Depletion of noradrenaline inhibits electrically-evoked pain in the skin of the human forearm

European Journal of Pain

Volumn 12, Issue 2, 2008, Pages 196-202

  Drummond, Peter D ^a  

^a MURDOCH UNIVERSITY   (Australia)

Author keywords

Electrical stimulation; Guanethidine; Iontophoresis; Noradrenaline; Pain; Sympathetic nervous system; Thermal hyperalgesia

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; GUANETHIDINE; NORADRENALIN; TYRAMINE;

ADRENERGIC TRANSMISSION; ADULT; ARTICLE; BURN; CONTROLLED STUDY; ELECTROSTIMULATION; FOREARM; HEAT SENSITIVITY; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; IONTOPHORESIS; NEUROPATHIC PAIN; NEUROTRANSMISSION; NOCICEPTION; NORMAL HUMAN; PAIN; PAIN THRESHOLD; PRIORITY JOURNAL; SKIN; SYMPATHETIC BLOCKING; VASOCONSTRICTION;

ADULT; DRUG ADMINISTRATION SCHEDULE; ELECTRIC STIMULATION; FOREARM; GUANETHIDINE; HUMANS; HYPERALGESIA; IONTOPHORESIS; MIDDLE AGED; NOREPINEPHRINE; PAIN; PAIN THRESHOLD; SKIN; SUNBURN; TIME FACTORS;

EID: 36549034830     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2007.05.001     Document Type: Article

References (45)

1. Ali Z., Ringkamp M., Hartke T.V., Chien H.F., Flavahan N.A., Campbell J.N., et al. Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey. J Neurophysiol 81 (1999) 455-466
2. Ali Z., Raja S.N., Wesselmann U., Fuchs P.N., Meyer R.A., and Campbell J.N. Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Pain 88 (2000) 161-168
3. Antonijevic I., Mousa S.A., Schafer M., and Stein C. Perineurial defect and peripheral opioid analgesia in inflammation. J Neurosci 15 (1995) 165-172
4. Baik E., Chung J.M., and Chung K. Peripheral norepinephrine exacerbates neuritis-induced hyperalgesia. J Pain 4 (2003) 212-221
5. Baron R., Schattschneider J., Binder A., Siebrecht D., and Wasner G. Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study. Lancet 359 (2002) 1655-1660
6. Baron R., Wasner G., Borgstedt R., Hastedt E., Schulte H., Binder A., et al. Effect of sympathetic activity on capsaicin-evoked pain, hyperalgesia, and vasodilatation. Neurology 52 (1999) 923-932
7. Burchiel K.J. Spontaneous impulse generation in normal and denervated dorsal root ganglia: sensitivity to alpha-adrenergic stimulation and hypoxia. Exp Neurol 85 (1984) 257-272
8. Chahl L.A. Antidromic vasodilatation and neurogenic inflammation. Pharmacol Ther 37 (1988) 275-300
9. Chang C.C., Costa E., and Brodie B.B. Interaction of guanethidine with adrenergic neurons. J Pharmacol Exp Ther 147 (1965) 303-312
10. Davis K.D., Treede R.D., Raja S.N., Meyer R.A., and Campbell J.N. Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain. Pain 47 (1991) 309-317
11. Drummond P.D. Noradrenaline increases hyperalgesia to heat in skin sensitized by capsaicin. Pain 60 (1995) 311-315
12. Drummond P.D. Independent effects of ischaemia and noradrenaline on thermal hyperalgesia in capsaicin-treated skin. Pain 67 (1996) 129-133
13. Drummond P.D. The effect of noradrenaline, angiotensin II and vasopressin on blood flow and sensitivity to heat in capsaicin-treated skin. Clin Auton Res 8 (1998) 87-93
14. Drummond P.D. Enhancement of thermal hyperalgesia by alpha-adrenoceptors in capsaicin-treated skin. J Auton Nerv Syst 69 (1998) 96-102
15. Drummond P.D. Nitroprusside inhibits thermal hyperalgesia induced by noradrenaline in capsaicin-treated skin. Pain 80 (1999) 405-412
16. Drummond P.D. The effect of sympathetic activity on thermal hyperalgesia in capsaicin-treated skin during body cooling and warming. Eur J Pain 5 (2001) 59-67
17. Drummond P.D., and Finch P.M. Persistence of pain induced by startle and forehead cooling after sympathetic blockade in patients with complex regional pain syndrome. J Neurol Neurosurg Psychiat 75 (2004) 98-102
18. Drummond P.D., and Lipnicki D.M. Noradrenaline provokes axon reflex hyperaemia in the skin of the human forearm. J Auton Nerv Syst 77 (1999) 39-44
19. Drummond P.D., Finch P.M., Skipworth S., and Blockey P. Pain increases during sympathetic arousal in patients with complex regional pain syndrome. Neurology 57 (2001) 1296-1303
20. Elam M., Olausson B., Skarphedinsson J.O., and Wallin B.G. Does sympathetic nerve discharge affect the firing of polymodal C-fibre afferents in humans?. Brain 122 Pt 12 (1999) 2237-2244
21. Fabiani M.E., and Story D.F. Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels. Pharmacol Res 33 (1996) 171-180
22. Fuchs P.N., Meyer R.A., and Raja S.N. Heat, but not mechanical hyperalgesia, following adrenergic injections in normal human skin. Pain 90 (2001) 15-23
23. Gonzales R., Goldyne M.E., Taiwo Y.O., and Levine J.D. Production of hyperalgesic prostaglandins by sympathetic postganglionic neurons. J Neurochem 53 (1989) 1595-1598
24. Houghton B.L., Meendering J.R., Wong B.J., and Minson C.T. Nitric oxide and noradrenaline contribute to the temperature threshold of the axon reflex response to gradual local heating in human skin. J Physiol 572 (2006) 811-820
25. Hu S.J., and Zhu J. Sympathetic facilitation of sustained discharges of polymodal nociceptors. Pain 38 (1989) 85-90
26. Kasai M., and Mizumura K. Increase in spontaneous action potentials and sensitivity in response to norepinephrine in dorsal root ganglion neurons of adjuvant inflamed rats. Neurosci Res 39 (2001) 109-113
27. Kinnman E., Nygards E.B., and Hansson P. Peripheral alpha-adrenoreceptors are involved in the development of capsaicin induced ongoing and stimulus evoked pain in humans. Pain 69 (1997) 79-85
28. Levine J.D., Taiwo Y.O., Collins S.D., and Tam J.K. Noradrenaline hyperalgesia is mediated through interaction with sympathetic postganglionic neurone terminals rather than activation of primary afferent nociceptors. Nature 323 (1986) 158-160
29. Lipnicki D.M., and Drummond P.D. Vascular and nociceptive effects of localized prolonged sympathetic blockade in human skin. Auton Neurosci 88 (2001) 86-93
30. Magerl W., Szolcsanyi J., Westerman R.A., and Handwerker H.O. Laser Doppler measurements of skin vasodilation elicited by percutaneous electrical stimulation of nociceptors in humans. Neurosci Lett 82 (1987) 349-354
31. McKain C.W., Urban B.J., and Goldner J.L. The effects of intravenous regional guanethidine and reserpine. A controlled study. J Bone Joint Surg Am 65 (1983) 808-811
32. Nicholson R., Dixon A.K., Spanswick D., and Lee K. Noradrenergic receptor mRNA expression in adult rat superficial dorsal horn and dorsal root ganglion neurons. Neurosci Lett 380 (2005) 316-321
33. Ochoa J., and Torebjork E. Sensations evoked by intraneural microstimulation of C nociceptor fibres in human skin nerves. J Physiol 415 (1989) 583-599
34. Pedersen J.L., Rung G.W., and Kehlet H. Effect of sympathetic nerve block on acute inflammatory pain and hyperalgesia. Anesthesiology 86 (1997) 293-301
35. Pluteanu F., Ristoiu V., Flonta M.L., and Reid G. Alpha(1)-adrenoceptor-mediated depolarization and beta-mediated hyperpolarization in cultured rat dorsal root ganglion neurones. Neurosci Lett 329 (2002) 277-280
36. Price D.D., Long S., Wilsey B., and Rafii A. Analysis of peak magnitude and duration of analgesia produced by local anesthetics injected into sympathetic ganglia of complex regional pain syndrome patients. Clin J Pain 14 (1998) 216-226
37. Ren Y., Zou X., Fang L., and Lin Q. Sympathetic modulation of activity in Adelta- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats. J Neurophysiol 93 (2005) 365-377
38. Sato J., and Perl E.R. Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science 251 (1991) 1608-1610
39. Sato J., Suzuki S., Iseki T., and Kumazawa T. Adrenergic excitation of cutaneous nociceptors in chronically inflamed rats. Neurosci Lett 164 (1993) 225-228
40. Schady W.J., Torebjork H.E., and Ochoa J.L. Peripheral projections of nerve fibres in the human median nerve. Brain Res 277 (1983) 249-261
41. Smith A.D. Mechanisms involved in the release of noradrenaline from sympathetic nerves. Br Med Bull 29 (1973) 123-129
42. Torebjork E., Wahren L., Wallin G., Hallin R., and Koltzenburg M. Noradrenaline-evoked pain in neuralgia. Pain 63 (1995) 11-20
43. Tuttle J.B., Etheridge R., and Creedon D.J. Receptor-mediated stimulation and inhibition of nerve growth factor secretion by vascular smooth muscle. Exp Cell Res 208 (1993) 350-361
44. Vasey M.W., and Thayer J.F. The continuing problem of false positives in repeated measures ANOVA in psychophysiology: a multivariate solution. Psychophysiology 24 (1987) 479-486
45. Zhang J.M., Song X.J., and LaMotte R.H. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain 72 (1997) 51-57