메뉴 건너뛰기




Volumn 18, Issue 3, 2007, Pages 79-94

A basic molecular analysis of the diabetic antigen GAD by homology modelling. Principles of the method and understanding of antigenicity and binding sites

Author keywords

Antigen; Epitopes; GAD 65; Homology modelling; Protein structure visualization

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; CARBIDOPA; GLUTAMATE DECARBOXYLASE 65;

EID: 36448997026     PISSN: 09334807     EISSN: 21954720     Source Type: Journal    
DOI: 10.1515/pteridines.2007.18.1.79     Document Type: Article
Times cited : (1)

References (45)
  • 4
    • 36448964026 scopus 로고    scopus 로고
    • Introduction of Three Complementary Technologies into Clinical Medicine: Development of New Diagnostic and Prognostic Parameters
    • Tilz GP, Wiltgen M, Demel U, Faschinger C, Schmiedinger H, Hermetter A. Introduction of Three Complementary Technologies into Clinical Medicine: Development of New Diagnostic and Prognostic Parameters. Am J Immunol 2006;2:12-18.
    • (2006) Am J Immunol , vol.2 , pp. 12-18
    • Tilz, G.P.1    Wiltgen, M.2    Demel, U.3    Faschinger, C.4    Schmiedinger, H.5    Hermetter, A.6
  • 5
    • 33947423376 scopus 로고    scopus 로고
    • New Insights into Ophthalmology: Introduction of SELDI-TOF in Combination with Molecular Modelling for the Analysis of Aqueous Humour. Principle and First results
    • Tilz GP, Wiltgen M, Demel U, Faschinger C, Scherbichler W. New Insights into Ophthalmology: Introduction of SELDI-TOF in Combination with Molecular Modelling for the Analysis of Aqueous Humour. Principle and First results. Pteridines 2006;17:129-134.
    • (2006) Pteridines , vol.17 , pp. 129-134
    • Tilz, G.P.1    Wiltgen, M.2    Demel, U.3    Faschinger, C.4    Scherbichler, W.5
  • 6
    • 21044455871 scopus 로고    scopus 로고
    • Clinical bioinformatics
    • Chang PL. Clinical bioinformatics. Chang Gung Med J 2005;28: 201-211.
    • (2005) Chang Gung Med J , vol.28 , pp. 201-211
    • Chang, P.L.1
  • 7
    • 0014412965 scopus 로고
    • Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 angstrom resolution: The atomic model
    • Perutz MF, Muirhead H, Cox JM, Goaman LC. Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 angstrom resolution: the atomic model. Nature 1968;219:131-139.
    • (1968) Nature , vol.219 , pp. 131-139
    • Perutz, M.F.1    Muirhead, H.2    Cox, J.M.3    Goaman, L.C.4
  • 8
    • 0025262173 scopus 로고
    • Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): A vehicle for direct determination of three-dimensional structure
    • Hendrickson WA, Horton JR, LeMaster DM. Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure. EMBO J 1990;9:1665-1672.
    • (1990) EMBO J , vol.9 , pp. 1665-1672
    • Hendrickson, W.A.1    Horton, J.R.2    LeMaster, D.M.3
  • 11
    • 0030851311 scopus 로고    scopus 로고
    • Cn3D: A new generation of threedimensional molecular structure viewer
    • Hogue C.W. Cn3D: A new generation of threedimensional molecular structure viewer. Trends Biochem Sci 1997;22:314-316.
    • (1997) Trends Biochem Sci , vol.22 , pp. 314-316
    • Hogue, C.W.1
  • 12
    • 0030814038 scopus 로고    scopus 로고
    • WebMol- a Java based PDB viewer
    • Walther D. WebMol- a Java based PDB viewer. Trends Biochem. Sci 1997;22:274-275.
    • (1997) Trends Biochem. Sci , vol.22 , pp. 274-275
    • Walther, D.1
  • 14
    • 3242878795 scopus 로고    scopus 로고
    • Java Protein Dossier: A novel web-based data visualization tool for comprehensive analysis of protein structure
    • Neshich G, Rocchia W, Mancini AL et al. Java Protein Dossier: a novel web-based data visualization tool for comprehensive analysis of protein structure. Nucleic Acids Res 2004;32:595-601.
    • (2004) Nucleic Acids Res , vol.32 , pp. 595-601
    • Neshich, G.1    Rocchia, W.2    Mancini, A.L.3
  • 15
    • 33947413772 scopus 로고    scopus 로고
    • Visualization in Bioinformatics: Protein Structures with Physicochemical and Biological Annotations
    • Zara J, Sloup J eds
    • Wiltgen M, Holzinger A. Visualization in Bioinformatics: Protein Structures with Physicochemical and Biological Annotations. In: Zara J, Sloup J (eds.). Central European Multimedia and Virtual reality Conference (CEMVR) 2005:69-74.
    • (2005) Central European Multimedia and Virtual reality Conference (CEMVR) , pp. 69-74
    • Wiltgen, M.1    Holzinger, A.2
  • 17
    • 33645734536 scopus 로고    scopus 로고
    • Protein structure modelling in the proteomic era
    • Fiser A. Protein structure modelling in the proteomic era. Expert Rev Proteomics 2004;1:97-110.
    • (2004) Expert Rev Proteomics , vol.1 , pp. 97-110
    • Fiser, A.1
  • 18
    • 0034567210 scopus 로고    scopus 로고
    • Comparative protein structure modeling. Introduction and practical examples with modeller
    • Sanchez R, Sali A. Comparative protein structure modeling. Introduction and practical examples with modeller. Methods Mol Biol 2000;143:97-129.
    • (2000) Methods Mol Biol , vol.143 , pp. 97-129
    • Sanchez, R.1    Sali, A.2
  • 19
    • 36448934363 scopus 로고    scopus 로고
    • Fiser A, Sanchez R, Melo F, Sali A. Comparative protein structure modelling. In: Watanabe M, Roux B, MacKerell AD Jr., Becker O, eds. Computational Biochemistry and Biophysics. Marcel Dekker. 2001;275-312.
    • Fiser A, Sanchez R, Melo F, Sali A. Comparative protein structure modelling. In: Watanabe M, Roux B, MacKerell AD Jr., Becker O, eds. Computational Biochemistry and Biophysics. Marcel Dekker. 2001;275-312.
  • 20
    • 0030053370 scopus 로고    scopus 로고
    • ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling
    • Peitsch MC. ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling. Biochem Soc Trans 1996;24:274-279.
    • (1996) Biochem Soc Trans , vol.24 , pp. 274-279
    • Peitsch, M.C.1
  • 22
    • 0023090843 scopus 로고
    • Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes
    • Baekkeskov S, Landing M, Kristenstensen, et al. Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 1987;79:926-934.
    • (1987) J Clin Invest , vol.79 , pp. 926-934
    • Baekkeskov, S.1    Landing, M.2    Kristenstensen3
  • 23
    • 0023933925 scopus 로고
    • Autoantibodies to glutamic acid Decarboxylase in a patient with Stiffman syndrome,and type I diabetes mellitus
    • Solimena M, Folli F, Denis-Donini S, Comi GC, Pozza G, De Camilli P, Vicari AM. Autoantibodies to glutamic acid Decarboxylase in a patient with Stiffman syndrome,and type I diabetes mellitus. N Engl J Med 1988;318:1012-1020.
    • (1988) N Engl J Med , vol.318 , pp. 1012-1020
    • Solimena, M.1    Folli, F.2    Denis-Donini, S.3    Comi, G.C.4    Pozza, G.5    De Camilli, P.6    Vicari, A.M.7
  • 24
    • 0036272672 scopus 로고    scopus 로고
    • The PEVKEK region of the pyridoxal phosphare binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera
    • Tong JC, Myers MA, Mackay IR, Zimmet PZ, Rowley MJ. The PEVKEK region of the pyridoxal phosphare binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera. Ann N Y Acad Sci 2002;958:182-189.
    • (2002) Ann N Y Acad Sci , vol.958 , pp. 182-189
    • Tong, J.C.1    Myers, M.A.2    Mackay, I.R.3    Zimmet, P.Z.4    Rowley, M.J.5
  • 25
    • 0033911363 scopus 로고    scopus 로고
    • Two amino acids in glutamic acid decarboxylase act in concert for maintenance of conformational determinants recognised by Type I diabetic autoantibodies
    • Tree TI, Morgenthaler NG, Duhindan N, Hicks KE, Madec AM, Scherbaum WA, Banga JP. Two amino acids in glutamic acid decarboxylase act in concert for maintenance of conformational determinants recognised by Type I diabetic autoantibodies. Diabetologia 2000;43:881-889.
    • (2000) Diabetologia , vol.43 , pp. 881-889
    • Tree, T.I.1    Morgenthaler, N.G.2    Duhindan, N.3    Hicks, K.E.4    Madec, A.M.5    Scherbaum, W.A.6    Banga, J.P.7
  • 26
    • 0031473847 scopus 로고    scopus 로고
    • SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modelling
    • Guex N, Peitsch MC. SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modelling. Electrophoresis 1997;18:2714-2723.
    • (1997) Electrophoresis , vol.18 , pp. 2714-2723
    • Guex, N.1    Peitsch, M.C.2
  • 30
    • 0027136282 scopus 로고
    • Comparative protein modelling by satisfaction of spatial restraints
    • Sali A, Blundell TL. Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 1993;234;779-815.
    • (1993) J Mol Biol , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 31
    • 0030908273 scopus 로고    scopus 로고
    • Advances in comparative protein-structure modelling
    • Sanchez R, Sali A. Advances in comparative protein-structure modelling. Curr Opin Struct Biol 1997;7:206-214.
    • (1997) Curr Opin Struct Biol , vol.7 , pp. 206-214
    • Sanchez, R.1    Sali, A.2
  • 32
    • 0033810049 scopus 로고    scopus 로고
    • Modeling of loops in protein structures
    • Fiser A, Kinh G, Do R, Sali A. Modeling of loops in protein structures. Protein Science 2000;9:1753-1773.
    • (2000) Protein Science , vol.9 , pp. 1753-1773
    • Fiser, A.1    Kinh, G.2    Do, R.3    Sali, A.4
  • 33
    • 15444381280 scopus 로고
    • Protein modelling by E-Mail
    • Peitsch MC. Protein modelling by E-Mail. Bio/Technology. 1995;13:658-660.
    • (1995) Bio/Technology , vol.13 , pp. 658-660
    • Peitsch, M.C.1
  • 35
    • 32144432437 scopus 로고    scopus 로고
    • The SWISS-MODEL workspace: A web-based environment for protein structure homology modelling
    • Arnold K, Bordoli L, Kopp J, Schwede T. The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics 2006;22:195-201.
    • (2006) Bioinformatics , vol.22 , pp. 195-201
    • Arnold, K.1    Bordoli, L.2    Kopp, J.3    Schwede, T.4
  • 36
    • 0042622380 scopus 로고    scopus 로고
    • SWISS-MODEL: An automated protein homology-modeling server
    • Schwede T, Kopp J, Guex N, Peitsch, MC. SWISS-MODEL: an automated protein homology-modeling server. Nucleic Acids Res 2003,31:3381-3385.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3381-3385
    • Schwede, T.1    Kopp, J.2    Guex, N.3    Peitsch, M.C.4
  • 39
    • 0029889221 scopus 로고    scopus 로고
    • Local alignment statistics
    • Altschul SF, Gish W. Local alignment statistics. Meth. Enzymol 1996; 266:460-480.
    • (1996) Meth. Enzymol , vol.266 , pp. 460-480
    • Altschul, S.F.1    Gish, W.2
  • 40
    • 0026458378 scopus 로고
    • Amino acid substitution matrices from protein blocks
    • Henikoff S, Henikoff JG. Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci USA 1992;89:10915-10919
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10915-10919
    • Henikoff, S.1    Henikoff, J.G.2
  • 45
    • 0020475449 scopus 로고
    • A simple method for displaying the hydropathic character of aprotein
    • Kyte, J, Doolittle, RF. A simple method for displaying the hydropathic character of aprotein. J Mol Biol 1982;157:105-132.
    • (1982) J Mol Biol , vol.157 , pp. 105-132
    • Kyte, J.1    Doolittle, R.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.