Aurora-A kinase regulates NF-kB activity: Lessons irom combination studies

Journal of B.U.ON.

Volumn 12, Issue SUPPL. 1, 2007, Pages

  Linardopoulos, Spiros ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Aurora A kinase; Inhibitors; NF kB

Indexed keywords

AURORA A KINASE; CISPLATIN; CYTOTOXIC AGENT; DOXORUBICIN; ETOPOSIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL;

BREAST CANCER; CANCER RESISTANCE; CANCER SUSCEPTIBILITY; CHEMOSENSITIVITY; CONFERENCE PAPER; DOWN REGULATION; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE AMPLIFICATION; GENETIC TRANSCRIPTION; HUMAN; NONHUMAN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; BCL-X PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; I-KAPPA B KINASE; LUNG NEOPLASMS; NEOPLASMS; NF-KAPPA B; OVARIAN NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 36749008500     PISSN: 11070625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Giet R, Prigent C. Aurora/Ip11p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. J Cell Sci 1999; 112: 3591-3601.
2. Francisco L, Wang W, Chan CS. Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Mol Cell Biol 1994; 14: 4731-4740.
3. Glover DM, Leibowitz MH, McLean DA, Parry H. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 1995; 81: 95-105.
4. Bischoff JR, Anderson L, Zhu Y et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. Embo J 1998; 17: 3052-3065.
5. Zhou H, Kuang J, Zhong L et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 1998; 20: 189-193.
6. Bernard M, Sanseau P, Henry C, Couturier A, Prigent C. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ip11 that maps on chromosome 19q13.3-ter. Genomics 1998; 53: 406-409.
7. Dutertre S, Descamps S, Prigent C. On the role of aurora-A in centrosome function. Oncogene 2002; 21: 6175-6183.
8. Honda K, Mihara H, Kato Y et al. Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway. Oncogene 2000; 19: 2812-2819.
9. Kallioniemi A, Kallioniemi OP, Piper J et al. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci U S A 1994; 91: 2156-2160.
10. Anand S, Penrhyn-Lowe S, Venkitaraman AR. AURORA-A amplification overrides the mitotic spmdle assembly checkpoint inducing resistance to Taxol. Cancer Cell 2003; 3: 51-62.
11. Zhang D, Hirota T, Marumoto T et al. Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene 2004; 23: 8720-8730.
12. Ewart-Toland A, Briassouli P, de Koning JP et al. Identification of Stk6/ STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet 2003; 34: 403-412.
13. Ewart-Toland A, Gao YT, Nagase H et al. Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis 2005; 26: 1368-1373.
14. Deng L, Wang C, Spencer E et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000; 103: 351-361.
15. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin MA. Cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 1997; 388: 548-554.
16. Kaltschmidt B, Kaltschmidt C, HeHNer SP, Droge W, Schmitz ML. Repression of NF-kappaB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators. Oncogene 1999; 18: 3213-3225.
17. Foo SY, Nolan GP. NF-kappaB to the rescue: RELs, apoptosis and cellular transformation. Trends Genet 1999; 15: 229-235.
18. Rayet B, Gelinas C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 1999; 18: 6938-6947.
19. Joyce D, Albanese C, Steer J, Fu M, Bouzahzah B, Pestell RG. NF-kappaB and cell-cycle regulation: the cyclin connection. Cytokine Growth Factor Rev 2001; 12: 73-79.
20. Briassouli P, Chan F, Savage K, Reis-Filho JS, Linardopoulos S. Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha. Cancer Res 2007; 67: 1689-1695.
21. Sun C, Chan F, Briassouli P, Linardopoulos S. Aurora kinase inhibition downregulates NF-kappaB and sensitises tumour cells to chemotherapeutic agents. Biochern Biophys Res Commun 2007; 352:220-225.