sasaki S, Perucho M, et al. Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability. Cancer Res. 2001;61:3139-44.
-
(2001)
Cancer Res
, vol.61
, pp. 3139-3144
-
-
Yamamoto, H.1
Itoh, F.2
Nakamura, H.3
Fukushima, H.4
Sasaki, S.5
Perucho, M.6
-
40
-
-
17644430199
-
Pancreatic adenocarcinoma with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology
-
Goggins M, Offerhaus GJ, Hilgers W, Griffin CA, Shekher M, Tang D, et al. Pancreatic adenocarcinoma with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Am J Pathol. 1998;152:1501-7.
-
(1998)
Am J Pathol
, vol.152
, pp. 1501-1507
-
-
Goggins, M.1
Offerhaus, G.J.2
Hilgers, W.3
Griffin, C.A.4
Shekher, M.5
Tang, D.6
-
41
-
-
0030024411
-
Pancreatic cancer: The potencial clinical relevance of alterations in growth factors and others receptors
-
Friess H, Berberat P, Schilling M. Pancreatic cancer: the potencial clinical relevance of alterations in growth factors and others receptors. J Mol Med. 1996;74:35-44.
-
(1996)
J Mol Med
, vol.74
, pp. 35-44
-
-
Friess, H.1
Berberat, P.2
Schilling, M.3
-
42
-
-
0038350026
-
Role of telomers ans telomerase in the pathogenesis of human cancer
-
Hahn WC. Role of telomers ans telomerase in the pathogenesis of human cancer. J Clin Oncol. 2003;21:2034-43.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2034-2043
-
-
Hahn, W.C.1
-
43
-
-
0034331743
-
Carcinoma colorrectal: Circunstancias inductores y vías de realización
-
Sánchez-Fayos P, Juzgado D, Bosch O, González-Guirado A, Porres JC. Carcinoma colorrectal: circunstancias inductores y vías de realización. Rev Clin Esp. 2000;200:605-15.
-
(2000)
Rev Clin Esp
, vol.200
, pp. 605-615
-
-
Sánchez-Fayos, P.1
Juzgado, D.2
Bosch, O.3
González-Guirado, A.4
Porres, J.C.5
-
45
-
-
0027404269
-
p53 and K-ras alterations in pancreatic epithelial cell lesions
-
Kalthoff H, Schmiegel W, Reeder C, Kasche D, Schmidt A, Laver G, et al. p53 and K-ras alterations in pancreatic epithelial cell lesions. Oncogene. 1993;8:289-98.
-
(1993)
Oncogene
, vol.8
, pp. 289-298
-
-
Kalthoff, H.1
Schmiegel, W.2
Reeder, C.3
Kasche, D.4
Schmidt, A.5
Laver, G.6
-
46
-
-
0028222269
-
Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma
-
Di Giuseppe JA, Hruban RH, Offerhaus GJ, Clement MJ, Van den Berg FM, Cameron JL, et al. Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma. Am J Pathol. 1994; 144:889-95.
-
(1994)
Am J Pathol
, vol.144
, pp. 889-895
-
-
Di Giuseppe, J.A.1
Hruban, R.H.2
Offerhaus, G.J.3
Clement, M.J.4
Van den Berg, F.M.5
Cameron, J.L.6
-
47
-
-
0030050945
-
Analysis os K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
-
Tada M, Ohashi M, Shiratori Y, Okudaira T, Komatsu Y, Kawabe T, et al. Analysis os K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology. 1996;110:227-31.
-
(1996)
Gastroenterology
, vol.110
, pp. 227-231
-
-
Tada, M.1
Ohashi, M.2
Shiratori, Y.3
Okudaira, T.4
Komatsu, Y.5
Kawabe, T.6
-
48
-
-
0030988302
-
p16 and K-ras mutation in the intraductal precursors of human pancreatic adenocarcinoma
-
Moskaluk CA, Hruban RH, Kern SE. p16 and K-ras mutation in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res. 1997;57:2140-3.
-
(1997)
Cancer Res
, vol.57
, pp. 2140-2143
-
-
Moskaluk, C.A.1
Hruban, R.H.2
Kern, S.E.3
-
49
-
-
0032748508
-
Duct changes and K-ras mutations in the disease-free pancreas
-
Luttges J, Reineke-Luthge A, Mollmann B, Menke MA, Clemens A, Klimpfinger M, et al. Duct changes and K-ras mutations in the disease-free pancreas. Wirchows Arch. 1999;435:461-8.
-
(1999)
Wirchows Arch
, vol.435
, pp. 461-468
-
-
Luttges, J.1
Reineke-Luthge, A.2
Mollmann, B.3
Menke, M.A.4
Clemens, A.5
Klimpfinger, M.6
-
50
-
-
12644290242
-
Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia
-
Rivera JA, Rall CJN, Graeme-Cook F. Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia. Surgery. 1997;121:42-9.
-
(1997)
Surgery
, vol.121
, pp. 42-49
-
-
Rivera, J.A.1
Rall, C.J.N.2
Graeme-Cook, F.3
-
51
-
-
0034032009
-
Loss of expression of DPC4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
-
Wilentz RE, Iacobuzio-Donahue CA, Argani P, McKarthy DM, Parsons JL, Yeo CJ, et al. Loss of expression of DPC4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res. 2000;60:2002-6.
-
(2000)
Cancer Res
, vol.60
, pp. 2002-2006
-
-
Wilentz, R.E.1
Iacobuzio-Donahue, C.A.2
Argani, P.3
McKarthy, D.M.4
Parsons, J.L.5
Yeo, C.J.6
|