A copper-free Sonogashira coupling reaction in ionic liquids and its application to a microflow system for efficient catalyst recycling

Organic Letters

Volumn 4, Issue 10, 2002, Pages 1691-1694

  Fukuyama, Takahide ^a   Shinmen, Masutaka ^a   Nishitani, Satoshi ^a   Sato, Masaaki ^a   Ryu, Ilhyong ^a  

^a Osaka Prefecture University   (Japan)

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ARTICLE;

EID: 0000621561     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0257732     Document Type: Article

References (52)

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51. 6] at the initial stage of the reaction, could clog the microchannels.
52. We confirmed that a miniflow reactor (T-shaped tubular glass reactor, 0.2 cm i.d., 4 cm length) resulted in a low conversion of substrates, which supports highly efficient mixing as the key to the observed smooth reaction with a micromixer.