Epidemiology and genetics of calcific aortic valve disease

Journal of Investigative Medicine

Volumn 55, Issue 6, 2007, Pages 284-291

  O'Brien, Kevin D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Aortic valve disease; Computed tomography; Echocardiography; Genetics; Genomics; Risk factors

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN E; C REACTIVE PROTEIN; LIPOPROTEIN; NOTCH1 RECEPTOR;

AORTA ATHEROSCLEROSIS; AORTA STENOSIS; AORTA VALVE DISEASE; AORTA VALVE REPLACEMENT; BLOOD VESSEL CALCIFICATION; CARDIOVASCULAR RISK; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; DOPPLER ECHOCARDIOGRAPHY; GENETIC POLYMORPHISM; GENOMICS; HUMAN; KIDNEY DYSFUNCTION; METABOLIC SYNDROME X; PATHOGENESIS; PHENOTYPE; PREMOLAR TOOTH; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 36749085228     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2007.00010     Document Type: Conference Paper

References (56)

1. Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol 1997;29:630-4.
2. Roberts WC. Anatomically isolated aortic valvular disease. The case against its being of rheumatic etiology. Am J Med 1970;49:151-9.
3. Otto CM, Kuusisto J, Reichenbach DD, et al. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 1994;90:844-53.
4. Otto CM, Burwash IG, Legget ME, et al. Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome. Circulation 1997;95:2262-70.
5. Otto CM, Pearlman AS, Gardner CL, et al. Experimental validation of Doppler echocardiographic measurement of volume flow through the stenotic aortic valve. Circulation 1988;78:435-41.
6. Otto CM, Lind BK, Kitzman DW, et al. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med 1999;341:142-7.
7. Bonow RO, Carabello BA, Kanu C, et al. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation 2006;114: e84-231.
8. Cosmi JE, Kort S, Tunick PA, et al. The risk of the development of aortic stenosis in patients with "benign" aortic valve thickening. Arch Intern Med 2002;162:2345-7.
9. Hatle L, Angelsen BA, Tromsdal A. Non-invasive assessment of aortic stenosis by Doppler ultrasound. Br Heart J 1980;43:284-92.
10. Otto CM, Pearlman AS, Comess KA, et al. Determination of the stenotic aortic valve area in adults using Doppler echocardiography. J Am Coll Cardiol 1986;7:509-17.
11. Otto CM, Pearlman AS. Doppler echocardiography in adults with symptomatic aortic stenosis. Diagnostic utility and cost-effectiveness. Arch Intern Med 1988;148:2553-60.
12. O'Brien KD, Zhao XQ, Shavelle DM, et al. Hemodynamic effects of the angiotensin-converting enzyme inhibitor, ramipril, in patients with mild to moderate aortic stenosis and preserved left ventricular function. J Investig Med 2004; 52:185-91.
13. Kizer JR, Gefter WB, deLemos AS, et al. Electron beam computed tomography for the quantification of aortic valvular calcification. J Heart Valve Dis 2001;10:361-6.
14. Budoff MJ, Mao S, Takasu J, et al. Reproducibility of electron-beam CT measures of aortic valve calcification. Acad Radiol 2002;9:1122-7.
15. Budoff MJ, Takasu J, Katz R, et al. Reproducibility of CT measurements of aortic valve calcification, mitral annulus calcification, and aortic wall calcification in the Multi-Ethnic Study of Atherosclerosis. Acad Radiol 2006;13: 166-72.
16. Cowell SJ, Newby DE, Prescott RJ, et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 2005;352:2389-97.
17. Shavelle DM, Budoff MJ, Buljubasic N, et al. Usefulness of aortic valve calcium scores by electron beam computed tomography as a marker for aortic stenosis. Am J Cardiol 2003;92:349-53.
18. Mohler ER III, Medenilla E, Wang H, Scott C. Aortic valve calcium content does not predict aortic valve area. J Heart Valve Dis 2006;15:322-8.
19. Aronow WS, Schwartz KS, Koenigsberg M. Correlation of serum lipids, calcium, and phosphorus, diabetes mellitus and history of systemic hypertension with presence or absence of calcified or thickened aortic cusps or root in elderly patients. Am J Cardiol 1987;59:998-9.
20. Mohler ER, Sheridan MJ, Nichols R, et al. Development and progression of aortic valve stenosis: atherosclerosis risk factors - a causal relationship? A clinical morphologic study. Clin Cardiol 1991;14:995-9.
21. Aronow WS, Ahn C, Kronzon I, Goldman ME. Association of coronary risk factors and use of statins with progression of mild valvular aortic stenosis in older persons. Am J Cardiol 2001;88:693-5.
22. Katz R, Wong ND, Kronmal R, et al. Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valve calcification in the Multi-Ethnic Study of Atherosclerosis. Circulation 2006;113:2113-9.
23. Briand M, Lemieux I, Dumesnil JG, et al. Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis. J Am Coll Cardiol 2006;47: 2229-36.
24. Briand M, Pibarot P, Despres JP, et al. Metabolic syndrome is associated with faster degeneration of bioprosthetic valves. Circulation 2006;114:1512-7.
25. Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112: 2735-52.
26. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005;365:1415-28.
27. O'Brien KD. Do bioprosthetic aortic valves deteriorate more rapidly in patients with the metabolic syndrome? Nat Clin Pract Cardiovasc Med 2007;4:192-3.
28. Maher ER, Pazianas M, Curtis JR. Calcific aortic stenosis: a complication of chronic uraemia. Nephron 1987;47: 119-22.
29. Michel PL. Aortic stenosis in chronic renal failure patients treated by dialysis. Nephrol Dial Transplant 1998;13 Suppl 4:44-8.
30. Varma R, Aronow WS, McClung JA, et al. Prevalence of valve calcium and association of valve calcium with coronary artery disease, atherosclerotic vascular disease, and all-cause mortality in 137 patients undergoing hemodialysis for chronic renal failure. Am J Cardiol 2005;95: 742-3.
31. Fox CS, Larson MG, Vasan RS, et al. Cross-sectional association of kidney function with valvular and annular calcification: the Framingham Heart Study. J Am Soc Nephrol 2006;17:521-7.
32. Ix JH, Shlipak MG, Katz R, et al. Kidney function and aortic valve and mitral annular calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 2007;50:412-20.
33. Sanchez PL, Santos JL, Kaski JC, et al. Relation of circulating C-reactive protein to progression of aortic valve stenosis. Am J Cardiol 2006;97:90-3.
34. Fox CS, Guo CY, Larson MG, et al. Relations of inflammation and novel risk factors to valvular calcification. Am J Cardiol 2006;97:1502-5.
35. Miller M, Zhan M, Havas S. High attributable risk ofelevated C-reactive protein level to conventional coronary heart disease risk factors: the Third National Health and Nutrition Examination Survey. Arch Intern Med 2005; 165:2063-8.
36. Folsom AR, Chambless LE, Ballantyne CM, et al. An assessment of incremental coronary risk prediction using C-reactive protein and other novel risk markers: the Atherosclerosis Risk in Communities Study. Arch Intern Med 2006;166:1368-73.
37. Ortlepp JR, Hoffmann R, Ohme F, et al. The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis. Heart 2001;85:635-8.
38. Avakian SD, Nicchino-Bizzachi JM, Grinberg M, et al. Apolipoproteins AI, B, and E polymorphisms in severe aortic valve stenosis. Clin Genet 2001;60:381-4.
39. Nordstrom P, Glader CA, Dahlen G, et al. Oestrogen receptor alpha gene polymorphism is related to aortic valve sclerosis in postmenopausal women. J Intern Med 2003; 254:140-6.
40. Novaro GM, Sachar R, Pearce GL, et al. Association between apolipoprotein E alleles and calcific valvular heart disease. Circulation 2003;108:1804-8.
41. Ortlepp JR, Pillich M, Mevissen V, et al. APOE alleles are not associated with calcific aortic stenosis. Heart 2006;92: 1463-6.
42. Chui MC, Newby DE, Panarelli M, et al. Association between calcific aortic stenosis and hypercholesterolemia: is there a need for a randomized controlled trial of cholesterollowering therapy? Clin Cardiol 2001;24:52-5.
43. Larson EW, Edwards WD. Risk factors for aortic dissection: a necropsy study of 161 cases. Am J Cardiol 1984;53: 849-55.
44. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002;39:1890-900.
45. Roberts WC, Ko JM. Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation. Circulation 2005;111:920-5.
46. Clementi M, Notari L, Borghi A, Tenconi R. Familial congenital bicuspid aortic valve: a disorder of uncertain inheritance. Am J Med Genet 1996;62:336-8.
47. Huntington K, Hunter AG, Chan KL. A prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve. J Am Coll Cardiol 1997;30:1809-12.
48. Loeys BL, Chen J, Neptune ER, et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet 2005;37:275-81.
49. Garg V, Muth AN, Ransom JF, et al. Mutations in NOTCH1 cause aortic valve disease. Nature 2005;437: 270-4.
50. Nistri S, Sorbo MD, Basso C, Thiene G. Bicuspid aortic valve: abnormal aortic elastic properties. J Heart Valve Dis 2002;11:369-73.
51. Schaefer BM, Lewin MB, Stout KK, et al. Usefulness of bicuspid aortic valve phenotype to predict elastic properties of the ascending aorta. Am J Cardiol 2007;99:686-90.
52. Wozney JM, Rosen V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop Relat Res 1998;346:26-37.
53. Rajamannan NM, Subramaniam M, Springett M, et al. Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve. Circulation 2002;105:2660-5.
54. Rajamannan NM, Subramaniam M, Rickard D, et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 2003;107:2181-4.
55. Arishiro K, Hoshiga M, Negoro N, et al. Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits. J Am Coll Cardiol 2007;49:1482-9.
56. Roden DM, Altman RB, Benowitz NL, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med 2006;145:749-57.