Changing the substrate specificity of creatine kinase from creatine to glycocyamine: Evidence for a highly evolved active site

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1774, Issue 12, 2007, Pages 1519-1527

  Jourden, Michael J ^a   Clarke, Callisia N ^a   Palmer, Allyson K ^a   Barth, Emily J ^a   Prada, Rebecca C ^a   Hale, Robyn N ^a   Fraga, Dean ^a   Snider, Mark J ^a   Edmiston, Paul L ^a  

^a 931 College Mall   (United States)

Author keywords

Creatine kinase; Phosphagen kinase evolution; Substrate specificity

Indexed keywords

CREATINE KINASE; GUANIDINE DERIVATIVE; GUANIDINOACETIC ACID; PHOSPHAGEN KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CREATINE; CREATINE KINASE, MM FORM; EVOLUTION, MOLECULAR; GENE EXPRESSION; GLYCINE; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PHYLOGENY; RABBITS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 36849031248     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2007.10.001     Document Type: Article

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