Electrophysiological actions of cyclosporin a and tacrolimus on rat hippocampal CA1 pyramidal neurons

Acta Pharmacologica Sinica

Volumn 28, Issue 12, 2007, Pages 1891-1897

  Yu, Yong ^a   Chen, Xue Qin ^b   Cui, Yao Yuan ^a   Hu, Guo Yuan ^b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Action potential; Calcineurin; Cyclosporin A; Delayed rectifier K+ channel; Hippocampus; Tacrolimus

Indexed keywords

CALCINEURIN; CALCIUM ION; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; TACROLIMUS;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN SLICE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ELECTROPHYSIOLOGY; HIPPOCAMPUS; NONHUMAN; POTASSIUM CURRENT; RAT; SPRAGUE DAWLEY RAT; STATISTICAL SIGNIFICANCE; VOLTAGE CLAMP;

ANIMALS; CYCLOSPORINE; HIPPOCAMPUS; IMMUNOSUPPRESSIVE AGENTS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TACROLIMUS;

EID: 36649007481     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00730.x     Document Type: Article

References (18)

1. Price NE, Mumby MC. Brain protein serine/threonine phosphatases. Curr Opin Neurobiol 1999 9:336 42.
2. Yakel JL. Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription. Trends Pharmacol Sci 1997 18:124 34.
3. Herzig S, Neumann J. Effects of serine/threonine protein phos-phatases on ion channels in excitable membranes. Physiol Rev 2000 80:173 210.
4. Mansuy IM, Shenolikar S. Protein serine/threonine phosphatases in neuronal plasticity and disorders of leaning and memory. Trends Neurosci 2006 29:679 86.
5. Misonou H, Mohapatra DP, Menegola M, Trimmer JS. Calcium-and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia. J Neurosci 2005 25:11 184 93.
6. Misonou H, Mohapatra DP, Park EW, Leung V, Zhen D, Misouno K, et al. Regulation of ion channel localization and phosphory-lation by neuronal activity. Nature Neurosci 2004 7:711 8.
7. Snyder SH, Lai MM, Burnett PE. Immunophilins in the nervous system. Neuron 1998 21:283 94.
8. Gao ZB, Chen XQ, Hu GY. Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus. Brain Res 2006 1111:41 7.
9. Magee JC. Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J Neurosci 1998 18:7613 24.
10. Hu GY, Biro Z, Hill RH, Grillner S. Intracellular depression of membrane potential oscillations in lamprey spinal neurons during fictive locomotion. J Neurophysiol 2002 87:2676 83.
11. + current by the immunosuppressant FK506 in rat hippocampal neurons. Brain Res 2007 1148:62 8.
12. Numann RE, Wadman WJ, Wong RKS. Outward currents of single hippocampal cells obtained from the adult guinea-pig. J Physiol 1987 393:331 53.
13. Klee R, Ficker E, Heinemann U. Comparison of voltage-dependent potassium currents in rat pyramidal neurons acutely isolated from hippocampal regions CA1 and CA3. J Neurophysiol 1995 74:1982 95.
14. Victor RG, Thomas GD, Marban E, O'Rourke B. Presynaptic modulation of cortical synaptic activity by calcineurin. Proc Natl Acad Sci USA 1995 92:6269 73.
15. + channel is modulated by FK506 and rapamycin. Brain Res 1998 786:255 8.
16. + currents in rat ventricular myocytes. J Physiol 1997 501:509 16.
17. + currents by the immunosuppressant FK506 in rat ventricle. Am J Physiol 1998 275 (Heart Circ Physiol 44 H2041 52.
18. Ahn HS, Kim SE, Choi BH, Choi JS, Kim MJ, Rhie DJ, et al. Calcineurin-independent inhibition of Kv1.3 by FK-506 (Tacrolimus): a novel pharmacological property. Am J Physiol Cell Physiol 2007 292:C1714 22.