메뉴 건너뛰기




Volumn 2, Issue 12, 2007, Pages 1513-1523

Integrated micro flow synthesis based on sequential Br-Li exchange reactions of p-, m-, and o-dibromobenzenes

Author keywords

Arenes; Flow reactions; Integrated micro flow synthesis; Lithiation; Microreactors

Indexed keywords


EID: 36949023573     PISSN: 18614728     EISSN: 1861471X     Source Type: Journal    
DOI: 10.1002/asia.200700231     Document Type: Article
Times cited : (112)

References (85)
  • 1
    • 36949006874 scopus 로고    scopus 로고
    • Examples: a A. Orita, J. Yaruva, J. Otera, Angew. Chem. 1999, 111, 2397;
    • Examples: a) A. Orita, J. Yaruva, J. Otera, Angew. Chem. 1999, 111, 2397;
  • 2
  • 4
    • 36949031191 scopus 로고    scopus 로고
    • Examples: a A. Dömling, I. Ugi, Angew. Chem. 2000, 112, 3300;
    • Examples: a) A. Dömling, I. Ugi, Angew. Chem. 2000, 112, 3300;
  • 5
  • 9
    • 0037423972 scopus 로고    scopus 로고
    • Examples: a K. C. Nicolaou, T. Montagnon, S. A. Snyder, Chem. Commun. 2003, 551;
    • Examples: a) K. C. Nicolaou, T. Montagnon, S. A. Snyder, Chem. Commun. 2003, 551;
  • 19
    • 36949029317 scopus 로고    scopus 로고
    • G. Shore, S. Morin, M. G. Organ, Angew. Chem. 2006, 118, 2827; Angew. Chem. Int. Ed. 2006, 45, 2761;
    • i) G. Shore, S. Morin, M. G. Organ, Angew. Chem. 2006, 118, 2827; Angew. Chem. Int. Ed. 2006, 45, 2761;
  • 26
    • 0003679611 scopus 로고    scopus 로고
    • Ed, W. Ehrfeld, Springer, Berlin
    • a) Microreaction Technology (Ed.: W. Ehrfeld), Springer, Berlin, 1998;
    • (1998) Microreaction Technology
  • 29
    • 0035820025 scopus 로고    scopus 로고
    • Reviews; a S. J. Haswell, R. J. Middleton, B. O'Sullivan, V. Skelton, P. Watts, P. Styring, Chem. Commun. 2001, 391;
    • Reviews; a) S. J. Haswell, R. J. Middleton, B. O'Sullivan, V. Skelton, P. Watts, P. Styring, Chem. Commun. 2001, 391;
  • 31
    • 36949037441 scopus 로고    scopus 로고
    • K. Jähnisch, V. Hessel, H. Löwe, M. Baerns, Angew. Chem. 2004, 116, 410; Angew. Chem. Int. Ed. 2004, 43, 406;
    • c) K. Jähnisch, V. Hessel, H. Löwe, M. Baerns, Angew. Chem. 2004, 116, 410; Angew. Chem. Int. Ed. 2004, 43, 406;
  • 33
    • 23944512793 scopus 로고    scopus 로고
    • Examples of selective chemical reactions: a A. Nagaki, M. Togai, S. Suga, N. Aoki, K. Mae, J. Yoshida, J. Am. Chem. Soc. 2005, 727, 11666;
    • Examples of selective chemical reactions: a) A. Nagaki, M. Togai, S. Suga, N. Aoki, K. Mae, J. Yoshida, J. Am. Chem. Soc. 2005, 727, 11666;
  • 41
  • 54
    • 36949030146 scopus 로고    scopus 로고
    • T. Kawaguchi, H. Miyata, K. Ataka, K. Mae, J. Yoshida, Angew. Chem. 2005,117, 2465; Angew. Chem. Int. Ed. 2005, 44, 2413;
    • a) T. Kawaguchi, H. Miyata, K. Ataka, K. Mae, J. Yoshida, Angew. Chem. 2005,117, 2465; Angew. Chem. Int. Ed. 2005, 44, 2413;
  • 61
    • 28944448747 scopus 로고    scopus 로고
    • Industrial applications of micro flow systems: a H. Wakami, J. Yoshida, Org. Process Res. Dev. 2005, 9, 787;
    • Industrial applications of micro flow systems: a) H. Wakami, J. Yoshida, Org. Process Res. Dev. 2005, 9, 787;
  • 62
    • 36949010490 scopus 로고    scopus 로고
    • L. Ducry, D. M. Roberge, Angew. Chem. 2005, 117, 8186; Angew. Chem. Int. Ed. 2005, 44, 7972;
    • b) L. Ducry, D. M. Roberge, Angew. Chem. 2005, 117, 8186; Angew. Chem. Int. Ed. 2005, 44, 7972;
  • 64
    • 3042648225 scopus 로고    scopus 로고
    • Halogen-lithium exchange reactions of simple aromatic halides in microsystems: a T. Schwalbe, V Autze, M. Hohmann, W. Stirner, Org. Process Res. Dev. 2004, 8, 440;
    • Halogen-lithium exchange reactions of simple aromatic halides in microsystems: a) T. Schwalbe, V Autze, M. Hohmann, W. Stirner, Org. Process Res. Dev. 2004, 8, 440;
  • 67
    • 36949011110 scopus 로고    scopus 로고
    • Residence time was controlled by changing the length of R1 at a fixed flow rate.
    • Residence time was controlled by changing the length of R1 at a fixed flow rate.
  • 68
    • 36949013561 scopus 로고    scopus 로고
    • Figures 2-4 was produced by Origin 7.5J (scientific graphing and analysis software of OriginLab).
    • Figures 2-4 was produced by Origin 7.5J (scientific graphing and analysis software of OriginLab).
  • 69
    • 36949022617 scopus 로고    scopus 로고
    • Although it is difficult to determine the mixing time for the T-shaped mixers, it seems to be much less than 0.049 s at the present flow rate, because most of the starting material, p-dibromobenzene, was consumed within this time
    • Although it is difficult to determine the mixing time for the T-shaped mixers, it seems to be much less than 0.049 s at the present flow rate, because most of the starting material, p-dibromobenzene, was consumed within this time.
  • 70
    • 14644397220 scopus 로고    scopus 로고
    • Microtube reactors made of stainless steel are quite effective for rapid heat transfer. Thermal decomposition of a radical initiator revealed that the temperature inside the microtube reactor is practically the same as the bath temperature even if highly exothermic radical polymerization takes place in the microtube reactor; see
    • Microtube reactors made of stainless steel are quite effective for rapid heat transfer. Thermal decomposition of a radical initiator revealed that the temperature inside the microtube reactor is practically the same as the bath temperature even if highly exothermic radical polymerization takes place in the microtube reactor; see: T. Iwasaki, J. Yoshida, Macromokcuks 2005, 38, 1159.
    • (2005) Macromokcuks , vol.38 , pp. 1159
    • Iwasaki, T.1    Yoshida, J.2
  • 79
    • 36949016558 scopus 로고    scopus 로고
    • Angew. Chem. Int. Ed. 2002, 47, 4272; see also:
    • Angew. Chem. Int. Ed. 2002, 47, 4272; see also:
  • 81
    • 0001317313 scopus 로고    scopus 로고
    • o-Bromophenylmagnesium reagents, which are more stable than the corresponding lithium reagents, have been reported in the literature: a T. Ghosh, H. Hart, J. Org. Chem. 1988, 53, 3555;
    • o-Bromophenylmagnesium reagents, which are more stable than the corresponding lithium reagents, have been reported in the literature: a) T. Ghosh, H. Hart, J. Org. Chem. 1988, 53, 3555;
  • 82
    • 36949014236 scopus 로고    scopus 로고
    • L. Boymond, M. Rottländer, G. Chiez, P. Knöchel, Angew. Chem. 1998, 110, 1801; Angew. Chem. Int. Ed. 1998, 37, 1701;
    • b) L. Boymond, M. Rottländer, G. Chiez, P. Knöchel, Angew. Chem. 1998, 110, 1801; Angew. Chem. Int. Ed. 1998, 37, 1701;
  • 84
    • 36949005999 scopus 로고    scopus 로고
    • A. Krasovskiy, P. Knöchel, Angew. Chem. 2004, 116, 3396; Angew. Chem. Int. Ed. 2004, 43, 3333.
    • d) A. Krasovskiy, P. Knöchel, Angew. Chem. 2004, 116, 3396; Angew. Chem. Int. Ed. 2004, 43, 3333.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.