Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: Dose-dependent pharmacokinetics in rats

International Journal of Pharmaceutics

Volumn 229, Issue 1-2, 2001, Pages 173-182

  Zhang, Xiaoping ^a   Mehvar, Reza ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Dextran methylprednisolone conjugate; Liver uptake; Nonlinear clearance; Nonlinear pharmacokinetics; Prodrug

Indexed keywords

DEXTRAN METHYLPREDNISOLONE SUCCINATE; DEXTRANASE; ESTERASE; METHYLPREDNISOLONE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HYDROLYSIS; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MACROMOLECULE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CHROMATOGRAPHY, GEL; DEXTRANS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROLYSIS; LIVER; MALE; METHYLPREDNISOLONE; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN;

EID: 0035965513     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00854-7     Document Type: Article

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