Aloe-emodin suppressed NMDA-induced apoptosis of retinal ganglion cells through regulation of ERK phosphorylation

Phytotherapy Research

Volumn 21, Issue 11, 2007, Pages 1007-1014

  Lin, Hui Ju ^a   Chao, Pei Dawn Lee ^b   Huang, Shiuan Yi ^a   Wan, Lai ^a   Wu, Chen Ju ^a   Tsai, Fuu Jen ^a  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Aloe emodin; EGK, ganglion cell; Glaucoma; Map kinase; NMDA; p38

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALOE EMODIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; N METHYL DEXTRO ASPARTIC ACID; STRESS ACTIVATED PROTEIN KINASE; UO 126;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; GLAUCOMA; MALE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RETINA GANGLION CELL;

ANIMALS; ANTHRAQUINONES; APOPTOSIS; CELL LINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; N-METHYLASPARTATE; PHOSPHORYLATION; RATS; RETINAL GANGLION CELLS; SIGNAL TRANSDUCTION;

ALOE;

EID: 36549014111     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2138     Document Type: Article

References (29)

1. Behrens A, Sibilia M, Wagner EF. 1999. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nature Genet 21: 326-329.
2. Boulton TG, Nye SH, Robbins DJ et al. 1991. ERKs: a family of protein serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65: 663-675.
3. Brooks DE, Garcia GA, Dreyer EB et al. 1997. Vitreous body glutamate concentration in dogs with glaucoma. Am J Vet Res 58: 864-867.
4. Dai Y, Rahmani M, Dent P et al. 2005. Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation. Mol Cell Biol 25: 5429-5444.
5. Dawson VL, Dawson TM, Bartley DA. 1993. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci 13: 2651-2661.
6. Dreyer EB, Zurakowski D, Schumer RA et al. 1996. Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol 114: 299-305.
7. Favata MF, Horiuchi KY, Manos EJ et al. 1998. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632.
8. Garcia-Valenzuela E, Shareef S, Walsh J et al. 1995. Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp Eye Res 61: 33-44.
9. Gu JW, Hasuo H, Takeya M et al. 2005. Effects of emodin on synaptic transmission in rat hippocampal CA1 pyramidal neurons in vitro. Neuropharmacology 49: 103-111.
10. Hehner SP, Heinrich M, Bork PM et al. 1998. Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta. J Biol Chem 273: 1288-1297.
11. Klemetti A. 1997. Low-tension glaucoma - a disease for ophthalmology or internal medicine? Duodecim 113: 1425-1426.
12. Koss MC. 1999. Functional role of nitric oxide in regulation of ocular blood flow. Eur J Pharmacol 374: 161-174.
13. Lee HZ, Wu CH, Chang SP. 2005. Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis. Int J Cancer 113: 971-976.
14. Li J, McRoberts JA, Nie J et al. 2004. Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons. Pain 109: 443-452.
15. Lipton SA, Rosenberg RA. 1994. Mechanisms of disease: Excitatory amino acids as a final common pathway in neurologic disorders. N Engl J Med 330: 613-622.
16. Lucas DR, Newhouse JP. 1957. The toxic effect of sodium L-glutamate on the inner layers of the retina. Am Med Assoc Arch Ophthalmol 58: 193-201.
17. Lu HF, Sue CC, Yu CS et al. 2004. Diallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cells. Food Chem Toxicol 42: 1543-1552.
18. Mielke K, Herdegen T. 2000. JNK and p38 stress kinases: degenerative effectors of signal-transduction-cascades in the nervous system. Prog Neurobiol 61: 45-60.
19. Olney JW, Ho OL. 1970. Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature 227: 609-611.
20. Olthof M, Hollman PCH, Vree TB et al. 2000. Bioavailabilities of quercetin-3-glucoside and quercetin-4′-glucoside do not differ in human. J Nutr 130: 1200-1203.
21. Osborne NN, Ugarte M, Chao M et al. 1999. Neuroprotection in relation to retinal ischemia and relevance to glaucoma. Surv Ophthalmol 43: S102-S128.
22. Quiqley HA. 1996. Number of people with glaucoma worldwide. Br J Ophthalmol 80: 389-403.
23. Raingeaud J, Gupta S, Rogers JS et al. 1995 Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270: 7420-7426.
24. Robinson MJ, Cobb MH. 1997. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 9: 180-186.
25. Seger R, Krebs EG. 1995. The MAPK signaling cascade. FASEB J 9: 726-735.
26. Stamm C, del Nido PJ. 2004. Protein kinase C and myocardial calcium handling during ischemia and reperfusion: lessons learned using Rhod-2 spectrofluorometry. Thor Cardiovasc Surg 52: 127-134.
27. Sucher NJ, Aizenman E, Lipton SA. 1991. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. J Neurosci 11: 966-971.
28. Wu T, Han C, Shelhamer JH. 2004. Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha- induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells. Cytokine 25: 11-20.
29. 2+ block of the N-methyl-D- aspartate receptor underlies receptor activation during inhibition of neuronal metabolism. J Neurochem 59: 1211-1220.