Antisense inhibition of 11βhydroxysteroid dehydrogenase type 1 improves diabetes in a novel cortisone-induced diabetic KK mouse model

Biochemical and Biophysical Research Communications

Volumn 365, Issue 4, 2008, Pages 740-745

  Bhat, B Ganesh ^a   Younis, Husam ^a   Herrera, Jocelyn ^a   Palacio, Kimbie ^a   Pascual, Bernadette ^a   Hur, George ^a   Jessen, Bart ^a   Ogilvie, Kathleen M ^a   Rejto, Paul A ^a  

^a PFIZER INC   (United States)

Author keywords

11 hydroxysteroid dehydrogenase; Animal model; Cortisol; Diabetes; Glucocorticoid

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ANTISENSE OLIGONUCLEOTIDE; CORTISONE; GLUCOCORTICOID; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; GENE SILENCING; GENE TARGETING; GENE THERAPY; GENETICS; METABOLISM; METHODOLOGY; PATHOLOGY; TREATMENT OUTCOME;

ANIMALIA; MUS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; CORTISONE; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; GENE SILENCING; GENE TARGETING; GENE THERAPY; MALE; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDES, ANTISENSE; TREATMENT OUTCOME;

EID: 36849035926     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.11.032     Document Type: Article

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