Kinetics of hydrolysis of dextran-methylprednisolone succinate, a macromolecular prodrug of methylprednisolone, in rat blood and liver lysosomes

Journal of Controlled Release

Volumn 68, Issue 1, 2000, Pages 53-61

  Mehvar, Reza ^a   Dann, Roger O ^b   Hoganson, Dean A ^b  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b DRAKE UNIVERSITY   (United States)

Author keywords

Blood hydrolysis; Lysosomes; Methylprednisolone; Methylprednisolone prodrugs; Methylprednisolone succinate

Indexed keywords

DEXTRAN; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; PRODRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG HYDROLYSIS; HALF LIFE TIME; IMMUNOSUPPRESSIVE TREATMENT; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DEXTRANS; HYDROLYSIS; LIVER; LYSOSOMES; MACROMOLECULAR SUBSTANCES; MALE; METHYLPREDNISOLONE HEMISUCCINATE; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034738844     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(00)00234-0     Document Type: Article

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