Erratum to: "A toxicologic and dermatologic assessment of salicylates when used as fragrance ingredients" [Food and Chemical Toxicology 45/1S1 (2007) S318-S361] (DOI:10.1016/j.fct.2007.09.066);A toxicologic and dermatologic assessment of salicylates when used as fragrance ingredients

Food and Chemical Toxicology

Volumn 45, Issue 1 SUPPL., 2007, Pages 2588-2589

  Belsito, D ^a   Bickers, D ^b   Bruze, M ^c   Calow, P ^d   Greim, H ^e   Hanifin, J M ^f   Rogers, A E ^g   Saurat, J H ^h   Sipes, I G ⁱ   Tagami, H ^j  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d Environmental Assessment Institute   (Denmark)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h GENEVA UNIVERSITY HOSPITALS   (Switzerland)

ⁱ UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^j NONE   (Japan)

more..

Author keywords

Fragrance; Review; Safety; Salicylates

Indexed keywords

4 HYDROXYBENZOIC ACID; BENGAY; BETA RESORCYLIC ACID; BUTYL PARABEN; BUTYLSALICYLATE; ETHYLHEXYLSALICYLATE; FRAGRANCE; PENTYLSALICYLATE; SALICYLALDEHYDE; SALICYLIC ACID; SALICYLIC ACID BENZYL ESTER; SALICYLIC ACID DERIVATIVE; SALICYLIC ACID ETHYL ESTER; SALICYLIC ACID HEXYL ESTER; SALICYLIC ACID METHYL ESTER; UNCLASSIFIED DRUG; VANILLIN;

CARCINOGENICITY; DERMATOLOGICAL PROCEDURES; DRUG ABSORPTION; DRUG METABOLISM; ENZYME INDUCTION; EYE IRRITATION; GENOTOXICITY; HUMAN; MUTAGENICITY; NONHUMAN; PHOTOALLERGY; PHOTOTOXICITY; REPRODUCTIVE TOXICITY; REVIEW; RHEUMATIC FEVER; SKIN ABSORPTION; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY; TOXICOLOGICAL PARAMETERS;

EID: 36549022225     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.03.003     Document Type: Erratum

References (229)

1. Abbott, D.D., Harrisson, J.W.E., 1978. Methyl salicylate: studies of osseous changes in the rat, reproduction in the rat and mouse, and liver and kidney effects in the dog. Unpublished report to the Flavor and Extract Manufactures Association, Washington, DC. Report number 26000.
2. Adams T.B., Cohen S.M., Doull J., Feron V.J., Goodman J.I., Marnett L.J., Munro I.C., Portoghese P.S., Smith R.L., Waddell W.J., and Wagner B.M. The FEMA GRAS assessment of hydroxy- and alkoxy-substituted benzyl derivatives used as flavor ingredients. Food and Chemical Toxicology 43 (2005) 1241-1271
3. Alam A.S., Gregoriades D., and Imondi A.R. Bioavailability of magnesium salicylate. Journal of Pharmacy and Pharmacology 33 (1981) 792-793
4. 14 carboxyl salicylic acid in the dog and in man. Journal of Pharmacology and Experimental Therapeutics 102 (1951) 150-155
5. Alvarez D.A., Stackelberg P.E., Petty J.D., Huckins J.N., Furlong E.T., Zaugg S.D., and Meyer M.T. Removal of fragrance materials during U.S. and European wastewater treatment. Environmental Science and Technology 36 (2005) 2839-2847
6. Anders M.W. Biotransformation and bioactivation of xenobiotics by the kidney. In: Hutson D.H., Caldwell J., and Paulson G.D. (Eds). Intermediary Xenobiotic Metabolism in Animals (1989), Taylor and Francis, New York 81-97
7. Bar V.F., and Griepentrog F. Die Situation in der gesundheitlichen Beurteilung der Aromatisierungsmittel fur Lebensmittel. (Where we stand concerning the evaluation of flavoring substances from the viewpoint of health). Medizin Ernahr 8 (1967) 244-251
8. BASF, A.G., Department of Toxicology, 1991. Report on the study of the oral toxicity of 2-ethylhexanol in rats after administration by gavage (aqueous emulsion) for 3 months. Unpublished report, project No. 31C0631/87077. On behalf of the Chemical Manufactures Association, Washington, USA.
9. Basketter D.A., and Gerberick G.F. An interlaboratory evaluation of the Buehler test for the identification and classification of skin sensitizers. Contact Dermatitis 35 (1996) 146-151
10. Basketter D.A., and Scholes W. Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens. Food and Chemical Toxicology 30 (1992) 65-69
11. Basketter D.A., York M., McFadden J.P., and Robinson M.K. Determination of skin irritation potential in the human 4-h patch test. Contact Dermatitis 51 1 (2004) 1-4
12. Bauer, K., Garbe, D., 1985. Common Flavor and Fragrance Materials. Verlagsgesellschaft mbH, D-6940, Weinheim, Germany [Cited In: FFHPVC, 2001].
13. Bertone L.L., and Monie I.W. Teratogenic effect of methyl salicylate and hypoxia in combination. The Anatomical Record 151 (1965) 443
14. Beutner R., Calesnick B., Powell E., and Bortin L. On the absorption and excretion of methylsalicylate administered by inunction. Journal of Laboratory and Clinical Medicine 28 (1943) 1655-1663
15. Boehnlein J., Sakr A., Lichtin J.L., and Bronaugh R.L. Characterization of esterase and alcohol dehydrogenase activity in skin. Metabolism of retinyl palmitate to retinol (vitamin A) during percutaneous absorption. Pharmacological Reviews 11 (1994) 1155-1159
16. Bonin A.M., Arlauskas A.P., Angus D.S., Baker R.S.U., Gallagher C.H., Greenoak G., Meher-Homji K.M., and Reeve V. UV-absorbing and other sun-protecting substances: genotoxicity of 2-ethylhexyl p-methoxycinnamate. Mutation Research 105 (1982) 303-308
17. Boyland E., and Huntsman-Mawson E. CCLVII. Experiments on the chemotherapy of cancer. II. The effect of aldehydes and glucosides. Biochemical Journal 32 (1938) 1982-1987
18. Bray H.G., Ryman B.E., and Thorpe W.V. The fate of certain organic acids and amides in the rabbit. Biochemical Journal 41 (1947) 212-218
19. Bray H.G., Ryman B.E., and Thorpe W.V. The fate of certain organic acids and amides in the rabbit. 5. o- and m-hydroxybenzoic acids and amides. Biochemical Journal 43 (1948) 561-567
20. Bray H.G., Thorpe W.V., and White K. Kinetic studies of the metabolism of foreign organic compounds. A mathematical model expressing the metabolic fate of phenols, benzoic acids and their precursors. Biochemical Journal 52 (1952) 423-430
21. Brown E.W., and Scott W.O. The absorption of methyl salicylate by the human skin. The Journal of Pharmacology and Experimental Therapeutics 50 (1934) 32-50
22. Brown E.W., and Scott W.O. The comparative absorption of certain salicylate esters by the human skin. The Journal of Pharmacology and Experimental Therapeutics 50 (1934) 373-385
23. Buchbauer G., Jirovetz L., Jager W., Plank C., and Dietrich H. Fragrance compounds and essential oils with sedative effects upon inhalation. Journal of Pharmaceutical Science 82 (1993) 660-664
24. Cadby P., Troy W.R., and Vey M.G.H. Consumer exposure to fragrance ingredients: providing estimates for safety evaluation. Regulatory Toxicology and Pharmacology 36 (2002) 246-252
25. Carpenter C.P., and Smyth H.F. Chemical burns of the rabbit cornea. American Journal of Ophthalmology 29 (1946) 1363-1372
26. Cekanova E., Larsson K.S., Morck E., and Aberg G. Interactions between salicylic acid and pyridyl-3-methanol: anti-inflammatory and teratogenic effects. Acta Pharmacologica et Toxicologica 35 (1974) 107-118
27. Chapin R.E., and Sloane R.A. Reproductive toxicology. Methyl salicylate. Environmental Health Perspectives 105 (1997) 199-395
28. Cosmetic Ingredient Review Panel, Cosmetic, Toiletry and Fragrance Association (CIR). Safety assessment of salicylic acid, butyloctyl salicylate, calcium salicylate, C12-15 alkyl salicylate, capryloyl salicylic acid, hexyldodecyl salicylate, isocetyl salicylate, isodecyl salicylate, magnesium salicylate, MEA-salicylate, ethylhexyl salicylate, potassium salicylate, methyl salicylate, myristyl salicylate, sodium salicylate, TEA-salicylate, and tridecyl salicylate. International Journal of Toxicology 22 (2003) 1-108
29. Clarke N.E., Clarke C.N., and Mosher R.E. Phenolic compounds in chemotherapy of rheumatic fever. American Journal of Medical Sciences 235 (1958) 7-22
30. Collins T.F.X., Hansen W.H., and Keeler H.V. Effect of methyl salicylate on rat reproduction. Toxicology and Applied Pharmacology 18 (1971) 755-765
31. Cross S.E., Anderson C., and Roberts M.S. Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies. British Journal of Clinical Pharmacology 46 (1998) 29-35
32. Cross S.E., Anderson C., Thompson M.J., and Roberts M.S. Is there tissue penetration after application of topical salicylate formulations?. Lancet 350 (1997) 636
33. Danon A., Ben-Shimon A., and Ben-Zvi Z. Effect of exercise and heat exposure on percutaneous absorption of methyl salicylate. European Journal of Clinical Pharmacology 31 (1986) 49-52
34. Daston G.P., Rehnberg B.F., Carver B., Rogers E.H., and Kavlock R.J. Functional teratogens of the rat kidney. I. Colchicine, dinoseb, and methyl salicylate. Fundamental and Applied Toxicology 11 (1988) 381-400
35. Davis D.P., Daston G.P., Odio M.R., York R.W., and Kraus A.L. Maternal reproductive effects of oral salicylic acid in Sprague-Dawley rats. The Toxicologist 14 (1994) 78
36. Davison C., Zimmerman E.F., and Smith P.K. On the metabolism & toxicity of methyl salicylate. The Journal of Pharmacology and Experimental Therapeutics 132 (1961) 207-211
37. Dirscherl W., and Wirtzfeld A. Vanillic acid in human urine, its isolation, determination, and origin. Hoppe-Seyler's Zeitsschrift für physiologische Chemie 336 (1964) 81-90
38. DiFrancesco A.M., Chiu P.C., Standley L.J., Allen H.E., and Salvito D.T. Dissipation of fragrance materials in sludge-amended soils. Environmental Science and Technology 38 (2004) 194-201
39. Done A.K. Salicylate intoxication. Significance of measurements of saliyclate in the blood in cases of acute ingestion. Pediatrics 26 (1960) 800-807
40. Doull J., Plzak V., and Brois S.J. A survey of compounds for radiation protection. Armed Services Technical Information Agency (1962) 1-124
41. Duncan E.J.S., Brown A., Lundy P., Sawyer T.W., Hamilton M., Hill I., and Conley J.D. Site-specific percutaneous absorption of methyl salicylate and VX in domestic swine. Journal of Applied Toxicology 22 (2002) 141-148
42. Drake J.J., Gaunt I.F., Butterworth K.R., Hooson J., Hardy J., and Gangolli S.G. Short-term toxicity of isoamyl salicylate in rats. Food and Cosmetics Toxicology 13 (1975) 185-193
43. Fishbeck W.A., Langer R.R., and Kociba R.J. Elevated urinary phenol levels not related to benzene exposure. American Industrial Hygiene Association Journal 36 (1975) 820-824
44. Forbes P.D., Urbach F., and Davies R.E. Phototoxicity testing of Fragrance Raw Materials. Food and Cosmetics Toxicology 15 (1977) 55-60
45. Ford R.A., Domeyer B., Easterday O., Maier K., and Middleton J. Criteria for development of a database for safety evaluation of fragrance ingredients. Regulatory Toxicology and Pharmacology 31 (2000) 166-181
46. Fujii T., Furukawa S., and Suzuki S. Studies on compounded perfumes for toilet goods. On the non-irritative compounded perfumes for soaps. Yukugaku 21 (1972) 904-908
47. Giri A.K., Adhikari N., and Khan K.A. Comparative genotoxicity of six salicylic acid derivatives in bone marrow. Mutation Research 370 (1996) 1-9
48. Giroux J., Granger R., and Monnier P. Comparative toxicity of methyl diethylacetylsalicylate and methyl salicylate. Société Pharmacie Montpellier 14 (1954) 383-390
49. Goldsmith L.A. Salicylic acid. International Journal of Dermatology 18 (1979) 32-36
50. Green B.G., and Shaffer G.S. Psychophysical assessment of the chemical irritability of human skin. Journal of the Society of Cosmetic Chemists Japan 43 (1992) 131-147
51. Hanzlik P.J., and Wetzel N.C. The excretion of salicyl after the administration of methyl salicylate to animals. Journal of Pharmacology 14 (1920) 43-46
52. Harrisson J.W.E., Abbott D.D., and Packman E.W. Salicylates and other hydroxybenzoates: effect upon osseous tissue of young rats. Federation Proceedings 22 (1963) 554
53. Hausen B.M., and Wollenweber E. Propolis allergy (III). Sensitization studies with minor constituents. Contact Dermatitis 19 (1988) 296-303
54. Heymann E. Carboxylesterases and amidases. In: Jakoby W.B., Bend J.R., and Caldwell J. (Eds). Enzymatic Basis of Detoxication. second ed. (1980), Academic Press, New York 291-323
55. Higo N., Sato S., Irie T., and Uekama K. Percutaneous penetration and metabolism of salicylic acid derivatives across hairless mouse skin in diffusion cell in vitro. Scientific and Technical Pharmacy - Pharmaceutical Sciences 5 (1995) 302-308
56. Howell M.D., Manetz T.S., and Meade B.J. Comparison of murine assays for the identification of chemical sensitizers. Toxicology Methods 10 (2000) 1-15
57. Imokawa G., and Kawai M. Differential hypermelanosis by allergic contact dermatitis. Journal of Investigative Dermatology 89 (1987) 540-546
58. International Fragrance Association (IFRA), 2004. Volume of Use Survey.
59. International Fragrance Association (IFRA), 2007. Code of Practice. Standard on benzyl salicylate. Brussels.
60. Inder, R, 1999. Salicylic acid. INCHEM. October 1999. IPCS - International Programme on Chemical Safety. .
61. Infurna R., Beyer B., Twitty L., Koehler G., and Daughtrey W. Evaluation of the dermal absorption and teratogenic potential of methyl salicylate in a petroleum based grease. Teratology 41 (1990) 566
62. Integrated Risk Information system (IRIS), 1998. Results of databank search on 23.10.98 for n-butyl alcohol. National Library of Medicine, Bethesda, MD, USA.
63. Ishidate Jr. M., Sofuni T., Yoshikawa K., Hayashi M., Nohmi T., Sawada M., and Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Food and Chemical Toxicology 22 (1984) 623-636
64. Ishihara M., Itoh M., Nishimura M., Kinoshita M., Kantoh H., Nogami T., and Yamada K. Closed epicutaneous test. Skin Research 28 (1986) 230-240
65. James M.O., Smith R.L., Williams R.T., and Reidenberg M. The conjugation of phenylacetic acid in man, sub-human primates, and some non-primate species. Proceedings Royal Society London, B 182 (1972) 25-35
66. James M.O., Smith R.L., and Robert L. Conjugation of phenylacetic acid in phenylketonurics. European Journal of Clinical Pharmacology 5 (1973) 243-246
67. Janssen K., Hollman P.C.H., Reichmann E., Venema D.P., van Staveren W.A., and Katan M.B. Urinary salicylate excretion in subjects eating a variety of diets shows that amounts of bioavailable salicylates in foods are low. American Journal of Clinical Nutrition 64 (1996) 743-747
68. Joint Expert Committee on Food Additives (JECFA), 1996. Safety evaluation of certain food additives and contaminants. WHO Food Additives Series: 37. Joint FAO/WHO Expert Committee on Food Additives World Health Organisation, Geneva 1996.
69. Joint Expert Committee on Food Additives (JECFA), 1998. Safety evaluation of certain food additives and contaminants. WHO Food Additives Series: 40. Joint FAO/WHO Expert Committee on Food Additives. World Health Organisation, Geneva 1998.
70. Joint Expert Committee on Food Additives (JECFA)), 2001. Safety evaluation of certain food additives. WHO Food Additives Series: 48. Prepared by the Fifty-seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organization, Geneva 2001.
71. Jenner P.M., Hagan E.C., Taylor J.M., Cook E.L., and Fitzhugh O.G. Food flavorings and compounds of related structure. I. Acute oral toxicity. Food and Cosmetics Toxicology 2 (1964) 327-343
72. Jiang R., Roberts M.S., Collins D.M., and Benson H.A.E. Skin penetration of sunscreen agents from commercial products. Perspectives in Percutaneous Penetration 5B (1997) 239-241
73. Jimbo Y. Penetration of fragrance compounds through human epidermis. Journal of Dermatology 10 (1983) 229-239
74. Jones P.S., Thigpen D., Morrison J.L., and Richardson A.P. p-Hydroxybenzoic acid esters as preservatives. III. The physiological disposition of p-hydroxybenzoic acid and its esters. Journal of the American Pharmaceutical Association 45 (1956) 268-273
75. Juberg D.R., David R.M., Katz G.V., Bernard L.G., Gordon D.R., Vlaovic M.S., and Topping D.C. 2-Ethylhexanoic acid: subchronic oral toxicity studies in the rat and mouse. Food and Chemical Toxicology 36 (1998) 429-436
76. Kashima T., Oyake Y., Okada J., and Ikeda Y. Studies of new short-period method for delayed contact hypersensitivity assay in the guinea pig. Contact Dermatitis 28 (1993) 235-242
77. Kavlock R.J., Chernoff N., Rogers E., Whitehouse D., Carver B., Gray J., and Robinson K. An analysis of fetotoxicity using biochemical endpoints of organ differentiation. Teratology 26 (1982) 183-194
78. Kieckebusch W., and Lang K. The tolerability of benzoic acid in chronic feeding experiments. Arzneimittel-Forschung 10 (1960) 1001-1003
79. Kimber I., Hilton J., Dearman R.J., Gerberick G.F., Ryan C.A., Basketter D.A., Scholes E.W., Ladies G.S., Loveless S.E., House R.V., and Guy A. An international evaluation of the murine local lymph node assay and comparison of modified procedures. Toxicology 103 (1995) 63-73
80. Kimber I., Hilton J., Botham P.A., Basketter D.A., Scholes E.W., Miller K., Robbins M.C., Harrison P.T.C., Gray T.J.B., and Waite S.J. The murine local lymph node assay: Results of an inter-laboratory trial. Toxicology Letters 55 (1991) 203-213
81. Kimber I., Hilton J., Dearman R.J., Gerberick G.F., Ryan C.A., Basketter D.A., Lea L., House R.V., Ladics G.S., Loveless S.E., and Hastings K.L. Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: an interlaboratory evaluation. Journal of Toxicology and Environmental Health 53 (1998) 563-579
82. Kimmel C.A., Wilson J.G., and Schumacher H.J. Studies on metabolism and identification of the causative agent in aspirin teratogenesis in rats. Teratology 4 (1971) 15-24
83. Klecak, G., 1979. The open epicutaneous test (OET), a predictive test procedure in the guinea pig for estimation of allergenic properties of simple chemical compounds, their mixtures and of finished cosmetic preparations. International Federation Societies Cosmetic Chemists, 9/18/79.
84. Klecak G., Geleick H., and Frey J.R. Screening of fragrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods. Journal of the Society of Cosmetic Chemists Japan 28 (1977) 53-64
85. Klecak G. The Freund's complete adjuvant test and the open epicutaneous test. In: Andersen K.E., and Maibach H.I. (Eds). Current Problems in Dermatology vol. 14 (1985), Karger, Basel, Switzerland 152-171
86. Kociba R.J., Kalnins R.V., Wade C.E., Garfield E.L., and Fishbeck W.A. Elevated urinary phenol levels in dogs ingesting salol. Toxicology and Applied Pharmacology 37 (1976) 121
87. Kolpin D.W., Skopec M., Meyer M.T., Furlong E.T., and Zaugg S.D. Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions. Science of the Total Environment 328 (2004) 119-130
88. Komsta E., Chu I., Secours V.E., Valli V.E., and Villeneuve D.C. Results of a short-term toxicity study for three organic chemicals found in Niagara River drinking water. Bulletin of Environmental Contamination and Toxicology 41 (1988) 515-522
89. Kozuka T., Hayashi H., Hiroyama H., Honoki S., Kakishima H., Katsumura Y., Kawai J., Nakagaki E., Obata K., Ozawa N., Tatsumi H., Fujimoto K., Nakagawa M., Yoshikawa Y., Ikeda Y., Ishii I., and Itoh K. Allergenicity of fragrance materials: collaborative study of the Second Research Group of the Japanese Society for Cutaneous Health. Environmental Dermatology 3 (1996) 326-335
90. Kuboyama N., and Fujii A. Mutagenicity of analgesics, their derivatives, and anti-inflammatory drugs with S-9 mix of several animal species. Journal of Nihon University School of Dentistry 34 (1992) 183-195
91. 3H]TdR) for assessing cell proliferation in the murine local lymph node assay. Toxicology Methods 5 (1995) 143-152
92. Levy G., and Tsuchiya T. Darvon poisoning with delayed salicylism: a case report. Pediatrics 49 (1972) 610-611
93. The MAK-Collection for Occupational Health and Safety. Part I: MAK Value Documentations Volume 22. Greim, H. (Ed.), Wiley-VCH Verlag GmbH & Co. KGaA, Germany. http://www3.interscience.wiley.com/cgi-bin/mrwhome/104554790/HOME.
94. Marchand B., Barbier P., Ducombs G., Foussereau J., Martin P., and Benezra C. Allergic contact dermatitis to various salols (phenyl salicylates). A structure-activity relationship study in man and in animal (guinea pig). Archives of Dermatological Research 272 (1982) 61-66
95. Martin D., Valdez J., Boren J., and Mayersohn M. Dermal absorption of camphor, menthol, and methyl salicylate in humans. Journal of Clinical Pharmacology 44 (2004) 1151-1157
96. Maurer T.H., Weirich E.G., and Hess R. The optimization test in the guinea pig in relation to other predictive sensitization methods. Toxicology 15 (1980) 163-171
97. McMahon T.F., Diliberto J.J., and Birnbaum L.S. Effects of age and dose on disposition and metabolism of salicylic acid in male Fischer F344 rats. Drug Metabolism and Disposition 18 (1990) 494-503
98. Montelius J., Wahlkvist H., and Boman A. Experience with the murine local lymph node assay: inability to discriminate between allergens and irritants. Acta Dermato-Venereologica 74 (1994) 22-27
99. Morra P., Bartle W.R., Walker S.E., Lee S.N., Bowles S.K., and Reeves R.A. Serum concentrations of salicylic acid following topically applied salicylate derivatives. The Annals of Pharmacotherapy 30 (1996) 935-940
100. Morrissey R.E., Lamb IV J.C., Morris R.W., Chapin R.E., Gulati D.K., and Heindel J.J. Results and evaluations of 48 continuous breeding reproduction studies conducted in mice. Fundamental and Applied Toxicology 13 (1989) 747-777
101. Mortelmans K., Haworth S., Lawlor T., Speck W., Tainer B., and Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environmental Mutagenesis 8 (1986) 1-119
102. Motoyoshi K., Toyoshima Y., Sato M., and Yoshimura M. Comparative studies on the irritancy of oils and synthetic perfumes to the skin of rabbit, guinea pig, rat, miniature swine and man. Cosmetics and Toiletries 94 (1979) 41-48
103. Nagahama M., Akiyama N., and Miki T. Experimental production of malformations due to salicylates (acetyl salicylate and phenyl salicylate) in rats. Congenital Anomalies (Senten Ijo) 6 (1966) 20-31
104. Nakayama H. Fragrance hypersensitivity and its control. In: Frosch P.J., Johansen J.D., and White I.R. (Eds). Fragrances. Beneficial and Adverse Effects (1998), Springer-Verlag, Berlin Heidelberg, Germany 83-91
105. National Toxicology Program (NTP), 1984a. Methyl salicylate: Reproduction and fertility assessment in CD-1 mice when administered by gavage. NTP-84-156; PB84-241140.
106. National Toxicology Program (NTP), 1984b. Methyl salicylate: Reproduction and fertility assessment in CD-1 mice when administered by gavage. NTP-85-022; PB85-164283.
107. Oda Y., Hamono Y., Inoue K., Yamamoto H., Niihara T., and Kunita N. Mutagenicity of food flavors in bacteria. Shokuhin Eisei Hen 9 (1978) 177-181
108. Ohsumi T., Kuroki K., Kimura T., and Murakami Y. A study on acute toxicities of essential oils used in endodontic treatment. Journal Kyushu Dental Society 38 (1984) 1064-1071
109. Overman D.O., and White J.A. Comparative dose-response analysis of the teratogenic effects of methyl salicylate applied orally or topically to hamsters. The Anatomical Record 190 (1978) 499
110. Overman D.O. Percutaneous administration of teratogens: Effects of treatment with methyl salicylate and dimethyl sulfoxide in the hamster. Teratology 19 (1979) 42A
111. Overman D.O., and White J.A. Comparative teratogenic effects of methyl salicylate applied orally or topically to hamsters. Teratology 28 (1983) 421-426
112. Owston E., Lough R., and Opdyke D.L. A 90-day study of phenylethyl alcohol in the rat. Food and Cosmetics Toxicology 19 (1981) 713-715
113. Packman E.W., Abbott D.D., Wagner B.M., and Harrisson J.W.E. Chronic oral toxicity of oil sweet birch (methyl salicylate). The Pharmacologist 3 (1961) 62
114. Patrick E., Maibach H.I., and Burkhalter A. Mechanisms of chemically induced skin irritation. Toxicology and Applied Pharmacology 81 (1985) 476-490
115. Patrick E., and Maibach H.I. Interspecies differences in sensitivity to inflammatory mediators modify dose response and time course of chemically induced skin irritation. Journal of Investigative Dermatology 86 (1986) 499
116. Patrick E., Maibach H.I., and Burkhalter A. Recent investigations of mechanisms of chemically induced skin irritation in laboratory mice. Journal of Investigative Dermatology 88 (1987) 24s-31s
117. Pratzel H.G., Schubert E., and Muhanna N. Pharmacokinetic study of percutaneous absorption of salicylic acid from baths with salicylate methyl ester and salicylic acid. Zeitschrift für Rheumatologie 49 (1990) 185-191
118. Pyun J.S. Effect of methyl salicylate on developing rat embryos. Ch'oesin Uthak 13 (1970) 63-72
119. RIFM (Research Institute for Fragrance Materials, Inc.), 1963. Eye irritation study of methyl salicylate in rabbits. Unpublished Report from IFF Incorporated, 29 November. Report number 12616 (RIFM, Woodcliff Lake, NJ, USA).
120. RIFM (Research Institute for Fragrance Materials, Inc.), 1964. Repeated insult patch test of methyl salicylate in human subjects. Unpublished Report from IFF Incorporated, 3 April. Report number 12617 (RIFM, Woodcliff Lake, NJ, USA).
121. RIFM (Research Institute for Fragrance Materials, Inc.), 1968a. Acute oral toxicity of octyl salicylate in rats. Unpublished Report from Felton International, 25 October. Report number 15430 (RIFM, Woodcliff Lake, NJ, USA).
122. RIFM (Research Institute for Fragrance Materials, Inc.), 1968b. Sensitization and irritation studies of fragrance materials in human subjects. Unpublished report from Givaudan Incorporated, 18a November. Report number 15453 (RIFM, Woodcliff Lake, NJ, USA).
123. RIFM (Research Institute for Fragrance Materials, Inc.), 1968c. Irritation study of 3-methyl-2-butenyl salicylate in rabbits. Unpublished report from IFF Incorporated, 11 October. Report number 15226 (RIFM, Woodcliff Lake, NJ, USA).
124. RIFM (Research Institute for Fragrance Materials, Inc.), 1970a. Acute oral toxicity studies in rats. RIFM report number 2734, July 1 (RIFM, Woodcliff Lake, NJ, USA).
125. RIFM (Research Institute for Fragrance Materials, Inc.), 1970b. Acute dermal toxicity study in rabbits. RIFM report number 2735, August 26 (RIFM, Woodcliff Lake, NJ, USA).
126. RIFM (Research Institute for Fragrance Materials, Inc.), 1970c. Toxicological studies of two salicylates: isobutyl salicylate and isoamyl salicylate. Unpublished Report from Fritzsche, Dodge and Olcott, Incorporated, 31 August. Report number 13837 (RIFM, Woodcliff Lake, NJ, USA).
127. RIFM (Research Institute for Fragrance Materials, Inc.), 1970d. Eye irritation study of 3-methyl-2-butenyl salicylate in rabbits. Unpublished report from IFF Incorporated, 7 April. Report number 15227 (RIFM, Woodcliff Lake, NJ, USA).
128. RIFM (Research Institute for Fragrance Materials, Inc.), 1970e. The contact sensitizing potential of fragrance materials in humans. RIFM report number 1760, October 7 (RIFM, Woodcliff Lake, NJ, USA).
129. RIFM (Research Institute for Fragrance Materials, Inc.), 1971. Irritation studies with octyl salicylate. Unpublished report from Felton International, 25 March. Report number 15431 (RIFM, Woodcliff Lake, NJ, USA).
130. RIFM (Research Institute for Fragrance Materials, Inc.), 1973a. Acute toxicity studies on rats and rabbits. RIFM report number 2021, February 23 (RIFM, Woodcliff Lake, NJ, USA).
131. RIFM (Research Institute for Fragrance Materials, Inc.), 1973b. Report on human maximization studies. RIFM report number 1803, November 26 (RIFM, Woodcliff Lake, NJ, USA).
132. RIFM (Research Institute for Fragrance Materials, Inc.), 1973c. Report on human maximization studies. RIFM report number 1802, May 21 and October 11b (RIFM, Woodcliff Lake, NJ, USA).
133. RIFM (Research Institute for Fragrance Materials, Inc.), 1974a. Acute toxicity study in rats and rabbits. RIFM report number 2025 July 17 (RIFM, Woodcliff Lake, NJ, USA).
134. RIFM (Research Institute for Fragrance Materials, Inc.), 1974b. Report on human maximization studies. RIFM report number 1801 August 19 (RIFM, Woodcliff Lake, NJ, USA).
135. RIFM (Research Institute for Fragrance Materials, Inc.), 1975a. Acute toxicity studies. RIFM report number 2020, January 31 and February 3 (RIFM, Woodcliff Lake, NJ, USA).
136. RIFM (Research Institute for Fragrance Materials, Inc.), 1975b. Acute toxicity studies. RIFM report number 2024, May 19 and June 10 (RIFM, Woodcliff Lake, NJ, USA).
137. RIFM (Research Institute for Fragrance Materials, Inc.), 1975c. Report on human maximization studies. RIFM report number 1799, January 15a, March 27 and May 16a,b (RIFM, Woodcliff Lake, NJ, USA).
138. RIFM (Research Institute for Fragrance Materials, Inc.), 1975d. Report on human maximization studies. RIFM report number 1798, January 31 and March 28 (RIFM, Woodcliff Lake, NJ, USA).
139. RIFM (Research Institute for Fragrance Materials, Inc.), 1975e. Sensitization test of benzyl salicylate in rabbits. Unpublished report from IFF Incorporated, 28 March. Report number 24192 (RIFM, Woodcliff Lake, NJ, USA).
140. RIFM (Research Institute for Fragrance Materials, Inc.), 1975f. Phototoxicity and irritation studies of fragrance materials in the mouse and miniature swine. RIFM report number 2038, February 28 (RIFM, Woodcliff Lake, NJ, USA).
141. RIFM (Research Institute for Fragrance Materials, Inc.), 1975g. Acute eye irritation study of benzyl salicylate in rabbits. Unpublished report from IFF Incorporated, 2 April. Report number 24191 (RIFM, Woodcliff Lake, NJ, USA).
142. RIFM (Research Institute for Fragrance Materials, Inc.), 1975h. Repeated insult patch test of benzyl salicylate on human subjects. Unpublished report from IFF Incorporated, 18 June. Report number 24190 (RIFM, Woodcliff Lake, NJ, USA).
143. RIFM (Research Institute for Fragrance Materials, Inc.), 1975i. Phototoxic potential of octyl salicylate on human skin. Unpublished Report from Felton International, September 5. Report number 15435 (RIFM, Woodcliff Lake, NJ, USA).
144. RIFM (Research Institute for Fragrance Materials, Inc.), 1976a. Acute toxicity studies. RIFM report number 2019, May 12 and September 7 (RIFM, Woodcliff Lake, NJ, USA).
145. RIFM (Research Institute for Fragrance Materials, Inc.), 1976b. Report on human maximization studies conducted with wintergreen oil. RIFM report number 1796, July 23 (RIFM, Woodcliff Lake, NJ, USA).
146. RIFM (Research Institute for Fragrance Materials, Inc.), 1976c. Report on human maximization studies. RIFM report number 1797, March 9a and June 25 (RIFM, Woodcliff Lake, NJ, USA).
147. RIFM (Research Institute for Fragrance Materials, Inc.), 1976d. Repeated insult patch test of octyl salicylate on human skin. Unpublished report from Felton International Incorporated, 17 February. Report number 15432 (RIFM, Woodcliff Lake, NJ, USA).
148. RIFM (Research Institute for Fragrance Materials, Inc.), 1976e. Phototoxicity and irritation studies on wintergreen oil in miniature swine and mice. RIFM report number 2039, July 20 (RIFM, Woodcliff Lake, NJ, USA).
149. RIFM (Research Institute for Fragrance Materials, Inc.), 1977a. Mutagenicity evaluation of octyl salicylate in rats. Unpublished Report from Felton International, 9 September. Report number 15434 (RIFM, Woodcliff Lake, NJ, USA).
150. RIFM (Research Institute for Fragrance Materials, Inc.), 1977b. Report on human maximization studies. RIFM report number 1702, November 3 (RIFM, Woodcliff Lake, NJ, USA).
151. RIFM (Research Institute for Fragrance Materials, Inc.), 1978a. Acute toxicity studies. RIFM report number 1699, February 1 and May 5 and May 8 (RIFM, Woodcliff Lake, NJ, USA).
152. RIFM (Research Institute for Fragrance Materials, Inc.), 1978b. Report on human maximization studies. RIFM report number 1698, June 2 (RIFM, Woodcliff Lake, NJ, USA).
153. RIFM (Research Institute for Fragrance Materials, Inc.), 1978c. Report on human maximization studies. RIFM report number 1787, February 28 (RIFM, Woodcliff Lake, NJ, USA).
154. RIFM (Research Institute for Fragrance Materials, Inc.), 1978d. Draize eye irritation study of octyl salicylate in rabbits. Unpublished Report from Felton International, 20 April. Report number 15433 (RIFM, Woodcliff Lake, NJ, USA).
155. RIFM (Research Institute for Fragrance Materials, Inc.), 1979. Report on human maximization studies. RIFM report number 1697, July 6 (RIFM, Woodcliff Lake, NJ, USA).
156. RIFM (Research Institute for Fragrance Materials, Inc.), 1980a. Acute toxicity studies. RIFM report number 1774, May 28 (RIFM, Woodcliff Lake, NJ, USA).
157. RIFM (Research Institute for Fragrance Materials, Inc.), 1980b. Report on human maximization studies. RIFM report number 1791, March 17 (RIFM, Woodcliff Lake, NJ, USA).
158. RIFM (Research Institute for Fragrance Materials, Inc.), 1980c. Sensitization studies with benzyl salicylate in human subjects. RIFM report number 3305, January 21 (RIFM, Woodcliff Lake, NJ, USA).
159. RIFM (Research Institute for Fragrance Materials, Inc.), 1981a. Acute dermal toxicity of 1,3-dimethyl-3-butenyl salicylate in rabbits. Unpublished report from Firmenich Incorporated, 10 April. Report number 39258 (RIFM, Woodcliff Lake, NJ, USA).
160. RIFM (Research Institute for Fragrance Materials, Inc.), 1981b. Acute oral toxicity study of 1,3-dimethyl-3-butenyl salicylate in rats. Unpublished report from Firmenich Incorporated, 10 April. Report number 39257 (RIFM, Woodcliff Lake, NJ, USA).
161. RIFM (Research Institute for Fragrance Materials, Inc.), 1981c. Repeated insult patch test/photosensitization study of 1,3-dimethyl-3-butenyl salicylate in human subjects. Unpublished report from Firmenich Incorporated, 20 May. Report number 39261 (RIFM, Woodcliff Lake, NJ, USA).
162. RIFM (Research Institute for Fragrance Materials, Inc.), 1981d. Primary skin irritation of 1,3-dimethyl-3-butenyl salicylate in rabbits. Unpublished report from Firmenich Incorporated, 10 April. Report number 39259 (RIFM, Woodcliff Lake, NJ, USA).
163. RIFM (Research Institute for Fragrance Materials, Inc.), 1981e. Guinea pig skin sensitisation test with hexyl salicylate. Unpublished report from Quest International, 12 November. Report number 46933 (RIFM, Woodcliff Lake, NJ, USA).
164. RIFM (Research Institute for Fragrance Materials, Inc.), 1981f. Guinea pig skin sensitisation test with pentyl salicylate. Unpublished report from Quest International, 12 November. Report number 46934 (RIFM, Woodcliff Lake, NJ, USA).
165. RIFM (Research Institute for Fragrance Materials, Inc.), 1981g. Guinea pig skin sensitisation test with phenethyl salicylate. Unpublished report from Quest International, 12 November. Report number 46935 (RIFM, Woodcliff Lake, NJ, USA).
166. RIFM (Research Institute for Fragrance Materials, Inc.), 1981h. Primary eye irritation study of 1,3-dimethyl-3-butenyl salicylate in rabbits. Unpublished report from Firmenich Incorporated, 10 April. Report number 39260 (RIFM, Woodcliff Lake, NJ, USA).
167. RIFM (Research Institute for Fragrance Materials, Inc.), 1982a. Acute toxicity studies in rats. Unpublished Report from Givaudan Incorporated, 13 and 27 September. Report number 1786 (RIFM, Woodcliff Lake, NJ, USA).
168. RIFM (Research Institute for Fragrance Materials, Inc.), 1982b. Acute toxicity studies. RIFM report number 1689, April 30 (RIFM, Woodcliff Lake, NJ, USA).
169. RIFM (Research Institute for Fragrance Materials, Inc.), 1982c. Report on human maximization studies. RIFM report number 1643, April 27 (RIFM, Woodcliff Lake, NJ, USA).
170. RIFM (Research Institute for Fragrance Materials, Inc.), 1982d. Phototoxicity study with benzyl salicylate in guinea pigs. Unpublished report from Givaudan Incorporated, 9 November. Report number 33514 (RIFM, Woodcliff Lake, NJ, USA).
171. RIFM (Research Institute for Fragrance Materials, Inc.), 1983a. Penetration studies "in vitro" on intact skin of naked rat and pig with benzyl salicylate. Unpublished report from Givaudan Incorporated, 31 August. Report number 33515 (RIFM, Woodcliff Lake, NJ, USA).
172. RIFM (Research Institute for Fragrance Materials, Inc.), 1983b. Phototoxicity and photoallergy tests with benzyl salicylate in the guinea pig. Unpublished report from Rhodia Incorporated, 13 June. Report number 40988 (RIFM, Woodcliff Lake, NJ, USA).
173. RIFM (Research Institute for Fragrance Materials, Inc.), 1983c. Phototoxicity test of benzyl salicylate in humans. Unpublished report from Givaudan Incorporated, 1 August. Report number 33513 (RIFM, Woodcliff Lake, NJ, USA).
174. RIFM (Research Institute for Fragrance Materials, Inc.), 1983d. Phototoxicity study of fragrance materials in hairless mice. RIFM report number 2043, February 3 (RIFM, Woodcliff Lake, NJ).
175. RIFM (Research Institute for Fragrance Materials, Inc.), 1984. Primary irritation test in rabbits. RIFM report number 1795, June 1 (RIFM, Woodcliff Lake, NJ).
176. RIFM (Research Institute for Fragrance Materials, Inc.), 1985. Primary irritation test in rabbits. RIFM report number 3099, June 1 (RIFM, Woodcliff Lake, NJ, USA).
177. RIFM (Research Institute for Fragrance Materials, Inc.), 1986a. Primary irritation test in rabbits. RIFM report number 5665, August 1 (RIFM, Woodcliff Lake, NJ, USA).
178. RIFM (Research Institute for Fragrance Materials, Inc.), 1986b. Primary irritation test in rabbits. RIFM report number 5664, June 1 (RIFM, Woodcliff Lake, NJ, USA).
179. RIFM (Research Institute for Fragrance Materials, Inc.), 1990. Acute oral toxicity (limit test) of pentyl salicylate in the rat. Unpublished report from Haarmann & Reimer GmbH, 12 April. Report number 35559 (RIFM, Woodcliff Lake, NJ, USA).
180. RIFM (Research Institute for Fragrance Materials, Inc.), 1997a. Human irritation study with benzyl salicylate. Unpublished report from Takasago International Corporation, 9 December. Report number 31608 (RIFM, Woodcliff Lake, NJ, USA).
181. RIFM (Research Institute for Fragrance Materials, Inc.), 1997b. Primary skin irritation study and phototoxicity study in guinea pigs with benzyl salicylate. Unpublished report from Takasago International Corporation, 9 December. Report number 31612 (RIFM, Woodcliff Lake, NJ, USA).
182. RIFM (Research Institute for Fragrance Materials, Inc.), 1997c. Delayed contact hypersensitivity study in guinea pigs with benzyl salicylate. Unpublished report from Takasago International Corporation, 9 December. Report number 31605 (RIFM, Woodcliff Lake, NJ, USA).
183. RIFM (Research Institute for Fragrance Materials, Inc.), 1999. Toxicology studies of cis-3-hexenyl salicylate in the guinea pig. Unpublished report from Takasago International Corporation, 13 July. Report number 35055 (RIFM, Woodcliff Lake, NJ, USA).
184. RIFM (Research Institute for Fragrance Materials, Inc.), 2003. Topical photoallergy screening test of hexyl salicylate and beta-methyl naphthyl ketone in male albino hairless guinea pigs [CRL: IAF(HA)-hrBR (outbred)], including primary irritation, phototoxicity and contact hypersensitivity evaluations. RIFM report number 44882, June 9 (RIFM, Woodcliff Lake, NJ, USA).
185. RIFM (Research Institute for Fragrance Materials, Inc.), 2004a. Repeated insult patch test with fragrance materials. RIFM report number 45130, May 3 (RIFM, Woodcliff Lake, NJ, USA).
186. RIFM (Research Institute for Fragrance Materials, Inc.), 2004b. Evaluation of phototoxicity of hexyl salicylate in humans. RIFM report number 45136, March 16 (RIFM, Woodcliff Lake, NJ, USA).
187. RIFM (Research Institute for Fragrance Materials, Inc.), 2004c. Repeated insult patch test with fragrance materials. RIFM report number 45129, May 3 (RIFM, Woodcliff Lake, NJ, USA).
188. RIFM (Research Institute for Fragrance Materials, Inc.), 2005. Local Lymph Node Assay with benzyl salicylate. RIFM report number 47378, January 20 (RIFM, Woodcliff Lake, NJ, USA).
189. RIFM (Research Institute for Fragrance Materials, Inc.), 2006. Phenyl ethyl salicylate: local Lymph Node Assay. RIFM report number 2353, January 11 (RIFM, Woodcliff Lake, NJ, USA).
190. Riviere J.E., Smith C.E., Budsaba K., Brooks J.D., Olajos E.J., Salem H., and Monteiro-Riviere N.A. Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard. The Toxicologist 54 (2000) 151-152
191. Riviere J.E., Smith C.E., Budsaba K., Brooks J.D., Olajos E.J., Salem H., and Monteiro-Riviere N.A. Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard. Journal of Applied Toxicology 21 (2001) 91-99
192. Roberts M.S., Favretto W.A., and Meyer A. Topical bioavailability of methyl salicylate. Australian and New Zealand Journal of Medicine 12 (1982) 303-305
193. Robinson D., and Williams R.T. Glucuronides of salicylic acid. Biochemical Journal 62 (1956) 23
194. Salvito D.T., Senna R.J., and Federle T.W. A Framework for prioritizing fragrance materials for aquatic risk assessment. Environmental Toxicology and Chemistry 21 (2002) 1301-1308
195. Sammons H.G., and Williams R.T. Studies in detoxication. The metabolism of vanillin and vanillic acid in the rabbit. The identification of glucurovanillin and the structure of glucurovanillic acid. Biochemical Journal 325 (1941) 1175-1188
196. Sax N. Dangerous Properties of Industrial Materials. fifth ed. (1979), Van Nostrand Reinhold, New York
197. Schilling K., Kayser M., Deckardt K., Kuttler K., and Klimisch H.J. Subchronic toxicity studies of 3-methyl-1-butanol and 2-methyl-1-propanol in rats. Human and Experimental Toxicology 16 (1997) 722-726
198. Sharp D.W. The sensitization potential of some perfume ingredients tested using a modified Draize procedure. Toxicology 9 (1978) 261-271
199. Shen J., Wanwimolruk S., Purves R.D., McQueen E.G., and Roberts M.S. Model representation of salicylate pharmacokinetics using unbound plasma salicylate concentrations and metabolite urinary excretion rates following a single oral dose. Journal of Pharmacokinetics and Biopharmaceutics 19 (1991) 575-595
200. Short C.R., Neff-Davis C.A., Hsieh L.C., Koritz G.D., Malbrough M.S., Barker S.A., and Davis L.E. Pharmacokinetics and elimination of salicylic acid in rabbits. Journal of Veterinary Pharmacology and Therapeutics 14 (1991) 70-77
201. Siddiqi M., and Ritschel W.A. pH-Effects on salicylate absorption through the intact rat skin. Scientia Pharmaceutica 40 (1972) 181-189
202. Simonich S.L., Begley W.M., Debaere G., and Eckhoff W.S. Trace analysis of fragrance materials in wastewater and treated wastewater. Environmental Science and Technology 34 (2000) 959-965
203. Simonich S.L., Federle T.W., Eckhoff W.S., Rottiers A., Webb S., Sabaliunas D., and De Wolf W. Removal of fragrance materials during U.S. and European wastewater treatment. Environmental Science and Technology 36 (2002) 2839-2847
204. Stofberg J., and Grundschober F. Consumption ratio and food predominance of flavoring materials. Perfumer Flavorist 12 (1987) 27
205. Stoner G.D., Shimkin M.B., Kniazeff A.J., Weisburger J.H., Weisburger E.K., and Go G.B. Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice. Cancer research 33 (1973) 3069-3085
206. Strand L.P., and Scheline R.R. The metabolism of vanillin and isovanillin in the rat. Xenobiotica 5 (1975) 49-63
207. Strong L.C. The effect of oil of wintergreen on the incidence of spontaneous carcinoma in mice. IV. Effect on growth rate and survival time after onset of malignancy. American Journal of Medicine 4 (1932) 546-553
208. Strong L.C. Possible effect of oil of Gaultheria in diet of mice susceptible to spontaneous carcinoma of the breast. I.A suggestion. Proceedings of the Society for Experimental Biology and Medicine 30 (1932) 386-390
209. Szybalski W. Special microbial systems. II. Observations on chemical mutaganesis in microorganisms. Annals New York Academy of Sciences 76 (1958) 475-489
210. Tanaka S., Kawashima K., Nakaura, et al. Studies on the teratogenicity of food additives (3). Teratogenic effect of dietary salicylic acid in rats. Shokuhin Eiseigaku Zasshi 14 (1973) 549-557
211. Tanaka S., Kawashima K., Nakaura, et al. Studies on the teratogenic effects of salicylic acid and aspirin in rats as related to fetal distribution. Congenital Anomalies (Senten Ijo) 13 (1973) 73-84
212. Treffel P., and Gabard B. Skin penetration and sun protection factor of ultraviolet filters from two vehicles. Pharmaceutical Research 13 (1996) 770-774
213. Tsuchiya S., Kondo M., Okamoto K., and Takase Y. Studies on contact hypersensitivity in the guinea pig. The cumulative contact enhancement test. Contact Dermatitis 8 (1982) 246-255
214. Vree T.B., van Ewijk-Beneken Kolmer E.W.J., Verwey-Van Wissen C.P.W.G.M., and Hekster Y.A. Direct gradient reversed-phase high-performance liquid chromatographic determination of salicylic acid, with the corresponding glycine and glucuronide conjugates in humans plasma and urine. Journal of Chromatography, B: Biomedical Sciences and Applications 652 (1994) 161-170
215. Vree T.B., van Ewijk-Beneken Kolmer E.W.J., Verwey-Van Wissen C.P.W.G.M., and Hekster Y.A. Effect of urinary pH on the pharmacokinetics of salicylic acid, with its glycine and glucuronide conjugates in humans. International Journal of Clinical Pharmacology and Therapeutics 32 (1994) 550-558
216. Walters K.A., Brain K.R., Howes D., James V.J., Kraus A.L., Teetsel L.M., Toulon M., Watkinson A.C., and Gettings S.D. Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro. Food and Chemical Toxicology 35 (1997) 1219-1225
217. Waltman R., Tricomi V., Shabanah E.H., and Arenas R. The effect of anti-inflammatory drugs on parturition parameters in the rat. Prostaglandins 4 (1973) 93-106
218. Warkany J., and Takacs E. Experimental production of congenital malformations in rats by salicylate poisoning. American Journal of Pathology 35 (1959) 315
219. Watkinson A.C., Brain K.R., Walters K.A., and Hadgraft J. Prediction of the percutaneous penetration of ultra-violet filters used in sunscreen formulations. International Journal of Cosmetic Science 14 (1992) 265-275
220. Webb W.K., and Hansen W.H. Chronic and subacute toxicology and pathology of methyl salicylate in dogs, rats and rabbits. Toxicology and Applied Pharmacology 5 (1963) 576-587
221. Webb W.K., and Hansen W.H. Chronic and subacute toxicology and pathology of methyl salicylate in dogs, rats and rabbits. Federation Proceedings 21 (1962) 255
222. Williams R.T. The metabolism of aromatic alcohols, ethers, aldehydes, ketones and quinones. Detoxication Mechanisms (1959), Chapman & Hall Ltd., London 318-320
223. Wolowich W.R., Hadley C.M., Kelley M.T., Walson P.D., and Casavant M.J. Plasma salicylate from methyl salicylate cream compared to oil of wintergreen. Journal of Toxicology: Clinical Toxicology 41 (2003) 355-358
224. Woo D.C., and Hoar R.M. "Apparent hydronephrosis" as a normal aspect of renal development in late gestation of rats: the effect of methyl salicylate. Teratology 6 (1972) 191-196
225. Yankell S.L. The effects of various vehicles on absorption rates in skin. In: Montagna W., Van Scott E.J., and Stoughton R.B. (Eds). Advances in Biology of Skin, Pharmacology and the Skin vol. 12 (1972), Oregon Regional Primate Research Center, Oregon 511-522
226. Yano T., Kanetake T., Saita M., and Noda K. Effects of l-menthol and dl-camphor on the penetration and hydrolysis of methyl salicylate in hairless mouse skin. Journal of Pharmacobio-Dynamics 14 (1991) 663-669
227. Yano T., Nakagawa A., Tsuji M., and Noda K. Skin permeability of various non-steroidal anti-inflammatory drugs in man. Life Sciences 39 (1986) 1043-1050
228. Yoshida Y., Oyake Y., Sakaguchi H., Okuda M., and Suzuki H. Comparison of the effect of allergen and irritant treatment on proliferation and subpopulation of the draining lymph node cells in mice and guinea pigs. The Toxicologist 54 (2000) 153
229. Zeiger E., Anderson B., Haworth S., Lawlor T., Mortelmans K., and Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environmental Mutagenesis 9 (1987) 1-109