Automated integrated forced degradation and drug-excipient compatibility studies

JALA - Journal of the Association for Laboratory Automation

Volumn 10, Issue 6, 2005, Pages 374-380

  Carlson, Eric ^a   Chandler, William ^a   Galdo, Isabel ^a   Kudla, Thomas ^a   Ta, Cuong ^a  

^a SYMYX TECHNOLOGIES   (United States)

Author keywords

Degradation; Excipient compatibility; Forced degradation; Formulation testing; Kinetics; Stress testing

Indexed keywords

AUTOMATION; DRUG PRODUCTS; KINETIC THEORY; PH; SOLUBILITY; THERMODYNAMIC STABILITY;

EXCIPIENT COMPATIBILITY; FORCED DEGRADATION; FORMULATION TESTING; STRESS TESTING;

DEGRADATION;

CHLORIDE; EXCIPIENT; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER; COMPUTER PROGRAM; COMPUTER SYSTEM; DRUG DEGRADATION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; EXCIPIENT COMPATIBILITY; HIGH THROUGHPUT SCREENING; LABORATORY AUTOMATION; LIQUID; PHARMACEUTICAL ENGINEERING; ROOM TEMPERATURE;

EID: 30344455338     PISSN: 15355535     EISSN: 15402452     Source Type: Journal    
DOI: 10.1016/j.jala.2005.09.005     Document Type: Article

References (9)

1. S.N. Pace G.W. Pace I. Pairkh A.K. Mishra Novel injectable formulations of insoluble drugs Pharm. Tech. March 1999 116-134
2. S. Sweetana M.J. Akers Solubility principles and practices for parenteral drug dosage form development PDA J. Pharm. Sci. Tech. 50 5 1996 330-342
3. R. Liu Ed. Water-Insoluble Drug Formulation 2000 Interpharm Press Denver, CO 1-4
4. L. Di E.H. Kerns Profiling drug-like properties in discovery research Curr. Opin. Chem. Biol. 7 3 2003 402-408
5. A.M. Fermier A.R. Oyler B.L. Armstrong B.A. Weber R.L. Rodriguez V. Weber James J.A. Nalasco Automation of chemical reaction kinetics and product distribution studies in pharmaceutical development J. Assoc. Lab. Autom. 7 1 2002
6. J.L. Sims J.K. Roberts A.G. Bateman J.A. Carreira M.J. Hardy An automated workstation for forced degradation of active pharmaceutical ingredients J. Pharm. Sci. 91 3 2002 884-892
7. E.D. Carlson C. Cong W.H. Chandler H.K. Chau T. Crevier P.J. Desrosiers R.D. Doolen C. Freitag L.A. Hall T. Kudla R. Luo C. Masui J. Rogers L. Song A. Tangkilisan K.Q. Ung L. Wu An integrated high-throughput workflow for pre-formulations: Polymorphs and salt selection studies Pharmachem 1 7/8 2003
8. E.D. Carlson Integrated workflow for development testing Genet Eng News 25 11 2005 40-44
9. W. Chandler R. Busacca E. Carlson W. Rust Extended Core Module-flexible and modular platform for scientific workflows J. Assoc. Lab. Autom. 10 2005 418-422