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Volumn 79, Issue 6, 2007, Pages 516-525

A post-transcriptional process contributes to efficient γ-globin gene silencing in definitive erythroid cells

Author keywords

Globin; mRNA stability; Post transcriptional regulation; Thalassemia

Indexed keywords

BETA GLOBIN; GAMMA GLOBIN; MESSENGER RNA;

EID: 36248989145     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2007.00970.x     Document Type: Article
Times cited : (12)

References (52)
  • 2
    • 30444432407 scopus 로고    scopus 로고
    • Regulation of human fetal hemoglobin: New players, new complexities
    • Bank A. Regulation of human fetal hemoglobin: new players, new complexities. Blood 2006 107 : 435 43.
    • (2006) Blood , vol.107 , pp. 435-43
    • Bank, A.1
  • 5
    • 0028918945 scopus 로고
    • Sequences located 3′ to the breakpoint of the hereditary persistence of fetal hemoglobin-3 deletion exhibit enhancer activity and can modify the developmental expression of the human fetal a gamma-globin gene in transgenic mice
    • Anagnou NP, Perez-Stable C, Gelinas R, Constantini F, Liapaki K, Constantopoulou M, Kosteas T, Moschonas NK, Stamatoyannopoulos G. Sequences located 3′ to the breakpoint of the hereditary persistence of fetal hemoglobin-3 deletion exhibit enhancer activity and can modify the developmental expression of the human fetal A gamma-globin gene in transgenic mice. J Biol Chem 1995 279 : 10256 63.
    • (1995) J Biol Chem , vol.279 , pp. 10256-63
    • Anagnou, N.P.1    Perez-Stable, C.2    Gelinas, R.3    Constantini, F.4    Liapaki, K.5    Constantopoulou, M.6    Kosteas, T.7    Moschonas, N.K.8    Stamatoyannopoulos, G.9
  • 6
    • 0007103565 scopus 로고
    • Increased Hb F in adult life
    • In: Higgs, D.R., Weatherall, D.J., eds. London: Balliere Tindall
    • Wood WG. Increased Hb F in adult life. In : Higgs DR, Weatherall DJ, eds. The hemoglobinopathies. London : Balliere Tindall, 1993.
    • (1993) The Hemoglobinopathies.
    • Wood, W.G.1
  • 7
    • 0142214623 scopus 로고    scopus 로고
    • Persistent [gamma]-globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences
    • Katsantoni EZ, Langeveld A, Wai AWK, Drabek D, Grosveld F, Anagnou NP, Strouboulis J. Persistent [gamma]-globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences. Blood 2003 102 : 3412 9.
    • (2003) Blood , vol.102 , pp. 3412-9
    • Katsantoni, E.Z.1    Langeveld, A.2    Wai, A.W.K.3    Drabek, D.4    Grosveld, F.5    Anagnou, N.P.6    Strouboulis, J.7
  • 8
    • 14944379039 scopus 로고    scopus 로고
    • The Corfu [delta][beta] thalassemia deletion disrupts [gamma]-globin gene silencing and reveals post-transcriptional retgulation of HbF expression
    • Chakalova L, Osborne CS, Dai Y-F, Goyenechea B, Metaxotou-Mavromati A, Kattamis A, Kattamis C, Fraser P. The Corfu [delta][beta] thalassemia deletion disrupts [gamma]-globin gene silencing and reveals post-transcriptional retgulation of HbF expression. Blood 2005 105 : 2154 60.
    • (2005) Blood , vol.105 , pp. 2154-60
    • Chakalova, L.1    Osborne, C.S.2    Dai, Y.-F.3    Goyenechea, B.4    Metaxotou-Mavromati, A.5    Kattamis, A.6    Kattamis, C.7    Fraser, P.8
  • 9
    • 0001046939 scopus 로고
    • Molecular genetics of thalassemia
    • In: Verma, R.S., ed. Greenwich: JAI Press
    • Russell JE, Liebhaber SA. Molecular genetics of thalassemia. In : Verma RS, ed. Advances in Genome Biology. Greenwich : JAI Press, 1993 : 283 353.
    • (1993) Advances in Genome Biology. , pp. 283-353
    • Russell, J.E.1    Liebhaber, S.A.2
  • 10
    • 0142260622 scopus 로고
    • Types of thalassemia-trait carriers as revealed by a study of their incidence in Greece
    • Malamos B, Fessas P, Stamatoyannopoulos G. Types of thalassemia-trait carriers as revealed by a study of their incidence in Greece. Br J Haemat 1962 8 : 5 14.
    • (1962) Br J Haemat , vol.8 , pp. 5-14
    • Malamos, B.1    Fessas, P.2    Stamatoyannopoulos, G.3
  • 11
    • 0015798180 scopus 로고
    • Haematological data in 312 cases of [beta]-thalassaemia trait in Thailand
    • Pootrakul P, Wasi P, Na-Nakorn S. Haematological data in 312 cases of [beta]-thalassaemia trait in Thailand. Br J Haemat 1973 24 : 703 12.
    • (1973) Br J Haemat , vol.24 , pp. 703-12
    • Pootrakul, P.1    Wasi, P.2    Na-Nakorn, S.3
  • 14
    • 0018764020 scopus 로고
    • [beta][zero] thalassemia: A nonsense mutation in man
    • Chang JC, Kan YW. [beta][zero] thalassemia: a nonsense mutation in man. Proc Natl Acad Sci USA 1979 76 : 2886 9.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 2886-9
    • Chang, J.C.1    Kan, Y.W.2
  • 16
    • 26544460603 scopus 로고    scopus 로고
    • Dynamic regulation of globin mRNA stability in [beta] thalassemia
    • abstr.).
    • Yu J, Russell JE. Dynamic regulation of globin mRNA stability in [beta] thalassemia. Blood 2000 96 : 561a (abstr.).
    • (2000) Blood , vol.96
    • Yu, J.1    Russell, J.E.2
  • 17
    • 0031033628 scopus 로고    scopus 로고
    • [alpha]-, [beta]-, and [gamma]-mRNA levels in [beta] thalassemia: Transcriptional and translational differences in heterozygotes, homozygotes, and compound heterozygotes
    • Smetanina N, Gu L-H, Simjanovska L, Momirovska A, Petkov G, Adekile A, Efremov G, Huisman T. [alpha]-, [beta]-, and [gamma]-mRNA levels in [beta] thalassemia: transcriptional and translational differences in heterozygotes, homozygotes, and compound heterozygotes. Hemoglobin 1997 21 : 27 39.
    • (1997) Hemoglobin , vol.21 , pp. 27-39
    • Smetanina, N.1    Gu, L.-H.2    Simjanovska, L.3    Momirovska, A.4    Petkov, G.5    Adekile, A.6    Efremov, G.7    Huisman, T.8
  • 18
    • 0034898553 scopus 로고    scopus 로고
    • Structural and functional analysis of an mRNP complex that mediates the high stability of human [beta]-globin mRNA
    • Yu J, Russell JE. Structural and functional analysis of an mRNP complex that mediates the high stability of human [beta]-globin mRNA. Mol Cell Biol 2001 21 : 5879 88.
    • (2001) Mol Cell Biol , vol.21 , pp. 5879-88
    • Yu, J.1    Russell, J.E.2
  • 19
    • 0030003151 scopus 로고    scopus 로고
    • Developmental silencing of the embryonic zeta-globin gene: Concerted action of the promoter and the 3′-flanking region combined with stage-specific silencing of the transcribed region
    • Liebhaber SA, Wang Z, Cash F, Monks B, Russell JE. Developmental silencing of the embryonic zeta-globin gene: concerted action of the promoter and the 3′-flanking region combined with stage-specific silencing of the transcribed region. Mol Cell Biol 1996 16 : 2637 46.
    • (1996) Mol Cell Biol , vol.16 , pp. 2637-46
    • Liebhaber, S.A.1    Wang, Z.2    Cash, F.3    Monks, B.4    Russell, J.E.5
  • 20
    • 0019345637 scopus 로고
    • Gel electrophoretic separation of globin chains
    • Alter BP. Gel electrophoretic separation of globin chains. Prog Clin Biol Res 1981 60 : 157 75.
    • (1981) Prog Clin Biol Res , vol.60 , pp. 157-75
    • Alter, B.P.1
  • 21
    • 0018189174 scopus 로고
    • Resolution of hemoglobin subunits by electrophoresis in acid urea polyacrylamide gels containing Triton X-100
    • Rovera G, Magarian C, Borun TW. Resolution of hemoglobin subunits by electrophoresis in acid urea polyacrylamide gels containing Triton X-100. Anal Biochem 1978 85 : 506 18.
    • (1978) Anal Biochem , vol.85 , pp. 506-18
    • Rovera, G.1    Magarian, C.2    Borun, T.W.3
  • 22
    • 0027938450 scopus 로고
    • Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy
    • Detloff PJ, Lewis J, John SW, Shehee WR, Langenbach R, Maeda N, Smithies O. Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy. Mol Cell Biol 1994 14 : 6936 43.
    • (1994) Mol Cell Biol , vol.14 , pp. 6936-43
    • Detloff, P.J.1    Lewis, J.2    John, S.W.3    Shehee, W.R.4    Langenbach, R.5    Maeda, N.6    Smithies, O.7
  • 23
    • 0031947553 scopus 로고    scopus 로고
    • Sequence divergence in the 3′UTRs of human zeta- and alpha-globin mRNA mediates a difference in their stabilities and contributes to efficient zeta-to-alpha gene developmental switching
    • Russell JE, Morales J, Makeyev A, Liebhaber SA. Sequence divergence in the 3′UTRs of human zeta- and alpha-globin mRNA mediates a difference in their stabilities and contributes to efficient zeta-to-alpha gene developmental switching. Mol Cell Biol 1998 18 : 2173 83.
    • (1998) Mol Cell Biol , vol.18 , pp. 2173-83
    • Russell, J.E.1    Morales, J.2    Makeyev, A.3    Liebhaber, S.A.4
  • 24
    • 0035989590 scopus 로고    scopus 로고
    • A 3′UTR mutation affects beta-globin expression without altering the stability of its fully processed mRNA
    • Bilenoglu O, Basak A, Russell JE. A 3′UTR mutation affects beta-globin expression without altering the stability of its fully processed mRNA. Br J Haemat 2002 119 : 1106 14.
    • (2002) Br J Haemat , vol.119 , pp. 1106-14
    • Bilenoglu, O.1    Basak, A.2    Russell, J.E.3
  • 25
    • 33846210354 scopus 로고    scopus 로고
    • Dynamic post-transcriptional regulation of [epsilon]-globin gene expression in vivo
    • He Z, Russell JE. Dynamic post-transcriptional regulation of [epsilon]-globin gene expression in vivo. Blood 2007 109 : 795 801.
    • (2007) Blood , vol.109 , pp. 795-801
    • He, Z.1    Russell, J.E.2
  • 26
    • 0030891730 scopus 로고    scopus 로고
    • Destabilization of human alpha-globin mRNA by translation anti-termination is controlled during erythroid terminal differentiation and paralleled by phased shortening of the poly(A) tail
    • Morales J, Russell JE, Liebhaber SA. Destabilization of human alpha-globin mRNA by translation anti-termination is controlled during erythroid terminal differentiation and paralleled by phased shortening of the poly(A) tail. J Biol Chem 1997 272 : 6607 13.
    • (1997) J Biol Chem , vol.272 , pp. 6607-13
    • Morales, J.1    Russell, J.E.2    Liebhaber, S.A.3
  • 27
    • 0024506821 scopus 로고
    • A dominant control region from human beta-globin locus conferring integration site-independent gene expression
    • Talbot D, Collis P, Antoniou M, Vidal M, Grosveld F, Greaves DR. A dominant control region from human beta-globin locus conferring integration site-independent gene expression. Nature 1989 33 : 352 5.
    • (1989) Nature , vol.33 , pp. 352-5
    • Talbot, D.1    Collis, P.2    Antoniou, M.3    Vidal, M.4    Grosveld, F.5    Greaves, D.R.6
  • 28
    • 0025891950 scopus 로고
    • Human gamma-globin genes silenced independently of other genes in the beta globin locus
    • Dillon N, Grosveld F. Human gamma-globin genes silenced independently of other genes in the beta globin locus. Nature 1991 350 : 252 4.
    • (1991) Nature , vol.350 , pp. 252-4
    • Dillon, N.1    Grosveld, F.2
  • 29
    • 0032213386 scopus 로고    scopus 로고
    • Reversal of lethal alpha- and beta-thalassemias in mice by expression of human embryonic globins
    • Russell JE, Liebhaber SA. Reversal of lethal alpha- and beta-thalassemias in mice by expression of human embryonic globins. Blood 1998 92 : 3057 63.
    • (1998) Blood , vol.92 , pp. 3057-63
    • Russell, J.E.1    Liebhaber, S.A.2
  • 30
    • 0018219299 scopus 로고
    • Competition of normal [beta] chains and sickle haemoglobin [beta] chains for [alpha] chains as a post-translational control mechanism
    • Shaeffer JR, Kingston RE, McDonald MJ, Bunn HF. Competition of normal [beta] chains and sickle haemoglobin [beta] chains for [alpha] chains as a post-translational control mechanism. Nature 1978 276 : 631 3.
    • (1978) Nature , vol.276 , pp. 631-3
    • Shaeffer, J.R.1    Kingston, R.E.2    McDonald, M.J.3    Bunn, H.F.4
  • 32
    • 0028148498 scopus 로고
    • Erythroid cell-specific determinants of alpha-globin mRNA stability
    • Weiss IM, Liebhaber SA. Erythroid cell-specific determinants of alpha-globin mRNA stability. Mol Cell Biol 1994 14 : 8123 32.
    • (1994) Mol Cell Biol , vol.14 , pp. 8123-32
    • Weiss, I.M.1    Liebhaber, S.A.2
  • 33
    • 0030006957 scopus 로고    scopus 로고
    • The stability of human beta-globin mRNA is dependent on structural determinants positioned within its 3′-untranslated region
    • Russell JE, Liebhaber SA. The stability of human beta-globin mRNA is dependent on structural determinants positioned within its 3′-untranslated region. Blood 1996 87 : 5314 23.
    • (1996) Blood , vol.87 , pp. 5314-23
    • Russell, J.E.1    Liebhaber, S.A.2
  • 34
    • 0028919677 scopus 로고
    • Erythroid cell-specific mRNA stability elements in the alpha(2)-globin 3′-nontranslated region
    • Weiss IM, Liebhaber SA. Erythroid cell-specific mRNA stability elements in the alpha(2)-globin 3′-nontranslated region. Mol Cell Biol 1995 15 : 2457 65.
    • (1995) Mol Cell Biol , vol.15 , pp. 2457-65
    • Weiss, I.M.1    Liebhaber, S.A.2
  • 35
    • 0028839055 scopus 로고
    • Detection and characterization of a 3′-untranslated region ribonucleoprotein complex associated with human alpha-globin mRNA stability
    • Wang X, Kiledjian M, Weiss IM, Liebhaber SA. Detection and characterization of a 3′-untranslated region ribonucleoprotein complex associated with human alpha-globin mRNA stability. Mol Cell Biol 1995 15 : 1769 77.
    • (1995) Mol Cell Biol , vol.15 , pp. 1769-77
    • Wang, X.1    Kiledjian, M.2    Weiss, I.M.3    Liebhaber, S.A.4
  • 36
    • 0029125496 scopus 로고
    • Identification of two KH domain proteins in the alpha-globin mRNP stability complex
    • Kiledjian M, Wang X, Liebhaber SA. Identification of two KH domain proteins in the alpha-globin mRNP stability complex. EMBO J 1995 14 : 4357 64.
    • (1995) EMBO J , vol.14 , pp. 4357-64
    • Kiledjian, M.1    Wang, X.2    Liebhaber, S.A.3
  • 37
    • 0019441903 scopus 로고
    • Differentiation of the mRNA transcripts originating from the alpha(1)- and alpha(2)-globin loci in normals and alpha thalassemics
    • Liebhaber SA, Kan YW. Differentiation of the mRNA transcripts originating from the alpha(1)- and alpha(2)-globin loci in normals and alpha thalassemics. J Clin Invest 1981 68 : 439 46.
    • (1981) J Clin Invest , vol.68 , pp. 439-46
    • Liebhaber, S.A.1    Kan, Y.W.2
  • 38
    • 0033066673 scopus 로고    scopus 로고
    • An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro
    • Wang Z, Day N, Trifillis P, Kiledjian M. An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro. Mol Cell Biol 1999 19 : 4552 60.
    • (1999) Mol Cell Biol , vol.19 , pp. 4552-60
    • Wang, Z.1    Day, N.2    Trifillis, P.3    Kiledjian, M.4
  • 39
    • 0033847384 scopus 로고    scopus 로고
    • The poly(A)-binding protein and an mRNA stability protein jointly regulate an endoribonuclease activity
    • Wang Z, Kiledjian M. The poly(A)-binding protein and an mRNA stability protein jointly regulate an endoribonuclease activity. Mol Cell Biol 2000 20 : 6334 41.
    • (2000) Mol Cell Biol , vol.20 , pp. 6334-41
    • Wang, Z.1    Kiledjian, M.2
  • 40
    • 0037315120 scopus 로고    scopus 로고
    • The KH-domain protein alpha CP has a direct role in the mRNA stabilization independent of its cognate binding site
    • Kong J, Ji X, Liebhaber SA. The KH-domain protein alpha CP has a direct role in the mRNA stabilization independent of its cognate binding site. Mol Cell Biol 2003 23 : 1125 34.
    • (2003) Mol Cell Biol , vol.23 , pp. 1125-34
    • Kong, J.1    Ji, X.2    Liebhaber, S.A.3
  • 41
    • 0029814694 scopus 로고    scopus 로고
    • Complementary change in cis determinants and trans factors in the evolution of an mRNP stability complex
    • Wang X, Liebhaber SA. Complementary change in cis determinants and trans factors in the evolution of an mRNP stability complex. EMBO J 1996 15 : 5040 51.
    • (1996) EMBO J , vol.15 , pp. 5040-51
    • Wang, X.1    Liebhaber, S.A.2
  • 42
    • 0033031221 scopus 로고    scopus 로고
    • Assembly of the alpha-globin mRNA stability complex reflects binary interaction between the pyrimidine-rich 3′-untranslated region determinant and poly(C) binding protein [alpha]CP
    • Chkheidze AN, Lyakhov DL, Makeyev AV, Morales J, Kong J, Liebhaber SA. Assembly of the alpha-globin mRNA stability complex reflects binary interaction between the pyrimidine-rich 3′-untranslated region determinant and poly(C) binding protein [alpha]CP. Mol Cell Biol 1999 19 : 4572 81.
    • (1999) Mol Cell Biol , vol.19 , pp. 4572-81
    • Chkheidze, A.N.1    Lyakhov, D.L.2    Makeyev, A.V.3    Morales, J.4    Kong, J.5    Liebhaber, S.A.6
  • 43
    • 33644750707 scopus 로고    scopus 로고
    • A nucleolin-binding 3′UTR element stabilizes [beta]-globin mRNA in vivo
    • Jiang Y, Xu X-S, Russell JE. A nucleolin-binding 3′UTR element stabilizes [beta]-globin mRNA in vivo. Mol Cell Biol 2006 26 : 2419 29.
    • (2006) Mol Cell Biol , vol.26 , pp. 2419-29
    • Jiang, Y.1    Xu, X.-S.2    Russell, J.E.3
  • 44
    • 0030630873 scopus 로고    scopus 로고
    • The role of globin mRNA stability in the control of globin gene expression
    • In: Moldave, K., ed. San Diego: Academic Press
    • Russell JE, Morales J, Liebhaber SA. The role of globin mRNA stability in the control of globin gene expression. In : Moldave K, ed. Progress in nucleic acids research and molecular biology. San Diego : Academic Press, 1997 : 259 87.
    • (1997) Progress in Nucleic Acids Research and Molecular Biology. , pp. 259-87
    • Russell, J.E.1    Morales, J.2    Liebhaber, S.A.3
  • 46
    • 0024380072 scopus 로고
    • Theta-, zeta-, and epsilon-globin messenger RNAs are expressed in adults
    • Albitar M, Pechle C, Liebhaber SA. Theta-, zeta-, and epsilon-globin messenger RNAs are expressed in adults. Blood 1989 74 : 629 37.
    • (1989) Blood , vol.74 , pp. 629-37
    • Albitar, M.1    Pechle, C.2    Liebhaber, S.A.3
  • 47
    • 0034879213 scopus 로고    scopus 로고
    • Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures
    • Lau ET, Kwok YK, Chui DH, Wong HS, Luo HY, Tang MH. Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures. Prenat Diagn 2001 21 : 529 39.
    • (2001) Prenat Diagn , vol.21 , pp. 529-39
    • Lau, E.T.1    Kwok, Y.K.2    Chui, D.H.3    Wong, H.S.4    Luo, H.Y.5    Tang, M.H.6
  • 48
    • 0026708201 scopus 로고
    • Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2
    • Dover GJ, Smith KD, Chang YC, Purvis S, Mays A, Meyers DA, Sheils C, Serjeant G. Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2. Blood 1992 80 : 816 24.
    • (1992) Blood , vol.80 , pp. 816-24
    • Dover, G.J.1    Smith, K.D.2    Chang, Y.C.3    Purvis, S.4    Mays, A.5    Meyers, D.A.6    Sheils, C.7    Serjeant, G.8
  • 50
  • 51
    • 0036181252 scopus 로고    scopus 로고
    • Evidence for genetic interaction between the beta-globin complex and chromosome 8q in the expression of fetal hemoglobin
    • Garner CP, Tatu T, Best S, Creary L, Thein SL. Evidence for genetic interaction between the beta-globin complex and chromosome 8q in the expression of fetal hemoglobin. Am J Hum Genet 2002 70 : 793 9.
    • (2002) Am J Hum Genet , vol.70 , pp. 793-9
    • Garner, C.P.1    Tatu, T.2    Best, S.3    Creary, L.4    Thein, S.L.5
  • 52
    • 4644344794 scopus 로고    scopus 로고
    • Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin
    • Garner C, Silver N, Best S, Menzel S, Martin C, Spector TD, Thein SL. Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin. Blood 2004 104 : 2184 6.
    • (2004) Blood , vol.104 , pp. 2184-6
    • Garner, C.1    Silver, N.2    Best, S.3    Menzel, S.4    Martin, C.5    Spector, T.D.6    Thein, S.L.7


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