Combination of indomethacin and statin compared with indomethacin and placebo in patients with a first episode of acute pericarditis: Preliminary findings

Clinical Science

Volumn 113, Issue 11-12, 2007, Pages 443-448

  Di Pasquale, Pietro ^a   Cannizzaro, Sergio ^a   Fasullo, Sergio ^a   Ganci, Filippo ^a   Marenghini, Giorgio ^a   Scalzo, Sebastiano ^a   Giambanco, Francesco ^a   Vitale, Giuseppe ^a   Polizzi, Giovanni ^b   Paterna, Salvatore ^c  

^a Ospedale GF Ingrassia   (Italy)

^b Partinico Hospital   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

Author keywords

Acute pericarditis; Hospitalization time; Indomethacin; Inflammatory marker; Non steroidal anti inflammatory drug (NSAID); Rosuvastatin

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; CREATINE KINASE; INDOMETACIN; ROSUVASTATIN; TROPONIN I;

ABDOMINAL PAIN; ADULT; ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; DYSPEPSIA; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FOLLOW UP; GASTRITIS; HOSPITAL DISCHARGE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PERICARDITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UNSPECIFIED SIDE EFFECT;

ACUTE DISEASE; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; C-REACTIVE PROTEIN; CARDIOVASCULAR AGENTS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ELECTROCARDIOGRAPHY; FEMALE; FLUOROBENZENES; FOLLOW-UP STUDIES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOMETHACIN; INFLAMMATION MEDIATORS; MALE; PERICARDITIS; PYRIMIDINES; RECURRENCE; SULFONAMIDES; TREATMENT OUTCOME;

EID: 36849065762     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20070092     Document Type: Article

References (34)

1. Spodick, D. H. (2001) Pericardial disease. In Heart Disease: a Textbook of Cardiovascular Medicine (Braunwald, E., Zipes, D. and Libby, P., eds), pp. 1823-1866, W.B. Saunders, Philadelphia
2. Spodick, D. H. (2003) Acute pericarditis: current concepts and practice. JAMA, J. Am. Med. Assoc. 289, 1150-1153
3. Adler, Y., Finkelstein, Y., Guindo, J. et al. (1998) Colchicine treatment for recurrent pericarditis: a decade of experience. Circulation 97, 2183-2185
4. Vane, J. R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol. 231, 232-235
5. Ridker, P. M., Rifai, N., Pfeffer, M. A. et al. (1999) Long-term effects of pravastatin on plasma concentration of C-reactive protein: the Cholesterol and Recurrent Events (CARE) Investigators. Circulation 100, 230-235
6. Ridker, P. M., Rifai, N. and Lowenthal, S. P. (2001) Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia. Circulation 103, 1191-1193
7. Strandberg, T. E., Vanhanen, H. and Tikkanen, M. J. (1999) Effect of statins on C-reactive protein in patients with coronary artery disease. Lancet 353, 118-119
8. Ridker, P. M., Rifai, N., Clearfield, M. et al. (2001) Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N. Engl. J. Med. 344, 1959-1965
9. Jialal, I., Stein, D., Balis, D. et al. (2001) Effect of hydroxymethyl glutaryl CoA reductase inhibitor therapy on high sensitive C-reactive protein levels. Circulation 103, 1933-1935
10. Permanyer-Miralda, G., Sagrista-Sauleda, J. and Soler-Soler, J. (1985) Primary acute pericardial disease: a prospective series of 231 consecutive patients. Am J. Cardiol. 56, 623-630
11. Imazio, M., Demichelis, B., Cecchi, E. et al. (2003) Cardiac troponin I in acute pericarditis. J. Am. Coll. Cardiol. 42, 2144-2148
12. Weitzman, L. B., Tinker, W. P., Kronzon, I. et al. (1984) The incidence and natural history of pericardial effusion after cardiac surgery: an echocardiographic study. Circulation 69, 506-511
13. Wæhre, T., Damås, J. K., Gullestad, L. et al. (2003) Hydroxymethylglutaryl coenzyme A reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease. J. Am. Coll. Cardiol. 41, 1460-1467
14. Nissen, S. E., Murat Tuzcu, E., Schoenhagen, P. et al. (2005) Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N. Engl. J. Med. 352, 29-38
15. Kinky, S., Schwartz, G. G., Olsson, A. G. et al. (2003) High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL Study. Circulation 108, 1560-1566
16. Weber, C., Erl, W., Weber, K. S. C. et al. (1997) HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia. J. Am. Coll. Cardiol. 30, 1212-1217
17. Kimura, M., Kurose, I., Russell, J. et al. (1997) Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats. Arterioscler. Thromb. Vasc. Biol. 17, 1521-1526
18. Rasmussen, L. M., Hansen, P. R., Nabipour, M. T. et al. (2001) Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. Biochem. J. 360, 363-370
19. Weitz-Schmidt, G., Welzenbach, K., Brinkmann, V. et al. (2001) Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat. Med. 7, 687-692
20. Leung, B. P., Sattar, N., Crilly, A. et al. (2003) A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J. Immunol. 170, 1524-1530
21. Hilgendorff, A., Muth, H., Parviz, B. et al. (2003) Statins differ in their ability to block NF-κB activation in human blood monocytes. Int. J. Clin. Pharmacol. Ther. 41, 397-401
22. Dechend, R., Fiebler, A., Lindschau, C. et al. (2001) Modulating angiotensin II-induced inflammation by HMG Co-A reductase inhibition. Am. J. Hypertens. 14, 55S-61S
23. Li, W. M., Liu, W., Gao, C. and Zhou, B. G. (2006) Immunoregulatory effects of atorvastatin on experimental autoimmune myocarditis in Lewis rats. Immunol. Cell. Biol. 84, 274-280
24. Aktas, O., Waiczies, S., Smorodchenko, A. et al. (2003) Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. J. Exp. Med. 197, 725-733
25. Youssef, S., Stüve, O., Patarroyo, J. C. et al. (2002) The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 420, 78-84
26. Kwak, B., Mulhaupt, F., Myit, S. et al. (2000) Statins as a newly recognized type of immunomodulator. Nat. Med. 6, 1399-1402
27. Kumagai, K., Nakashima, H. and Saku, K. (2004) The HMG-CoA reductase inhibitor atorvastatin prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model. Cardiovasc. Res. 62, 105-111
28. Siu, C. W., Lau, C. P. and Tse, H. F. (2003) Prevention of atrial fibrillation recurrence by statin therapy in patients with lone atrial fibrillation after successful cardioversion. Am. J. Cardiol. 92, 1343-1345
29. McCarey, D. W., McInnes, P. B., Madhok, R. et al. (2004) Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial, Lancet 363, 2015-2021
30. Brooks, G., Yu, X. M., Wang, Y., Crabbe, M. J., Shattock, M. J. and Harper, J. V. (2003) Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit vascular smooth muscle cell proliferation via differential effects on the cell cycle. J. Pharm. Pharmacol. 55, 519-526
31. Zhang, X., Morham, S. G., Langenbach, R. and Young, D. A. (1999) Malignant transformation and antineoplastic actions of nonsteroidal anti-inflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts. J. Exp. Med. 190, 451-459
32. Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M. and Kliewer, S. A. (1997) Peroxisome proliferator activated receptors and are activated by indomethacin and other non-steroidal anti-inflammatory drugs. Biol. Chem. 272, 3406-3410
33. Hirai, H., Tanaka, K., Takano, S., Ichimasa, M., Nakamura, M. and Nagata, K. (2002) Agonistic effect of indomethacin on a prostaglandin D2 Receptor, CRTH2. J. Immunol. 168, 981-985
34. Rossen, J. W., Bouma, J., Raatgeep, R. H., Buller, H. A. and Einerhand, A. W. (2004) Inhibition of cyclooxygenase activity reduces rotavirus infection at a postbinding step. J. Virol. 78, 9721-9730