Role of acetyltransferases in the metabolism and carcinogenicity of aromatic amines

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 376, Issue 1-2, 1997, Pages 123-128

  King, Charles M ^a   Land, Susan J ^a   Jones, Richard F ^a   Debiec Rychter, Maria ^a   Lee, Mei Sie ^a   Wang, Ching Y ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Acelyltransferase; Aromatic amine; Arylalkylamine; Genotoxicity; Histological localization

Indexed keywords

ACYLTRANSFERASE; ARALKYLAMINE; AROMATIC AMINE;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; GENOTOXICITY; HISTOLOGY; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; XENOBIOTIC METABOLISM;

ACETYLATION; AMINES; ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; BIOTRANSFORMATION; CARCINOGENS; HUMANS; TISSUE DISTRIBUTION;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0031000414     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00034-1     Document Type: Article

References (23)

1. Allaben, W.T., C.E. Weeks, C.C. Weis, G.T. Burger and C.M. King (1982) Rat mammary gland carcinogenesis after local injection of N-hydroxy-N-acyl-2-aminfluorenes: relationship to metabolic activation, Carcinogenesis, 3, 233-240.
2. Allaben, W.T., C.C. Weis, N. Fullerton, and F.A. Beland (1983) Formation and persistence of DNA adducts from carcinogen N-hydroxy-2-acetylaminofluorene in rat mammary gland in vivo, Carcinogenesis, 4, 1067-1070.
3. Bartsch, H., M. Dworkin, J.A. Miller and E.C. Miller (1972) Electrophilic N-acetoxyaminoarenes derived from carcinogenic N-hydroxy-N-acetylaminoarenes by enzymatic deacetylation and transacetylation in liver, Biochim. Biophys. Acta, 286, 272-298.
4. Bartsch, H., D. Dworkin, E.C. Miller and J.A. Miller (1973) Formation of electrophilic N-acetoxyarylamines in cytosols from rat mammary gland and other tissues by transacetylation from the carcinogen N-hydroxy-4-acetylaminobiphenyl, Biochim. Biophys. Acta, 304, 42-55.
5. Beland, F.A., D.T. Beranek, K.L. Dooley, R.H. Heflich and F.F. Kadlubar (1983) Arylamine - DNA adducts in vitro and in vivo: their role in bacterial mutagenesis and urinary bladder carcinogenesis, Environ. Health Perspect., 49, 125-134.
6. Debiec-Rychter, M., S.J. Land and C.M. King (1996) Histological localization of messenger RNAs for rat acetyltransferases that acetylate serotonin and genotoxic arylamines, Cancer Res., 56, 1517-1525.
7. Flammang, T.J., J.G. Westra, F.F. Kadlubar and F.A. Beland (1985) DNA adducts formed from the probable proximate carcinogen, N-hydroxy-3,2′-dimethyl-4-aminobiphenyl, by acid catalysis or S-acetyl coenzyme A-dependent enzymatic esterification, Carcinogenesis, 6, 251-258.
8. Garner, R.C., C.N. Martin and D.B. Clayson (1984) Carcinogenic Aromatic Amines and Related Compounds, in: C. Searle (Ed.), Chemical Carcinogens, 2nd Edition, American Chemical Society, Washington, D.C., pp. 175-276.
9. Glowinski, I.B., W.W. Weber, J.M. Fysh, J.B. Vaught and C.M. King (1980) Evidence that arylhydroxamic acid N,O-acyltransferase and the genetically polymorphic N-acetyltransferase are properties of the same enzyme in rabbit liver, J. Biol. Chem., 255, 7883-7890.
10. Jones, R.F., S.J. Land and C.M. King (1996) Recombinant rat and hamster acetyltransferase-1 and -2: Relative rates of N-acetylation of arylamines and N,O-acyltransfer with arylhydroxamic acids, Carcinogenesis, 17, 1729-1733.
11. King, C.M. (1974) Mechanism of reaction, tissue distribution, and inhibition of arylhydroxamic acid acyltransferase, Cancer Res., 34, 1503-1515.
12. King, C.M., N.R. Traub, Z.M. Lortz and M.R. Thissen (1979) Metabolic activation of arylhydroxamic acids by N,O-acyltransferase of rat mammary gland, Cancer Res., 39, 3369-3372.
13. King, C.M. (1985) Metabolism and the 'Initiation' of Tumors by Chemicals, in: L.J. Marnett (Ed.), Arachidonic Acid Metabolism and Tumor Initiation, Martinus Nijhoff Publishing, Boston, MA, pp. 1-37.
14. King, C.M. and W.T. Allaben (1978) The role of arylhydroxamic acid N,O-acyltransferase in the carcinogenicity of aromatic amines, in: A. Aitio (Ed.), Conjugation Reactions in Drug Biotransformation, Elsevier, New York, pp. 431-441.
15. Kirlin, W.G., A. Trinidad, T. Yerokun, F. Ogolla, R.J. Ferguson, A.F. Andrews, P.K. Brady and D.W. Hein (1989) Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol, Cancer Res., 49, 2448-2454.
16. Land, S.J., K. Zukowski, M.-S. Lee, M. Debiec-Rychter, C.M. King and C.Y. Wang (1989) Metabolism of aromatic amines: Relationships of N-acetylation, O-acetylation, N,O-acetyltransfer and deacetylation in human liver and urinary bladder, Carcinogenesis, 10, 727-731.
17. Land, S.J., K. Zukowski, M.-S. Lee, C.Y. Wang and C.M. King (1993) Purification and characterization of a rat hepatic acetyltransferase that can metabolize aromatic amine derivatives, Carcinogenesis, 14, 1441-1449.
18. Land, S.J., R.F. Jones and C.M. King (1994) Biochemical and genetic analysis of two acetyltransferases from hamster tissues that can metabolize aromatic amine derivatives, Carcinogenesis, 15, 1585-1596.
19. Mattano, S.S., S. Land, C.M. King and W.W. Weber (1989) Purification and biochemical characterization of hepatic arylamine N-acetyltransferase from rapid and slow acetylator mice: Identity with arylhydroxamic acid N,O-acyltransferase and N-hydroxyarylamine O-acetyltransferase, Mol. Pharmacol., 35, 599-609.
20. Shirai, T., J.M. Fysh, M. Lee, J.B. Vaught and C.M. King (1981a) Relationship of metabolic activation of N-hydroxy-N-acylarylamines to biological response in the liver and mammary gland of the female CD rat, Cancer Res., 41, 4346-4353.
21. Shirai, T., M.-S. Lee, C.Y. Wang and C.M. King (1981b) Effects of partial hepatectomy and dietary phenobarbital on liver and mammary tumorigenesis by two N-hydroxy-N-acylaminobiphenyls in female CD rats, Cancer Res., 41, 2450-2456.
22. Trinidad, A., D.W. Hein, T.D. Rustan, R.J. Ferguson, L.S. Miller, K.D. Bucher, W.G. Kirlin, F. Ogolla and A.F. Andrews (1990) Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: Identity with polymorphic N-hydroxyarylamine-O-acetyltransferase, Cancer Res., 50, 7942-7949.
23. Weber, W.W. (1987) The Acetylator Genes and Drug Response, Oxford University Press, New York, NY.