Can we build synthetic, multicellular systems by controlling developmental signaling in space and time?

Current Opinion in Chemical Biology

Volumn 11, Issue 6, 2007, Pages 604-611

  Ismagilov, Rustem F ^a   Maharbiz, Michel M ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHOGEN;

APOPTOSIS; CELL DEATH; CELL TRANSFER; CHICKEN; COELENTERATE; DEVELOPMENTAL BIOLOGY; DROSOPHILA MELANOGASTER; EXTRACELLULAR MATRIX; HUMAN; MOLECULAR BIOLOGY; MYOBLAST; NERVE FUNCTION; NONHUMAN; REVIEW; SEA URCHIN; SIGNAL TRANSDUCTION; SPACE; TIME; VOLVOX; VOLVOX CARCERI; ZEBRA FISH;

DEVELOPMENTAL BIOLOGY; PROTEIN ENGINEERING; SIGNAL TRANSDUCTION;

EID: 36549068747     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2007.10.003     Document Type: Review

References (64)

1. Wolpert L., Beddington R., Jessell T.M., Lawrence P., Meyerowitz E.M., and Smith J. Principles of Development. edn 2 (2002), Oxford University Press, New York
2. In: Moody S.A. (Ed). Cell Lineage and Fate Determination (1998), Academic Press, San Diego
3. Gregor T., Wieschaus E.F., McGregor A.P., Bialek W., and Tank D.W. Stability and nuclear dynamics of the bicoid morphogen gradient. Cell 130 (2007) 141-152
4. Gregor T., Tank D.W., Wieschaus E.F., and Bialek W. Probing the limits to positional information. Cell 130 (2007) 153-164. Both papers by Gregor et al. observe and analyze gradients of the gene transcription factor Bicoid in live fruit fly embryos during development. Previous studies largely quantified Bicoid with stains on fixed tissue. Not only do they provide data on the development of the Bicoid morphogen gradient in real time (using a bicoid-eGFP construct), the authors also provide good estimates for the absolute concentrations of the factor across the embryo and discuss the impact of the data on various models of pattern formation.
5. Eldar A., Shilo B.Z., and Barkai N. Elucidating mechanisms underlying robustness of morphogen gradients. Curr Opin Genet Dev 14 (2004) 435-439
6. Swartz M.A. Signaling in morphogenesis: transport cues in morphogenesis. Curr Opin Biotechnol 14 (2003) 547-550
7. Lander A.D., Nie Q., and Wan F.Y.M. Do morphogen gradients arise by diffusion?. Dev Biol 247 (2002) 471-1471
8. Ashe H.L., and Briscoe J. The interpretation of morphogen gradients. Development 133 (2006) 385-394. A review of current models and molecular mechanisms of pattern formation via morphogen gradients. In particular, summarizes current thinking on how graded concentrations of factors might trigger all-or-nothing gene regulation events during differentiation.
9. Whitesides G.M. The origins and the future of microfluidics. Nature 442 (2006) 368-373. Concise and comprehensive summary of the basic technology (polymer microfluidics) that underlies most biomedical research microsystems in current use.
10. El-Ali J., Sorger P.K., and Jensen K.F. Cells on chips. Nature 442 (2006) 403-411. A review of microfluidic applications in cell biology, with emphasis on cell culture, cell signaling, and biochemical analysis tools. Specifically, provides an overview of the current 'lab-on-a-chip' paradigm.
11. Ingber D., and Levin M. What lies at the interface of regenerative medicine and developmental biology?. Development 134 (2007) 2541-2547. A paper highly complementary to our article. A fascinating account of a recent meeting that focused on opportunities in developmental biology ('on stem cell differentiation, embryonic pattern formation, and organ regeneration') and microsystems ('engineered cell microenvironments, synthetic biomaterials, and artificial tissue fabrication'), and their medicinal applications.
12. Khademhosseini A., Langer R., Borenstein J., and Vacanti J.P. Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci U S A 103 (2006) 2480-2487. A review of microsystem applications in regenerative medicine. Focuses largely on efforts which employ microtechnology to alter cells' chemical and mechanical microenvironment for tissue engineering applications.
13. Weibel D.B., DiLuzio W.R., and Whitesides G.M. Microfabrication meets microbiology. Nat Rev Microbiol 5 (2007) 209-218
14. Keymer J.E., Galajda P., Muldoon C., Park S., and Austin R.H. Bacterial metapopulations in nanofabricated landscapes. Proc Natl Acad Sci U S A 103 (2006) 17290-17295
15. Marcy Y., Ouverney C., Bik E.M., Lösekann T., Ivanova N., Martin H.G., Szeto E., Platt D., Hugenholtz P., Relman D.A., et al. Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth. Proc Natl Acad Sci U S A 104 (2007) 11889-11894
16. Yeh B.J., Rutigliano R.J., Deb A., Bar-Sagi D., and Lim W.A. Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature 447 (2007) 596-600. Yeh et al. developed a method for generating synthetic guanine nucleotide exchange factors (GEF's) to link cytoskeletal responses to normally unrelated signaling pathways. In this way, they could re-program rat embryonic fibroblasts to express motility-associated phenotypes (such as filopodial responses) in response to normally unrelated signals-like protein kinase A (PKA).
17. Basu S., Gerchman Y., Collins C.H., Arnold F.H., and Weiss R. A synthetic multicellular system for programmed pattern formation. Nature 434 (2005) 1130-1134. This paper is a demonstration of a designed multicellular pattern formation system. Authors alter E. coli into populations of 'receiver' and 'sender' cells: the receivers are programmed to respond to certain ranges of acyl-homoserine lactone (which is synthesized by the 'sender' cells). By altering the range within which the 'receiver' cells respond to AHL, the receivers can be made to migrate and assemble in user-defined patterns around senders.
18. Lartigue C., Glass J.I., Alperovich N., Pieper R., Parmar P.P., Hutchison C.A., Smith H.O., and Venter J.C. Genome transplantation in bacteria: changing one species to another. Science 317 (2007) 632-638
19. Bonner J.T. First Signals: The Evolution of Multicellular Development (2000), Princeton University Press, Princeton
20. Tyson J.J., Chen K.C., and Novak B. Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol 15 (2003) 221-231
21. Bergmann S., Sandler O., Sberro H., Shnider S., Schejter E., Shilo B.Z., and Barkai N. Pre-steady-state decoding of the bicoid morphogen gradient. Plos Biol 5 (2007) 232-242
22. Kawakami Y., Raya A., Raya R.M., Rodriguez-Esteban C., and Belmonte J.C.I. Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435 (2005) 165-171
23. Sawamoto K., Wichterle H., Gonzalez-Perez O., Cholfin J.A., Yamada M., Spassky N., Murcia N.S., Garcia-Verdugo J.M., Marin O., Rubenstein J.L.R., et al. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science 311 (2006) 629-632
24. Mitchell B., Jacobs R., Li J., Chien S., and Kintner C. A positive feedback mechanism governs the polarity and motion of motile cilia. Nature 447 (2007) U97-U98
25. Nelson C.M., Jean R.P., Tan J.L., Liu W.F., Sniadecki N.J., Spector A.A., and Chen C.S. Emergent patterns of growth controlled by multicellular form and mechanics. Proc Natl Acad Sci U S A 102 (2005) 11594-11599
26. du Roure O., Saez A., Buguin A., Austin R.H., Chavrier P., Siberzan P., and Ladoux B. Force mapping in epithelial cell migration. Proc Natl Acad Sci U S A 102 (2005) 2390-2395
27. Delgado J.M.R., Leal J., Monteagudo J.L., and Gracia M.G. Embryological changes induced by weak, extremely low-frequency electromagnetic-fields. J Anat 134 (1982) 533-551
28. Ben-Tabou de-Leon S., and Davidson E.H. Gene regulation: gene control network in development. Annu Rev Biophys Biomol Struct 36 (2007) 191-212
29. Zhang Y.P., and Oertner T.G. Optical induction of synaptic plasticity using a light-sensitive channel. Nat Meth 4 (2007) 139-141
30. Arenkiel B.R., Peca J., Davison I.G., Feliciano C., Deisseroth K., Augustine G.J., Ehlers M.D., and Feng G.P. In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron 54 (2007) 205-218
31. Gorostiza P., Volgraf M., Numano R., Szobota S., Trauner D., and Isacoff E.Y. Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor. Proc Natl Acad Sci U S A 104 (2007) 10865-10870
32. Weibel D.B., and Whitesides G.M. Applications of microfluidics in chemical biology. Curr Opin Chem Biol 10 (2006) 584-591
33. Irimia D., Geba D.A., and Toner M. Universal microfluidic gradient generator. Anal Chem 78 (2006) 3472-3477
34. Jeon N.L., Baskaran H., Dertinger S.K.W., Whitesides G.M., Van de Water L., and Toner M. Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nat Biotechnol 20 (2002) 826-830
35. Burdick J.A., Khademhosseini A., and Langer R. Fabrication of gradient hydrogels using a microfluidics/photopolymerization process. Langmuir 20 (2004) 5153-5156
36. Kosar T.F., Tourovskaia A., Figueroa-Masot X., Adams M.E., and Folch A. A nanofabricated planar aperture as a mimic of the nerve-muscle contact during synaptogenesis. Lab Chip 6 (2006) 632-638
37. Park J., Bansal T., Pinelis M., and Maharbiz M.M. A microsystem for sensing and patterning oxidative microgradients during cell culture. Lab Chip 6 (2006) 611-622
38. Grover W.H., Ivester R.H.C., Jensen E.C., and Mathies R.A. Development and multiplexed control of latching pneumatic valves using microfluidic logical structures. Lab Chip 6 (2006) 623-631
39. Studer V., Hang G., Pandolfi A., Ortiz M., Anderson W.F., and Quake S.R. Scaling properties of a low-actuation pressure microfluidic valve. J Appl Phys 95 (2004) 393-398
40. Petty R.T., Li H.-W., Maduram J.H., Ismagilov R., and Mrksich M. Attachment of cells to islands presenting gradients of adhesion ligands. J Am Chem Soc 129 (2007) 8966-8967
41. Lahann J., Mitragotri S., Tran T.N., Kaido H., Sundaram J., Choi I.S., Hoffer S., Somorjai G.A., and Langer R. A reversibly switching surface. Science 299 (2003) 371-374
42. Collier J.H., and Mrksich M. Engineering a biospecific communication pathway between cells and electrodes. Proc Natl Acad Sci U S A 103 (2006) 2021-2025
43. In: Solnica-Krezel L. (Ed). Pattern Formation in Zebrafish (2002), Springer-Verlag, Berlin
44. Pearse V., Pearse J., Buchsbaum R., and Buchsbaum M. Living Invertebrates. edn 10 (1987), Blackwell Scientific Publications, Pacific Grove
45. Gierer A., Bode H., Berking S., Schaller H., Trenkner E., Hansmann G., David C.N., and Flick K. Regeneration of hydra from reaggregated cells. Nat New Biol 239 (1972) 98
46. Fujisawa T. Hydra regeneration and epitheliopeptides. Dev Dynam 226 (2003) 182-189
47. Xi J.Z., Schmidt J.J., and Montemagno C.D. Self-assembled microdevices driven by muscle. Nat Mater 4 (2005) 180-U167. This work presents a versatile method for integrating cardiomyocytes (and possibly other cell types) with nonorganic microstructures for building hybrid machines. Specifically, the authors demonstrate two devices: a force transducer for studying muscle fibers and a muscle/silicon hybrid machine that locomotes via contraction of cardiomyocytes.
48. Kirk D.L. Volvox: A Search for the Molecular and Genetic Origins of Multicellularity and Cellular Differentiation. edn 1 (1998), Cambridge University Press, New York
49. Jakab K., Neagu A., Mironov V., Markwald R.R., and Forgacs G. Engineering biological structures of prescribed shape using self-assembling multicellular systems. Proc Natl Acad Sci U S A 101 (2004) 2864-2869
50. Ye Z.H. Vascular tissue differentiation and pattern formation in plants. Annu Rev Plant Biol 53 (2002) 183-202
51. Mattsson J., Ckurshumova W., and Berleth T. Auxin signaling in Arabidopsis leaf vascular development. Plant Physiol 131 (2003) 1327-1339
52. Sachs T. In: Bard J.B.L., Barlow P.W., and Kirk D.L. (Eds). Pattern Formation in Plant Tissues (1991), Cambridge University Press, New York
53. Vincent J.F.V. Structure of wood. Curr Opin Solid State Mater Sci 3 (1998) 228-231
54. Lucchetta E.M., Lee J.H., Fu L.A., Patel N.H., and Ismagilov R.F. Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature 434 (2005) 1134-1138
55. Lucchetta E.M., Munson M.S., and Ismagilov R.F. Characterization of the local temperature in space and time around a developing Drosophila embryo in a microfluidic device. Lab Chip 6 (2006) 185-190
56. Meinhardt H. Models of biological pattern formation: common mechanism in plant and animal development. Int J Dev Biol 40 (1996) 123-134
57. Garfinkel A., Tintut Y., Petrasek D., Bostrom K., and Demer L.L. Pattern formation by vascular mesenchymal cells. Proc Natl Acad Sci U S A 101 (2004) 9247-9250. A demonstration of a Turing-style reaction-diffusion morphogen system at work in mammalian tissue which includes both experimental results and finite-element modeling of the reaction-diffusion system.
58. Sick S., Reinker S., Timmer J., and Schlake T. WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism. Science 314 (2006) 1447-1450
59. Kerszberg M., and Wolpert L. Mechanisms for positional signalling by morphogen transport: a theoretical study. J Theor Biol 191 (1998) 103-114
60. Bhutkar A. Synthetic biology: navigating the challenges ahead. J Biolaw Business 8 (2005) 19-29
61. Henon PR: Human embryonic or adult stem cells: an overview on ethics and perspectives for tissue engineering. In Tissue Engineering, Stem Cells and Gene Therapies. Edited by: KLUWER ACADEMIC/PLENUM PUBL; 2003:27-45. [Advances in Experimental Medicine and Biology, vol 534.]
62. Runyon M.K., Johnson-Kerner B.L., Kastrup C.J., Van Ha T.G., and Ismagilov R.F. Propagation of blood clotting in the complex biochemical network of hemostasis is described by a simple mechanism. J Am Chem Soc 129 (2007) 7014
63. Kastrup C.J., Runyon M.K., Shen F., and Ismagilov R.F. Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis. Proc Natl Acad Sci U S A 103 (2006) 15747-15752
64. Runyon M.K., Johnson-Kerner B.L., and Ismagilov R.F. Minimal functional model of hemostasis in a biomimetic microfluidic system. Angew Chem-Int Ed 43 (2004) 1531-1536