Bioenergetic status and hypoxia in lewis lung carcinoma assessed by 31P NMR spectroscopy: Correlation with tumor progression

Experimental Oncology

Volumn 29, Issue 3, 2007, Pages 207-211

  Bubnovskaya, L ^a   Mikhailenko, V ^a   Kovelskaya, A ^a   Osinsky, S ^a  

^a R E KAVETSKY INSTITUTE OF EXPERIMENTAL PATHOLOGY   (Ukraine)

Author keywords

Bioenergetic; Hypoxia; Lewis lung carcinoma; Metastasis; NMR spectroscopy

Indexed keywords

PERCHLORIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CONTROLLED STUDY; CORRELATIONAL STUDY; HYPOXIA; LEWIS CARCINOMA; LUNG METASTASIS; MOUSE; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; TUMOR GROWTH;

ANIMALS; CARCINOMA, LEWIS LUNG; CELL HYPOXIA; DISEASE PROGRESSION; ENERGY METABOLISM; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED C57BL; PHOSPHORUS ISOTOPES;

EID: 36749025185     PISSN: 18129269     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Le Q-T, Denko NC, Giaccia AJ. Hypoxic gene expression and metastasis. Cancer Met Rev 2004; 23: 293-310.
2. Rofstad EK, Galappathi K, Mathiesen B, Ruud E-BM. Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis. Clin Cancer Res 2007; 13: 1971-8.
3. Ciaccia AJ, Koumenis C, Denko N. The influence of tumor hypoxia on malignant progression. In: P Vaupel, D Kelleher (eds), Tumor Hypoxia: pathophysiology, clinical significance and therapeutic perspectives. Stuttgart, Wissenschaftliche Verlagsgesellschaft: 1999: 115-24.
4. Eriksen JG, Horsman MR. Tumor hypoxia - a characteristic feature with a complex molecular background. Radiother Oncol 2006; 81: 119-21.
5. Evans SM, Koch CJ. Prognostic significance of tumor oxygenation in humans. Cancer Lett 2003; 195: 1-16.
6. Bussink J, Kaanders JHAM, van der Kogel AJ. Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers. Radiother Oncol 2003; 67: 3-15.
7. 2 tension measurements in a murine fibrosarcoma. Radiat Res 1989; 120: 477-93.
8. 31P NMR spectroscopy measurements, tumor size, hypoxic fraction and cell survival after radiotherapy. Int J Radiat Oncol Biol Phys 1990; 18: 1341-50.
9. 31P MR Spectroscopy. Amer J Roentgenol 1991; 157: 243-8.
10. Evolhoch J L, Gillies RJ, Karczmar GS, Koutcher JA, Maxwell RJ, Nalciouglu O, Raghunand N, Ronen SM, Ross BD, Swartz HM. Application of Magnetic Resonance in model systems: cancer therapeutics. Neoplasia 2000; 2: 152-65.
11. 31P magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia. Cancer Res 1988; 48: 5440-6.
12. Podo F. Tumor phospholipid metabolism. NMR Biomed 1999; 12: 413-39.
13. Merchant TE, Kasimos JN, Vroom T, de Bree E, Iwata JL, de Graaf PW, Glonek T. Malignant breast tumor phospholipid profiles using 31P magnetic resonance. Cancer Lett 2002; 176: 159-67.
14. 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy. Int J Radiat Oncol Biol Phys 2005; 61: 480-91.
15. 31P-NMR spectroscopy of murine tumors before and after localized hyperthermia. Int J Hyperthermia 1990; 6: 15-31.
16. Osinsky SP, Ganusevich II, Bubnovskaya LN, Valkovskaya NV, Kovelskaya AV, Sergienko TK, Zimina SV. Hypoxia level and matrix metalloproteinases-2 and -9 activity in Lewis lung carcinoma: correlation with metastasis. Exp Oncol 2005; 27: 202-5.
17. Zhou J, Schmidt T, Schnitzer S, Bruene B. Tumor hypoxia and cancer progression. Cancer Lett 2006; 237: 10-21.
18. Rofstad EK, Galappathi K, Mathiesen B, Ruud E-BM. Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis. Clin Cancer Res 2007; 13: 1971-8.
19. Chaudary N, Hill RP. Hypoxia and metastasis. Clin Cancer Res 2007; 13: 1947-9.
20. Wouters BG, Weppler SA, Koritzinsky M, Landuyt W, Nuyts S, Theys J, Chiu RK, Lambin P. Hypoxia as a target for combined modality treatments. Eur J Cancer 2002; 38: 240-57.
21. Lukacova S, Overgaard J, Alsner J, Horsman MR. Strain and tumor specific variations in the effect of hypoxia on osteopontin levels in experimental models. Radiother Oncol 2006; 80: 165-71.
22. Nelson DW, Cao H, Zhu Y, Sunar-Redder B, Choi CYH, Faix JD, Brown JM, Koong AC, Giaccia AJ, Le Q-T. A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia. Cancer Res 2005; 65: 6151-8.
23. 31P NMR for non-invasive evaluation of tumor metabolic status. Int J Radiat Oncol Biol Phys 1986; 12: 793-9.
24. 31P MRS observation of tumor energy metabolism. NMR Biomed 1992; 5: 279-89.
25. Vaupel P, Hoeckel M. Oxygenation of human tumors. In: Blood perfusion and microenvironment of human tumors. Molls M, Vaupel P, eds. Berlin-Heidelberg, Springer Verlag 1998, pp. 63-72.
26. 31P magnetic resonance spectroscopy: an experimental study of human melanoma xenografts. Radiother Oncol 1999; 52: 261-7.
27. Osinsky S, Gluzman D, Olijnichenko G, Bubnovskaya L, Ganusevich I, Osinsky D, Merentsev S, Gumenjuk L. Hypoxia-regulated proteins in gastric cancer: correlation with disseminated tumor cells and clinical outcome. Eur J Cancer Suppl 2006; 4: 49 (P60).