Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 323, Issue 3, 2007, Pages 771-777

  Khan, Farah D ^a,d   Vyas, Piyush M ^a,e   Gaspari, Anthony A ^b   Svensson, Craig K ^a,c  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c PURDUE UNIVERSITY   (United States)

^d RUTGERS UNIVERSITY   (United States)

^e RILEY HOSPITAL FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CELL ADHESION MOLECULE; CYTOKINE; DAPSONE; DRUG METABOLITE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; SULFAMETHOXAZOLE; TUMOR NECROSIS FACTOR ALPHA; URIC ACID;

ARTICLE; CELL ACTIVATION; CELL STRESS; CYTOKINE RELEASE; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

CELLS, CULTURED; CYTOKINES; DAPSONE; HEAT-SHOCK PROTEINS; HUMANS; HYDROXYLAMINES; IMMUNITY, NATURAL; INTERCELLULAR ADHESION MOLECULE-1; KERATINOCYTES; MICROSCOPY, FLUORESCENCE; SULFAMETHOXAZOLE; URIC ACID;

EID: 36348994962     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.126615     Document Type: Article

References (42)

1. Arnold-Schild D, Hanau D, Spehner D, Schmid C, Rammensee HG, de la Salle H, and Schild H (1999) Cutting edge: Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells. J Immunol 162:3757-3760.
2. Asea A, Kraeft SK, Kurt-Jones A, Stevenson MA, Chen LB, Finberg RW, Koo GC, and Calderwood SK (2000) HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 6:435-442.
3. Barbaud AM, Bene MC, Schmutz JL, Ehlinger A, Weber M, and Faure GC (1997) Role of delayed cellular hypersensitivity and adhesion molecules in amoxicillin-induced morbilliform rashes. Arch Dermatol 133:481-486.
4. Basu S, Binder RJ, Suto R, Anderson KM, and Srivastava PK (2000) Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway. Int Immunol 12:1539-1546.
5. Campisi J, Leem TH, and Fleshne M (2003) Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune system. Cell Stress Chaperones 8:272-286.
6. Carroll S and Wood E (2000) Exposure of human keratinocytes and fibroblasts in vitro to nickel sulphate ions induces synthesis of stress proteins Hsp72 and Hsp90. Acta Derm Venereol 80:94-97.
7. Cumberbatch M, Dearman RJ, Griffiths CEM, and Kimber I (2000) Langerhans cell migration: experimental dermatology. Clin Exp Dermatol 25:413-418.
8. Gaspari A (1997) The role of keratinocytes in the pathophysiology of contact dermatitis. Immunol Allergy Clin North Am 17:377-405.
9. Guéniche A, Viac J, and Lizard G (1994) Effect of nickel on the activation state of normal human keratinocytes through interleukin 1 and intercellular adhesion molecule 1 expression. Br J Dermatol 131:250-256.
10. Hari Y, Frutigchnyder K, Hurni M, Yawalkar N, Zanni MP, Schnyder B, Kappeler A, von Greyerz S, Braathen LR, and Pichler WJ (2001) T cell involvement in cutaneous drug eruptions. Clin Exp Allergy 31:1398-1408.
11. Hulette B, Ryan C, and Gerberick G (2002) Elucidating changes in surface marker expression of dendritic cells following chemical allergen treatment. Toxicol Appl Pharmacol 182:226-233.
12. Jakob T, Ring J, and Udey MC (2001) Multistep navigation of Langerhans/dendritic cells in and out of the skin. J Allergy Clin Immunol 108:688-696.
13. Ju C and Uetrecht JP (2002) Mechanism of idiosyncratic drug reactions: reactive metabolite formation, protein binding and the regulation of the immune system. Curr Drug Metab 3:367-377.
14. Kandimalla ER, Bhagat L, Zhu F-G, Yu D, Cong Y-P, Wang D, Tang JX, Tang J-Y, Knetter CF, Lien E, et al. (2003) A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif. Proc Natl Acad Sci U S A 100:14303-14308.
15. Khan FD, Roychowdhury S, Gaspari AA, and Svensson CK (2006) Immune response to xenobiotics in the skin: from contact sensitivity to drug allergy. Expert Opin Drug Metab Toxicol 2:261-272.
16. Kimber I, Cumberbatch M, Dearman RJ, Bhushan M, and Griffiths CEM (2000) Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization. Br J Dermatol 142:401-412.
17. Kuppner MC, Gastpar R, Gelwer S, Nössner E, Ochmann O, Scharner A, and Issels R (2001) The role of heat shock protein (hsp70) in dendritic cell maturation: hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors.. Eur J Dermatol 31:1602-1609.
18. la Sala A, Ferrari D, Di Virgilio F, Idzko M, Norgauer J, and Girolomoni G (2003) Alerting and tuning the immune response by extracellular nucleotides. J Leukoc Biol 73:339-343.
19. Medzhitov R and Janeway CJ (2000) The Toll receptor family and microbial recognition. Trends Microbiol 8:452-456.
20. Nickoloff B, Turka L, Mitra R, and Nestle F (1995) Direct and indirect control of T-cell activation by keratinocytes. J Invest Dermatol 105:25S-29S.
21. Nickoloff BJ and Turka LA (1994) Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes. Immunol Today 15:464-469.
22. Nishioka K, Groreishi M, and Yokozeki H (1999) Heat shock proteins and skin diseases. Curr Opin Infect Dis 12:171-176.
23. Park BK, Naisbitt DJ, Gordon SF, Kitteringham NR, and Pirmohamed M (2001) Metabolic activation in drug allergies. Toxicology 158:11-23.
24. Park BK, Tingle MD, Grabowski PS, Coleman JW, and Kitteringham NR (1987) Drug-protein conjugates. XI. Disposition and immunogenicity of dinitrofluorobenzene, a model compound for the investigation of drugs as haptens. Biochem Pharmacol 36:591-599.
25. Reilly TP, Bellevue FHI, Woster PM, and Svensson CK (1998) Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone. Biochem Pharmacol 55:803-810.
26. Reilly TP, Lash LH, Doll MA, Hein DW, Woster PM, and Svensson CK (2000) A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. J Invest Dermatol 114:1164-1173.
27. Reilly TP, MacArthur RD, Farrough MJ, Crane LR, Woster PM, and Svensson CK (1999) Is hydroxylamine-induced cytotoxicity a valid marker for hypersensitivity reactions to sulfamethoxazole in human immunodeficiency virus-infected individuals? J Pharmacol Exp Ther 291:1356-1364.
28. Roychowdhury S, Vyas PM, Reilly TP, Gaspari AA, and Svensson CK (2005) Characterization of the formation and localization of sulfamethoxazole and dapsone-associated drug-protein adducts in human epidermal keratinocytes. J Pharmacol Exp Ther 314:43-52.
29. Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, and Bhardwaj N (2000) Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 191:423-434.
30. Shi Y, Evans EE, and Rock KL (2003) Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425:516-521.
31. Shindo Y, Witt E, Han D, Epstein W, and Packer L (1994) Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol 102:122-124.
32. Shiohara T, Nickoloff B, Gomi T, and Nagashima M (1989) Fixed drug eruption: expression of epidermal keratinocyte intercellular adhesion molecule-1 (ICAM-1). Arch Dermatol 125:1371-1376.
33. Srivastava P (2002) Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu Rev Immunol 20:395-425.
34. Stoof FJ, Boorsma DM, and Nickoloff BJ (1994) Keratinocytes, in The Keratinocyte Handbook (Leigh IM, Watt F, and Lane E eds) pp 357-370, Cambridge University Press, Cambridge, UK.
35. Svensson CK, Cowen EW, and Gaspari AA (2001) Cutaneous drug reactions. Pharmacol Rev 53:357-379.
36. Todryk SM, Melcher AA, Dalgleish AG, and Vile RG (2000) Heat shock proteins refine the danger theory. Immunology 99:334-337.
37. Uetrecht JP (1999) New concepts in immunology relevant to idiosyncratic drug reactions: the 'danger hypothesis' and innate immune system. Chem Res Toxicol 12:387-395.
38. Vyas PM, Roychowdhury S, Woster PM, and Svensson CK (2005) Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes. Biochem Pharmacol 70:275-286.
39. Wakem P, Burns R, Ramirez F, Zlotnick D, Ferbel B, Haidaris C, and Gaspari A (2000) Allergens and irritants transcriptionally upregulate CD80 gene expression in human keratinocytes. J Invest Dermatol 114:1085- 1092.
40. Wang B, Amerio P, and Sauder DN (1999) Role of cytokines in epidermal Langerhans cell migration. J Leukoc Biol 66:33-39.
41. Wikner N, Huff JC, Norris DA, Boyce ST, Cary M, Kissinger M, Weston WL (1986) Study of HLA-DR synthesis in cultured human keratinocytes. J Invest Dermatol 87:559-564.
42. Wilmer J, Burleson F, and Kayama F (1994) Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical-induced inflammation in mouse skin. J Invest Dermatol 102:915-922.