PcrA/UvrD/Rep DNA helicases in bacterial genomes

Biochemical Systematics and Ecology

Volumn 36, Issue 2, 2008, Pages 101-109

  Chène, Patrick ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

DNA helicases; Drug discovery; PcrA; PURL; Rep; UvrD

Indexed keywords

BACTERIUM; DRUG DEVELOPMENT; ENZYME; GENOME; HYDROLYSIS; SURVIVAL;

BACTERIA (MICROORGANISMS);

EID: 37049018021     PISSN: 03051978     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bse.2007.08.001     Document Type: Article

References (32)

1. Altschul S., Gish W., Miller W., Myers E., and Lipman D. Basic local alignment search tool. J. Mol. Biol. 215 (1990) 403-410
2. Bailis J.M., and Forsburg S.L. MCM proteins: DNA damage, mutagenesis and repair. Curr. Opin. Genet. Dev. 14 (2004) 17-21
3. Borowski P., Schalinski S., and Schmitz H. Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy. Antivir. Res. 55 (2002) 397-412
4. Boussau B., Karlberg E.O., Frank A.C., Legault B.A., and Andersson S.G.E. Computational inference of scenarios for a-proteobacterial genome evolution. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 9722-9727
5. Carrasco B., Fernandez S., Petit M.A., and Alonso J.C. Genetic recombination in Bacillus subtilis 168: effect of ΔhelD on DNA repair and homologous recombination. J. Bacteriol. 183 (2001) 5772-5777
6. Caruthers J.M., and McKay D.B. Helicase structure and mechanism. Curr. Opin. Struct. Biol. 12 (2002) 123-133
7. Delagoutte E., and von Hippel P.H. Helicase mechanisms and the coupling of helicases within macromolecular machines, part I: structures and properties of isolated helicases. Q. Rev. Biophys. 35 (2002) 431-478
8. Delagoutte E., and von Hippel P.H. Helicase mechanisms and the coupling of helicases within macromolecular machines. Part II: integration of helicases into cellular processes. Q. Rev. Biophys. 36 (2003) 1-69
9. Dubaele S., Jahnke W., Schoepfer J., Fuchs J., and Chene P. Inhibition of DNA helicases with DNA-competitive inhibitors. Bioorg. Med. Chem. Lett. 16 (2006) 923-927
10. Felsentein J. PHYLIP phylogeny inference package. Cladistics 5 (1989) 164-166
11. Frick D.N. Helicases as antiviral drug targets. Drugs News Perspect. 16 (2003) 355-362
12. Garrity G.M., Bell J.A., and Lilburn T.G. Taxonomic outline of the prokaryotes. Bergey's Manual of Systematic Bacteriology. second ed. (2004), Springer-Verlag, New York Release 5.0
13. Gorbalenya A.E., and Koonin E.V. Helicases: amino acid sequence comparisons and structure-function relationships. Curr. Biol. 3 (1993) 419-429
14. Gupta R.S., Pereira M., Chandrasekera C., and Johari V. Molecular signatures in protein sequences that are characteristic of cyanobacteria and plastid homologues. Int. J. Syst. Evol. Microbiol. 53 (2003) 1833-1842
15. Higgins D., Thompson J., Gibson T., Thompson J., Higgins D., and Gibson T. CLUSTALW: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22 (1994) 4673-4680
16. Hugenholtz P. Exploring prokaryotic diversity in the genomic era. Genome Biol. 3 (2002) 1-8
17. Ji Y., Zhang B., Van Horn S.F., Warren P., Woodnutt G., Burnham M.K.R., and Rosenberg M. Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA. Science 293 (2001) 2266-2269
18. Karow J.K., Wu L., and Hickson I.D. RecQ family helicases: role in cancer and aging. Curr. Opin. Genet. Dev. 10 (2000) 32-38
19. Kleymann G. Helicase primase: targeting the Achilles heel of herpes simplex viruses. Antivir. Chem. Chemother. 15 (2004) 135-140
20. Kobayashi K., Ehrlich S.D., Albertini A., Amati G., Andersen K.K., Arnaud M., Asai K., Ashikaga S., et al. Essential Bacillus subtilis genes. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 4678-4683
21. Kwong A.D., Rao B.G., and Jeang K.T. Viral and cellular RNA helicases as antiviral targets. Nat. Rev. Drug Discov. 4 (2005) 845-853
22. Lehmann A.R. The xeroderma pigmentosum group D, XPD gene: one gene, two functions, three diseases. Genes Dev. 15 (2001) 15-23
23. Martins-Pinheiro M., Galhardo R.S., Lage C., Lima-Bessa K.M., and Menck C.F.M. Different patterns of evolution for duplicated DNA repair genes in bacteria of the Xanthomonadales group. BMC Evol. Biol. 4 (2004) 29
24. Mendonca V.M., Kaiser-Rogers K., and Matson S.W. Double helicase II, uvrD-helicase IV, helD deletion mutants are defective in the recombination pathways of Escherichia coli. J. Bacteriol. 175 (1993) 4641-4651
25. Moran N.A., and Plague G.R. Genomic changes following host restriction in bacteria. Curr. Opin. Gen. Dev. 14 (2004) 627-633
26. Notredame C., Higgins D., and Heringa J. T-Coffee: a novel method for multiple sequence alignments. J. Mol. Biol. 302 (2000) 205-217
27. Petit M.A., Dervyn E., Rose M., Entian K.D., McGovern S., Ehrlich S.D., and Bruand C. PcrA is an essential DNA helicase of Bacillus subtilis fulfilling both repair and rolling-circle replication. Mol. Microbiol. 29 (1998) 261-273
28. Petit M.A., and Ehrlich D. Essential bacterial helicases that counteract the toxicity of recombination proteins. EMBO J. 21 (2002) 3137-3147
29. Salama N., Shepherd B., and Falkow S. Global transposon mutagenesis and essential gene analysis of Helicobacter pylori. J. Bacteriol. 186 (2004) 7926-7935
30. Sallstrom B., and Andersson S.G.E. Genome reduction in the a-Proteobacteria. Curr. Opin. Microbiol. 8 (2005) 579-585
31. Taucher-Scholtz G., Abdel-Monem M., and Hoffman-Berling H. Functions of DNA helicases in Escherichia coli. In: Cozzarelli N.R. (Ed). Mechanism of DNA Replication and Recombination (1983) New York
32. Velankar S.S., Soultanas P., Dillingham M.S., Subramanya H.S., and Wigley D.B. Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate and inchworm mechanism. Cell 97 (1999) 75-84