Salmonella type III-mediated heterologous antigen delivery: A versatile oral vaccination strategy to induce cellular immunity against infectious agents and tumors

International Journal of Medical Microbiology

Volumn 298, Issue 1-2, 2008, Pages 99-103

  Panthel, Klaus ^a   Meinel, Katrin M ^a   Sevil Domènech, Victòria E ^a   Trülzsch, Konrad ^a   Rüssmann, Holger ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Anti tumor immunity; Memory CD8 T cells; Salmonella T3SS; Sequential translocation

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GENE PRODUCT; HYBRID PROTEIN; INTERLEUKIN 7 RECEPTOR; L SELECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN P60; PROTEIN SSPH2; UNCLASSIFIED DRUG; VACCINE;

ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; CANCER IMMUNIZATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIVISION; CELL SURVIVAL; CELLULAR IMMUNITY; CHIMERA; CYTOSOL; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; FIBROSARCOMA; GENETIC TRANSFECTION; IMMUNE RESPONSE; LISTERIA MONOCYTOGENES; MACROPHAGE; MEMORY CELL; NONHUMAN; PATHOGENICITY ISLAND; PROTEIN TRANSPORT; SALMONELLA; SALMONELLA TYPHIMURIUM; SHORT SURVEY; SPLEEN;

EID: 36749009252     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2007.07.002     Document Type: Short Survey

References (29)

1. Beuzon C.R., Meresse S., Unsworth K.E., Ruiz-Albert J., Garvis S., Waterman S.R., Ryder T.A., Boucrot E., and Holden D.W. Salmonella maintains the integrity of its intracellular vacuole through the action of SifA. EMBO J. 19 (2000) 3235-3249
2. Boon T., Cerottini J.C., Van den Eynde B., van der Bruggen P., and Van Pel A. Tumor antigens recognized by T-lymphocytes. Annu. Rev. Immunol. 12 (1994) 337-365
3. Fu Y., and Galán J.E. A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion. Nature 401 (1999) 293-297
4. Galán J.E. Molecular genetic bases of Salmonella entry into host cells. Mol. Microbiol. 20 (1996) 262-271
5. Galán J.E., and Collmer A. Type III secretion machines: bacterial devices for protein delivery into host cells. Science 284 (1999) 1322-1328
6. Garcia-del Portillo F., Zwick M.B., Leung K.Y., and Finlay B.B. Salmonella induces the formation of filamentous structures containing lysosomal membrane glycoproteins in epithelial cells. Proc. Natl. Acad. Sci. USA 90 (1993) 10544-10548
7. Geginat G., Lalic M., Kretschmar M., Goebel W., Hof H., Palm D., and Bubert A. Th1 cells specific for a secreted protein of Listeria monocytogenes are protective in vivo. J. Immunol. 160 (1998) 6046-6055
8. Harty J.T., and Pamer E.G. CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection. J. Immunol. 154 (1995) 4642-4650
9. Hensel M. Salmonella pathogenicity island 2. Mol. Microbiol. 36 (2000) 1015-1023
10. Huster K.M., Busch V., Schiemann M., Linkemann K., Kerksiek K.M., Wagner H., and Busch D.H. Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc. Natl. Acad. Sci. USA 101 (2004) 5610-5615
11. Igwe E.I., Geginat G., and Rüssman H. Concomitant cytosolic delivery of two immunodominant listerial antigens by Salmonella enterica serovar Typhimurium confers superior protection against murine listeriosis. Infect. Immun. 70 (2002) 7114-7119
12. Kotton C.N., and Hohmann E.L. Enteric pathogens as vaccine vectors for foreign antigen delivery. Infect. Immun. 72 (2004) 5535-5547
13. Marzo A.L., Lake R.A., Robinson B.W., and Scott B. T-cell receptor transgenic analysis of tumor specific CD8 and CD4 responses in the eradication of solid tumors. Cancer Res. 59 (1999) 1071-1079
14. Masopust D., Vezys V., Marzo A.L., and Lefrancois L. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291 (2001) 2413-2417
15. Medina E., and Guzmán C.A. Use of bacterial vaccine vectors for antigen delivery: potential and limitations. Vaccine 19 (2001) 1573-1580
16. Melief C.J., Toes R.E., Medema J.P., van der Burg S.H., Ossendorp F., and Offringa R. Strategies for immunotherapy of cancer. Adv. Immunol. 75 (2000) 235-282
17. Miao E.A., Scherer C.A., Tsolis R.M., Kingsley R.A., Adams L.G., Bäumler A.J., and Miller S.I. Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems. Mol. Microbiol. 34 (1999) 850-864
18. Miao E.A., Brittnacher M., Haraga A., Jeng R.L., Welch M.D., and Miller S.I. Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton. Mol. Microbiol. 48 (2003) 401-415
19. Minev B.R., Mc Farland B.J., Spiess O.J., Rosenberg S.A., and Restifo N.P. Insertion signal sequence fused to minimal peptides elicits specific CD8+ T-cell responses and prolongs survival of thymoma-bearing mice. Cancer Res. 54 (1994) 4155-4161
20. Pamer E.G., Harty J.T., and Bevan M.J. Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes. Nature 352 (1991) 852-855
21. Panthel K., Meinel K.M., Sevil Domènech V.E., Retzbach H., Igwe E.I., Hardt W.-D., and Rüssmann H. Salmonella pathogenicity island 2-mediated overexpression of chimeric SspH2 proteins for simultaneous induction of antigen-specific CD4 and CD8 T cells. Infect. Immun. 73 (2005) 334-341
22. Panthel K., Meinel K.M., Sevil Domènech V.E., Geginat G., Linkemann K., Busch D.H., and Rüssmann H. Prophylactic anti-tumor immunity against a murine fibrosarcoma triggered by the Salmonella type III secretion system. Microbes Infect. 8 (2006) 2539-2546
23. Rüssmann H. Bacterial type III translocation: a unique mechanism for cytosolic display of heterologous antigens by attenuated Salmonella. Int. J. Med. Microbiol. 293 (2003) 107-112
24. Rüssmann H., Shams H., Poblete F., Fu Y., Galán J.E., and Donis R.O. Delivery of epitopes by the Salmonella type III secretion system for vaccine development. Science 281 (1998) 565-568
25. Rüssmann H., Igwe E.I., Sauer J., Hardt W.-D., Bubert A., and Geginat G. Protection against murine listeriosis by oral vaccination with recombinant Salmonella expressing hybrid Yersinia type III proteins. J. Immunol. 167 (2001) 357-365
26. Sallusto F., Lenig D., Forster R., Lipp M., and Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401 (1999) 708-712
27. Schaible U.E., Collins H.L., and Kaufmann S.H.E. Confrontation between intracellular bacteria and the immune system. Adv. Immunol. 71 (1999) 267-377
28. Staveley-O'Carroll K., Sotomayor E., Montgomery J., Borrello I., Hwang L., Fein S., Pardoll D., and Levitsky H. Induction of antigen-specific T cell anergy: an early event in the course of tumor progression. Proc. Natl. Acad. Sci. USA 95 (1998) 1178-1183
29. Stender S., Friebel A., Linder S., Rohde M., Mirold S., and Hardt W.-D. Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell. Mol. Microbiol. 36 (2000) 1206-1221