Keratinocyte migration requires α2β1 integrin-mediated interaction with the laminin 5 γ2 chain

Journal of Cell Science

Volumn 114, Issue 4, 2001, Pages 811-823

  Decline, Françoise ^a   Rousselle, Patricia ^a  

^a INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

Author keywords

Cell migration; Extracellular matrix; Integrin; Keratinocyte; Laminin 5

Indexed keywords

ANTIMITOTIC AGENT; COLLAGEN TYPE 4; FIBRONECTIN; INTEGRIN; KALININ; LIGAND; PLASTIC; PROTEIN SUBUNIT; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL SPREADING; CONTROLLED STUDY; EPITHELIUM CELL; EPITHELIZATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; KERATINOCYTE; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; WOUND HEALING;

EID: 0035085802     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Adachi, M., Taki, T., Huang, C., Higashijama, M., Doi, O., Tsuji, T. and Miyake, M. (1998). Reduced integrin alpha3 expression as a factor of poor prognosis of patients with adenocarcinoma of the lung. J. Clin. Oncol. 16, 1060-1067.
2. Adams, J. C. and Watt, F. M. (1990). Changes in keratinocyte adhesion during terminal differentiation: reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface. Cell 63, 425-435.
3. Amano, S., Scott, I. C., Takahara, K., Koch, M., Champliaud, M. F., Gerecke, D. R., Keene, D. R., Hudson, D. L., Nishiyama, T., Lee, S., Greenspan, D. S. and Burgeson R. E. (2000). Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain. J. Biol. Chem. 275, 22728-22735.
4. Baker, S. E., Hopkinson S. B., Fitchmun, M., Andreason, G. L., Frasier, F., Plopper, G., Quaranta, V. and Jones, J. C. (1996). Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly. J. Cell Sci. 109, 2509-2520.
5. Barr, L. F., Campbell, S. E., Bochner, B. S. and Dang, C. V. (1998). Association of the decreased expression of alpha3 beta1 integrin with the altered cell: environmental interactions and enhanced soft agar cloning ability of c-myc-overexpressing small cell lung cancer cells. Cancer Res. 58, 5537-5545.
6. Weitzman, J. B., Pasqualini, R., Takada, Y. and Hemler, M. E. (1993). The function and distinctive regulation of VLA-3 in cell adhesion, spreading, and homotypic cell aggregation. J. Biol. Chem. 268, 8651-8657.
7. Wu, C., Chung, A. E. and McDonald, J. A. (1995). A novel role for alpha 3 beta 1 integrins in extracellular matrix assembly. J. Cell Sci. 108, 2511-2523.
8. Zambruno, G., Marchisio, P. C., Marconi, A., Vaschieri, C., Melchiori, A., Giannetti, A. and De Luca, M. (1995). Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing. J. Cell Biol. 129, 853-865.
9. Zhang, K. and Kramer, R. H. (1996). Laminin 5 deposition promotes keratinocyte motility. Exp. Cell Res. 227, 309-322.
10. Zicha, D., Genot, E., Dunn, G. A. and Kramer I. M. (1999). TGFbetal induces a cell-cycle-dependent increase in motility of epithelial cells. J. Cell Sci. 112, 447-454.