Quantification of phosphorylated cAMP-response element-binding protein expression throughout the brain of amphetamine-sensitized rats: Activation of hypothalamic orexin A-containing neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 323, Issue 3, 2007, Pages 805-812

  McPherson, Cameron S ^a   Featherby, Travis ^a   Krstew, Elena ^a   Lawrence, Andrew J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; AMPHETAMINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; N (2 METHYL 6 BENZOXAZOLYL) N'' 1,5 NAPHTHYRIDIN 4 YL UREA; OREXIN 1 RECEPTOR; OREXIN A; PROTEIN C FOS; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; CELL ACTIVATION; CONTROLLED STUDY; DRUG MEGADOSE; EFFERENT NERVE; HYPOTHALAMUS; LIMBIC SYSTEM; LOW DRUG DOSE; MALE; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; REINFORCEMENT; REWARD; SENSITIZATION; SUBSTANTIA NIGRA;

AMPHETAMINE-RELATED DISORDERS; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEXTROAMPHETAMINE; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEURONS; NEUROPEPTIDES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 36348981692     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.125732     Document Type: Article

References (41)

1. Anand BK and Brobeck JR (1951) Hypothalamic control of food intake in rats and cats. Yale J Biol Med 24:123-140.
2. Berke JD and Hyman SE (2000) Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25:515-532.
3. Berridge KC and Robinson TE (1995) The mind of an addicted brain: neural sensitization of wanting versus liking. Curr Dir Psychol Sci 4:71-75.
4. Blendy JA and Maldonado R (1998) Genetic analysis of drug addiction: the role of cAMP response element binding protein. J Mol Med 76:104-110.
5. Borgland SL, Taha SA, Sarti F, Fields HL, and Bonci A (2006) Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 49:589-601.
6. Boudreau AC and Wolf ME (2005) Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens. J Neurosci 25:9144-9151.
7. Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, and de Lecea L (2005) Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci U S A 102:19168-19173.
8. Cha-Molstad H, Keller DM, Yochum GS, Impey S, and Goodman RH (2004) Cell-type-specific binding of the transcription factor CREB to the cAMP-response element. Proc Natl Acad Sci U S A 101:13572-13577.
9. Choe ES, Chung KT, Mao L, and Wang JQ (2002) Amphetamine increases phosphorylation of extracellular signal-regulated kinase and transcription factors in the rat striatum via group I metabotropic glutamate receptors. Neuropsychopharmacology 27:565-575.
10. Choe ES and Wang JQ (2002) CaMKII regulates amphetamine-induced ERK1/2 phosphorylation in striatal neurons. Neuroreport 13:1013-1016.
11. Cole RL, Konradi C, Douglass J, and Hyman SE (1995) Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14:813-823.
12. Crews F, He J, and Hodge C (2007) Adolescent cortical development: a critical period of vulnerability for addiction. Pharmacol Biochem Behav 86:189-199.
13. Edwards S, Graham DL, Bachtell RK, and Self DW (2007) Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. Eur J Neurosci 25:2201-2213.
14. Fadel J, Bubser M, and Deutch AY (2002) Differential activation of orexin neurons by antipsychotic drugs associated with weight gain. J Neurosci 22:6742-6746.
15. Fuchs RA, Branham RK, and See RE (2006) Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen. J Neurosci 26:3584-3588.
16. Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, Eisch AJ, Yanagisawa M, Nestler EJ, and DiLeone RJ (2003) Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci 23:3106-3111.
17. Harris GC and Aston-Jones G (2006) Arousal and reward: a dichotomy in orexin function. Trends Neurosci 29:571-577.
18. Harris GC, Wimmer M, and Aston-Jones G (2005) A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437:556-559.
19. Herdegen T and Leah JD (1998) Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res Brain Res Rev 28:370-490.
20. Kelley AE (2004) Memory and addiction: shared neural circuitry and molecular mechanisms. Neuron 44:161-179.
21. Konradi C, Cole RL, Heckers S, and Hyman SE (1994) Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci 14:5623-5634.
22. Kreibich AS and Blendy JA (2004) cAMP response element-binding protein is required for stress but not cocaine-induced reinstatement. J Neurosci 24:6686-6692.
23. Lawrence AJ, Cowen MS, Yang HJ, Chen F, and Oldfield B (2006) The orexin system regulates alcohol-seeking in rats. Br J Pharmacol 148:752-759.
24. Liu J, Yu B, Orozco-Cabal L, Grigoriadis DE, Rivier J, Vale WW, Shinnick-Gallagher P, and Gallagher JP (2005) Chronic cocaine administration switches corticotropin-releasing factor2 receptor-mediated depression to facilitation of glutamatergic transmission in the lateral septum. J Neurosci 25:577-583.
25. McDougall SJ, Widdop RE, and Lawrence AJ (2004) Medial prefrontal cortical integration of psychological stress in rats. Eur J Neurosci 20:2430-2440.
26. McPherson CS and Lawrence AJ (2006) Exposure to amphetamine in rats during periadolescence establishes behavioural and extrastriatal neural sensitization in adulthood. Int J Neuropsychopharmacol 9:377-392.
27. McPherson CS and Lawrence AJ (2007) The nuclear transcription factor CREB: involvement in addiction, deletion models and looking forward. Curr Neuropharmacol 5:202-212.
28. Miller CA and Marshall JF (2005) Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory. Neuron 47:873-884.
29. Nelson A and Killcross S (2006) Amphetamine exposure enhances habit formation. J. Neurosci 26:3805-3812.
30. Nestler EJ (2004) Molecular mechanisms of drug addiction. Neuropharmacology 47(Suppl 1):24-32.
31. Paulson PE, Camp DM, and Robinson TE (1991) Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats. Psychopharmacology (Berl) 103:480-492.
32. Paxinos G and Watson C (1986) The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, CA.
33. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, and Kilduff TS (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996-10015.
34. Pierce RC and Kalivas PW (1997) A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Brain Res Rev 25:192-216.
35. Sakurai T (2007) The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci 8:171-181.
36. Sax KW and Strakowski SM (2001) Behavioral sensitization in humans. J Addict Dis 20:55-65.
37. See RE, Fuchs RA, Ledford CC, and McLaughlin J (2003) Drug addiction, relapse, and the amygdala. Ann NY Acad Sci 985:294-307.
38. Shaywitz AJ and Greenberg ME (1999) CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68:821-861.
39. Sotomayor R, Forray MI, and Gysling K (2005) Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area. J Neurosci Res 81:132-139.
40. Turgeon SM, Pollack AE, and Fink JS (1997) Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization. Brain Res 749:120-126.
41. Uslaner JM, Norton CS, Watson SJ, Akil H, and Robinson TE (2003) Amphetamineinduced c-fos mRNA expression in the caudate-putamen and subthalamic nucleus: interactions between dose, environment, and neuronal phenotype. J Neurochem 85:105-114.