TGF-β up-regulates serum response factor in activated hepatic stellate cells

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1772, Issue 11-12, 2007, Pages 1250-1257

  Herrmann, Jens ^a   Haas, Ute ^a   Gressner, Axel M ^a   Weiskirchen, Ralf ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Smooth muscle actin; Gene regulation; Hepatic stellate cell; Liver fibrogenesis; Myocardin; Serum response factor; siRNA; Smooth muscle cell; Transdifferentiation; Transforming growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; MYOCARDIN; SERUM RESPONSE FACTOR; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL NUCLEUS; CONTROLLED STUDY; DNA BINDING; FIBROGENESIS; GENETIC TRANSCRIPTION; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; SMOOTH MUSCLE FIBER; STELLATE CELL; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; DNA; HEPATOCYTES; MALE; MYOCYTES, SMOOTH MUSCLE; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; SERUM RESPONSE FACTOR; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 36849015380     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2007.10.006     Document Type: Article

References (38)

1. Miano J.M., Long X., and Fujiwara K. Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Am. J. Physiol., Cell Physiol 292 (2007) C70-C81
2. Owens G.K., Kumar M.S., and Wamhoff B.R. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol. Rev 84 (2004) 767-801
3. Qiu P., Feng X.H., and Li L. Interaction of Smad3 and SRF-associated complex mediates TGF-β1 signals to regulate SM22 transcription during myofibroblast differentiation. J. Mol. Cell. Cardiol 35 (2003) 1407-1420
4. Marais R.M., Hsuan J.J., McGuigan C., Wynne J., and Treisman R. Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange. EMBO J 11 (1992) 97-105
5. Flück M., Booth F.W., and Waxham M.N. Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiples sites. Biochem. Biophys. Res. Comm 270 (2000) 488-494
6. Iyer D., Belaguli N., Flück M., Rowan B.G., Wie L., Weigel N.L., Booth F.W., Epstein H.F., Schwartz R.J., and Balasubramanyam A. Novel phosphorylation target in the serum response factor MADS box regulates α-actin transcription. Biochemistry 42 (2003) 7477-7486
7. Iyer D., Chang D., Marx J., Olson E.N., Parmacek M.S., Balasubramanyam A., and Schwartz R.J. Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs. Proc. Natl. Acad. Sci. U. S. A 103 (2006) 4516-4521
8. Hirschi K.K., Lai L., Belaguli N.S., Dean D.A., Schwartz R.J., and Zimmer W.E. Transforming growth factor-β induction of smooth muscle cell phenotype requires transcriptional and post-transcriptional control of serum response factor. J. Biol. Chem 277 (2002) 6287-6295
9. Gineitis D., and Treisman R. Differential usage of signal transduction pathways defines two types of serum response factor target gene. J. Biol. Chem 276 (2001) 24531-24539
10. Mack C.P., Somlyo A.V., Hautmann M., Somlyo A.P., and Owens G.K. Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization. J. Biol. Chem 276 (2001) 341-347
11. Kaplan-Albuquerque N., Garat C., Desseva C., Jones P.L., and Nemenoff R.A. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. J. Biol. Chem 278 (2003) 39830-39838
12. Du K.L., Ip H.S., Li J., Chen M., Dandre F., Yu W., Lu M.M., Owens G.K., and Parmacek M.S. Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol. Cell. Biol 23 (2003) 2425-2437
13. Yoshida T., Sinha S., Dandre F., Wamhoff B.R., Hoofnagle M.H., Kremer B.E., Wang D.Z., Olson E.N., and Owens G.K. Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circ. Res 92 (2003) 856-864
14. Gressner A.M., Weiskirchen R., Breitkopf K., and Dooley S. Roles of TGF-β in hepatic fibrosis. Front. Biosci 7 (2002) d793-d807
15. Rockey D., Boyles J., Gabbiani G., and Friedman S.L. Rat hepatic stellate cells express smooth muscle actin upon activation in vivo and in culture. J. Submicrosc. Cytol 24 (1992) 193-203
16. Herrmann J., Arias M., Van de Leur E., Gressner A.M., and Weiskirchen R. CSRP2, TIMP-1, and SM22α promoter fragments direct hepatic stellate cell-specific transgene expression in vitro, but not in vivo. Liver Int 24 (2004) 69-79
17. Cui X., Shimizu I., Lu G., Itonaga M., Inoue H., Shono M., Tamaki K., Fukuno H., Ueno H., and Ito S. Inhibitory effect of a soluble transforming growth factor β type II receptor on the activation of rat hepatic stellate cells in primary culture. J. Hepatol 39 (2003) 731-737
18. Arias M., Lahme B., Van de Leur E., Gressner A.M., and Weiskirchen R. Adenoviral delivery of an antisense RNA complementary to the 3′ coding sequence of transforming growth factor-β1 inhibits fibrogenic activities of hepatic stellate cells. Cell Growth Diff 13 (2002) 265-273
19. Dooley S., Hamzavi J., Breitkopf K., Wiercinska E., Said H.M., Lorenzen J., Ten Dijke P., and Gressner A.M. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology 125 (2003) 178-191
20. Wang X., Tang X., Gong X., Albanis E., Friedman S.L., and Mao Z. Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2. Gastroenterology 127 (2004) 1174-1188
21. Rombouts K., Knittel T., Machesky L., Braet F., Wielant A., Hellemans K., De Bleser P., Gelman I., Ramadori G., and Geerts A. Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. J. Hepatol 37 (2002) 788-796
22. Kawada N., Seki S., Kuroki T., and Kaneda K. ROCK inhibitor Y-27632 atenuates stellate cell contraction and portal pressure increase induced by endothelin-1. Biochem. Biophys. Res. Comm 266 (1999) 269-300
23. Latasa M.U., Couton D., Charvet C., Lafanechere A., Guidotti J.E., Li Z., Tuil D., Daegelen D., Mitchell C., and Gilgenkrantz H. Delayed liver regeneration in mice lacking liver serum response factor. Am. J. Physiol. Gasterointest. Liver Physiol 292 (2007) G996-G1001
24. Yang Y., Zhe X., Phan S.H., Ullenbruch M., and Schuger L. Involvement of serum response factor isoforms in myofibroblast differentiation during bleomycin-induced lung injury. Am. J. Respir. Cell Mol. Biol 29 (2003) 583-590
25. Chai J., Norng M., Tarnawski A.S., and Chow J. A critical role of serum response factor in myofibroblast differentiation during experimental oesophagal ulcer healing in rats. Gut 56 (2007) 621-630
26. Weiskirchen R., and Gressner A.M. Isolation and culture of hepatic stellate cells. Methods Mol. Med 117 (2005) 99-113
27. Herrmann J., Borkham-Kamphorst E., Haas U., Van de Leur E., Fraga M.F., Esteller M., Gressner A.M., and Weiskirchen R. The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-β in smooth muscle and hepatic stellate cells. Biochem. Biophys. Res. Commun 345 (2006) 1526-1535
28. Halayko A.J., Camoretti-Mercado B., Forsythe S.M., Vieira J.E., Mitchell R.W., Wylam M.E., Hershenson M.B., and Solway J. Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes. Am. J. Physiol 276 (1999) L197-L206
29. Chang D.F., Belaguli N.S., Iyer D., Roberts W.B., Wu S.P., Dong X.R., Marx J.G., Moore M.S., Beckerle M.C., Majesky M.W., and Schwartz R.J. Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev. Cell 4 (2003) 107-118
30. Weiskirchen R., Moser M., Weiskirchen S., Erdel M., Dahmen S., Buettner R., and Gressner A.M. LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of STAT1. Biochem. J 359 (2001) 485-496
31. Camoretti-Mercado B., Liu H.W., Halayko A.J., Forsythe S.M., Kyle J.W., Li B., Fu Y., McConville J., Kogut P., Vieira J.E., Patel N.M., Hershenson M.B., Fuchs E., Sinha S., Miano J.M., Parmacek M.S., Burkhardt J.K., and Solway J. Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor. J. Biol. Chem 275 (2000) 30387-30393
32. Camoretti-Mercado B., Fernandes D.J., Dewundara S., Churchill J., Ma L., Kogut P.C., McConville J.F., Parmacek M.S., and Solway J. Inhibition of transforming growth factor-β-enhanced serum response factor-dependent transcription by Smad7. J. Biol. Chem 281 (2006) 20383-20392
33. Massague J., Seoane J., and Wotton D. Smad transcription factors. Genes Dev 19 (2005) 2783-2810
34. Liu H.W., Halayko A.J., Fernandes D.J., Harmon G.S., McCauley J.A., Kocieniewski P., McConville J., Fu Y., Forsythe S.M., Kogut P., Bellam S., Dowell M., Churchill J., Lesso H., Kassiri K., Mitchell R.W., Hershenson M.B., Camoretti-Mercado B., and Solway J. The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor. Am. J. Respir. Cell. Mol. Biol 29 (2003) 39-47
35. Tada S., Iwamoto H., Kakamuta M., Sugimoto R., Enjoji M., Nakashima Y., and Nawata H. A selective ROCK inhibitor Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats. J. Hepatol 34 (2001) 529-536
36. Dooley S., Delvoux B., Streckert M., Bonzel L., Stopa M., ten Dijke P., and Gressner A.M. Transforming growth factor β signal transduction in hepatic stellate cells via Smad2/3 phosphorylation a pathway that is abrogated during in vitro progression to myofibroblasts. TGFβ signal transduction during transdifferentiation of hepatic stellate cells. FEBS Lett 502 (2001) 4-10
37. Chen S., Crawford M., Day R.M., Briones V.R., Leader J.E., Jose P.A., and Lechleider R.J. RhoA modulates Smad signaling during transforming growth factor-β-mediated smooth muscle differentiation. J. Biol. Chem 281 (2006) 1765-1770
38. + hepatic stellate cells are progenitor cells. Biochem. Biophys. Res. Commun 352 (2007) 410-417