Peripheral α-adrenoreceptors are involved in the development of capsaicin induced ongoing and stimulus evoked pain in humans

Pain

Volumn 69, Issue 1-2, 1997, Pages 79-85

  Kinnman, Erik ^a   Nygårds, Eva Britt ^a   Hansson, Per ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adrenergic receptor; Allodynia; Capsaicin; Hyperalgesia; Pain; Phentolamine; Sympathetic nervous system

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; CAPSAICIN; PHENTOLAMINE; PHENTOLAMINE MESYLATE;

ADRENERGIC SYSTEM; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG THERAPY; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; MALE; NORMAL HUMAN; PAIN; PRIORITY JOURNAL; SKIN TEMPERATURE; SUBCUTANEOUS DRUG ADMINISTRATION;

ADRENERGIC ALPHA-ANTAGONISTS; ADULT; ARM; CAPSAICIN; FEMALE; HUMANS; INJECTIONS, INTRADERMAL; INJECTIONS, SUBCUTANEOUS; MALE; MIDDLE AGED; PAIN; PHENTOLAMINE; PHYSICAL STIMULATION; RECEPTORS, ADRENERGIC, ALPHA; REGIONAL BLOOD FLOW; SKIN TEMPERATURE;

EID: 0342327338     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(96)03257-5     Document Type: Article

References (49)

1. Arnér, S., Intravenous phentolamine test: diagnostic and prognostic use in reflex sympathetic dystrophy, Pain, 46 (1991) 17-22.
2. Bonica, J.J., Causalgia and other reflex sympathetic dystrophies. In: J.J. Bonica (Ed.), The Management of Pain, 2nd edn., Lea and Febinger, Philadelphia, 1990, pp. 220-243.
3. Cline, M.A., Ochoa, J. and Torebjork, H.E., Chronic hyperalgesia and skin warming caused by sensitized C nociceptors, Brain, 112 (1989) 621-647.
4. Cook, A.J., Woolf, C.J., Wall, P.D. and McMahon, S.B., Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input, Nature, 325 (1987) 151-153.
5. Davis, K.D., Treede, R.D., Raja, S.N., Meyer, R.A. and Campbell, J.N., Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain, Pain, 47 (1991) 309-317.
6. Dickenson, A.H. and Sullivan, A.F., Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep dorsal horn nociceptive neurons following C fibre stimulation, Neuropharmacology, 26 (1987) 1235-1238.
7. Dollery, C., Therapeutic Drugs, Churchill Livingstone, Edinburgh, 1991.
8. Drummond, P.D., Noradrenaline increases hyperalgesia to heat in skin sensitized by capsaicin, Pain, 60 (1995) 311-315.
9. Gold, M.S., White, D.M., Ahlgren, S.C., Guo, M. and Levine, J.D., Catecholamine-induced mechanical sensitization of cutaneous nocieptors in the rat, Neurosci. Lett., 175 (1994) 166-170.
10. Hardy, J.D., Woolf, H.G. and Goodell, H., Experimental evidence on the nature of cutaneous hyperalgesia, J. Clin. Invest., 29 (1950) 115-140.
11. Kilo, S., Schmelz, M., Koltzenburg, M. and Handwerker, H.O., Different patterns of hyperalgesia induced by experimental inflammation in human skin, Brain, 117 (1994) 385-396.
12. Kim, S.H. and Chung, J.M., Sympathectomy alleviates mechanical allodynia in an experimental animal model for neuropathy in the rat, Neurosci. Lett, 134 (1991) 131-134.
13. Kim, S.H., Na, H.S., Sheen, K. and Chung, J.M., Effects of sympathectomy on a rat model of peripheral neuropathy, Pain, 55 (1993) 85-92.
14. Kinnman, E. and Levine, J.D., Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat, Neuroscience, 65 (1995a) 283-291.
15. Kinnman, E. and Levine, J.D., Sensory and sympathetic contributions to nerve injury-induced sensory abnormalities in the rat, Neuroscience, 64 (1995b) 751-767.
16. Koltzenburg, M., Lundberg, L.E. and Torebjörk, H.E., Dynamic and static components of mechanical hyperalgesia in human hairy skin, Pain, 51 (1992) 207-219.
17. Koltzenburg, M., Torebjörk, H.E. and Wahren, L.K., Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain, Brain, 117 (1994) 579-591.
18. Konietzny, F. and Hensel, H., The effect of capsaicin on the response characteristics of human C-polymodal nociceptors, J. Therm. Biol., 8 (1983) 213-215.
19. Kress, M., Koltzenburg, M., Reeh, P.W. and Handwerker, H.O., Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro, J. Neurophysiol., 68 (1992) 581-595.
20. LaMotte, R.H., Lundberg, L.E. and Torebjork, H.E., Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans, J. Physiol. (London), 448 (1992a) 765-780.
21. LaMotte, R.H., Lundberg, L.E. and Torebjork, H.E., Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin, J. Physiol. (London), 448 (1992b) 749-764.
22. LaMotte, R.H., Shain, C.N., Simone, D.A. and Tsai, E.F., Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms, J. Neurophysiol., 66 (1991) 190-211.
23. Levine, J.D., Fields, H.L. and Basbaum, A.I., Peptides and the primary afferent nociceptor, J. Neurosci., 13 (1993) 2273-2286.
24. Levine, J.D., Taiwo, Y.O., Collins, S.D. and Tam, J.K., Noradrenaline hyperalgesia is mediated through interaction with sympathetic postganglionic neurone terminals rather than activation of primary afferent nociceptors, Nature, 323 (1986) 158-169.
25. Lewis, T., Experiments relating to cutaneous hyperalgesia and its spread through somatic nerves, Clin. Sci., 2 (1935) 373-423.
26. Lindblom, U., Assessment of abnormal evoked pains in neurological pain patients and its relation to spontaneous pain: a descriptive and conceptual model with some analytical results. In: H.L. Fields, R. Dubner and F. Cervero (Eds.), Advances in Pain Research and Therapy, Vol. 9, Raven Press, New York, 1985, pp. 409-423.
27. McMahon, S.B. and Koltzenburg, M., The changing role of primary afferent neurons in pain, Pain, 43 (1990) 269-272.
28. McMahon, S.B. and Wall, P.D., Receptive fields of rat lamina I projection cells move to incorporate a nearby region of injury, Pain, 19 (1984) 235-247.
29. Meyer, R.A., Davis, K.D., Cohen, R.H., Treede, R.-D. and Campbell, J.N., Mechanically insensitive afferents (MIAs) in cutaneous nerves of monkey, Brain Res., 561 (1991) 252-261.
30. Neil, A., Attal, N. and Guilbaud, G., Effects of guanethidine on sensitization to natural stimuli and self-mutilating behaviour in rats with a peripheral neuropathy, Brain Res., 565 (1991) 237-246.
31. Raja, S.N., Treede, R.D., Davis, K.D. and Campbell, J.N., Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain, Anesthesiology, 74 (1991) 691-698.
32. Roberts, W.J. and Elardo, S.M., Sympathetic activation of a-delta nociceptors, Somatosens. Res., 3 (1985a) 33-44.
33. Roberts, W.J. and Elardo, S.M., Sympathetic activation of unmyelinated mechanoreceptors in cat skin, Brain Res., 339 (1985b) 123-125.
34. Sato, J. and Perl, E.R., Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury, Science, 251 (1991) 1608-1610.
35. Schmidt, R.F., Schmelz, M., Forster, C., Ringkamp, M., Torebjörk, E. and Handwerker, H., Novel classes of responsive and unresponsive C nociceptors in human skin, J. Neurosci., 15 (1995) 333-341.
36. Seltzer, Z., Cohn, S., Ginzburg, R. and Beilin, B., Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge, Pain, 45 (1991) 69-75.
37. Shir, Y. and Seltzer, Z., A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats, Neurosci. Lett., 115 (1990) 62-67.
38. Shir, Y. and Seltzer, Z., Effects of sympathectomy in a model of causalgiform pain produced by partial sciatic nerve injury in rats, Pain, 45 (1991) 309-320.
39. Shyu, B.C., Danielsen, M., Andersson, S.A. and Dahlin, L.B., Effects of sympathetic stimulation on C-fibre response after peripheral nerve compression: an experimental study in the rabbit common peroneal nerve, Acta Physiol. Scand., 140 (1990) 237-243.
40. Simone, D.A., Baumann, T.K. and Lamotte, R.H., Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin, Pain, 38 (1989) 99-107.
41. Simone, D.A., Sorkin, L.S., Oh, U., Chung, J.M., Owens, C., LaMotte, R.H. and Willis, W.D., Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons, J. Neurophysiol., 66 (1991) 228-246.
42. Torebjörk, H.E., Lundberg, L.E. and LaMotte, R.H., Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans, J. Physiol. (London), 448 (1992) 765-780.
43. Treede, R.D., Davis, K.D., Campbell, J.N. and Raja, S.N., The plasticity of cutaneous hyperalgesia during sympathetic ganglion blockade in patients with neuropathic pain, Brain, 115 (1992) 607-621.
44. Wahren, L.K., Torebjörk, E. and Nyström, B., Quantitative sensory testing before and after regional guanethidine block in patients with neuralgia in the hand, Pain, 46 (1991) 23-30.
45. Wall, P.D. and Woolf, C.J., Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat, J. Physiol. (London), 356 (1984) 443-458.
46. Woolf, C.J., Evidence for a central component of post-injury pain hyper-sensitivity, Nature, 306 (1983) 686-688.
47. Woolf, C.J. and King, A.E., Subthreshold components of the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat lumbar spinal cord, J. Neurophysiol., 62 (1989) 907-916.
48. Woolf, C.J. and King, A.E., Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord, J. Neurosci., 10 (1990) 2717-2726.
49. Xie, Y.K. and Xiao, W.H., Electrophysiological evidence for hyperalgesia in the peripheral neuropathy, Sci. China b, 33 (1990) 663-672.