메뉴 건너뛰기




Volumn 4, Issue 6, 1997, Pages 363-370

Liver targeting of antiviral nucleoside analogues through the asialoglycoprotein receptor

Author keywords

Antiviral nucleoside analogues; Asialoglycoprotein receptor; Liver targeting of drugs; Viral hepatitis

Indexed keywords

ALPHA FETOPROTEIN; ANTIVIRUS AGENT; ARABINOGALACTAN; ASIALOFETUIN; ASIALOGLYCOPROTEIN; ASIALOGLYCOPROTEIN RECEPTOR; CELL SURFACE RECEPTOR; DRUG CARRIER; GALACTAN; LACTOSE; LIPOPROTEIN; NUCLEOSIDE; POLYLYSINE; SERUM ALBUMIN; VIDARABINE PHOSPHATE;

EID: 0031308726     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.1997.00067.x     Document Type: Review
Times cited : (47)

References (61)
  • 1
    • 0015526064 scopus 로고
    • Chemotherapy through lysosomes with a DNA-daunorubicin complex
    • Trouet A, Deprez-De Campeneere D, De Duve C. Chemotherapy through lysosomes with a DNA-daunorubicin complex. Nature New Biol 1972; 239:110-112.
    • (1972) Nature New Biol , vol.239 , pp. 110-112
    • Trouet, A.1    Deprez-De Campeneere, D.2    De Duve, C.3
  • 2
    • 0016394081 scopus 로고
    • In vitro effect of a 5-fluorodeoxyuridine albumin conjugate on tumor cells and on peritoneal macrophages
    • Barbanti-Brodano G, Fiume L. In vitro effect of a 5-fluorodeoxyuridine albumin conjugate on tumor cells and on peritoneal macrophages. Experientia 1974; 30: 1180-1181.
    • (1974) Experientia , vol.30 , pp. 1180-1181
    • Barbanti-Brodano, G.1    Fiume, L.2
  • 3
    • 0017132337 scopus 로고
    • Activity of albumin conjugates of 5-fluorodeoxyuridine and cytosine arabinoside on poxviruses as a lysosomotropic approach to antiviral chemotherapy
    • Balboni PG, Minia A, Grossi MP, Barbanti-Brodano G, Mattioli A, Fiume L. Activity of albumin conjugates of 5-fluorodeoxyuridine and cytosine arabinoside on poxviruses as a lysosomotropic approach to antiviral chemotherapy. Nature 1976; 264: 181-183.
    • (1976) Nature , vol.264 , pp. 181-183
    • Balboni, P.G.1    Minia, A.2    Grossi, M.P.3    Barbanti-Brodano, G.4    Mattioli, A.5    Fiume, L.6
  • 4
    • 0014408285 scopus 로고
    • Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo
    • Morell AG, Irvine RA, Sternlieb I, Scheinberg IH, Ashwell G. Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo. J Biol Chem 1968; 243: 155-159.
    • (1968) J Biol Chem , vol.243 , pp. 155-159
    • Morell, A.G.1    Irvine, R.A.2    Sternlieb, I.3    Scheinberg, I.H.4    Ashwell, G.5
  • 5
    • 0020021127 scopus 로고
    • Carbohydrate-specific receptors of the liver
    • Ashwell G, Harford J. Carbohydrate-specific receptors of the liver. Annu Rev Biochem 1982; 51: 531-534.
    • (1982) Annu Rev Biochem , vol.51 , pp. 531-534
    • Ashwell, G.1    Harford, J.2
  • 6
    • 0018500290 scopus 로고
    • Enhanced inhibition of virus DNA synthesis in heptocytes by trifluorothymidine coupled to asialofetuin
    • Fiume L, Mattioli A, Balboni PG et al. Enhanced inhibition of virus DNA synthesis in heptocytes by trifluorothymidine coupled to asialofetuin. FEBS Lett 1979; 103: 47-51.
    • (1979) FEBS Lett , vol.103 , pp. 47-51
    • Fiume, L.1    Mattioli, A.2    Balboni, P.G.3
  • 7
    • 0019211060 scopus 로고
    • Selective inhibition of Ectromelia virus DNA synthesis in hepatocytes by adenine-9-β-D-arabinofuranoside (ara-A) and adenine-β-D-arabinofuranoside 5′-monophosphate (ara-AMP) conjugated to asialofetuin
    • Fiume L, Mattioli A, Busi C et al. Selective inhibition of Ectromelia virus DNA synthesis in hepatocytes by adenine-9-β-D-arabinofuranoside (ara-A) and adenine-β-D-arabinofuranoside 5′-monophosphate (ara-AMP) conjugated to asialofetuin. FEBS Lett 1980; 116: 185-188.
    • (1980) FEBS Lett , vol.116 , pp. 185-188
    • Fiume, L.1    Mattioli, A.2    Busi, C.3
  • 8
    • 0015212069 scopus 로고
    • Hepatic uptake of proteins coupled to fetuin glycopeptide
    • Rogers JC, Kornfeld S. Hepatic uptake of proteins coupled to fetuin glycopeptide. Biochem Biophys Res Commun 1971; 45: 622-629.
    • (1971) Biochem Biophys Res Commun , vol.45 , pp. 622-629
    • Rogers, J.C.1    Kornfeld, S.2
  • 10
    • 0020359596 scopus 로고
    • Conjugates of adenine-9-β-D-arabinofuranoside monophosphate (ara-AMP) with lactosaminated homologous albumin are not immunogenic in the mouse
    • Fiume L, Mattioli A, Busi C, Spinosa G, Wieland T. Conjugates of adenine-9-β-D-arabinofuranoside monophosphate (ara-AMP) with lactosaminated homologous albumin are not immunogenic in the mouse. Experientia 1982; 38: 1087-1089.
    • (1982) Experientia , vol.38 , pp. 1087-1089
    • Fiume, L.1    Mattioli, A.2    Busi, C.3    Spinosa, G.4    Wieland, T.5
  • 11
    • 0019440950 scopus 로고
    • Hepatocyte targeting of adenine-9-β-D-arabinofuranoside 5′-monophosphate (ara-AMP) coupled to lactosaminated albumin
    • Fiume L, Busi C, Mattioli A, Balboni PG, Barbanti-Brodano G. Hepatocyte targeting of adenine-9-β-D-arabinofuranoside 5′-monophosphate (ara-AMP) coupled to lactosaminated albumin. FEBS Lett 1981; 129: 261-264.
    • (1981) FEBS Lett , vol.129 , pp. 261-264
    • Fiume, L.1    Busi, C.2    Mattioli, A.3    Balboni, P.G.4    Barbanti-Brodano, G.5
  • 12
    • 0022516737 scopus 로고
    • Drug targeting in antiviral chemotherapy. A chemically stable conjugate of 9-β-D-arabinofuranosyladenine 5′-monophosphate with lactosaminated albumin accomplishes a selective delivery of the drug to liver cells
    • Fiume L, Bassi B, Busi C, Mattioli A, Spinosa G. Drug targeting in antiviral chemotherapy. A chemically stable conjugate of 9-β-D-arabinofuranosyladenine 5′-monophosphate with lactosaminated albumin accomplishes a selective delivery of the drug to liver cells. Biochem Pharmacol 1986; 35: 967-972.
    • (1986) Biochem Pharmacol , vol.35 , pp. 967-972
    • Fiume, L.1    Bassi, B.2    Busi, C.3    Mattioli, A.4    Spinosa, G.5
  • 13
    • 0017397591 scopus 로고
    • Proteins containing reductively aminated disaccharides. Synthesis and chemical characterization
    • Schwartz BA, Gray GR. Proteins containing reductively aminated disaccharides. Synthesis and chemical characterization. Arch Biochem Biophys 1977; 181: 542-549.
    • (1977) Arch Biochem Biophys , vol.181 , pp. 542-549
    • Schwartz, B.A.1    Gray, G.R.2
  • 14
    • 0017817475 scopus 로고
    • Effect of reductive lactosamination on the hepatic uptake of bovine pancreatic ribonuclease A dimer
    • Wilson G. Effect of reductive lactosamination on the hepatic uptake of bovine pancreatic ribonuclease A dimer. J Biol Chem 1978; 253: 2070-2072.
    • (1978) J Biol Chem , vol.253 , pp. 2070-2072
    • Wilson, G.1
  • 15
    • 0017092940 scopus 로고
    • Attachment of thioglycosides to proteins: Enhancement of liver membrane binding
    • Krantz MJ, Holtzman NA, Stowell CP, Lee YC. Attachment of thioglycosides to proteins: enhancement of liver membrane binding. Biochemistry 1976; 15: 3963-3968.
    • (1976) Biochemistry , vol.15 , pp. 3963-3968
    • Krantz, M.J.1    Holtzman, N.A.2    Stowell, C.P.3    Lee, Y.C.4
  • 16
    • 0023550778 scopus 로고
    • Conjugates of ara-AMP with lactosaminated albumin: A study on their immunogeneticity in mouse and rat
    • Fiume L, Busi C, Preti P, Spinosa G. Conjugates of ara-AMP with lactosaminated albumin: a study on their immunogeneticity in mouse and rat. Cancer Drug Delivery 1987; 4: 145-150.
    • (1987) Cancer Drug Delivery , vol.4 , pp. 145-150
    • Fiume, L.1    Busi, C.2    Preti, P.3    Spinosa, G.4
  • 17
    • 0025217335 scopus 로고
    • Antiviral therapy: Hepatitis B
    • Jacyna MR, Thomas HC. Antiviral therapy: Hepatitis B. Br Med Bull 1990; 46: 368-382.
    • (1990) Br Med Bull , vol.46 , pp. 368-382
    • Jacyna, M.R.1    Thomas, H.C.2
  • 18
    • 0023896297 scopus 로고
    • Conjugates of 9-β-D-arabinofuranosyladenine 5′-monophosphate (ara-AMP) with lactosaminated albumin: Characterization of the drug-carrier bonds
    • Fiume L, Bassi B, Bongini A. Conjugates of 9-β-D-arabinofuranosyladenine 5′-monophosphate (ara-AMP) with lactosaminated albumin: Characterization of the drug-carrier bonds. Pharm Acta Helv 1988; 63: 137-139.
    • (1988) Pharm Acta Helv , vol.63 , pp. 137-139
    • Fiume, L.1    Bassi, B.2    Bongini, A.3
  • 19
    • 0023013450 scopus 로고
    • 9-β-D-arabinofuranosyl-adenine 5′-monophosphate coupled to lactosaminated albumin is not metabolized in mouse bloodstream
    • Fiume L, Balboni PG, Bassi B, Busi C, Mattioli A, Spinosa G. 9-β-D-arabinofuranosyl-adenine 5′-monophosphate coupled to lactosaminated albumin is not metabolized in mouse bloodstream. Pharm Acta Helv 1986; 61: 342-344.
    • (1986) Pharm Acta Helv , vol.61 , pp. 342-344
    • Fiume, L.1    Balboni, P.G.2    Bassi, B.3    Busi, C.4    Mattioli, A.5    Spinosa, G.6
  • 20
    • 0028278870 scopus 로고
    • Organ distribution of a conjugate of adenine arabinoside monophosphate with lactosaminated albumin in rat
    • Fiume L, Busi C, Corzani S, Di Stefano G, Gervasi GB, Mattioli A. Organ distribution of a conjugate of adenine arabinoside monophosphate with lactosaminated albumin in rat. J Hepatol 1994; 20: 681-682.
    • (1994) J Hepatol , vol.20 , pp. 681-682
    • Fiume, L.1    Busi, C.2    Corzani, S.3    Di Stefano, G.4    Gervasi, G.B.5    Mattioli, A.6
  • 21
    • 0028417287 scopus 로고
    • Targeting of antiviral drugs to the liver using glycoprotein carriers
    • Fiume L, Busi C, Di Stefano G, Mattioli A. Targeting of antiviral drugs to the liver using glycoprotein carriers. Adv Drug Deliv Rev 1994; 14: 51-65.
    • (1994) Adv Drug Deliv Rev , vol.14 , pp. 51-65
    • Fiume, L.1    Busi, C.2    Di Stefano, G.3    Mattioli, A.4
  • 22
    • 0025775859 scopus 로고
    • Adenine arabinoside monophosphate and acyclovir monophosphate coupled to lactosaminated albumin reduce woodchuck hepatitis virus viremia at doses lower than do the unconjugated drugs
    • Ponzetto A, Fiume L, Forzani B et al. Adenine arabinoside monophosphate and acyclovir monophosphate coupled to lactosaminated albumin reduce woodchuck hepatitis virus viremia at doses lower than do the unconjugated drugs. Hepatology 1991; 14: 16-24.
    • (1991) Hepatology , vol.14 , pp. 16-24
    • Ponzetto, A.1    Fiume, L.2    Forzani, B.3
  • 23
    • 0023883633 scopus 로고
    • Inhibition of hepatitis B virus replication by vidarabine monophosphate conjugated with lactosaminated serum albumin
    • Fiume L, Torrani Cerenzia MR, Bonino F et al. Inhibition of hepatitis B virus replication by vidarabine monophosphate conjugated with lactosaminated serum albumin. Lancet 1988; 2: 13-15.
    • (1988) Lancet , vol.2 , pp. 13-15
    • Fiume, L.1    Torrani Cerenzia, M.R.2    Bonino, F.3
  • 24
    • 0028353592 scopus 로고
    • Inhibition of hepatitis B virus replication by adenine arabinoside monophosphate coupled to lactosaminated albumin. Efficacy and minimal effective dose
    • Torrani Cerenzia MR, Fiume L, Busi C et al. Inhibition of hepatitis B virus replication by adenine arabinoside monophosphate coupled to lactosaminated albumin. Efficacy and minimal effective dose. J Hepatol 1994; 20: 307-309.
    • (1994) J Hepatol , vol.20 , pp. 307-309
    • Torrani Cerenzia, M.R.1    Fiume, L.2    Busi, C.3
  • 25
    • 33749767889 scopus 로고    scopus 로고
    • Adenine arabinoside monophosphate coupled to lactosaminated albumin, administered for 4 weeks to patients with chronic type B hepatitis, decreased viremia without producing significant side effects
    • Torrani-Cerenzia MR, Fiume L, De Bernardi Venon W et al. Adenine arabinoside monophosphate coupled to lactosaminated albumin, administered for 4 weeks to patients with chronic type B hepatitis, decreased viremia without producing significant side effects. Hepatology 1996; 23: 657-661.
    • (1996) Hepatology , vol.23 , pp. 657-661
    • Torrani-Cerenzia, M.R.1    Fiume, L.2    De Bernardi Venon, W.3
  • 26
    • 0021328173 scopus 로고
    • Randomized controlled trial of adenine arabinoside monophosphate for chronic type B hepatitis
    • Hoofnagle JH, Hanson RG, Minuk GY et al. Randomized controlled trial of adenine arabinoside monophosphate for chronic type B hepatitis. Gastroenterology 1984; 86: 150-157.
    • (1984) Gastroenterology , vol.86 , pp. 150-157
    • Hoofnagle, J.H.1    Hanson, R.G.2    Minuk, G.Y.3
  • 28
    • 0018596726 scopus 로고
    • Effects of interferon and adenine arabinoside treatment of hepatitis B virus infection on cellular immune responses
    • Hafkin B, Pollard RB, Tiku ML, Robinson WS, Merigan TC. Effects of interferon and adenine arabinoside treatment of hepatitis B virus infection on cellular immune responses. Antimicrob Agents Chemother 1979; 16: 781-787.
    • (1979) Antimicrob Agents Chemother , vol.16 , pp. 781-787
    • Hafkin, B.1    Pollard, R.B.2    Tiku, M.L.3    Robinson, W.S.4    Merigan, T.C.5
  • 29
    • 0022500368 scopus 로고
    • Galactosylated poly(L-lysine) as a hepatotropic carrier of 9-β-D-arabinofuranosyladenine 5′-monophosphate
    • Fiume L, Bassi B, Busi C, Mattioli A, Spinosa G, Faulstich H. Galactosylated poly(L-lysine) as a hepatotropic carrier of 9-β-D-arabinofuranosyladenine 5′-monophosphate. FEBS Lett 1986; 203: 203-206.
    • (1986) FEBS Lett , vol.203 , pp. 203-206
    • Fiume, L.1    Bassi, B.2    Busi, C.3    Mattioli, A.4    Spinosa, G.5    Faulstich, H.6
  • 31
    • 0028897933 scopus 로고
    • Adenine arabinoside 5′-monophosphate in patients with chronic hepatitis B: Comparison of the efficacy in patients with high and low viral replication
    • Marcellin P, Poureau M, Loriot MA et al. Adenine arabinoside 5′-monophosphate in patients with chronic hepatitis B: comparison of the efficacy in patients with high and low viral replication. Gut 1995; 36: 422-426.
    • (1995) Gut , vol.36 , pp. 422-426
    • Marcellin, P.1    Poureau, M.2    Loriot, M.A.3
  • 32
    • 0028269209 scopus 로고
    • A conjugate of lactosaminated poly-L-lysine with adenine arabinoside monophosphate, administered to mice by intramuscular route, accomplishes a selective delivery of the drug to the liver
    • Fiume L, Di Stefano G, Busi C, Mattioli A. A conjugate of lactosaminated poly-L-lysine with adenine arabinoside monophosphate, administered to mice by intramuscular route, accomplishes a selective delivery of the drug to the liver. Biochem Pharmacol 1994; 47: 643-650.
    • (1994) Biochem Pharmacol , vol.47 , pp. 643-650
    • Fiume, L.1    Di Stefano, G.2    Busi, C.3    Mattioli, A.4
  • 33
    • 0029008855 scopus 로고
    • Selective delivery to the liver of antiviral nucleoside analogs coupled to a high molecular mass lactosaminated poly-L-lysine and administered to mice by intramuscular route
    • Di Stefano G, Busi C, Mattioli A, Fiume L. Selective delivery to the liver of antiviral nucleoside analogs coupled to a high molecular mass lactosaminated poly-L-lysine and administered to mice by intramuscular route. Biochem Pharmacol 1995; 49: 1769-1775.
    • (1995) Biochem Pharmacol , vol.49 , pp. 1769-1775
    • Di Stefano, G.1    Busi, C.2    Mattioli, A.3    Fiume, L.4
  • 34
    • 0029117195 scopus 로고
    • Inhibition of wood-chuck hepatitis virus replication by adenine arabinoside monophosphate coupled to lactosaminated poly-L-lysine and administered by intramuscular route
    • Fiume L, Di Stefano G, Busi C et al. Inhibition of wood-chuck hepatitis virus replication by adenine arabinoside monophosphate coupled to lactosaminated poly-L-lysine and administered by intramuscular route. Hepatology 1995; 22: 1072-1077.
    • (1995) Hepatology , vol.22 , pp. 1072-1077
    • Fiume, L.1    Di Stefano, G.2    Busi, C.3
  • 36
    • 0031058406 scopus 로고    scopus 로고
    • Hepatotropic conjugate of adenine arabinoside monophosphate with lactosaminated poly-L-lysine. Synthesis of the carrier and pharmacological properties of the conjugate
    • Fiume L, Di Stefano G, Busi C et al. Hepatotropic conjugate of adenine arabinoside monophosphate with lactosaminated poly-L-lysine. Synthesis of the carrier and pharmacological properties of the conjugate. J Hepatol 1997; 26: 253-259.
    • (1997) J Hepatol , vol.26 , pp. 253-259
    • Fiume, L.1    Di Stefano, G.2    Busi, C.3
  • 37
    • 0026784838 scopus 로고
    • The pathogenesis of vacuoles produced in rat and mouse liver cells by a conjugate of adenine arabinoside monophosphate with lactosaminated albumin
    • Fiume L, Betts MC, Busi C et al. The pathogenesis of vacuoles produced in rat and mouse liver cells by a conjugate of adenine arabinoside monophosphate with lactosaminated albumin. J Hepatol 1992; 15: 314-322.
    • (1992) J Hepatol , vol.15 , pp. 314-322
    • Fiume, L.1    Betts, M.C.2    Busi, C.3
  • 38
    • 0028122848 scopus 로고
    • A pilot study of combination therapy with ribavirin plus interferon alfa for interferon alfa-resistant chronic hepatitis C
    • Brillanti S, Garson J, Foli M et al. A pilot study of combination therapy with ribavirin plus interferon alfa for interferon alfa-resistant chronic hepatitis C. Gastroenterology 1994; 107: 812-817.
    • (1994) Gastroenterology , vol.107 , pp. 812-817
    • Brillanti, S.1    Garson, J.2    Foli, M.3
  • 39
    • 0029564107 scopus 로고
    • The effect of interferon alfa and ribavirin combination therapy in naive patients with chronic hepatitis C
    • Chemello L, Cavalletto L, Bernardinello E, Guido M, Pontisso P, Alberti A. The effect of interferon alfa and ribavirin combination therapy in naive patients with chronic hepatitis C. J Hepatol 1995; 23 (suppl 2): 8-12.
    • (1995) J Hepatol , vol.23 , Issue.2 SUPPL. , pp. 8-12
    • Chemello, L.1    Cavalletto, L.2    Bernardinello, E.3    Guido, M.4    Pontisso, P.5    Alberti, A.6
  • 40
    • 0029610001 scopus 로고
    • Future studies of combination therapy for chronic hepatitis C: Optimizing response rates for each hepatitis C population
    • Main J. Future studies of combination therapy for chronic hepatitis C: optimizing response rates for each hepatitis C population. J Hepatol 1995; 23 (suppl 2): 32-36.
    • (1995) J Hepatol , vol.23 , Issue.2 SUPPL. , pp. 32-36
    • Main, J.1
  • 41
    • 84984533465 scopus 로고    scopus 로고
    • Long term efficacy of ribavirin plus interferon alfa in the treatment of chronic hepatitis C
    • Lai MY, Kao JH, Yang PM et al. Long term efficacy of ribavirin plus interferon alfa in the treatment of chronic hepatitis C. Gastroenterology 1996; 111: 1307-1312.
    • (1996) Gastroenterology , vol.111 , pp. 1307-1312
    • Lai, M.Y.1    Kao, J.H.2    Yang, P.M.3
  • 42
    • 0030979346 scopus 로고    scopus 로고
    • Ribavirin enhances the efficacy but not the adverse effects of interferon in chronic hepatitis C. Meta-analysis of individual patients from European centers
    • Schalm SW, Hansen BE, Chemello L et al. Ribavirin enhances the efficacy but not the adverse effects of interferon in chronic hepatitis C. Meta-analysis of individual patients from European centers. J Hepatol 1997; 26: 961-966.
    • (1997) J Hepatol , vol.26 , pp. 961-966
    • Schalm, S.W.1    Hansen, B.E.2    Chemello, L.3
  • 43
    • 0003077552 scopus 로고
    • 14C-ribavirin: Distribution and pharmacokinetic studies in rats, baboons and man
    • Smith RA, Kirkpatrick W, eds. New York: Academic Press
    • 14C-ribavirin: distribution and pharmacokinetic studies in rats, baboons and man. In: Smith RA, Kirkpatrick W, eds. Ribavirin: A Broad Spectrum Antiviral Agent. New York: Academic Press, 1980: 83-98.
    • (1980) Ribavirin: A Broad Spectrum Antiviral Agent , pp. 83-98
    • Catlin, D.H.1    Smith, R.A.2    Samuels, A.I.3
  • 44
    • 0023267604 scopus 로고
    • Ribavirin disposition in high-risk patients for acquired immunodeficiency syndrome
    • Laskin OL, Longstreth JA, Hart CC et al. Ribavirin disposition in high-risk patients for acquired immunodeficiency syndrome. Clin Pharmacol Ther 1987; 41: 546-555.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 546-555
    • Laskin, O.L.1    Longstreth, J.A.2    Hart, C.C.3
  • 45
    • 0028609810 scopus 로고
    • Increase in hepatic iron stores following prolonged therapy with ribavirin in patients with chronic hepatitis C
    • Di Bisceglie AM, Bacon BR, Kleiner DE, Hoofnagle H. Increase in hepatic iron stores following prolonged therapy with ribavirin in patients with chronic hepatitis C. J Hepatol 1994; 21: 1109-1112.
    • (1994) J Hepatol , vol.21 , pp. 1109-1112
    • Di Bisceglie, A.M.1    Bacon, B.R.2    Kleiner, D.E.3    Hoofnagle, H.4
  • 46
    • 28644436399 scopus 로고
    • Hepatic iron deposition during ribavirin therapy of chronic hepatitis C
    • abstract 736
    • Fiel MI, Guido M, Thung SN et al. Hepatic iron deposition during ribavirin therapy of chronic hepatitis C. Hepatology 1995; 290A: abstract 736.
    • (1995) Hepatology , vol.290 A
    • Fiel, M.I.1    Guido, M.2    Thung, S.N.3
  • 48
    • 0030868838 scopus 로고    scopus 로고
    • Ribavirin conjugated with lactosaminatcd poly-L-lysine: Selective delivery to the liver and increased antiviral activity in mice with viral hepatitis
    • Di Stefano G, Colonna FP, Bongini A, Busi C, Mattioli A, Fiume L. Ribavirin conjugated with lactosaminatcd poly-L-lysine: selective delivery to the liver and increased antiviral activity in mice with viral hepatitis. Biochem Pharmacol 1997; 54: 357-363.
    • (1997) Biochem Pharmacol , vol.54 , pp. 357-363
    • Di Stefano, G.1    Colonna, F.P.2    Bongini, A.3    Busi, C.4    Mattioli, A.5    Fiume, L.6
  • 49
    • 0019119997 scopus 로고
    • Metabolism of native and of lactosylated human low density lipoprotein: Evidence for two pathways for catabolism of exogenous proteins in rat hepatocytes
    • Attie AD, Pittman RC, Steinberg D. Metabolism of native and of lactosylated human low density lipoprotein: evidence for two pathways for catabolism of exogenous proteins in rat hepatocytes. Proc Natl Acad Sci USA 1980; 77: 5923-5927.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 5923-5927
    • Attie, A.D.1    Pittman, R.C.2    Steinberg, D.3
  • 50
    • 0025096258 scopus 로고
    • Native and modified lipoproteins as drug delivery systems
    • Bijsterbosch MK, van Berkel TJC. Native and modified lipoproteins as drug delivery systems. Adv Drug Del Rev 1990; 5: 231-251.
    • (1990) Adv Drug del Rev , vol.5 , pp. 231-251
    • Bijsterbosch, M.K.1    Van Berkel, T.J.C.2
  • 51
    • 0027967602 scopus 로고
    • Synthesis of the dioleoyl derivative of iododeoxyuridine and its incorporation into reconstituted high density lipoprotein particles
    • Bijsterbosch MK, Schouten D, van Berkel TJC. Synthesis of the dioleoyl derivative of iododeoxyuridine and its incorporation into reconstituted high density lipoprotein particles. Biochemistry 1994; 33: 14073-14080.
    • (1994) Biochemistry , vol.33 , pp. 14073-14080
    • Bijsterbosch, M.K.1    Schouten, D.2    Van Berkel, T.J.C.3
  • 52
    • 0029262268 scopus 로고
    • Conjugation of adenine arabinoside 5′-monophosphate to arabinogalactan: Synthesis, characterization, and antiviral activity
    • Enriquez PM, Jung C, Josephson L, Tennant BC. Conjugation of adenine arabinoside 5′-monophosphate to arabinogalactan: synthesis, characterization, and antiviral activity. Bioconjugate Chem 1995; 6: 195-202.
    • (1995) Bioconjugate Chem , vol.6 , pp. 195-202
    • Enriquez, P.M.1    Jung, C.2    Josephson, L.3    Tennant, B.C.4
  • 53
    • 0023609037 scopus 로고
    • Distribution of a conjugate of 9-β-D-arabinofuranosyladenine 5′-monophosphate (ara-AMP) with lactosaminated albumin in parenchymal and sinusoidal cells of rat liver
    • Fiume L, Mattioli A, Spinosa G. Distribution of a conjugate of 9-β-D-arabinofuranosyladenine 5′-monophosphate (ara-AMP) with lactosaminated albumin in parenchymal and sinusoidal cells of rat liver. Cancer Drug Deliv 1987; 4: 11-16.
    • (1987) Cancer Drug Deliv , vol.4 , pp. 11-16
    • Fiume, L.1    Mattioli, A.2    Spinosa, G.3
  • 54
    • 28644449918 scopus 로고
    • The distribution and storage of blue antigenic azoproteins in the tissues of mice
    • Kruse H, McMaster PD. The distribution and storage of blue antigenic azoproteins in the tissues of mice. J Exp Med 1949; 90: 425-445.
    • (1949) J Exp Med , vol.90 , pp. 425-445
    • Kruse, H.1    McMaster, P.D.2
  • 56
    • 0018188016 scopus 로고
    • Serum desialylated glycoproteins in patients with hepatobiliary dysfunction
    • Marshall JS, Williams S, Jones P. Serum desialylated glycoproteins in patients with hepatobiliary dysfunction. J Lab Clin Med 1978; 92: 30-37.
    • (1978) J Lab Clin Med , vol.92 , pp. 30-37
    • Marshall, J.S.1    Williams, S.2    Jones, P.3
  • 57
    • 0021716818 scopus 로고
    • Hypersialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma. Asialoglycoprotein receptor in cirrhosis and liver cell carcinoma
    • Sawamura T, Nakada H, Hazama H, Shiozaki Y, Sameshima Y, Tashiro Y. Hypersialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma. Asialoglycoprotein receptor in cirrhosis and liver cell carcinoma. Gastroenterology 1984; 87: 1217-1221.
    • (1984) Gastroenterology , vol.87 , pp. 1217-1221
    • Sawamura, T.1    Nakada, H.2    Hazama, H.3    Shiozaki, Y.4    Sameshima, Y.5    Tashiro, Y.6
  • 58
    • 0026540432 scopus 로고
    • Abnormal surface distribution of the human asialoglycoprotein receptor in cirrhosis
    • Burgess JB, Baenzinger JU, Brown W. Abnormal surface distribution of the human asialoglycoprotein receptor in cirrhosis. Hepatology 1992; 15: 702-706.
    • (1992) Hepatology , vol.15 , pp. 702-706
    • Burgess, J.B.1    Baenzinger, J.U.2    Brown, W.3
  • 59
    • 0018332865 scopus 로고
    • 3H]Raffinose, a novel radioactive label for determining organ sites of catabolism of protein in circulation
    • 3H]Raffinose, a novel radioactive label for determining organ sites of catabolism of protein in circulation. J Biol Chem 1979; 254: 3547-3553.
    • (1979) J Biol Chem , vol.254 , pp. 3547-3553
    • Van Zile, J.1    Henderson, L.A.2    Baynes, J.W.3    Thorpe, S.R.4
  • 60
    • 0002228845 scopus 로고    scopus 로고
    • The mechanism of action of antiviral agents in chronic hepatitis B
    • Luscombe CA, Locarnini SA. The mechanism of action of antiviral agents in chronic hepatitis B. Viral Hep Rev 1996; 2: 1-35.
    • (1996) Viral Hep Rev , vol.2 , pp. 1-35
    • Luscombe, C.A.1    Locarnini, S.A.2
  • 61
    • 0029786431 scopus 로고    scopus 로고
    • Long-term ganciclovir chemotherapy for congenital duck hepatitis B virus infection in vivo: Effect on intrahepatic-viral DNA, RNA, and protein expression
    • Luscombe C, Pedersen J, Uren E, Locarnini S. Long-term ganciclovir chemotherapy for congenital duck hepatitis B virus infection in vivo: effect on intrahepatic-viral DNA, RNA, and protein expression. Hepatology 1996; 24: 766-773.
    • (1996) Hepatology , vol.24 , pp. 766-773
    • Luscombe, C.1    Pedersen, J.2    Uren, E.3    Locarnini, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.