Acute and chronic hyperammonemia modulate antioxidant enzymes differently in cerebral cortex and cerebellum

Neurochemical Research

Volumn 33, Issue 1, 2008, Pages 103-113

  Singh, Santosh ^a   Koiri, Raj K ^a   Trigun, Surendra Kumar ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Ammonia neurotoxicity; Antioxidant enzymes; Cerebellum; Cerebral cortex; Hyperammonemia; Oxidative stress

Indexed keywords

AMMONIUM ACETATE; ANTIOXIDANT; CATALASE; ENZYME; GLUTATHIONE PEROXIDASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; HYPERAMMONEMIA; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACUTE DISEASE; ANIMALS; ANTIOXIDANTS; CATALASE; CEREBELLUM; CEREBRAL CORTEX; CHRONIC DISEASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYPERAMMONEMIA; MALE; OXIDATIVE STRESS; RATS; SUPEROXIDE DISMUTASE;

RATTUS;

EID: 36948999820     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-007-9422-x     Document Type: Article

References (52)

1. Felipo V, Butterworth RF (2002) Neurobiology of ammonia. Prog Neurobiol 67:259-279
2. Butterworth RF (2000) Hepatic encephalopathy: a neuropsychiatric disorder involving multiple neurotransmitter systems. Curr Opin Neurol 13:721-727
3. Marcaida G, Felipo V, Hermengildo C et al (1992) Acute ammonia toxicity is mediated by the NMDA type of glutamate receptor. FEBS Lett 296:67-68
4. Rama Rao KV, Norenberg MD (2001) Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia. Metab Brain Dis 16:67-78
5. Kosenko E, Felipo V, Montoliu C et al (1996) Effects of acute hyperammonemia in vivo on oxidative metabolism in nonsynaptic rat brain mitochondria. Metab Brain Dis 12:69-82
6. Rama Rao KV, Jayakumar AR, Norenberg MD (2005) Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultered astrocytes. Neurochem Int 47:31-38
7. Murthy CRK, Rama Rao KV, Bai G et al (2001) Ammonia induced production of free radicals in primary culture of rat astrocytes. J Neurosci Res 66:282-288
8. Kosenko E, Kaminski Y, Lopata O et al (1999) Blocking of NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication. Free Radical Res 26:1369-1374
9. Norenberg MD, Jayakumar AR, Rama Rao KV (2004) Oxidative stress in the pathogenesis of hepatic encephalopathy. Metab Brain Dis 19:313-329
10. Sathyasaikumar KV, Swapna I, Reddy PVB et al (2007) Fulminant hepatic failure in rats induces oxidative stress differentially in cerebral cortex, cerebellum and pons medula. Neurochem Res 32:517-524
11. Hermenegildo C, Montoliu C, Llansola M et al (1998) Chronic hyperammonemia impairs the glutamate-nitric oxide-cyclicGMP pathway in cerebellar neurons in culture and in the rat in vivo. Eur J Neurosci 10:3201-3209
12. Rodrigo R, Felipo V (2006) Brain regional alternations in the modulation of the glutamate-nitric oxide-cGMP pathway in liver cirrhosis: role of hyperammonemia and cell types involved. Neorochem Int 48:472-477
13. Kosenko E, Kaminsky YG, Felipo V et al (1993) Chronic hyperammonemia prevents changes in brain energy and ammonia metabolism induced by acute ammonia intoxication. Biochim Biophys Acta 1180:321-326
14. Gilberstadt SJ, Gilberstadt H, Zieve L et al (1980) Psychomotor performance defects in cirrhotic patients without overt encephalopathy. Arch Int Med 140:519-521
15. Tarter RE, Hegedus AM, Van Thiel DH et al (1984) Non-alcoholic cirrhosis associated with neuropsychological dysfunction in the absence of overt evidence of hepatic encephalopathy. Gastroenterology 86:1421-1427
16. Corbalan R, Chaturet N, Behrends S et al (2002) Region selective alternation of soluble guanylate cyclase content and modulation in brain of cirrhotic patients. Hepatology 6:1155-1162
17. Mates JM (2000) Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153:83-104
18. Magistretti PJ (2003) Brain energy metabolism. In: Fundamental neuroscience, 2nd edn. Elsevier Science, New York, pp339-360
19. Tureen JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552:335-344
20. Flohe RB (1999) Tissue-specific function of individual glutathione peroxidases. Free Radical Biol Med 27:951-965
21. Gsell W, Conrad R, Hickethier M et al (1995) Decreased catalase activity but unchanged superoxide dismutase activity in brain of patients of Alzheimer type. J Neurochem 64:1216-1233
22. Frey BN, Valvassori SS, Reus GS et al (2006) Changes in antioxidant defense enzymes after d-amphetamine exposure: implications as an animal model of mania. Neurochem Res 31:699-703
23. Furtunato JJ, Feier G, Vitali AM (2006) Malathione-induced oxidative stress in rat brain regions. Neurochem Res 31:671-678
24. Hilgier W, Albrecht J, Lisy V et al (1990) The effect of acute and chronic hyperammonemia on y-glutamyl transpeptidase in various brain regions of young and adult rats. Mol Chem Neuropathol 13:47-56
25. Pandey P, Singh SK, Trigun SK (2005) Developing brain of moderately hypothyroid mice shows adaptive changes in the key enzymes of glucose metabolism. Neurol Psych Brain Res 12:159-164
26. Lowry OH, Rosebrough NJ, Farr AL et al (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
27. Placer ZA, Cushman LL, Johnson BC (1966) Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem 16: 359-364
28. Sedlak J, Raymond HL (1968) Estimation of total thiol, protein bound, and non protein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 25:192-205
29. Kakkar P, Das B, Viswanathan PN (1984) A modified spectrophotometric assay of superoxide dismutase ( SOD). Ind J Biochem Biophys 21:130-132
30. Sinha KA (1972) Colorimetric assay of catalase. Anal Biochem 47:389-394
31. Trigun SK, Singh AP, Asthana RK et al (2006) Assessment of bioactivity of a Fischerella species colonizing Azadirachta Indica (neem) Bark. Appl Ecol Environ Res 4:119-128
32. Beauchamp C, Fridovich I (1971) Superoxide dismutase:improved assays and an assay applicable to acrylamide gels. Anal Biochem 44:276-287
33. Sun Y, Elwell JH, Oberley LW (1988) A simultaneous visualization of the antioxidant enzymes glutathione peroxidase and catalase on polyacrylamide gels. Free Radical Res Commun 5:67-75
34. Lin CL, Chen HJ, Hou WC (2002) Activity staining of glutathione peroxidase after electrophoresis on native and sodium dodecylsulfate polyacrylamide gels. Electrophoresis 23:513-516
35. Carlberg I, Mannervik B (1975) Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J Biol Chem 250:5475-5480
36. Wang H (2000) Over expression of L-PhGPx in MCF-7 cells. In: The role of mitochondrial phospholipids hydroperoxide glutathione peroxide in cancer therapy. Ph.D. thesis. The University of Iowa, Iowa, pp16-56
37. Kanamori K, Ross BD, Chung JC et al (1996) Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutmine synthetase in vivo. J Neurochem 67:1584-1594
38. Lockwood AH (2004) Blood ammonia levels and hepatic encephalopathy. Metab Brain Dis 19:345-349
39. Halliwell B, Gutteridge JMC (1985) Oxygen radicals and nervous system. Trends Neurosci 8:22-26
40. Kosenko E, Venediktova N, Kamanisky Y et al (2003) Sources of oxygen radical in brain in acute ammonia intoxication in vivo. Brain Res 981:193-200
41. Dringen R, Pawlowski PG, Hirrlinger J (2005) Peroxide detoxification by brain cells. J Neurosci Res 79:157-165
42. Hovatta I, Tennant RS, Helton R et al (2005) Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature 438:662-666
43. Murthy Ch RK, Bender AS, Dombro RS et al (2000) Elevation of glutathione level by ammonium ions in primary cultures of rat astrocytes. Neurochem Int 37:255-268
44. Halliwell B (2001) Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drug Aging 18:685-716
45. Patenaude A, Murthy MR, Mirault ME (2005) Emerging roles of thioredoxin cycle enzymes in the central nervous system. Cell Mol Life Sci 62:1063-1080
46. Imai H, Nakagawa Y (2003) Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radical Biol Med 34:145-169
47. Bray RC, Cockel SA, Fielden EM et al (1974) Reduction and inactivation of superoxide dismutase by hydrogen peroxide. Biochem J 139:43-48
48. Salo DC, Pacifici RE, Lin SW (1990) Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation. J Biol Chem 265:11919-11927
49. Mokni M, Elkahoui S, Limam F et al (2007) Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rat. Neurochem Res 32:981-987
50. Hazell AS, Normandin L, Norenberg MD et al (2006) Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment. Neurosci Lett 396:167-171
51. Takeda A (2003) Manganese action in brain function. Brain Res Rev 41:79-87
52. Maitre B, Jornot L, Jonod AF (1993) Effects of inhibition of catalase and superoxide dismutase activity on antioxidant enzyme mRNA levels. Am J Physiol 265:636-643