Large conductance Ca2+-activated K+ (BKCa) channels are involved in the vascular relaxations elicited by piceatannol isolated from Rheum undulatum rhizome

Planta Medica

Volumn 73, Issue 14, 2007, Pages 1441-1446

  Oh, Kwang Seok ^a   Shi, Yong Ryu ^a   Young, Sup Kim ^a   Byung, Ho Lee ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

BKCa channels; Ca 2+ activated K+ channel; Piceatannol; Polygonaceae; Rat aorta; Rheum undulatum; Vasorelaxation

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; APAMIN; ATROPINE; BARIUM CHLORIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM CHANNEL L TYPE; CHARYBDOTOXIN; GLIBENCLAMIDE; IBERIOTOXIN; INDOMETACIN; METHYLENE BLUE; MUSCARINIC RECEPTOR BLOCKING AGENT; NIFEDIPINE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLEPHRINE; PICEATANNOL; POTASSIUM CHANNEL BLOCKING AGENT; PROPRANOLOL; PROSTAGLANDIN SYNTHASE INHIBITOR; VERAPAMIL; 3,3',4,5'-TETRAHYDROXYSTILBENE; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CELL MEMBRANE CONDUCTANCE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; NONHUMAN; RAT; RHEUM UNDULATUM; RHIZOME; RHUBARB; SPRAGUE DAWLEY RAT; VASODILATATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ELECTRIC CONDUCTIVITY; ISOLATION AND PURIFICATION; METABOLISM;

POLYGONACEAE; RATTUS; RHEUM UNDULATUM;

ANIMALS; AORTA; ELECTRIC CONDUCTIVITY; MOLECULAR STRUCTURE; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; RATS, SPRAGUE-DAWLEY; RHEUM; RHIZOME; STILBENES; VASODILATION;

EID: 36949024032     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-990246     Document Type: Article

References (27)

1. Curin Y, Andriantsitohaina R. Polyphenols as potential therapeutical agents against cardiovascular diseases. Pharmacol Rep 2005; 57: 97-107.
2. Pechanova O, Rezzani R, Babal P, Bernatova I, Andriantsitohaina R. Beneficial effects of provinols: cardiovascular system and kidney. Physiol Res 2006; 55: S17-30.
3. Wu JM, Wang ZR, Hsieh TC, Bruder JL, Zou JG, Huang YZ. Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine. Int J Mol Med 2001; 8: 3-17.
4. Ferrigni NR, McLaughlin JL, Powell RG, SmithCR Jr. Use of potato disc and brine shrimp bioassays to detect activity and isolate piceatannol as the antileukemic principle from the seeds of Euphorbia lagascae. J Nat Prod 1984; 47: 347-52.
5. Wieder T, Prokop A, Bagci B, Essmann F, Bernicke D, Schulze-Osthoff K et al. Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts. Leukemia 2001; 15: 1735-42.
6. Geahlen RL, McLaughlin JL. Piceatannol (3,4,3′,5′- tetrahydroxy-transstilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochem Biophys Res Commun 1989; 165: 241-5.
7. Matsuda H, Kageura T, Morikawa T, Toguchida I, Harima S, Yoshikawa M. Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages. Bioorg Med Chem Lett 2000; 10: 323-7.
8. Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaB alpha kinase and p65 phosphorylation. J Immunol 2002; 169: 6490-7.
9. Moon MK, Kang DG, Lee JK, Kim JS, Lee HS. Vasodilatory and anti-imflammatory effects of the aqueous extract of rhubarb via a NO-cGMP pathway. Life Sci 2006; 78: 1550-7.
10. Yoo MY, Oh KS, Lee JW, Seo HW, Yon GH, Kwon DY et al. Vasorelaxation effect of stilbenes from rhizome extract of rhubarb (Rheum undulatum) on the contractility of rat aorta. Phytother Res 2007; 21: 186-9.
11. Lee BH, Lee CO, Kwon MJ, Yi KY, Yoo SE, Choi SU. Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity. Anticancer Drugs 2003; 14: 175-81.
12. Rapoport RM, Draznin MB, Murad F. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 1983; 306: 174-6.
13. Olson LJ, Knych ET Jr, Herzig TC, Crewett JG. Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. Hypertension 1997; 29: 254-61.
14. Abebe W, Maddux WF. Roles of nitric oxide and prostacyclin in triethyleneglycol dimethacrylate (TEGDMA)-induced vasorelaxation. 2006; 22: 37-44.
15. Kang DG, Yin MH, Oh H, Lee DH, Lee HS. Vasorelaxation by amentoflavone isolated from Selaginella tamariscina. Planta Med 2004; 70: 718-22.
16. Wang GJ, Wu XC, Chen CF, Lin LC, Huang YT, Shan J et al. Vasorelaxing action of rutaecarpine: effects of rutaecarpine on calcium channel activities in vascular endothelial and smooth muscle cells. J Pharmacol Exp Ther 1999; 289: 1237-44.
17. Pirotton S, Raspe E, Demolle D, Erneux C, Boeynaems JM. Involvement of inositol 1,4,5-triphosphate and calcium in the action of adenosine nucleotides on aortic endothelial cells. J Biol Chem 1987; 262: 17461-6.
18. Kuhberger E, Kukovetz WR, Groschner K. Cromakalim inhibits multiple mechanisms of smooth muscle activation with similar stereoselectivity. J Cardiovasc Pharmacol 1993; 21: 947-54.
19. + is an endothelium-derived hyperpolarizing factor in rat arteries. Nature 1998; 396: 269-72.
20. Knot HJ, Zimmermann PA, Nelson MT. Extracellular K(+)-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K(+) channels. J Physiol 1996; 492: 419-30.
21. Awe SO, Adeagbo AS, D'Souza SE, Bhatnagar A, Conklin DJ. Acrolein induces vasodilatation of rodent mesenteric bed via an EDHF-dependent mechanism. Toxicol Appl Pharmacol 2006; 217: 266-76.
22. Standen NB, Quayle JM, Davies NW, Brayden JE, Huang Y, Nelson MT. Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle. Science 1989; 245: 77-80.
23. Chrissobolis S, Sobey CG. Inwardly rectifying potassium channels in the regulation of vascular tone. Curr Drug Targets 2003; 4: 281-9.
24. Li NF, Chen SA, Wu SN. Evidence for the stimulatory effect of resveratrol on Ca(2+)-activated K+ current in vascular endothelial cells. Cardiovasc Res 2000; 45: 1035-45.
25. Calderone V, Martelli A, Testai L, Martinotti E, Breschi MC. Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels. Naunyn Schmiedebergs Arch Pharmacol 2007; 375: 73-80.
26. Ca channel opener, in vascular smooth muscle. Br J Pharmacol 1994; 113: 1538-47.
27. Chen SJ, Wu CC, Yang SN, Lin CI, Yen MG. Abnormal activation of K(+) channels in aortic smooth muscle of rats with endotoxic shock: electrophysiological and functional evidence. Br J Pharmacol 2000; 131: 213-22.