Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2

Biochemistry

Volumn 46, Issue 48, 2007, Pages 13742-13751

  Murray, Euan ^a   McKenna, Ekaterina O ^c   Burch, Lindsay R ^a   Dillon, John ^b   Langridge Smith, Pat ^a   Kolch, Walter ^c   Pitt, Andrew ^c   Hupp, Ted R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMERS; DIAGNOSTIC ASSAYS; IMMUNOBLOT; PROTEOMIC TECHNOLOGIES;

BIOASSAY; BIOPSY; MUTAGENESIS; PROTEINS;

BIOMARKERS;

ANTERIOR GRADIENT 2 PROTEIN; BIOLOGICAL MARKER; EPITOPE; PEPTIDE APTAMER; PEPTIDE LIBRARY; POLYPEPTIDE; PROTEIN; PROTEIN INHIBITOR; PROTEIN P53; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BIOASSAY; BIOTINYLATION; COMBINATORIAL LIBRARY; ENZYME LINKED IMMUNOSORBENT ASSAY; LIGAND BINDING; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PURIFICATION; PROTEIN TARGETING; PROTEOMICS; SCREENING;

AMINO ACID SEQUENCE; ANIMALS; APTAMERS, PEPTIDE; BIOLOGICAL MARKERS; CHROMATOGRAPHY, AFFINITY; COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN ARRAY ANALYSIS; PROTEINS; SWINE;

EID: 36849085340     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7008739     Document Type: Article

References (29)

1. Adam, P. J., Boyd, R., Tyson, K. L., Fletcher, G. C., Stamps, A., Hudson, L., Poyser, H. R., Redpath, N., Griffiths, M., Steers, G., Harris, A. L., Patel, S., Berry, J., Loader, J. A., Townsend, R. R., Daviet, L., Legrain, P., Parekh, R., and Terrett, J. A. (2003) Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer, J. Biol. Chem. 278, 6482-6489.
2. Hermeking, H. (2003) Serial analysis of gene expression and cancer, Curr. Opitt. Oncol. 15, 44-49.
3. Pohler, E., Craig, A. L., Cotton, J., Lawrie, L., Dillon, J. F., Ross, P., Kernohan, N., and Hupp, T. R. (2004) The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage, Mol. Cell. Proteomics 3, 534-547.
4. Wang, Z., Shen, D., Parsons, D. W., Bardelli, A., Sager, J., Szabo, S., Ptak, J., Silliman, N., Peters, B. A., van der Heijden, M. S., Parmigiani, G., Yan, H., Wang, T. L., Riggins, G., Powell, S. M., Willson, J. K., Markowitz, S., Kinzler, K. W., Vogelstein, B., and Velculescu, V. E. (2004) Mutational analysis of the tyrosine phosphatome in colorectal cancers, Science 304, 1164-1166.
5. McEntyre, J. R., and Gibson, T. J. (2004) Patterns and clusters , within the PSM column in TiBS, 1992-2004, Trends Biochem. Sci. 29, 627-633.
6. Burch, L. R., Scott, M., Pohler, E., Meek, D., and Hupp, T. (2004) Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1, J. Mol. Biol. 337, 115-128.
7. Burch, L., Shimizu, H., Smith, A., Patterson, C., and Hupp, T. R. (2004) Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein, J. Mol. Biol. 337, 129-145.
8. Bronchud, M. H. (2002) Is cancer really a 'local' cellular clonal disease?, Med. Hypotheses 59, 560-565.
9. Olivier, M., Eeles, R., Hollstein, M., Khan, M. A., Harris, C. C., and Hainaut, P. (2002) The IARC TP53 database: new online mutation analysis and recommendations to users, Hum. Mutat. 19, 607-614.
10. Fitzgerald, R. C., and Farthing, M. J. (2003) The pathogenesis of Barrett's esophagus, Gastrointest. Endosc. Clin. N. Am. 13, 233-255.
11. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. (1994) Mutations in the p53 tumor suppressor gene clues to cancer etiology and molecular pathogenesis, Cancer Res. 54, 4855-4878
12. Morgan, C., Alazawi, W., Sirieix, P., Freeman, T., Coleman, N., and Fitzgerald, R. (2004) In vitro acid exposure has a differential effect on apoptotic and proliferative pathways in a Barrett's adenocarcinoma cell line, Am. J. Gastroenterol. 99, 218-224.
13. Yagui-Beltran, A., Craig, A. L., Lawrie, L., Thompson, D., Pospisilova, S., Johnston, D., Kernohan, N., Hopwood, D., Dillon, J. F., and Hupp, T. R. (2001) The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response, Eur. J. Biochem. 268, 5343-5355.
14. Darragh, J., Hunter, M., Pohler, E., Dillon, J. F., Ross, P., Kernohan, N., and Hupp, T. R. (2006) The Calcium Binding Domain of SEP53 is Required for Survival in Response to DCA-Mediated Stress, FEBS J. 273, 1930-1947.
15. McManus, D. T., Olaru, A., and Meltzer, S. J. (2004) Biomarkers of esophageal adenocarcinoma and Barrett's esophagus, Cancer Res. 64, 1561-1569.
16. Campomenosi, P., Conio, M., Bogliolo, M., Urbini, S., Assereto, P., Aprile, A., Monti, P., Aste, H., Lapertosa, G., Inga, A., Abbondandolo, A., and Fronza, G. (1996) p53 is frequently mutated in Barrett's metaplasia of the intestinal type, Cancer Epidemiol. Biomarkers Prev. 5, 559-565.
17. Prevo, L. J., Sanchez, C. A., Galipeau, P. C., and Reid, B. J. (1999) p53-mutant clones and field effects in Barrett's esophagus, Cancer Res. 59, 4784-4787.
18. Liu, D., Rudland, P. S., Sibson, D. R., Platt-Higgins, A., and Barraclough, R. (2005) Human homologue of cement gland protein, a novel metastasis inducer associated with breast carcinomas, Cancer Res. 65, 3796-3805.
19. Hopwood, D., Moitra, S., Vojtesek, B., Johnston, D. A., Dillon, J. F., and Hupp, T. R. (1997) Biochemical analysis of the stress protein response in human oesophageal epithelium, Gut 41, 156-163.
20. Nissim, A., Hoogenboom, H. R., Tomlinson, I. M., Flynn, G., Midgley, C., Lane, D., and Winter, G. (1994) Antibody fragments from a 'single pot' phage display library as immunochemical reagents, EMBO J. 13, 692-698.
21. Krebs, B., Rauchenberger, R., Reiffert, S., Rothe, C., Tesar, M., Thomassen, E., Cao, M., Dreier, T., Fischer, D., Hoss, A., Inge, L., Knappik, A., Marget, M., Pack, P., Meng, X. Q., Schier, R., Sohlemann, P., Winter, J., Wolle, J., and Kretzschmar, T. (2001) High-throughput generation and engineering of recombinant human antibodies, J. Immunol. Methods 254, 67-84.
22. Shimizu, H., Burch, L. R., Smith, A. J., Dornan, D., Wallace, M., Ball, K. L., and Hupp, T. R. (2002) The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo, J. Biol. Chem. 277, 28446-28458.
23. Wallace, M., Worrall, E., Pettersson, S., Hupp, T., and Ball, K. (2006) Dual Site Regulation of the E3 Ligase Activity of MDM2, Mol. Cell 23, 251-263.
24. Dornan, D., Shimizu, H., Burch, L., Smith, A. J., and Hupp, T. R. (2003) The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53, Mol. Cell. Biol. 23, 8846-8861.
25. Finlan, L., and Hupp, T. R. (2004) The N-terminal interferon-binding domain (IBiD) homology domain of p300 binds to peptides with homology to the p53 transactivation domain, J. Biol. Chem. 279, 49395-49405.
26. Hinestrosa, M. C. et al. (2007) Shaping the future of biomarker research in breast cancer to ensure clinical relevance. Nat. Rev. Cancer 7, 309-315.
27. Sato, A. K., et cl. (2002) Development of mammalian serum albumin affinity purification media by peptide phage display, Biotechnol. Prog. 18, 182-192.
28. Kelly, B., Booth, J., Tannatt, M., Wu, Q., Ladner, R., Wu, W., Poter, D., and Ley, A. (2004) Isolation of a peptide ligand for affinity purification of factor VIII using phage display, J. Chromatogr., A 1038, 121-130.
29. Little, T., Nelson, L., and Hupp, T. R. (2007) Adaptive evolution of a stress response protein, PLoS ONE (in press).