메뉴 건너뛰기




Volumn 102, Issue 6, 2007, Pages 1542-1552

Molecular cloning and characterization of the Xenopus hypoxia-inducible factor 1α (xHIF1α)

Author keywords

Arnt; bHLH pas; Embryogenesis; HIF1 ; Hypoxia; Normoxia; PAS proteins; Xenopus

Indexed keywords

HETERODIMER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2ALPHA;

EID: 36849036245     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21376     Document Type: Article
Times cited : (12)

References (52)
  • 1
    • 33646175288 scopus 로고    scopus 로고
    • The hypoxia-inducible factor hydroxylases bring fresh air into hypoxia signalling
    • Berra E, Ginouvès A, Pouysségur J. 2006. The hypoxia-inducible factor hydroxylases bring fresh air into hypoxia signalling. EMBO Rep 7:41-45.
    • (2006) EMBO Rep , vol.7 , pp. 41-45
    • Berra, E.1    Ginouvès, A.2    Pouysségur, J.3
  • 2
    • 0034818277 scopus 로고    scopus 로고
    • Molecular cloning and embryonic expression of the Xenopus Arnt gene
    • Bollérot K, Angelier N, Coumailleau P. 2001. Molecular cloning and embryonic expression of the Xenopus Arnt gene. Mech Dev 108:227-231.
    • (2001) Mech Dev , vol.108 , pp. 227-231
    • Bollérot, K.1    Angelier, N.2    Coumailleau, P.3
  • 4
    • 0033986948 scopus 로고    scopus 로고
    • Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1α
    • Carrero P, Okamoto K, Coumailleau P, O'Brien S, Tanaka H, Poellinge L. 2000. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1α. Mol Cell Biol 20:402-415.
    • (2000) Mol Cell Biol , vol.20 , pp. 402-415
    • Carrero, P.1    Okamoto, K.2    Coumailleau, P.3    O'Brien, S.4    Tanaka, H.5    Poellinge, L.6
  • 5
    • 0033728401 scopus 로고    scopus 로고
    • Characterization and developmental expression of xSim, a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded
    • Coumailleau P, Penrad-Mobayed M, Lecomte C, Bollérot K, Simon F, Poellinger L, Angelier N. 2000. Characterization and developmental expression of xSim, a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded. Mech Dev 99:63-166.
    • (2000) Mech Dev , vol.99 , pp. 63-166
    • Coumailleau, P.1    Penrad-Mobayed, M.2    Lecomte, C.3    Bollérot, K.4    Simon, F.5    Poellinger, L.6    Angelier, N.7
  • 6
    • 0142247787 scopus 로고    scopus 로고
    • bHLH/PAS proteins: Essential transcription factors involved in organism response to environmental stress and in developmental processes
    • Coumailleau P. 2002. bHLH/PAS proteins: Essential transcription factors involved in organism response to environmental stress and in developmental processes. Recent Res Devel Mol Cell Biol 3:113-153.
    • (2002) Recent Res Devel Mol Cell Biol , vol.3 , pp. 113-153
    • Coumailleau, P.1
  • 7
    • 0042203622 scopus 로고    scopus 로고
    • Xenopus single-minded (xSim) is a nuclear factor allowing nuclear translocation of its cytoplasmic partner xArnt
    • Coumailleau P, Bollérot K, Lecomte C, Angelier N. 2003. Xenopus single-minded (xSim) is a nuclear factor allowing nuclear translocation of its cytoplasmic partner xArnt. Exp Cell Res 287:237-248.
    • (2003) Exp Cell Res , vol.287 , pp. 237-248
    • Coumailleau, P.1    Bollérot, K.2    Lecomte, C.3    Angelier, N.4
  • 8
    • 0032872915 scopus 로고    scopus 로고
    • Remembrance of things PAS: Regulation of development by bHLH-PAS proteins
    • Crews ST, Fan CM. 1999. Remembrance of things PAS: Regulation of development by bHLH-PAS proteins. Curr Opin Genet Dev 9:580-587.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 580-587
    • Crews, S.T.1    Fan, C.M.2
  • 9
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. 1997. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 94:4273-4278.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 10
    • 0343683375 scopus 로고    scopus 로고
    • HRF, a putative basic helix-loop-helix-PAS-domain transcription factor that is closely related to hypoxia-inducible factor 1α and developmental expressed in blood vessels
    • Flamme I, Frolich T, von Reutern M, Kappel A, Damert A, Risau W. 1997. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor that is closely related to hypoxia-inducible factor 1α and developmental expressed in blood vessels. Mech Dev 63:51-60.
    • (1997) Mech Dev , vol.63 , pp. 51-60
    • Flamme, I.1    Frolich, T.2    von Reutern, M.3    Kappel, A.4    Damert, A.5    Risau, W.6
  • 11
    • 11244264337 scopus 로고    scopus 로고
    • Loss of Gata1 but not Gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos
    • Galloway JL, Wingert RA, Thisse C, Thisse B, Zon LI. 2005. Loss of Gata1 but not Gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell 8:109-116.
    • (2005) Dev Cell , vol.8 , pp. 109-116
    • Galloway, J.L.1    Wingert, R.A.2    Thisse, C.3    Thisse, B.4    Zon, L.I.5
  • 12
    • 33646016261 scopus 로고    scopus 로고
    • Sensing and responding to hypoxia via HIF in model invertebrates
    • Gorr TA, Gassmann M, Wappner P. 2006. Sensing and responding to hypoxia via HIF in model invertebrates. J Insect Physiol 52:349-364.
    • (2006) J Insect Physiol , vol.52 , pp. 349-364
    • Gorr, T.A.1    Gassmann, M.2    Wappner, P.3
  • 13
    • 7444262496 scopus 로고    scopus 로고
    • The status, quality, and expansion of the NIH full-length cDNA project: The mammalian gene collection (MGC)
    • Gerhard DS, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: The mammalian gene collection (MGC). Genome Res 14:2121-2127.
    • (2004) Genome Res , vol.14 , pp. 2121-2127
    • Gerhard, D.S.1
  • 14
    • 0034116376 scopus 로고    scopus 로고
    • The PAS superfamily: Sensors of environmental and developmental signals
    • Gu YZ, Hogenesh JB, Bradfield CA. 2000. The PAS superfamily: Sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol 40:519-561.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 519-561
    • Gu, Y.Z.1    Hogenesh, J.B.2    Bradfield, C.A.3
  • 15
    • 0030963616 scopus 로고    scopus 로고
    • The hypoxic response: Huffing and HIFing
    • Guillemin K, Krasnow MA. 1997. The hypoxic response: Huffing and HIFing. Cell 89:9-12.
    • (1997) Cell , vol.89 , pp. 9-12
    • Guillemin, K.1    Krasnow, M.A.2
  • 16
    • 0026285616 scopus 로고
    • In situ hybridization: An improved whole mount method for Xenopus embryos
    • Harland RM. 1991. In situ hybridization: An improved whole mount method for Xenopus embryos. Methods Cell Biol 36:675-685.
    • (1991) Methods Cell Biol , vol.36 , pp. 675-685
    • Harland, R.M.1
  • 17
    • 0035651033 scopus 로고    scopus 로고
    • Dissecting hypoxia-dependent and hypoxia-independant steps in the HIF1 alpha activation cascade: Implications for gene therapy
    • Hofer T, Desbaillets I, Hopfl G, Gassmann M, Wenger RH. 2001. Dissecting hypoxia-dependent and hypoxia-independant steps in the HIF1 alpha activation cascade: Implications for gene therapy. FASEB J 14:2715-2717.
    • (2001) FASEB J , vol.14 , pp. 2715-2717
    • Hofer, T.1    Desbaillets, I.2    Hopfl, G.3    Gassmann, M.4    Wenger, R.H.5
  • 18
    • 0030887045 scopus 로고    scopus 로고
    • Characterization of a subset of the basic-helix-loop- helix-PAS superfamily that interacts with components of the dioxin signaling pathway
    • Hogenesh JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA. 1997. Characterization of a subset of the basic-helix-loop- helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem 272:8581-8593.
    • (1997) J Biol Chem , vol.272 , pp. 8581-8593
    • Hogenesh, J.B.1    Chan, W.K.2    Jackiw, V.H.3    Brown, R.C.4    Gu, Y.Z.5    Pray-Grant, M.6    Perdew, G.H.7    Bradfield, C.A.8
  • 20
    • 0031971047 scopus 로고    scopus 로고
    • Expression of Arnt, Arnt2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse
    • Jain S, Maltepe E, Lu MM, Simon C, Bradfield CA. 1998. Expression of Arnt, Arnt2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse. Mech Dev 73:117-123.
    • (1998) Mech Dev , vol.73 , pp. 117-123
    • Jain, S.1    Maltepe, E.2    Lu, M.M.3    Simon, C.4    Bradfield, C.A.5
  • 21
    • 0034940761 scopus 로고    scopus 로고
    • The Caenorhabitis elegans Hif1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia
    • Jiang H, Guo R, Powell-Coffman J. 2001. The Caenorhabitis elegans Hif1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia. PNAS USA 14:7916-7921.
    • (2001) PNAS USA , vol.14 , pp. 7916-7921
    • Jiang, H.1    Guo, R.2    Powell-Coffman, J.3
  • 22
    • 0032538797 scopus 로고    scopus 로고
    • Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor 1α
    • Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L. 1998. Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor 1α. EMBO J 17:6573-6586.
    • (1998) EMBO J , vol.17 , pp. 6573-6586
    • Kallio, P.J.1    Okamoto, K.2    O'Brien, S.3    Carrero, P.4    Makino, Y.5    Tanaka, H.6    Poellinger, L.7
  • 23
    • 0345708353 scopus 로고    scopus 로고
    • The mammalian basic helix-loop-helix/PAS family of transcriptional regulators
    • Kewley RJ, Whitelaw ML, Chapman-Smith A. 2004. The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. Int J Biochem Cell Biol 36:189-204.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 189-204
    • Kewley, R.J.1    Whitelaw, M.L.2    Chapman-Smith, A.3
  • 24
    • 0036896487 scopus 로고    scopus 로고
    • Genetic and genomic tools for Xenopus research: The NIH Xenopus Initiative
    • Klein SL, et al. 2002. Genetic and genomic tools for Xenopus research: The NIH Xenopus Initiative. Dev Dyn 225:384-391.
    • (2002) Dev Dyn , vol.225 , pp. 384-391
    • Klein, S.L.1
  • 25
    • 0033562569 scopus 로고    scopus 로고
    • Defective vascularization of HIF1 apha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
    • Kotch LE, Iyer NV, Laughner E, Semenza GL. 1999. Defective vascularization of HIF1 apha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 209:254-267.
    • (1999) Dev Biol , vol.209 , pp. 254-267
    • Kotch, L.E.1    Iyer, N.V.2    Laughner, E.3    Semenza, G.L.4
  • 26
    • 27644559519 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptors in the frog Xenopus laevis: Two AhR1 paralogs exhibit low affinity for 2,3,7,8-Tetrachlorodibenzo-b-Dioxin (TCDD)
    • Lavine JA, Rowatt AJ, Klimova T, Whitington AJ, Dengler E, Beck C, Powell WH. 2005. Aryl hydrocarbon receptors in the frog Xenopus laevis: Two AhR1 paralogs exhibit low affinity for 2,3,7,8-Tetrachlorodibenzo-b-Dioxin (TCDD). Toxicol Sci 88:60-72.
    • (2005) Toxicol Sci , vol.88 , pp. 60-72
    • Lavine, J.A.1    Rowatt, A.J.2    Klimova, T.3    Whitington, A.J.4    Dengler, E.5    Beck, C.6    Powell, W.H.7
  • 27
    • 0029017976 scopus 로고
    • Protein-protein interaction via PAS domains: Role of the pAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex
    • Lindebro MC, Poellinger L, Whitelaw ML. 1995. Protein-protein interaction via PAS domains: Role of the pAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex. EMBO J 14:3528-3539.
    • (1995) EMBO J , vol.14 , pp. 3528-3539
    • Lindebro, M.C.1    Poellinger, L.2    Whitelaw, M.L.3
  • 28
    • 33744807179 scopus 로고    scopus 로고
    • Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling
    • Morin RD, et al. 2007. Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling. Genome Res 16:796-803.
    • (2007) Genome Res , vol.16 , pp. 796-803
    • Morin, R.D.1
  • 29
    • 0030012683 scopus 로고    scopus 로고
    • The melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1α and Dropshila single-minded
    • Nambu J, Chen W, Hu S, Crews S. 1996. The melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1α and Dropshila single-minded. Gene 172:249-254.
    • (1996) Gene , vol.172 , pp. 249-254
    • Nambu, J.1    Chen, W.2    Hu, S.3    Crews, S.4
  • 31
    • 0024002556 scopus 로고
    • Luciferase reporter gene vectors for analysis of promoters and enhancers
    • Nordeen SK. 1988. Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 6:454-458.
    • (1988) Biotechniques , vol.6 , pp. 454-458
    • Nordeen, S.K.1
  • 33
    • 0034682513 scopus 로고    scopus 로고
    • The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular modeling
    • Peng J, Zhang L, Drysdale L, Fong GH. 2000. The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular modeling. Proc Natl Acad Sci USA 97:8386-8391.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8386-8391
    • Peng, J.1    Zhang, L.2    Drysdale, L.3    Fong, G.H.4
  • 34
    • 0842303171 scopus 로고    scopus 로고
    • HIF-1 and hypoxic response: The plot thickens
    • Poellinger L, Johnson RS. 2004. HIF-1 and hypoxic response: The plot thickens. Curr Opin Genet Dev 14:81-85.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 81-85
    • Poellinger, L.1    Johnson, R.S.2
  • 35
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW, Ratcliffe PJ. 2003. Regulation of angiogenesis by hypoxia: Role of the HIF system. Nat Med 9:677-684.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 36
    • 0028144972 scopus 로고
    • Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT)
    • Reisz-Porszask S, Probst MR, Fukunaga BN, Hankinson O. 1994. Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Mol Cell Biol 14:6075-6086.
    • (1994) Mol Cell Biol , vol.14 , pp. 6075-6086
    • Reisz-Porszask, S.1    Probst, M.R.2    Fukunaga, B.N.3    Hankinson, O.4
  • 37
    • 0346752495 scopus 로고    scopus 로고
    • ARNT gene multiplicity in Amphibians: Characterization of Arnt2 from the frog Xenopus laevis
    • Rowatt AJ, Depowell JJ, Powel WH. 2003. ARNT gene multiplicity in Amphibians: Characterization of Arnt2 from the frog Xenopus laevis. J Exp Zool 300B:48-57.
    • (2003) J Exp Zool , vol.300 B , pp. 48-57
    • Rowatt, A.J.1    Depowell, J.J.2    Powel, W.H.3
  • 38
    • 0037064141 scopus 로고    scopus 로고
    • Functional analysis of hypoxia-inducible factor 1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein
    • Ruas JL, Poellinger L, Pereira T. 2002. Functional analysis of hypoxia-inducible factor 1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein. J Biol Chem 277:38723-38730.
    • (2002) J Biol Chem , vol.277 , pp. 38723-38730
    • Ruas, J.L.1    Poellinger, L.2    Pereira, T.3
  • 39
    • 24344443670 scopus 로고    scopus 로고
    • Hypoxia-dependent activation of HIF into a transcriptional regulator
    • Ruas JL, Poellinger L. 2005. Hypoxia-dependent activation of HIF into a transcriptional regulator. Sem Cell Dev Biol 16:514-522.
    • (2005) Sem Cell Dev Biol , vol.16 , pp. 514-522
    • Ruas, J.L.1    Poellinger, L.2
  • 40
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1α is required for solid tumor formation and embryonic vascularization
    • Ryan HE, Lo J, Johnson RS. 1998. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J 17:3005-3015.
    • (1998) EMBO J , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 42
    • 2442709029 scopus 로고    scopus 로고
    • Short upstream region drives dynamic expression of hypoxia-inducible factor 1α during Xenopus development
    • Sipe CW, Gruber EJ, Saha MS. 2004. Short upstream region drives dynamic expression of hypoxia-inducible factor 1α during Xenopus development. Dev Dyn 230:229-238.
    • (2004) Dev Dyn , vol.230 , pp. 229-238
    • Sipe, C.W.1    Gruber, E.J.2    Saha, M.S.3
  • 43
    • 0035827617 scopus 로고    scopus 로고
    • Characterization of a hypoxia-inducible factor (HIF1α) from rainbow trout. Accumulation of protein occurs at normal venous oxygen tension
    • Soitamo AJ, Raberg CM, Gassmann M, Sistonen L, Nikinmaa M. 2001. Characterization of a hypoxia-inducible factor (HIF1α) from rainbow trout. Accumulation of protein occurs at normal venous oxygen tension. J Biol Chem 276:19699-19705.
    • (2001) J Biol Chem , vol.276 , pp. 19699-19705
    • Soitamo, A.J.1    Raberg, C.M.2    Gassmann, M.3    Sistonen, L.4    Nikinmaa, M.5
  • 44
    • 0030700310 scopus 로고    scopus 로고
    • The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development
    • Sonnefeld M, Ward M, Nystrom G, Mosher J, Stahl S, Crews S. 1997. The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development. Development 124:4571-4582.
    • (1997) Development , vol.124 , pp. 4571-4582
    • Sonnefeld, M.1    Ward, M.2    Nystrom, G.3    Mosher, J.4    Stahl, S.5    Crews, S.6
  • 46
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS), a transcription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russel DW. 1997. Endothelial PAS domain protein 1 (EPAS), a transcription factor selectively expressed in endothelial cells. Genes Dev 11:72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russel, D.W.3
  • 47
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL. 1998. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12:3320-3324.
    • (1998) Genes Dev , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3    Russell, D.W.4    McKnight, S.L.5
  • 48
    • 0027968068 scopus 로고
    • Clustal W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice
    • Thompson JD, Higgins DG, Gibson TJ. 1994. Clustal W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673-4680.
    • (1994) Nucleic Acids Res , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 49
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL. 1995. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92:5510-5514.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 50
    • 0036320934 scopus 로고    scopus 로고
    • Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
    • Wenger RH. 2002. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J 16:1151-1162.
    • (2002) FASEB J , vol.16 , pp. 1151-1162
    • Wenger, R.H.1
  • 51
    • 0037178551 scopus 로고    scopus 로고
    • Nuclear expression of hypoxia-inducible factor 1α protein is heterogeneous in human malignant cells under normoxic conditions
    • Zhong H, Mabjeesh NJ, Williard MT, Simons JW. 2002. Nuclear expression of hypoxia-inducible factor 1α protein is heterogeneous in human malignant cells under normoxic conditions. Cancer Lett 181:233-238.
    • (2002) Cancer Lett , vol.181 , pp. 233-238
    • Zhong, H.1    Mabjeesh, N.J.2    Williard, M.T.3    Simons, J.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.