메뉴 건너뛰기




Volumn 8, Issue 6, 2007, Pages 472-476

Central nervous system-acting agents and the treatment of erectile and sexual dysfunction

Author keywords

[No Author keywords available]

Indexed keywords

APOMORPHINE; MELANOTAN II; N ACETYLNORLEUCYLASPARTYLHISTIDYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLLYSINE 2,7 CYCLIC AMIDE; OXYTOCIN; PHOSPHODIESTERASE V INHIBITOR; SEROTONIN; SILDENAFIL; TRAZODONE; UNCLASSIFIED DRUG;

EID: 36348944580     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-007-0051-3     Document Type: Review
Times cited : (6)

References (38)
  • 1
    • 2442497286 scopus 로고    scopus 로고
    • Melanocortin receptors and erectile function
    • Excellent review of the clinical and basic science data associated with sexual function and the melanocortin system
    • Martin WJ, MacIntyre DE: Melanocortin receptors and erectile function. Eur Urol 2004, 45:706-713. Excellent review of the clinical and basic science data associated with sexual function and the melanocortin system.
    • (2004) Eur Urol , vol.45 , pp. 706-713
    • Martin, W.J.1    MacIntyre, D.E.2
  • 2
    • 0031805936 scopus 로고    scopus 로고
    • Central control of penile erection
    • McKenna KE. Central control of penile erection: Int J Impot Res 1998, 10:S25-S34.
    • (1998) Int J Impot Res , vol.10
    • McKenna, K.E.1
  • 3
    • 33745201018 scopus 로고    scopus 로고
    • CNS arousal mechanisms bearing on sex and other biologically regulated behaviors
    • Devidze N, Lee AW, Zhou J, Pfaff DW: CNS arousal mechanisms bearing on sex and other biologically regulated behaviors. Physiol Behav 2006, 88:283-293.
    • (2006) Physiol Behav , vol.88 , pp. 283-293
    • Devidze, N.1    Lee, A.W.2    Zhou, J.3    Pfaff, D.W.4
  • 4
    • 0034130955 scopus 로고    scopus 로고
    • Central neural regulation of penile erection
    • Giuliano F, Rampin O: Central neural regulation of penile erection. Neurosci Biobehav Rev, 24:517-533.
    • Neurosci Biobehav Rev , vol.24 , pp. 517-533
    • Giuliano, F.1    Rampin, O.2
  • 5
    • 15844370516 scopus 로고    scopus 로고
    • Physiology of female sexual function: Animal models
    • Giraldi A, Marson L, Nappi R, et al.: Physiology of female sexual function: animal models. J Sex Med 2004, 1:237-253.
    • (2004) J Sex Med , vol.1 , pp. 237-253
    • Giraldi, A.1    Marson, L.2    Nappi, R.3
  • 6
    • 22744447482 scopus 로고    scopus 로고
    • Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus
    • Argiolas A, Melis MR. Central control of penile erection: role of the paraventricular nucleus of the hypothalamus. Prog Neurobiol 2005, 76:1-21.
    • (2005) Prog Neurobiol , vol.76 , pp. 1-21
    • Argiolas, A.1    Melis, M.R.2
  • 7
    • 34548818179 scopus 로고    scopus 로고
    • Melanocortin receptors, melanotropic peptides, and penile erection
    • King SH, Mayorov AV, Balse-Srinivasan P, et al.: Melanocortin receptors, melanotropic peptides, and penile erection. Curr Top Med Chem 2007, 7:1111-1119.
    • (2007) Curr Top Med Chem , vol.7 , pp. 1111-1119
    • King, S.H.1    Mayorov, A.V.2    Balse-Srinivasan, P.3
  • 8
    • 33644856126 scopus 로고    scopus 로고
    • Oxytocin - anatomy and functional assignments: A minireview
    • Kiss A, Mikkelsen JD: Oxytocin - anatomy and functional assignments: a minireview. Endocr Regul 2005, 39:97-105.
    • (2005) Endocr Regul , vol.39 , pp. 97-105
    • Kiss, A.1    Mikkelsen, J.D.2
  • 9
    • 3042741857 scopus 로고    scopus 로고
    • What can animal models tell us about human sexual response?
    • Pfaus JG, Kippin TE, Coria-Avila G: What can animal models tell us about human sexual response? Annu Rev Sex Res 2003, 14:1-63.
    • (2003) Annu Rev Sex Res , vol.14 , pp. 1-63
    • Pfaus, J.G.1    Kippin, T.E.2    Coria-Avila, G.3
  • 10
    • 3142584047 scopus 로고    scopus 로고
    • Has dopamine a physiological role in the control of sexual behavior? A critical review of the evidence
    • Paredes RG, Agmo A: Has dopamine a physiological role in the control of sexual behavior? A critical review of the evidence. Prog Neurobiol 2004, 73:179-226.
    • (2004) Prog Neurobiol , vol.73 , pp. 179-226
    • Paredes, R.G.1    Agmo, A.2
  • 11
    • 5444225659 scopus 로고    scopus 로고
    • Dopamine and serotonin: Influences on male sexual behavior
    • Hull EM, Muschamp JW, Sato S: Dopamine and serotonin: influences on male sexual behavior. Physiol Behav 2004, 83:291-307.
    • (2004) Physiol Behav , vol.83 , pp. 291-307
    • Hull, E.M.1    Muschamp, J.W.2    Sato, S.3
  • 12
    • 0036193045 scopus 로고    scopus 로고
    • Apomorphine SL (Uprima): Preclinical and clinical experiences learned from the first central nervous system-acting ED drug
    • Giuliano F, Allard J: Apomorphine SL (Uprima): preclinical and clinical experiences learned from the first central nervous system-acting ED drug. Int J Impot Res 2002, 14:S53-S556.
    • (2002) Int J Impot Res , vol.14
    • Giuliano, F.1    Allard, J.2
  • 13
    • 0035258441 scopus 로고    scopus 로고
    • Key issues from the clinical trials of apomorphine SL
    • Heaton JP. Key issues from the clinical trials of apomorphine SL. World J Urol 2001, 19:25-31.
    • (2001) World J Urol , vol.19 , pp. 25-31
    • Heaton, J.P.1
  • 14
    • 0034916235 scopus 로고    scopus 로고
    • Double-blind, crossover comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL in male erectile dysfunction
    • discussion 564
    • Dula E, Bukofzer S, Perdok R, George M: Double-blind, crossover comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL in male erectile dysfunction. Eur Urol 2001, 39:558-553; discussion 564.
    • (2001) Eur Urol , vol.39 , pp. 558-553
    • Dula, E.1    Bukofzer, S.2    Perdok, R.3    George, M.4
  • 15
    • 0034878165 scopus 로고    scopus 로고
    • An open-label, uncontrolled dose-optimization study of sublingual apomorphine in erectile dysfunction
    • Mulhall JP, Bukofzer S, Edmonds AL, George M: An open-label, uncontrolled dose-optimization study of sublingual apomorphine in erectile dysfunction. Clin Ther 2001, 23:1260-1271.
    • (2001) Clin Ther , vol.23 , pp. 1260-1271
    • Mulhall, J.P.1    Bukofzer, S.2    Edmonds, A.L.3    George, M.4
  • 16
    • 0036223259 scopus 로고    scopus 로고
    • A European multicentre study to evaluate the tolerability of apomorphine sublingual administered in a forced dose-escalation regimen in patients with erectile dysfunction
    • Von Keitz AT, Stroberg P, Bukofzer S, et al.: A European multicentre study to evaluate the tolerability of apomorphine sublingual administered in a forced dose-escalation regimen in patients with erectile dysfunction. BJU Int 2002, 89:409-415.
    • (2002) BJU Int , vol.89 , pp. 409-415
    • Von Keitz, A.T.1    Stroberg, P.2    Bukofzer, S.3
  • 17
    • 33947151071 scopus 로고    scopus 로고
    • Comparative trial of treatment satisfaction, efficacy and tolerability of sildenafil versus apomorphine in erectile dysfunction - an open, randomized cross-over study with flexible dosing
    • Porst H, Behre HM, Jungwirth A, Burkart M: Comparative trial of treatment satisfaction, efficacy and tolerability of sildenafil versus apomorphine in erectile dysfunction - an open, randomized cross-over study with flexible dosing. Eur J Med Res 2007, 12:61-67.
    • (2007) Eur J Med Res , vol.12 , pp. 61-67
    • Porst, H.1    Behre, H.M.2    Jungwirth, A.3    Burkart, M.4
  • 18
    • 2942754237 scopus 로고    scopus 로고
    • Eardley I, Wright P, MacDonagh R, et al.: An open-label, randomized, flexible-dose, crossover study to assess the comparative efficacy and safety of sildenafil citrate and apomorphine hydrochloride in men with erectile dysfunction. BJU Int 2004, 93:1271-1275. Controlled trial of PDE5 inhibitor sildenafil in comparison with CNS stimulant apomorphine in clinical treatment of ED in a real-world setting.
    • Eardley I, Wright P, MacDonagh R, et al.: An open-label, randomized, flexible-dose, crossover study to assess the comparative efficacy and safety of sildenafil citrate and apomorphine hydrochloride in men with erectile dysfunction. BJU Int 2004, 93:1271-1275. Controlled trial of PDE5 inhibitor sildenafil in comparison with CNS stimulant apomorphine in clinical treatment of ED in a real-world setting.
  • 19
    • 0032323804 scopus 로고    scopus 로고
    • Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Double-blind, placebo controlled crossover study
    • Wessells H, Fuciarelli K, Hansen J, et al.: Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. J Urol 1998, 160:389-393.
    • (1998) J Urol , vol.160 , pp. 389-393
    • Wessells, H.1    Fuciarelli, K.2    Hansen, J.3
  • 20
    • 0242418191 scopus 로고    scopus 로고
    • Ac-Nle-c[Asp-His-DPhe-Arg- Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors
    • Wessells H, Hruby VJ, Hackett J, et al.: Ac-Nle-c[Asp-His-DPhe-Arg- Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors. Neuroscience 2003, 118:755-762.
    • (2003) Neuroscience , vol.118 , pp. 755-762
    • Wessells, H.1    Hruby, V.J.2    Hackett, J.3
  • 21
    • 34447261924 scopus 로고    scopus 로고
    • Melanocortins in the treatment of male and female sexual dysfunction
    • Best and most up-to-date review of the melanocortins and clinical and laboratory evidence for their effectiveness in the treatment of sexual dysfunction
    • Shadiack AM, Sharma SD, Earle DC, et al.: Melanocortins in the treatment of male and female sexual dysfunction. Curr Top Med Chem 2007, 7:1137-1144. Best and most up-to-date review of the melanocortins and clinical and laboratory evidence for their effectiveness in the treatment of sexual dysfunction.
    • (2007) Curr Top Med Chem , vol.7 , pp. 1137-1144
    • Shadiack, A.M.1    Sharma, S.D.2    Earle, D.C.3
  • 22
    • 1642483808 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction
    • Diamond LE, Earle DC, Rosen RC, et al.: Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. Int J Impot Res 2004, 16:51-59.
    • (2004) Int J Impot Res , vol.16 , pp. 51-59
    • Diamond, L.E.1    Earle, D.C.2    Rosen, R.C.3
  • 23
    • 2342453337 scopus 로고    scopus 로고
    • Rosen RC, Diamond LE, Earle DC, et al.: Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res 2004, 16:135-142. Trial of CNS agent bremelanotide in men poorly responsive to sildenafil. Responses suggest place for this agent in the treatment of severe ED and as a supplement for PDE5 inhibitor failure.
    • Rosen RC, Diamond LE, Earle DC, et al.: Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res 2004, 16:135-142. Trial of CNS agent bremelanotide in men poorly responsive to sildenafil. Responses suggest place for this agent in the treatment of severe ED and as a supplement for PDE5 inhibitor failure.
  • 24
    • 4143081589 scopus 로고    scopus 로고
    • Control of penile erection by the melanocortinergic system: Experimental evidences and therapeutic perspectives
    • Giuliano F: Control of penile erection by the melanocortinergic system: experimental evidences and therapeutic perspectives. J Androl 2004, 25:683-691.
    • (2004) J Androl , vol.25 , pp. 683-691
    • Giuliano, F.1
  • 25
    • 85047698627 scopus 로고    scopus 로고
    • Sniffing neuropeptides: A transnasal approach to the human brain
    • Born J, Lange T, Kern W, et al.: Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neurosci 2002, 5:514-516.
    • (2002) Nat Neurosci , vol.5 , pp. 514-516
    • Born, J.1    Lange, T.2    Kern, W.3
  • 26
    • 0038051139 scopus 로고    scopus 로고
    • MT-II induces penile erection via brain and spinal mechanisms
    • Wessells H, Hruby VJ, Hackett J, et al.: MT-II induces penile erection via brain and spinal mechanisms. Ann N Y Acad Sci 2003, 994:90-95.
    • (2003) Ann N Y Acad Sci , vol.994 , pp. 90-95
    • Wessells, H.1    Hruby, V.J.2    Hackett, J.3
  • 27
    • 17144389402 scopus 로고    scopus 로고
    • Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response
    • Diamond LE, Earle DC, Garcia WD, Spana C: Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response. Urology 2005, 65:755-759.
    • (2005) Urology , vol.65 , pp. 755-759
    • Diamond, L.E.1    Earle, D.C.2    Garcia, W.D.3    Spana, C.4
  • 28
    • 33745230160 scopus 로고    scopus 로고
    • An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist
    • First reported trial of the effect of the CNS agent bremelanotide and sexual dysfunction in women. Suggests a place for these agents in the treatment of FSD
    • Diamond LE, Earle DC, Heiman JR, et al.: An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist. J Sex Med 2006, 3:628-638. First reported trial of the effect of the CNS agent bremelanotide and sexual dysfunction in women. Suggests a place for these agents in the treatment of FSD.
    • (2006) J Sex Med , vol.3 , pp. 628-638
    • Diamond, L.E.1    Earle, D.C.2    Heiman, J.R.3
  • 29
    • 33745252614 scopus 로고    scopus 로고
    • Oxytocin - its role in male reproduction and new potential therapeutic uses
    • Thackare H, Nicholson HD, Whittington K: Oxytocin - its role in male reproduction and new potential therapeutic uses. Hum Reprod Update 2006, 12:437-448.
    • (2006) Hum Reprod Update , vol.12 , pp. 437-448
    • Thackare, H.1    Nicholson, H.D.2    Whittington, K.3
  • 30
    • 33846879393 scopus 로고    scopus 로고
    • Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin
    • Succu S, Sanna F, Melis T, et al.: Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: involvement of central oxytocin. Neuropharmacology 2007, 52:1034-1043.
    • (2007) Neuropharmacology , vol.52 , pp. 1034-1043
    • Succu, S.1    Sanna, F.2    Melis, T.3
  • 31
    • 33646133643 scopus 로고    scopus 로고
    • Vasopressin interactions with oxytocin in the control of female sexual behavior
    • Pedersen CA, Boccia ML: Vasopressin interactions with oxytocin in the control of female sexual behavior. Neuroscience 2006, 139:843-851.
    • (2006) Neuroscience , vol.139 , pp. 843-851
    • Pedersen, C.A.1    Boccia, M.L.2
  • 32
    • 0023840023 scopus 로고
    • Priapism associated with trazodone therapy
    • Carson CC 3rd, Mino RD: Priapism associated with trazodone therapy. J Urol 1988, 139:369-370.
    • (1988) J Urol , vol.139 , pp. 369-370
    • Carson 3rd, C.C.1    Mino, R.D.2
  • 33
    • 0030824364 scopus 로고    scopus 로고
    • Trazodone, a double blind trial for treatment of erectile dysfunction
    • Meinhardt W, Schmitz PI, Kropman RF, et al.: Trazodone, a double blind trial for treatment of erectile dysfunction. Int J Impot Res 1997, 9:163-165.
    • (1997) Int J Impot Res , vol.9 , pp. 163-165
    • Meinhardt, W.1    Schmitz, P.I.2    Kropman, R.F.3
  • 34
    • 36348992750 scopus 로고    scopus 로고
    • Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons
    • Mar 28 [Epub ahead of print
    • Lee JJ, Hahm ET, Lee CH, Cho YW: Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons. Neuropsychopharmacology 2007, Mar 28 [Epub ahead of print].
    • (2007) Neuropsychopharmacology
    • Lee, J.J.1    Hahm, E.T.2    Lee, C.H.3    Cho, Y.W.4
  • 35
    • 34249294441 scopus 로고    scopus 로고
    • Sexual behavior in male rodents
    • Hull EM, Dominguez JM: Sexual behavior in male rodents. Horm Behav 2007, 52:45-55.
    • (2007) Horm Behav , vol.52 , pp. 45-55
    • Hull, E.M.1    Dominguez, J.M.2
  • 36
    • 36348978284 scopus 로고    scopus 로고
    • Song Y, Rajasekaran M: Characterization of hippocampal glutamate receptor subtypes in the central regulation of penile erection. J Urol 2004, (Suppl 380) [abstract 1442(171)].
    • Song Y, Rajasekaran M: Characterization of hippocampal glutamate receptor subtypes in the central regulation of penile erection. J Urol 2004, (Suppl 380) [abstract 1442(171)].
  • 37
    • 0034666561 scopus 로고    scopus 로고
    • EP 60761 and EP 50885, two hexarelin analogues, induce penile erection in rats
    • Melis MR, Succu S, Spano MS, et al.: EP 60761 and EP 50885, two hexarelin analogues, induce penile erection in rats. Eur J Pharmacol 2000, 404:137-143.
    • (2000) Eur J Pharmacol , vol.404 , pp. 137-143
    • Melis, M.R.1    Succu, S.2    Spano, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.