The stability of human β-globin mRNA is dependent on structural determinants positioned within its 3′ untranslated region

Blood

Volumn 87, Issue 12, 1996, Pages 5314-5323

  Russell, J Eric ^a   Liebhaber, Stephen A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; MESSENGER RNA;

ANIMAL CELL; ARTICLE; ERYTHROID CELL; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA STRUCTURE; RNA TRANSLATION;

ANIMALS; BASE SEQUENCE; ERYTHROID PROGENITOR CELLS; GENE EXPRESSION REGULATION, LEUKEMIC; GLOBINS; HALF-LIFE; HUMANS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; RIBOSOMES; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030006957     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.12.5314.bloodjournal87125314     Document Type: Article

References (48)

1. Russell JE, Liebhaber SA: Molecular genetics of thalassemia, in Verma RS (ed): Advances in Genome Biology, vol 2. Greenwich, CT, JA1, 1993, p 283
2. Mignotte V, Wall L, deBoer E, Grosveld F, Romeo PH: Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene. Nucleic Acids Res 17:37, 1989
3. Ney PA, Sorrentino BP, McDonagh KT, Nienhuis AW: Tandem AP-1 binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells. Genes Dev 4:993, 1990
4. Yu CY, Chen J, Lin LI, Tam M, Shen CK: Cell type-specific protein-DNA interactions in the human zeta-globin upstream promoter region: Displacement of Sp1 by the erythroid cell-specific factor NF-E2. Mol Cell Biol 10:282, 1990
5. Zon LI, Tsai S-F, Burgess S, Matsudaira P, Burns GP, Orkin SH: The major human erythroid DNA binding protein (GF-1): Primary sequence and localization of the gene to the X-chromosome. Proc Natl Acad Sci USA 87:668, 1990
6. Chan JY, Han XL, Kan YW: Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. Proc Natl Acad Sci USA 90:11371, 1993
7. Miller IJ, Bicker JJ: A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol 13:2776, 1993
8. Moi P, Chan K, Asunis I, Cao A, Kan YW: Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci USA 91:9926, 1994
9. Sun C-W, Donze D, Farmer S, Ciavatta DJ, Townes TJ: Cloning and functional characterization of LCR-F1: A bzip transcription factor that activates erythroid-specific, human globin gene expression. Blood 84:218a, 1994 (abstr, suppl 1)
10. Tuan D, Solomon D, Li Q, London M: The β-like globin gene domain in human erythroid cells. Proc Natl Acad Sci USA 82:6384, 1985
11. Forrester WC, Thompson C, Elder JT, Groudine M: A developmentally stable chromatin structure in the human β-globin gene cluster. Proc Natl Acad Sci USA 83:1359, 1986
12. Higgs DR, Wood WG, Jarman AP, Sharpe J, Lida J, Pretorius I-M, Ayyub H: A major positive regulatory region located far upstream of the human alpha-globin gene locus. Genes Dev 4:1588, 1990
13. Aγ-globin gene. EMBO J 6:2997, 1987
14. Trudel M, Constantini F: A 3′ enhancer contributes to the stage-specific expression of the human β-globin gene. Genes Dev 1:954, 1987
15. Cao SX, Gutman PD, Dave HPG, Schechter AN: Identification of a transcriptional silencer in the 5′ flanking region of the human ε-globin gene. Proc Natl Acad Sci USA 86:5306, 1989
16. Ross J: Messenger RNA turnover in eucaryotic cells. Mol Biol Med 5:1, 1988
17. Hargrove JL, Schmidt FH: The role of mRNA and protein stability in gene expression. FASEB J 3:2360, 1989
18. Aviv H, Volloch Z, Bastos R, Levy S: Biosynthesis and stability of globin mRNA in erythroleukemia Friend cells. Cell 8:495, 1976
19. Lodish HF. Small B: Different lifetimes of reticulocyte messenger RNA. Cell 7:59, 1976
20. Bastos RN, Aviv H: Theoretical analysis of a model for globin messenger RNA accumulation during erythropoiesis. J Mol Biol 110:204, 1977
21. Ross J, Pizarro A: Human beta and delta globin messenger RNAs turn over at different rates. J Mol Biol 167:607, 1983
22. Krowczynska A, Yanofsky R, Brawerman G: Regulation of messenger RNA stability in mouse erythroleukemia cells. J Mol Biol 181:231, 1985
23. Ross J, Sullivan TD: Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes. Blood 66:1149, 1985
24. Kabnick KS, Housman D: Determinants that contribute to cyloplasmic stability of human c-fos and β-globin mRNAs are located at several sites in each mRNA. Mol Cell Biol 8:3244, 1988
25. Bastos RN, Volloch Z, Aviv H: Messenger RNA population analysis during erythroid differentiation: A kinetic approach. J Mol Biol 110:191, 1977
26. Liebhaher SA, Kan YW: Differentiation of the mRNA transcripts originating from the α1- and α2-globin loci in normals and α-thalassemics. J Clin Invest 68:439, 1981
27. Hunt DM, Higgs DR, Winichagoon P, Clegg JB, Weatherall DJ: Haemaglobin Constant Spring has an unstable a chain messenger RNA. Br J Haematol 51:405, 1982
28. Weiss IM, Liebhaber SA: Erythroid cell-specific determinants of α-globin mRNA stability. Mol Cell Biol 14:8123, 1994
29. Milner PF, Clegg JB, Weatherall DJ: Unique haemoglobin variant with an elongated α-chain. Lancet 1:729, 1971
30. Weiss IW, Liebhaber SA: Erythroid cell specific mRNA stability elements in the α2-globin 3′ nontranslating region. Mol Cell Biol 15:2457, 1995
31. Wang X, Kiledjian M, Weiss IM, Liebhaber SA: Detection and characterization of a 3′ untranslated region ribonucleoprotein complex associated with human α-globin mRNA stability. Mol Cell Biol 15:1769, 1995
32. Flatz G, Kinderlerer JL, Kilmantin JV, Lehmann H: Hemoglobin Tak: A variant with additional residues at the end of the β-chains. Lancet 1:732, 1971
33. Bunn HF, Schmidt GJ, Haney DN, Dluhy RG: Hemoglobin Cranston, an unstable variant having an elongated β-chain due to nonhomologous crossover between two normal β-chain genes. Proc Natl Acad Sci USA 72:3609, 1975
34. Delanoe-Garin J, Blouquit Y, Arous N, Kister J, Poyart C, North AL, Bardakjian J, Lacombe C, Rosa J, Galacteras F: Hb Saverne: A new variant with an elongated beta-chain: Structural and functional properties. Hemoglobin 12:337, 1988
35. 109LEU→ARG). Blood 76:2630, 1990
36. Tyr gene in mammalian cells. Nucleic Acids Res 10:4609, 1983
37. Liebhaber SA, Emery JG, Urbanek M, Wang X, Cooke NE: Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. Nucleic Acids Res 18:3871, 1990
38. Liebhaber SA, Cash FE, Shakin SH: Translationally associated helix-destabilizing activity in rabbit reticulocyte lysate. J Biol Chem 259:15597, 1984
39. Rovera G, Magarian C, Borun TW: Resolution of hemaglobin subunits by electrophoresis in acid urea polyacrylamide gels containing Triton X-100. Anal Biochem 85:506, 1978
40. Wisdom R, Lee W: The protein coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors. Genes Dev 5:232, 1991
41. Zandomini R, Weinmann R: Inhibitory effect of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on a protein kinase. J Biol Chem 259:14804, 1984
42. Butler ET, Chamberlin MJ: Bacteriophage SP6-specific RNA polymerase. I. Isolation and characterization of the enzyme. J Biol Chem 257:5772, 1982
43. Carter BZ, Malter JS: Regulation of mRNA stability and its relevance to disease. Lab Invest 65:610, 1991
44. Papayannopoulou T, Abkowitz J: Biology of erythropoiesis, erythroid differentiation, and maturation, in Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ (eds): Hematology: Basic Principles and Practice. New York, NY, Churchill Livingstone, 1991, p 252
45. Erslev AJ: Production of erythrocytes, in Williams WJ, Beutler E, Erslev AJ, Lichtman MA (eds): Hematology. New York, NY, McGraw-Hill, 1990, p 389
46. Goodman M, Weiss ML, Czelusniak J: Molecular evolution above the species level: Branching pattern, rates, and mechanisms. Systematic Zool 31:376, 1982
47. Pandy NB, Marzluff WF: The stem-loop structure at the end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability. Mol Cell Biol 7:4557, 1987
48. Mullner EW, Kuhn LC: A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm. Cell 53:815, 1988