Dysregulation of growth factor receptor-bound protein 2 and fascin in hippocampus of mice polytransgenic for chromosome 21 structures

Hippocampus

Volumn 17, Issue 12, 2007, Pages 1180-1192

  Shin, Joo Ho ^a   Guedj, Fayçal ^b   Delabar, Jean Maurice ^b   Lubec, Gert ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Chromosome 21; Down syndrome; Hippocampus; MALDI TOF; Polytransgenic mice; Two dimensional gel electrophoresis

Indexed keywords

FASCIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME 21; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOSKELETON; DOWN SYNDROME; GEL ELECTROPHORESIS; HIPPOCAMPUS; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEOMICS; STATISTICAL ANALYSIS;

ANIMALS; BEHAVIOR, ANIMAL; CARRIER PROTEINS; CHROMOSOMES, HUMAN, PAIR 21; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION REGULATION; GRB2 ADAPTOR PROTEIN; HIPPOCAMPUS; HUMANS; MALE; MAZE LEARNING; MICE; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 36949032159     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.20351     Document Type: Article

References (42)

1. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
2. Branchi I, Bichler Z, Minghetti L, Delabar JM, Malchiodi-Albedi F, Gonzalez MC, Chettouh Z, Nicolini A, Chabert C, Smith DJ, Rubin EM, Migliore-Samour D, Alleva E. 2004. Transgenic mouse in vivo library of human Down syndrome critical region 1: Association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration. J Neuropathol Exp Neurol 63:429-440.
3. Chabert C, Jamon M, Cherfouh A, Duquenne V, Smith DJ, Rubin E, Roubertoux PL. 2004. Functional analysis of genes implicated in Down syndrome. 1. Cognitive abilities in mice transpolygenic for Down Syndrome Chromosomal Region-1 (DCR-1). Behav Genet 34:559-569.
4. Challapalli KK, Zabel C, Schuchhardt J, Kaindl AM, Klose J, Herzel H. 2004. High reproducibility of large-gel two-dimensional electrophoresis. Electrophoresis 25:3040-3047.
5. Chapman RS, Hesketh LJ. 2000. Behavioral phenotype of individuals with Down syndrome. Ment Retard Dev Disabil Res Rev 6:84-95.
6. Chrast R, Scott HS, Madani R, Huber L, Wolfer DP, Prinz M, Aguzzi A, Lipp HP, Antonarakis SE. 2000. Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Hum Mol Genet 9:1853-1864.
7. Colledge M, Froehner SC. 1997. Tyrosine phosphorylation of nicotinic acetylcholine receptor mediates Grb2 binding. J Neurosci 17:5038-5045.
8. Davisson MT, Schmidt C, Akeson EC. 1990. Segmental trisomy of murine chromosome 16: A new model system for studying Down syndrome. Prog Clin Biol Res 360:263-280.
9. Davisson MT, Schmidt C, Reeves RH, Irving NG, Akeson EC, Harris BS, Bronson RT. 1993. Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res 384:117-133.
10. Delabar JM, Theophile D, Rahmani Z, Chettouh Z, Blouin JL, Prieur M, Noel B, Sinet PM. 1993. Molecular mapping of twenty-four features of Down syndrome on chromosome 21. Eur J Hum Genet 1:114-124.
11. Diao WF, Höger H, Chen WQ, Pollak A, Lubec G. 2007. Estrous-cycle-dependent hippocampal levels of signaling proteins. Hippocampus 17:563-576.
12. Edwards RA, Herrera-Sosa H, Otto J, Bryan J. 1995. Cloning and expression of a murine fascin homolog from mouse brain. J Biol Chem 270:10764-10770.
13. Engidawork E, Lubec G. 2001. Protein expression in Down syndrome brain. Amino Acids 21:331-361.
14. Engidawork E, Gulesserian T, Fountoulakis M, Lubec G. 2003a. Aberrant protein expression in cerebral cortex of fetus with Down syndrome. Neuroscience 122:145-154.
15. Engidawork E, Lubec G. 2003b. Molecular changes in fetal Down syndrome brain. J Neurochem 84:895-904.
16. Epstein CJ. 1995. Down's syndrome (trisomy 21). In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The Metabolic and Molecular Bases of Inherited Disease, 7th ed. New York: McGraw Hill, pp 749-794.
17. Frischer T, Myung JK, Maurer G, Eichler I, Szepfalusi Z, Lubec G. 2006. Possible dysregulation of chaperon and metabolic proteins in cystic fibrosis bronchial tissue. Proteomics 6:3381-3388.
18. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Henning S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML. 2000. Chromosome 21 mapping and sequencing consortium. The DNA sequence of human chromosome 21. Nature 405:311-319.
19. Huang Y, Chen-Hwang MC, Dolios G, Murakami N, Padovan JC, Wang R, Hwang YW. 2004. Mnb/Dyrk1A phosphorylation regulates the interaction of dynamin 1 with SH3 domain-containing proteins. Biochemistry 43:10173-10185.
20. Korenberg JR, Chen XN, Schipper R, Sun Z, Gonsky R, Gerwehr S, Carpenter N, Daumer C, Dignan P, Disteche C, Graham JM Jr, Hudgins L, McGillivray B, Miyazaki K, Ogasawara N, Park JP, Pagon R, Pueschel S, Sack G, Say B, Schuffenhauer S, Soukup S, Yamanaka T. 1994. Down syndrome phenotypes: The consequences of chromosomal imbalance. Proc Natl Acad Sci USA 91:4997-5001.
21. Lamprecht R, Farb CR, LeDoux JE. 2002. Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex. Neuron 36:727-738.
22. Lippa CF, Schmidt ML, Lee VM, Trojanowski JQ. 1999. Antibodies to α-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann Neurol 45:353-357.
23. Lubec G, Engidawork E. 2002. The brain in Down syndrome (TRISOMY 21). J Neurol 249:1347-1356.
24. Nemoto Y, Arribas M, Haffner C, DeCamilli P. 1997. Synaptojanin 2, a novel synaptojanin isoform with a distinct targeting domain and expression pattern. J Biol Chem 272:30817-30821.
25. Ma L, Huang YZ, Pitcher GM, Valtschanoff JG, Ma YH, Feng LY, Lu B, Xiong WC, Salter MW, Weinberg RJ, Mei L. 2003. Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. J Neurosci 23:3164-3175.
26. McPherson PS, Czernik AJ, Chilcote TJ, Onofri F, Benfenati F, Greengard P, Schlessinger J, De Camilli P. 1994. Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I. Prot Natl Acad Sci USA 91:6486-6490.
27. McPherson PS, Garcia EP, Slepnev VI, David C, Zhang X, Grabs D, Sossin WS, Bauerfeind R, Nemoto Y, De Camilli P. 1996. A presynaptic inositol-5-phosphatase. Nature 379:353-357.
28. Moeller ML, Shi Y, Reichardt LF, Ethell IM. 2006. EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation. J Biol Chem 281:1587-1598.
29. Onofri F, Giovedi S, Kao HT, Valtorta F, Bongiorno Borbone L, De Camilli P, Greengard P, Benfenati F. 2000. Specificity of the binding of synapsin I to Src homology 3 domains. J Biol Chem 275:29857-29867.
30. Shin JH, Weitzdoerfer R, Fountoulakis M, Lubec G. 2004. Expression of cystathionine β-synthase, pyridoxal kinase, and ES1 protein homolog (mitochondrial precursor) in fetal Down syndrome brain. Neurochem Int 45:73-79.
31. Shin JH, London J, Le Pecheur M, Weitzdoerfer R, Hoeger H, Lubec G. 2005. Proteome analysis in hippocampus of mice overexpressing human Cu/Zn-superoxide dismutase 1. Neurochem Int 46:641-653.
32. Shin JH, Gulesserian T, Verger E, Delabar JM, Lubec G. 2006. Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the down syndrome critical region. J Proteome Res 5:44-53.
33. Smith DJ, Rubin EM. 1997. Functional screening and complex traits: Human 21q22.2 sequences affecting learning in mice. Hum Mol Genet 6:1729-1733.
34. Smith DJ, Zhu Y, Zhang J, Cheng JF, Rubin EM. 1995. Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics 27:425-434.
35. Smith DJ, Stevens ME, Sudanagunta SP, Bronson RT, Makhinson M, Watabe AM, O'Dell TJ, Fung J, Weier HU, Cheng JF, Rubin EM. 1997. Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome. Nat Genet 16:28-36.
36. Suen KL, Bustelo XR, Pawson T, Barbacid M. 1993. Molecular cloning of the mouse grb2 gene: Differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Mol Cell Biol 13:550-5512.
37. Suzuki T, Mitake S, Murata S. 1999. Presence of up-stream and downstream components of a mitogen-activated protein kinase pathway in the PSD of the rat forebrain. Brain Res 840:36-44.
38. Vaccaro P, Dente L, Onofri F, Zucconi A, Martinelli S, Valtorta F, Greengard P, Cesareni G, Benfenati F. 1997. Anti-synapsin monoclonal antibodies: Epitope mapping and inhibitory effects on phosphorylation and Grb2 binding. Brain Res Mol Brain Res 52:1-16.
39. Weitzdoerfer R, Stolzlechner D, Dierssen M, Ferreres J, Fountoulakis M, Lubec G. 2001. Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain. J Neural Transm Suppl 61:347-359.
40. Yoo BC, Vlkolinsky R, Engidawork E, Cairns N, Fountoulakis M, Lubec G. 2001. Differential expression of molecular chaperones in brain of patients with Down syndrome. Electrophoresis 22:1233-1241.
41. Zhan Y, Tremblay MR, Melian N, Carbonetto S. 2005. Evidence that dystroglycan is associated with dynamin and regulates endocytosis. J Biol Chem 280:18015-18024.
42. Zhao W, Chen H, Xu H, Moore E, Meiri N, Quon MJ, Alkon DL. 1999. Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem 274:34893-34902.