Bacterial type III translocation: A unique mechanism for cytosolic display of heterologous antigens by attenuated Salmonella

International Journal of Medical Microbiology

Volumn 293, Issue 1, 2003, Pages 107-112

  Rüssmann, Holger ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

CD8 T cell priming; MHC class I; Translocation; Type III secretion

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CD8 ANTIGEN; DRUG CARRIER; EPITOPE; HYBRID PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PROTEASOME; PROTEIN SUBUNIT; SALMONELLOSIS VACCINE; VIRUS ANTIGEN; VIRUS NUCLEOPROTEIN;

ANTIGEN EXPRESSION; ANTIGENICITY; BACTERIAL TRANSLOCATION; BACTERIUM IDENTIFICATION; CARBOXY TERMINAL SEQUENCE; CELLULAR IMMUNITY; CORRELATION ANALYSIS; CYTOTOXIC T LYMPHOCYTE; DRUG DELIVERY SYSTEM; EUKARYOTIC CELL; GENETIC MANIPULATION; HOST CELL; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; INFECTION PREVENTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MICROBIAL ATTENUATION; NONHUMAN; PATHOGENICITY; PROTEIN SECRETION; REVIEW; SALMONELLA; SALMONELLA ENTERICA; SALMONELLOSIS; WILD TYPE; YERSINIA; YERSINIA ENTEROCOLITICA;

EID: 0038636535     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4221-00249     Document Type: Review

References (41)

1. Aizawa, S. I.: Flagellar assembly in Salmonella typhimurium. Mol. Microbiol. 19, 1-5 (1996).
2. Alpuche-Aranda, C. M., Racoosin, E. L., Swanson, J. A., Miller, S. I.: Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes. J. Exp. Med. 179, 601-608 (1994).
3. Autenrieth, I. B., Heesemann, J.: In vivo neutralization of tumor necrosis factor-alpha and interferon-gamma abrogates resistance to Yersinia enterocolitica infection in mice. Med. Microbiol. Immunol. Berl. 181, 333-338 (1992).
4. Black, D. S., Bliska, J. B.: Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions. EMBO J. 16, 2730-2744 (1997).
5. Black, D. S., Bliska, J. B.: The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence. Mol. Microbiol. 37, 515-527 (2000).
6. Bubert, A., Kuhn, M., Goebel, W., Köhler, S.: Structural and functional properties of the p60 protein from different Listeria species. J. Bacteriol. 174, 8166-8171 (1992).
7. Cornelis, G. R., Boland, A., Boyd, A. P., Geuijen, C., Iriarte, M., Neyt, C., Sory, M.-P., Stanier, I.: The virulence plasmid of Yersinia, an antihost genome. Microbiol. Mol. Rev. 62, 1315-1352 (1998).
8. Fu, Y., Galán, J. E.: The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton. Mol. Microbiol. 27, 359-368 (1998).
9. Galán, J. E.: Molecular genetic bases of Salmonella entry into host cells. Mol. Microbiol. 20, 263-271 (1996).
10. Galán, J. E.: Interactions of Salmonella with host cells: Encounters of the closest kind. Proc. Natl. Acad. Sci. USA 95, 14006-14008 (1998).
11. Germain, R. N.: MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte avtivation. Cell 76, 287-299 (1994).
12. Germain, R. N.: The biochemistry and cell biology of antigen presentation by MHC class I and II molecules: implications for development of combination vaccines. Ann. NY Acad. Sci. 754, 114-125 (1995).
13. Hakansson, S., Schesser, K., Persson, C., Galyov, E. E., Rosqvist, R., Homble, F., Wolf-Watz, H.: The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell membrane and displays a contact-dependent membrane disrupting activity. EMBO J. 15, 5812-5823 (1996).
14. Harty, J. T., Pamer, E. G.: CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection. J. Immunol. 154, 4642-4650 (1995).
15. Harty, J. T., Bevan, M. J.: Responses of CD8+T cells to intracellular bacteria. Curr. Opin. Immunol. 11, 89-93 (1999).
16. Hueck, C. J. 1998.: Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol. Mol. Biol. Rev. 62, 379-433 (1998).
17. Igwe, E. I., Geginat, G., Rüssmann, H.: Concomitant cytosolic delivery of two immunodominant listerial antigens by Salmonella enterica serovar Typhimurium confers superior protection against murine listeriosis. Infect. Immun. 70, 7114-7119 (2002).
18. Jacobi, C. A., Roggenkamp, A., Rakin, A., Zumbihl, R., Leitritz, L., Heesemann, J.: In vitro and in vivo expression studies of YopE from Yersinia enterocolitica using the gfp reporter gene. Mol. Microbiol. 30, 865-882 (1998).
19. Kaniga, K., Uralil, J., Bliska, J. B., Galán, J. E.: A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurium. Mol. Microbiol. 21, 633-641 (1996).
20. Kubori, T., Matsushima, Y., Nakamura, D., Uralil, J., Lara-Tejero, M., Sukhan, A., Galán, J. E., Aizawa, S. I.: Supramolecular structure of the Salmonella typhimurium type III protein secretion system. Science 280, 602-605 (1998).
21. Lee, C. A.: Type III secretion systems: machines to deliver bacterial proteins into eukaryotic cells. Trends Microbiol. 5, 148-156 (1997).
22. Lee, V. T., Anderson, D. M. Schneewind, O.: Targeting of Yersinia Yop proteins into the cytosol of HeLa cells: one-step translocation of YopE across bacterial and eukaryotic membranes is dependent on SycE chaperone. Mol. Microbiol. 28, 593-601 (1998).
23. Neyt, C., Cornelis, G. R.: Insertion of a Yop translocation pore into the macrophage plasma membrane by Yersinia enterocolitica: requirement for translocators YopB and YopD, but not LcrG. Mol. Microbiol. 33, 971-981 (1999).
24. Pamer, E. G., Harty, J. T., Bevan, M. J.: Precise prediction of a dominant class I-restricted epitope of Listeria monocytogenes. Nature 353, 852-855 (1991).
25. Pamer, E. G.: Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope. J. Immunol. 152, 686-694 (1994).
26. Rosqvist, R., Bolin, I., Wolf-Watz, H.: Inhibition of phagocytosis in Yersinia pseudotuberculosis: a virulence plasmid-encoded ability involving the Yop2b protein. Infect. Immun. 56, 2139-2143 (1988).
27. Rosqvist, R., Forsberg, A., Wolf-Watz, H.: Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption. Infect. Immun. 59, 4562-4569 (1991).
28. Rosqvist, R., Magnusson, K. E., Wolf-Watz, H.: Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. EMBO J. 13, 964-972 (1994).
29. Rosqvist, R., Hakansson, S., Forsberg, A., Wolf-Watz, H.: Functional conservation of the secretion and translocation machinery for virulence proteins of Yersiniae, Salmonellae and Shigellae. EMBO J. 14, 4187-4195 (1995).
30. Ruckdeschel, K., Roggenkamp, A., Lafont, V., Mangeat, P., Heesemann, J., Rouot, B.: Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell death through apoptosis. Infect. Immun. 65, 4813-4821 (1997).
31. Rüssmann, H., Shams, H., Poblete, F., Fu, Y., Galán, J. E., Donis, R. O.: Delivery of epitopes by the Salmonella type III secretion system for vaccine development. Science 281, 565-568 (1998).
32. Rüssmann, H., Weissmüller, A., Geginat, G., Igwe, E. I., Roggenkamp, A., Bubert, A., Goebel, W., Hof, H., Heesemann, J.: Yersinia enterocolitica-mediated translocation of defined fusion proteins to the cytosol of mammalian cells results in MHC class I-restricted antigen presentation. Eur. J. Immunol. 30, 1375-1384 (2000).
33. Rüssmann, H., Igwe, E. I., Sauer, J., Hardt, W.-D., Bubert, A., Geginat, G.: Protection against murine listeriosis by oral vaccination with recombinant Salmonella expressing hybrid Yersinia type III proteins. J. Immunol. 167, 357-365 (2001).
34. Schesser, K., Frithz-Lindsten, E., Wolf-Watz, H.: Delineation and mutational analysis of the Yersinia pseudotuberculosis YopE domains which mediate translocation across bacterial and eukaryotic cellular membranes. J. Bacteriol. 178, 7227-7233 (1996).
35. Sijts, A. J. A. M., Neisig, A., Neefjes, J., Pamer, E. G.: Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies. J. Immunol. 156, 683-692 (1996).
36. Simonet, M., Richard, S., Berche, P.: Electron microscopic evidence for in vivo extracellular localization of Yersinia pseudotuberculosis harboring the pYV plasmid. Infect. Immun. 58, 841-845 (1990).
37. Sory, M.-P., Cornelis, G. R.: Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells. Mol. Microbiol. 14, 583-594 (1994).
38. Sory, M.-P., Boland, A., Lambermont, I., Cornelis, G. R. 1995.: Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach. Proc. Natl. Acad. Sci. USA 92, 1998-2002 (1995).
39. Vijh, S., Pamer, E. G.: Immunodominant and subdominant CTL responses to Listeria monocytogenes infection. J. Immunol. 158, 3366-3371 (1997).
40. Von Pawel-Rammingen, U., Telepnev, M. V., Schmidt, G., Aktories, K., Wolf-Watz, H. Rosqvist, R.: GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure. Mol. Microbiol. 36, 737-748 (2000).
41. Wick, M. J., Harding, C. V., Normark, S. J., Pfeifer, J. D.: Parameters that influence the processing efficiency of antigenic epitopes expressed in Salmonella typhimurium. Infect. Immun. 62, 4542-4548 (1994).