Suppression of plasma matrix metalloproteinase-9 following montelukast treatment in childhood asthma

Pediatrics International

Volumn 49, Issue 6, 2007, Pages 918-922

  Chuang, Shih Sung ^a   Hung, Chih Hsing ^b,c,d   Hua, Yi Ming ^e   Tien, Chiung Hsi ^e   Yang, Kuender D ^f   Jong, Yuh Jyh ^b,c,d   Hsu, Shih Hsien ^d   Lin, Chang Shen ^d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b School of Medicine   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^f CHANG GUNG CHILDREN S HOSPITAL   (Taiwan)

Author keywords

Exhaled nitric oxide; Ketotifen; Matrix metalloproteinase 9; Montelukast; Tissue inhibitor of metalloproteinase 1

Indexed keywords

GELATINASE B; KETOTIFEN; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ARTICLE; ASTHMA; CLINICAL ARTICLE; DISEASE SEVERITY; DRUG EFFECT; FEMALE; HUMAN; INFLAMMATION; MALE; PEAK EXPIRATORY FLOW; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; STATISTICAL SIGNIFICANCE;

ACETATES; ADOLESCENT; ANTI-ASTHMATIC AGENTS; ASTHMA; BREATH TESTS; CHILD; FEMALE; HISTAMINE H1 ANTAGONISTS; HUMANS; KETOTIFEN; LEUKOTRIENE ANTAGONISTS; MALE; MATRIX METALLOPROTEINASE 9; NITRIC OXIDE; PEAK EXPIRATORY FLOW RATE; QUINOLINES; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 36649014699     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2007.02497.x     Document Type: Article

References (26)

1. Barnes PJ, Chung KF, Page CP. Inflammatory mediators of asthma: An update. Pharmacol. Rev. 1998 50 : 515 96.
2. Jatakanon A, Lim S, Kharitonov SA et al. Correlation between exhaled nitric oxide, sputum eosinophils and methacholine responsiveness in patient with mild asthma. Thorax 1998 53 : 91 5.
3. Tsai YG, Lee MY, Yang KD et al. A single dose of nebulized budesonide decreases exhaled nitric oxide in children with acute asthma. J. Pediatr. 2001 139 : 433 7.
4. Bisgaard H, Loland L, Anhoj J. NO in exhaled air of asthmatic children is reduced by the leukotriene receptor antagonist montelukast. Am. J. Respir. Crit. Care Med. 1999 160 : 1227 31.
5. Heyman SN, Karmeli F, Brezis M et al. The effect of ketotifen on nitric oxide synthase activity. Br. J. Pharmacol. 1997 120 : 1545 51.
6. Tanaka H, Masuda T, Tokuoka S et al. The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma. Inflamm. Res. 2001 50 : 616 24.
7. Ohno I, Ohtani H, Nitta Y et al. Eosinophils as a source of matrix metalloproteinase-9 in asthmatic airway inflammation. Am. J. Respir. Cell Mol. Biol. 1997 16 : 212 19.
8. Kumagai K, Ohno I, Okada S et al. Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma. J. Immunol. 1999 162 : 4212 19.
9. Cataldo D, Munaut C, Noel A et al. MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease. Int. Arch. Allergy Immunol. 2000 123 : 259 67.
10. Belleguic C, Corbel M, Germain N et al. Increased release of matrix metalloproteinase-9 in the plasma of acute severe asthmatic patients. Clin. Exp. Allergy 2002 32 : 217 23.
11. Expert Panel. Guideline for the Diagnosis and Management of Asthma, Report No. 2. National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD, 1997.
12. Nagase H, Woessner JF. Matrix metalloproteinases. J. Biol. Chem. 1999 274 : 21 491 4.
13. Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2002 2 : 161 74.
14. McQuibban GA, Gong JH, Wong JP, Wallace JL, Clark-Lewis I, Overall CM. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood 2002 100 : 1160 67.
15. Atkinson JJ, Senior RM. Matrix metalloproteinase-9 in lung remodeling. Am. J. Respir. Cell Mol. Biol. 2003 28 : 12 24.
16. Mautino G, Oliver N, Chanez P, Bousquet J, Capony F. Increased release of matrix metalloproteinase-9 in bronchoalveolar lavage fluid and by alveolar macrophages of asthmatics. Am. J. Respir. Cell Mol. Biol. 1997 17 : 583 91.
17. Lee YC, Lee HB, Rhee YK, Song CH. The involvement of matrix metalloproteinase-9 in airway inflammation of patients with acute asthma. Clin. Exp. Allergy 2001 31 : 1623 30.
18. Kelly EA, Busse WW, Jarjour NN. Increased matrix metalloproteinase-9 in the airway after allergen challenge. Am. J. Respir. Crit. Care Med. 2000 162 : 1157 61.
19. Chua PK, Melish ME, Yu Q, Yanagihara R, Yamamoto KS, Nerurkar VR. Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Clin. Diagn. Lab. Immunol. 2003 10 : 308 14.
20. McMillan SJ, Kearley J, Campbell JD et al. Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation. J. Immunol. 2004 172 : 2586 94.
21. Jayaram L, Pizzichini E, Lemiere C et al. Steroid naive eosinophilic asthma: Anti-inflammatory effects of fluticasone and montelukast. Thorax 2005 60 : 100 105.
22. Bustos GJ, Bustos D, Bustos GJ et al. Prevention of asthma with ketotifen in preasthmatic children: A three-year follow-up study. Clin. Exp. Allergy 1995 25 : 568 73.
23. Kabra SK, Pandey RM, Singh R et al. Ketotifen for asthma in children aged 5 to 15 years: A randomized placebo-controlled trial. Ann. Allergy Asthma Immunol. 2000 85 : 46 52.
24. Croce J, Negreiros EB, Mazzei JAM et al. A double-blind, placebo-controlled comparison of sodium cromoglycate and ketotifen in the treatment of children asthma. Allergy 1995 50 : 524 7.
25. Pizzichini E, Leff JA, Reiss TF et al. Montelukast reduces airway eosinophilic inflammation in asthma: A randomized, control trial. Eur. Respir. J. 1999 14 : 12 18.
26. Oshita Y, Koga T, Kamimura T et al. Increased circulating 92 kDa matrix metalloproteinase (MMP-9) activity in exacerbations of asthma. Thorax 2003 58 : 757 60.