Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of α-difluoromethylornithine in breast cancer cells

Breast Cancer Research and Treatment

Volumn 107, Issue 1, 2008, Pages 63-70

  Xu, Haifang ^a   Washington, Sharlene ^a   Verderame, Michael F ^a   Manni, Andrea ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Breast cancer; DFMO; Invasion; Polyamines; Proliferation; Protein kinase A

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EFLORNITHINE; JANUS KINASE; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; STAT1 PROTEIN; STAT3 PROTEIN;

ARTICLE; BIOCHEMISTRY; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EFLORNITHINE; ENZYME INHIBITORS; HUMANS; ISOQUINOLINES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 36549061894     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-007-9536-5     Document Type: Article

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