Synthesis, analysis, in vitro characterization, and in vivo disposition of a lamivudine-dextran conjugate for selective antiviral delivery to the liver

Bioconjugate Chemistry

Volumn 18, Issue 6, 2007, Pages 2097-2108

  Chimalakonda, Krishna C ^a   Agarwal, Hitesh K ^b   Kumar, Anil ^b   Parang, Keykavous ^b   Mehvar, Reza ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; TARGETED DRUG DELIVERY;

ANTI-VIRAL DRUGS; ANTIVIRALS; IN-VITRO; IN-VIVO; LAMIVUDINE; PRODRUGS; SIZE EXCLUSION; SYNTHESIS ANALYSIS; VITRO AND IN VIVO; VITRO CHARACTERIZATION;

DEXTRAN;

5' O (SUCCINATE) 2',3' DIDEOXY 3' THIACYTIDINE; ANTIVIRUS AGENT; BUFFER; DEXTRAN 5' O (SUCCINATE) 2',3' DIDEOXY 3' THIACYTIDINE; DEXTRAN DERIVATIVE; LAMIVUDINE; PRODRUG; SUCCINIC ACID; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONJUGATE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG STABILITY; DRUG SYNTHESIS; DRUG TISSUE LEVEL; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LIVER; LIVER LYSOSOME; MALE; NONHUMAN; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SLOW DRUG RELEASE;

RATTUS;

EID: 36849030888     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc700193d     Document Type: Article

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