Oxytocin - Its role in male reproduction and new potential therapeutic uses

Human Reproduction Update

Volumn 12, Issue 4, 2006, Pages 437-448

  Thackare, Hemlata ^a   Nicholson, Helen D ^b   Whittington, Kate ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Cell growth; Male reproductive pathology; Oxytocin; Reproductive tract contractility; Steroidogenesis

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; ADRENERGIC RECEPTOR STIMULATING AGENT; ANDROGEN; ANDROSTANOLONE; ANTIANDROGEN; NALOXONE; OPIATE ANTAGONIST; OPIATE RECEPTOR; OXYTOCIN; OXYTOCIN RECEPTOR; SEROTONIN AGONIST; SEROTONIN UPTAKE INHIBITOR; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ANDROGEN METABOLISM; CELL GROWTH; CELL PROLIFERATION; CLINICAL TRIAL; DEPRESSION; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG TISSUE LEVEL; EJACULATION; EJACULATION DISORDER; ENZYME ACTIVITY; EPIDIDYMIS; HORMONE ACTION; HORMONE DETERMINATION; HORMONE RELEASE; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; MALE; MALE INFERTILITY; MUSCLE CONTRACTION; MUSCLE EXCITATION; NEUROHYPOPHYSIS; NONHUMAN; OXYTOCIN BLOOD LEVEL; PARACRINE SIGNALING; PATHOGENESIS; PENILE BLOOD FLOW; PENIS ERECTION; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; SEMINIFEROUS TUBULE; SEXUAL BEHAVIOR; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MIGRATION; STEROIDOGENESIS; SYSTEMIC CIRCULATION; TESTIS; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ANIMALS; CELL PROLIFERATION; GENITALIA, MALE; HUMANS; INFERTILITY, MALE; MALE; MUSCLE CONTRACTION; OXYTOCIN; PROSTATIC HYPERPLASIA; RECEPTORS, OXYTOCIN; REPRODUCTION; SEXUAL BEHAVIOR; STEROIDS;

EID: 33745252614     PISSN: 13554786     EISSN: 14602369     Source Type: Journal    
DOI: 10.1093/humupd/dmk002     Document Type: Review

References (128)

1. Abrahamsson PA (1999) Neuroendocrine differentiation in prostatic carcinoma. Prostate 39,135-148.
2. Acher R and Chauvet J (1995) The neurohypophysial endocrine regulatory cascade: Precursors, mediators, receptors, and effectors. Front Neuroendocrinol 16,237-289.
3. Adashi EY and Hsueh AJ (1981) Direct inhibition of testicular androgen biosynthesis by arginine-vasopressin: Mediation through pressor-selective testicular recognition sites. Endocrinology 109,1793-1795.
4. Agmo A, Andersson R and Johansson C (1978) Effect of oxytocin on sperm numbers in spontaneous rat ejaculates. Biol Reprod 18,346-349.
5. Ang HL, Ungofroren H, De Bree F, Foo NC, Carter D, Burbach JP, Ivell R and Murphy D (1991) Testicular oxytocin gene expression in seminiferous tubules of cattle and transgenic mice. Endocrinology 128,2110-2117.
6. Ang HL, Ivell R, Walther N, Nicholson H, Ungefroren H, Millar M, Carter D and Murphy D (1994) Over-expression of oxytocin in the testis of a transgenic mouse model. J Endocrinol 140,53-62.
7. Argiolas A (1992) Oxytocin stimulation of penile erection. Pharmacology, site, and mechanism of action. Ann N Y Acad Sci 12,194-203.
8. Armstrong DT and Hansel W (1958) Effects of hormone treatment on testis development and pituitary function. Int J Fertil 3,296-306.
9. Assinder SJ and Nicholson NH (2004) Effects of steroids on oxytocin secretion by the human prostate in vitro. Int J Androl 27,12-18.
10. Assinder SJ, Carey M, Parkinson T and Nicholson HD (2000) Oxytocin and vasopressin expression in the ovine testis and epididymis: Changes with the onset of spermatogenesis. Biol Reprod 63,448-456.
11. Assinder SJ, Rezvani A and Nicholson HD (2002) Oxytocin promotes spermiation and sperm transfer in the mouse. Int J Androl 25,19-27.
12. Assinder SJ, Johnson C, King K and Nicholson HD (2004) Regulation of 5alpha-reductase isoforms by oxytocin in the rat ventral prostate. Endocrinology 145,5767-5773.
13. Barberis C, Mouillac B and Durroux T (1998) Structural bases of vasopressin/ oxytocin receptor function. J Endocrinol 156,223-229.
14. Bathgate RAD and Sernia C (1994) Characterisation and localisation of oxytocin receptors in the rat testis. J Endocrinol 141,343-352.
15. Berndtson WE and Igboeli G (1988) Spermatogenesis, sperm output and seminal quality of Holstein bulls electroejaculated after administration of oxytocin. J Reprod Fertil 82,467-475.
16. Berry SJ, Coffey DS, Walsh PC and Ewing LL (1984) The development of benign prostatic hyperplasia with age. J Urol 132,343-352.
17. Bitran D and Hull EM (1987) Pharmacological analysis of male rat sexual behaviour. Neurosci Biobehav Rev 11,365-389.
18. Bodanszky M, Sharaf H, Roy JB and Said SI (1992) Contractile activity of vasotocin, oxytocin and vasopressin on mammalian prostate. Eur J Pharmacol 216,311-313.
19. Bussolati G, Cassoni P, Ghisolfi G, Negro, F and Sapino, A (1996) Immunolocalization and gene expression of oxytocin receptors in carcinomas and non-neoplastic tissues of the breast. Am J Pathol 148,1895-1903.
20. Byrne M, Rolf C, Depenbusch M, Cooper TG and Nieschlag E (2003) Lack of effect of a single i.v. dose of oxytocin on sperm output in severely oligozoospermic men. Hum Reprod 18,2098-2102.
21. Caine M, Raz S and Zeigler M (1975) Adrenergic and cholinergic receptors in the human prostate, prostatic capsule and bladder neck. Br J Urol 47,193-202.
22. Cantor JM, Binik YM and Pfaus JG (1999) Chronic fluoxetine inhibits sexual behaviour in the male rat: Reversal with oxytocin. Psychopharmacology (Berl) 144,355-362.
23. Carmichael MS, Humbert R, Dixen J, Palmisano G, Greenleaf W and Davidson JM (1987) Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab 64,27-31.
24. Carmichael MS, Warburton VL, Dixen J and Davidson JM (1994) Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activity. Arch Sex Behav 23,59-79.
25. Cassoni P, Sapino A, Negro F and Bussolati G (1994) Oxytocin inhibits proliferation of human breast cancer cell lines. Virchows Arch 425,467-472.
26. Cassoni P, Marrocco T, Deaglio S, Sapino A and Bussolati G (2001) Biological relevance of oxytocin and oxytocin receptors in cancer cells and primary tumours. Ann Oncol 12(Suppl. 2),S37-S39.
27. Cassoni P, Catalano MG, Sapino A, Marrocco T, Fazzari A, Bussolati G and Fortunati N (2002) Oxytocin modulates estrogen receptor alpha expression and function in MCF7 human breast cancer cells. Int J Oncol 21,375-378.
28. Chard T (1989) Fetal and maternal oxytocin in human parturition. Am J Perinatol 2,145-152.
29. Chini B, Mouillac B, Balestre MN, Trumpp-Kallmeyer S, Hoflack J, Hibert M, Andriolo M, Pupier S, Jard S and Barberis C (1996) Two aromatic residues regulate the response of the human oxytocin receptor to the partial agonist arginine vasopressin. FEBS Lett 397,201-206.
30. Davies P and Eaton CL (1991) Regulation of prostate growth. J Endocrinol 131,5-17.
31. Debackere M, Verbeke R, Lauryssens M and Peeters G (1961) Influence of oxytocin in the male rat. Arch Int Pharmacodyn Ther 1,476-477.
32. De Groot AN, Vree TB, Hekster YA, Pesman GJ, Sweep FC, Van Dongen PJ and Van Roosmalei J (1995) Bioavailability and pharmacokinetics of sublingual oxytocin in male volunteers. J Pharm Pharmacol 47,571-575.
33. Einspanier A and Ivell R (1997) Oxytocin and oxytocin receptor expression in reproductive tissues of the male marmoset monkey. Biol Reprod 56,416-422.
34. Evans JJ, Youssef AH, Abbas MM and Schwartz J (1999) GnRH and oxytocin have nonidentical effects on the cellular LH response by gonadotrophs at pro-oestrus. J Endocrinol 163,345-351.
35. Filippi S, Luconi M, Granchi S, Vignozzi L, Bettuzzi S, Tozzi P, Ledda F, Forti G and Maggi M (2002a) Estrogens, but not androgens, regulate expression and functional activity of oxytocin receptor in rabbit epididymis. Endocrinology 143,4271-4280.
36. Filippi S, Vannelli GB, Granchi S, Luconi M, Crescioli C, Mancina R, Natali A, Brocchi S, Vignozzi L, Bencini E et al. (2002b) Identification, localisation and functional activity of oxytocin receptors in epididymis. Mol Cell Endocrinol 193,89-100.
37. Filippi S, Morelli A, Vignozzi L, Vannelli GB, Marini M, Ferruzzi P, Mancina R, Crescioli C, Mondaini N, Forti G et al. (2005) Oxytocin mediates the estrogen-dependent contractile activity of endothelin-1 in human and rabbit epididymis. Endocrinology 146,3506-3517.
38. Fink JW, McLeod BJ, Assinder SJ, Parry LJ and Nicholson HD (2005) Seasonal changes in mesotocin and localisation of its receptor in the prostate of the bushtail possum (Trichosurus vulpecula) Biol Reprod 72,470-478.
39. Foo NC, Carter D, Murphy D and Ivell R (1991) Vasopressin and oxytocin gene expression in rat testis. Endocrinology 128,2118-2128.
40. Frayne J and Nicholson HD (1995) Effect of oxytocin on testosterone production by isolated rat Leydig cells is mediated via a specific oxytocin receptor. Biol Reprod 52,1268-1273.
41. Frayne J and Nicholson HD (1998) Localization of oxytocin receptors in the human and macaque monkey male reproductive tracts: Evidence for a physiological role of oxytocin in the male. Mol Hum Reprod 4,527-532.
42. Frayne J, Townsend D and Nicholson HD (1996) Effects of oxytocin on sperm transport in the pubertal rat. J Reprod Fertil 107,299-306.
43. Fuchs AR, Husslein P and Fuchs F (1981) Oxytocin and the initiation of human parturition. II. Stimulation of prostaglandin production in human decidua by oxytocin. Am J Obstet Gynecol 141,694-697.
44. Gerendai I and Csernus V (1995) Effect of intratesticular administration of oxytocin on testicular steroidogenesis in immature rats. Andrologia 27,291-297.
45. Gimpl G and Fahrenholz F (2000) Human oxytocin receptors in cholesterol-rich vs. cholesterol-poor microdomains of the plasma membrane. Eur J Biochem 267,2483-2497.
46. Gimpl G and Fahrenholz F (2001) The oxytocin receptor system: Structure, function, and regulation. Physiol Rev 81,629-683.
47. Guzzi F, Zanchetta D, Chini B and Parenti M (2001) Thioacetylation is required for targeting G-protein gubunit G (olalpha) to detergent-insoluble caveolin-containing membrane domains. Biochem J 355(Pt 2),323-331.
48. Guzzi F, Zanchetta D, Cassoni P, Guzzi V, Francolini M, Parenti M and Chini B (2002) Localization of the human oxytocin receptor in caveolin-1 enriched domains turns the receptor-mediated inhibition of cell growth into a proliferative response. Oncogene 21,1658-1667.
49. Hargrove JL, MacIndoe JH and Ellis LC (1977) Testicular contractile cells and sperm transport. Fertil Steril 28,1146-1157.
50. Harris GC and Nicholson HD (1998a) Stage-related differences in rat seminiferous tubule contractility in vitro and their response to oxytocin. J Endocrinol 157,251-257.
51. Harris GC and Nicholson HD (1998b) Characterisation of the biological effects of neurohypophysial peptides on seminiferous tubules. J Endocrinol 156,35-42.
52. Harris GC, Frayne J and Nicholson HD (1996) Epididymal oxytocin in the rat; its origin and regulation. Int J Androl 19,278-286.
53. Hib J (1974) The in vitro effects of oxytocin and vasopressin on the spontaneous contractility of the mouse cauda epididymis. Biol Reprod 11,436-439.
54. Hib J (1977) The 'in vivo' effects of oxytocin and vasopressin on spontaneous contractility of the rat epididymis. Int J Fertil 22,63-64.
55. Howl J, Rudge SA, Lavis RA, Davies AR, Parslow RA, Hughes PJ, Kirk CJ, Michell RH and Wheatley M (1995) Rat testicular myoid cells express vasopressin receptors: Receptor structure, signal transduction, and developmental regulation. Endocrinology 136,2206-2213.
56. Hughes AM, Everitt BJ, Lightman SL and Todd K (1987) Oxytocin in the central nervous system and sexual behaviour in male rats. Brain Res 414,133-137.
57. Inaba T, Nakayama Y, Tani H, Tamada H, Kawate N and Sawada T (1999) Oxytocin gene expression and action in goat testis. Theriogenology 52,425-434.
58. Ivell R and Richter D (1984) Structure and comparison of the oxytocin and vasopressin genes from rat. Proc Natl Acad Sci USA 81,2006-2010.
59. Ivell R, Furuya K, Brackmann B, Dawood Y and Khan-Dawood F (1990) Expression of the oxytocin and vasopressin genes in human and baboon gonadal tissues. Endocrinology 127,2990-2996.
60. Ivell R, Balvers M, Rust W, Bathgate R and Einspanier A (1997) Oxytocin and male reproductive function. Adv Exp Med Biol 424,253-264.
61. Jenkin L and Nicholson HD (1999) Evidence for the regulation of prostatic oxytocin by gonadal steroids in the rat. J Androl 20,80-87.
62. Kamischke A and Nieschlag E (1999) Analysis of medical treatment of male infertility. Hum Reprod 14(Suppl. 1), 1-23.
63. Kimura T, Tanizawa O, Mori K, Brownstein MJ and Okayama H (1992) Structure and expression of a human oxytocin receptor. Nature 356,526-529.
64. Knickerbocker JJ, Sawyer HR, Amann RP, Tekpetey FR and Niswender GD (1988) Evidence for the presence of oxytocin in the ovine epididymis. Biol Reprod 39,391-397.
65. Knight TW (1974) A qualitative study of factors affecting the contractions of the epididymis and ductus deferens of the ram. J Reprod Fertil 40,19-29.
66. Ku CY, Qian A, Wen Y, Anwer K and Sanborn BM (1995) Oxytocin stimulates myometrial guanosine triphosphatase and phospholipase-C activities via coupling to G alpha q/11. Endocrinology 136,1509-1515.
67. Kwan TK and Gower DB (1988) Inhibition of rat testicular microsomal steroidogenesis by oxytocin and metyrapone. Biochem Int 16,629-637.
68. Land H, Grez M, Ruppert S, Schmale H, Rehbein M, Richter D and Schutz G (1983) Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA. Nature 302,342-344.
69. Luke MC and Coffey DS (1994) The male sex accessory tissues. In Knobil E and Neill JD (eds), The Physiology of Reproduction. Raven Press, New York, pp. 1435-1487.
70. Maggi M, Malozowski S, Kassis S, Guardabasso V and Rodbard D (1987) Identification and characterisation of two classes of receptors for oxytocin and vasopressin in porcine tunica albuginea, epididymis and vas deferens. Endocrinology 120,986-994.
71. Mahalati K, Okanoya K, Witt DM and Carter CS (1991) Oxytocin inhibits male sexual behaviour in prairie voles. Pharmacol Biochem Behav 39,219-222.
72. Marshall I, Burt RP, Green GM, Hussain MB and Chapple CR (1996) Different subtypes of a-adrenoreceptor mediating contraction of rat epdidymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonists RS 17053. Br J Pharmacol 119,407-415.
73. McCracken JA, Custer EE and Lamsa JC (1999) Luteolysis: A neuroendocrinemediated event. Physiol Rev 79,263-323.
74. Melis MR, Argiolas A and Gessa GL (1986) Oxytocin-induced penile erection and yawning: Site of action in the brain. Brain Res 398,259-265.
75. Mitchell BF, Fang X and Wong S (1998) Oxytocin: A paracrine hormone in the regulation of parturition? Rev Reprod 3,113-122.
76. Mohr E, Schmitz E and Richter D (1988) A single rat genomic fragment encodes both the oxytocin and vasopressin genes separated by 11 kilobases and orientated in opposite transcriptional directions. Biochimie 70,649-654.
77. Moore HDM (1995) Post-testicular sperm maturation and transport in the excurrent ducts. In Grudzinskas JG and Yovich JL (eds) Gametes - The Spermatozoon (Cambridge Reviews in Human Reproduction, Press Syndicate of the University of Cambridge). Cambridge University Press, Cambridge, pp. 140-156.
78. Morita T, Shibata K, Kikkawa F, Kajiyama H, Ino K and Mizutani S (2004) Oxytocin inhibits the progression of human ovarian carcinoma cells in vitro and in vivo. Int J Cancer 109,525-532.
79. Murphy MR, Seckl JR, Burton S, Checkley SA and Lightman SL (1987) Changes in oxytocin and vasopressin secretion during sexual activity in men. J Clin Endocrinol Metab 65,738-741.
80. Murphy MR, Checkley SA, Seckl JR and Lightman SL (1990) Naloxone inhibits oxytocin release at orgasm in man. J Clin Endocrinol Metab 71,1056-1058.
81. Nicholson HD (1996) Oxytocin: A paracrine regulator of prostatic function. Rev Reprod 1,69-72.
82. Nicholson HD and Hardy MP (1992) Luteinising hormone differentially regulates the secretion of testicular oxytocin and testosterone by purified rat Leydig cells in vitro. Endocrinology 130,671-677.
83. Nicholson HD and Jenkin L (1994) 5α-reductase activity is increased by oxytocin in the rat testis. In Bartke A (ed.) Function of Somatic cells in the Testis. Springer Verlag, New York, 278-285.
84. Nicholson H and Jenkin L (1995) Oxytocin and prostatic function. Adv Exp Med Biol 395,529-538.
85. Nicholson HD, Swann RW, Burford GD, Wathes DC, Porter DG and Pickering BT (1984) Identification of oxytocin and vasopressin in the testis and in adrenal tissue. Regul Pept 8,141-146.
86. Nicholson HD, Worley RT, Guldenaar SE and Pickering BT (1987) Ethan-1,2-dimethanesulphonate reduces testicular oxytocin content and seminiferous tubule movements in the rat. J Endocrinol 112,311-316.
87. Nicholson HD, Guldenaar SE, Boer GJ and Pickering BT (1991) Testicular oxytocin: Effects of intratesticular oxytocin in the rat. J Endocrinol 130,231-238.
88. Nicholson HD, Parkinson TJ and Lapwood KR (1999) Effects of oxytocin and vasopressin on sperm transport from the cauda epididymis in sheep. J Reprod Fertil 117,299-305.
89. Niemi M and Kormano M (1965) Histochemical demonstration of a C-esterase activity in the seminiferous tubules of the rat testis. J Reprod Fertil 10,49-54.
90. Nishimori K, Young LJ, Guo Q, Wang Z, Insel TR and Matzuk MM (1996) Oxytocin is required for nursing but is not essential for parturition or reproductive behaviour. Proc Natl Acad Sci USA 93,11699-11704.
91. Oakley RH, Laporte SA, Holt JA, Barak LS and Caron MG (2001) Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis. J Biol Chem 276,19452-19460.
92. Ogawa S, Kudo S, Kitsunai Y and Fukuchi S (1980) Increase in oxytocin secretion at ejaculation in male. Clin Endocrinol (Oxf) 13,95-97.
93. Parry LJ and Bathgate ADR (1998) Mesotocin receptor gene and protein expression in the prostate gland but not testis of Tammar wallaby, Macropus eugenii. Biol Reprod 59,1101-1107.
94. Pequeux C, Breton C, Hendrick JC, Hagelstein MT, Martens H, Winkler R, Geenen V and Legros JJ (2002) Oxytocin synthesis and oxytocin receptor expression by cells of human small cell carcinoma of the lung stimulate tumour growth through autocrine/paracrine signalling. Cancer Res 62,4623-4629.
95. Petersson M, Lagumdzija A, Stark A and Bucht E (2002) Oxytocin stimulates proliferation of human osteoblast-like cells. Peptides 23,1121-1126.
96. Phaneuf S, Europe-Finner GN, Varney M, MacKenzie IZ, Watson SP and Lopez Bernal A (1993) Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: Involvement of pertussis toxin-sensitive and - insensitive G-proteins. J Endocrinol 136,497-509.
97. Pickering BT, Ayad VJ, Birkett SD, Gilbert CL, Guldenaar SE, Nicholson HD, Worley RT and Wathes DC (1990) Neurohypophysial peptides in the gonads: Are they real and do they have a function? Reprod Fertil Dev 2,245-246.
98. Plecas B, Popovic A, Jovovic D and Hristic M (1992) Mitotic activity and cell deletion in ventral prostate epithelium of intact and castrated oxytocintreated rats. J Endocrinol Invest 15,249-253.
99. Popovic A, Jovovic D and Hristic M (1982) The effect of oxytocin on anterior pituitary gonadotrophic function in male rats. Yugoslav Physiol Pharmacol Acta 18,95-106.
100. Popovic A, Plecas B, Milicevic Z, Hristic M and Jovovic D (1990) Stereologic analysis of ventral oxytocin treated rats. Arch Androl 24,247-253.
101. Rao VV, Loffler C, Battey J and Hansmann I (1992) The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization. Cytogenet Cell Genet 61,271-273.
102. Renaud LP and Bourque CW (1991) Neurophysiology and neuropharmacology of hypothalamic magnocellular neurons secreting vasopressin and oxytocin. Prog Neurobiol 36,131-169.
103. Rimoldi V, Reversi A, Taverna E, Rosa P, Francolini M, Cassoni P and Chini B (2003) Oxytocin receptor elicits different EGFR/MAPK activation patterns depending on its localization in caveolin-1 enriched domains. Oncogene 22,6054-6060.
104. Robinson AG (1987) The neurohypophysis: Recent developments. J Lab Clin Med 109,336-345.
105. Rolf C, Schepers A, Gassner P, Behre, HM and Nieschlag, E (2000) Oxytocin treatment prior to ICSI may prevent the necessity for testicular biopsy and testicular spermatozoa extraction (TESE) in azoospermic or severe oligozoospermic patients. Abstract of the 16th Annual meeting of the ESHRE, Bologna, Italy: 113.
106. Roosen-Runge EC (1951) Quantitative studies on spermatogenesis in the albino rat. II. The duration of spermatogenesis and some effects of colchicine. Am J Anat 88,163-176.
107. Sanborn BM, Dodge K, Monga M, Qian A, Wang W and Yue C (1998) Molecular mechanisms regulating the effects of oxytocin on myometrial intracellular calcium. Adv Exp Med Biol 449,277-286.
108. Sausville E, Carney D and Battey J (1985) The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line. J Biol Chem 260,10236-10241.
109. Sharpe RM and Cooper I (1987) Comparison of the effects on purified Leydig cells of four hormones (oxytocin, vasopressin, opiates and LHRH) with suggested paracrine roles in the testis. J Endocrinol 113,89-96.
110. Shibata Y, Ito K, Suzuki K, Nakano K, Fukabori Y, Suzuki R, Kawabe Y, Honma S and Yamanka H (2000) Changes in the endocrine environment of the human prostate transition zone with aging: Simultaneous quantitative analysis of prostatic steroids and comparison with human prostatic histological composition. Prostate 42,45-55.
111. Stoneham MD, Everitt BJ, Hansen S, Lightman SL and Todd K (1985) Oxytocin and sexual behaviour in the male rat and rabbit. J Endocrinol 107,97-106.
112. Studdard PW, Stein JL and Cosentino MJ (2002) The effects of oxytocin and arginine vasopressin in vitro on epididymal contractility in the rat. Int J Androl 25,65-71.
113. Tahri-Joutei A and Pointis G (1988) Time-related effects of arginine vasopressin on steroidogenesis in cultured mouse Leydig cells. J Reprod Fertil 82,247-254.
114. Uckert SBA, Ness BO, Stief CG, Scheller F, Knapp WH and Jonas U (2003) Oxytocin plasma levels in the systemic and cavernous blood of healthy males during different penile conditions. World J Urol 20,323-326.
115. Ungefroren H, Davidoff M and Ivell R (1994) Post transcriptional block in oxytocin gene expression within the seminiferous tubules of the bovine testis. J Endocrinol 140,63-72.
116. Uvnas-Moberg K, Hillegaart V, Alster P and Ahlenius S (1996) Effects of 5-HT agonists, selective for different receptor subtypes, on oxytocin, CCK, gastrin and somatostatin plasma levels in the rat. Neuropharmacology 35,1635-1640.
117. Veeramachaneni DN and Amann RP (1990) Oxytocin in the ovine ductuli efferentes and caput epididymis; immunolocalisation and endocytosis from luminal fluid. Endocrinology 126,1156-1164.
118. Vignozzi L, Filippi S, Luconi M, Morelli A, Mancina R, Marini M, Vannelli GB, Granchi S, Orlando C, Gelmini S et al. (2004) Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility. Endocrinology 145,1823-1834.
119. Vignozzi L, Morelli A, Mancina R, Marini M, Ferruzzi P, Crescioli C, Luconi M, Donati S, Fisher AD, Baldi E et al. (2005) Identification, characterization and biological activity of oxytocin receptor in the developing penis. Mol Hum Reprod 11,99-106.
120. Walch K (2001) The effect of single-dose oxytocin application on time to ejaculation and seminal parameters in men. J Assist Reprod Genet 18,655-659.
121. Whittington K, Assinder SJ, Parkinson T, Lapwood KR and Nicholson HD (2001) Function and localization of oxytocin receptors in the reproductive tissue of rams. Reproduction 122,317-325.
122. Whittington K, Assinder S, Gould M and Nicholson H (2004) Oxytocin, oxytocin associated neurophysin and the oxytocin receptor in human prostate. Cell Tissue Res 318,375-382.
123. Wilson JD (1982) The pathogenesis of benign prostatic hyperplasia. Am J Med 68,745-756.
124. Worley RT and Leendertz JA (1988) A videomicrographic low-frequency movement analyser (VLMA) and perifusion chamber for recording and analysis of the physical behaviour of seminiferous tubules and other contractile tissues in vitro. J Microsc 151(Pt 1),61-69.
125. Worley RTS, Nicholson HD and Pickering BT (1985) Testicular oxytocin: An initiator of seminiferous tubule movement? In Saez JM, Forest MG, Dazord A and Bertrand J (eds) Recent Progress in Cellular Endocrinology of the Testis, colloques de l'INSERM, Vol. 123. INSERM, Paris, pp. 205-212.
126. Yanagimoto M, Honda K, Goto Y and Negoro H (1996) Afferents originating from the dorsal penile nerve excite oxytocin cells in the hypothalamic paraventricular nucleus of the rat. Brain Res 733,292-296.
127. Zhang XH, Vignozzi L, Morelli A, Mancina R, Luconi M, Donati S, Marini M, Vannelli GB, Forti G and Maggi M (2005) Identification, localisation and functional in vitro and in vivo activity of oxytocin receptors in the rat penis. J Endocrinol 184,567-576.
128. Zimmerman EA, Robinson AG, Husain MK, Acosta M, Frantz AG and Sawyer WH (1974) Neurohypophysial peptides in the bovine hypothalamus: The relationship of neurophysin I to oxytocin, and neurophysin II to vasopressin in supraoptic and paraventricular regions. Endocrinology 95,931-936.