Human brain endothelial cells (HUBEC) promote SCID repopulating cell expansion through direct contact

Growth Factors

Volumn 25, Issue 3, 2007, Pages 141-150

  Cheng, Xiangfei ^a   Macvittie, Thomas ^a   Meisenberg, Barry ^a   Welty, Emily ^a   Farese, Ann ^a   Tadaki, Douglas ^b   Takebe, Naoko ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b NAVAL MEDICAL RESEARCH CENTER   (United States)

Author keywords

CD34+ CD38 ; Contact culture; Cord blood CD34+ cells; Wnt catenin

Indexed keywords

BETA CATENIN; CD34 ANTIGEN; CD38 ANTIGEN; CYTOKINE; FRIZZLED PROTEIN; RECOMBINANT PROTEIN; WNT3 PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; CD34 SELECTION; CELL CONTACT; CELL POPULATION; CELL SURFACE; COCULTURE; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; ENDOTHELIUM CELL; EX VIVO STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION;

ANIMALS; ANTIGENS, CD34; ANTIGENS, CD38; BETA CATENIN; BRAIN; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HEMATOPOIETIC STEM CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, SCID; SEVERE COMBINED IMMUNODEFICIENCY; WNT PROTEINS;

EID: 36749050381     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.1080/08977190701671662     Document Type: Article

References (28)

1. Austin, TW, Solar, GP, Ziegler, FC, Liem, L. and Matthews, W. (1997) A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells. Blood, 89:10, pp. 3624-3635.
2. Chiba, H., Kobune, M., Kato, J., Kawano, Y., Ito, Y., Nakamura, K., Asakura, S., Hamada, H. and Niitsu, Y. (2004) Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells. Exp Hematol, 32:12, pp. 1194-1203.
3. Chute, JP, Clark, W., Saini, A., Wells, M. and Harlan, D. (2002) Rescue of hematopoietic stem cells following high-dose radiation injury using ex vivo culture on endothelial monolayers. Mil Med, 167:2, pp. 74-77.
4. Chute, JP, Saini, AA, Chute, DJ, Wells, MR, Clark, WB, Harlan, DM, Park, J., Stull, MK, Civin, C. and Davis, TA (2002) Ex vivo culture with human brain endothelial cells increases the SCID-repopulating capacity of adult human bone marrow. Blood, 100:13, pp. 4433-4439.
5. Chute, JP, Muramoto, G., Fung, J. and Oxford, C. (2004) Quantitative analysis demonstrates expansion of SCID-repopulating cells and increased engraftment capacity in human cord blood following ex vivo culture with human brain endothelial cells. Stem Cells, 22:2, pp. 202-215.
6. Chute, JP, Muramoto, GG, Fung, J. and Oxford, C. (2005) Soluble factors elaborated by human brain endothelial cells induce the concomitant expansion of purified human BM CD34+CD38 - cells and SCID-repopulating cells. Blood, 105:2, pp. 576-583.
7. Davis, TA, Robinson, DH, Lee, KP and Kessler, SW (1995) Porcine brain microvascular endothelial cells support the in vitro expansion of human primitive hematopoietic bone marrow progenitor cells with a high replating potential: Requirement for cell-to-cell interactions and colony-stimulating factors. Blood, 85:7, pp. 1751-1761.
8. Fujisaki, T., Berger, MG, Rose-John, S. and Eaves, CJ (1999) Rapid differentiation of a rare subset of adult human lin(-)CD34(-)CD38(-) cells stimulated by multiple growth factors in vitro. Blood, 94:6, pp. 1926-1932.
9. Ishigaki, K., Namba, H., Nakashima, M., Nakayama, T., Mitsutake, N., Hayashi, T., Maeda, S., Ichinose, M., Kanematsu, T. and Yamashita, S. (2002) Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer. J Clin Endocrinol Metab, 87:7, pp. 3433-3440.
10. Karanu, FN, Murdoch, B., Gallacher, L., Wu, DM, Koremoto, M., Sakano, S. and Bhatia, M. (2000) The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J Exp Med, 192:9, pp. 1365-1372.
11. Katoh, M. (2001) Molecular cloning and characterization of human WNT3. Int J Oncol, 19:5, pp. 977-982.
12. Kiel, MJ, Yilmaz, OH, Iwashita, T., Yilmaz, OH, Terhorst, C. and Morrison, SJ (2005) SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell, 121:7, pp. 1109-1121.
13. Kirstetter, P., Anderson, K., Porse, BT, Jacobsen, SE and Nerlov, C. (2006) Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol, 7:10, pp. 1048-1056.
14. Lie, DC, Colamarino, SA, Song, HJ, Desire, L., Mira, H., Consiglio, A., Lein, ES, Jessberger, S., Lansford, H. and Dearie, AR (2005) Wnt signalling regulates adult hippocampal neurogenesis. Nature, 437:7063, pp. 1370-1375.
15. Li, W., Johnson, SA, Shelley, WC and Yoder, MC (2004) Hematopoietic stem cell repopulating ability can be maintained in vitro by some primary endothelial cells. Exp Hematol, 32:12, pp. 1226-1237.
16. Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A. and Niehrs, C. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature, 411:6835, pp. 321-325.
17. Murdoch, B., Chadwick, K., Martin, M., Shojaei, F., Shah, KV, Gallacher, L., Moon, RT and Bhatia, M. (2003) Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci USA, 100:6, pp. 3422-3427.
18. Rafii, S., Shapiro, F., Pettengell, R., Ferris, B., Nachman, RL, Moore, MA and Asch, AS (1995) Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors. Blood, 86:9, pp. 3353-3363.
19. Reya, T., Duncan, AW, Ailles, L., Domen, J., Scherer, DC, Willert, K., Hintz, L., Nusse, R. and Weissman, IL (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature, 423:6938, pp. 409-414.
20. Robinson, DH, Kang, YH, Deschner, SH and Nielsen, TB (1990) Morphologic plasticity and periodicity: Porcine cerebral microvascular cells in culture. In Vitro Cell Dev Biol, 26:2, pp. 169-180.
21. Saitoh, T., Hirai, M. and Katoh, M. (2001) Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region. Biochem Biophys Res Commun, 284:5, pp. 1168-1175.
22. Smolich, BD, McMahon, JA, McMahon, AP and Papkoff, J. (1993) Wnt family proteins are secreted and associated with the cell surface. Mol Biol Cell, 4:12, pp. 1267-1275.
23. Ueno, H., Sakita-Ishikawa, M., Morikawa, Y., Nakano, T., Kitamura, T. and Saito, M. (2003) A stromal cell-derived membrane protein that supports hematopoietic stem cells. Nat Immunol, 4:5, pp. 457-463.
24. Berg, DJ Van Den, Sharma, AK, Bruno, E. and Hoffman, R. (1998) Role of members of the Wnt gene family in human hematopoiesis. Blood, 92:9, pp. 3189-3202.
25. Wang, JC, Doedens, M. and Dick, JE (1997) Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood, 89:11, pp. 3919-3924.
26. Willert, K., Brown, JD, Danenberg, E., Duncan, AW, Weissman, IL, Reya, T., Yates III, JR and Nusse, R. (2003) Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature, 423:6938, pp. 448-452.
27. Yamane, T., Kunisada, T., Tsukamoto, H., Yamazaki, H., Niwa, H., Takada, S. and Hayashi, SI (2001) Wnt signaling regulates hemopoiesis through stromal cells. J Immunol, 167:2, pp. 765-772.
28. Yin, T. and Li, L. (2006) The stem cell niches in bone. J Clin Invest, 116:5, pp. 1195-1201.